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At least 181 records · Page 10

Determination of cardiac size from chest roentgenograms following Skylab missions

Decreased cardiothoracic transverse diameter ratios following Mercury, Gemini and Apollo space flights have been reported previously. To evaluate further changes in cardiac size, standard posteroanterior chest films in systole and diastole were obtained before flight and within a few hours after recovery on each of the Skylab astronauts. Postflight chest X-rays were visually compared to the preflight roentgenograms for possible changes in pulmonary vasculature, lung parenchyma, bony or soft tissue structures. From these roentgenograms the following measurements were obtained: cardiac and thoracic transverse diameters, cardiothoracic transverse diameter ratio, cardiac area from the product of both diagonal diameters, cardiac silhouette area by planimetry, thoracic cage area and cardiothoracic area ratio. The postflight frontal cardiac silhouette sizes were significantly decreased when compared with the respective preflight values (P0.05 or 0.01). The observed changes are thought to be related to postflight decrease in the intracardiac chamber volume.

Nicogossian, A. E.↗

Zone-forming fungi experiment MA-147

Streptomyces levoris was used as an experimental microorganism during the Apollo Soyuz Test Project to study specific biological considerations that may be influenced by space flight factors. Preflight, inflight, and postflight growth rates of the cultures were compared by photographing the specimens at regular intervals. Preliminary results based on visual comparison of the photographic data indicate that an increased growth rate occurred during space flight in two of eight flight specimens. The increased growth rate continued in the two specimens during the postflight period until termination of the experiment. Radiation effects may be responsible for the absence of spores in two areas of the last spore ring that was formed during the inflight period in one of the flight cultures; however, the radiation studies related to this experiment have not been completed. Distinct morphological differences in spore rings were observed when postflight spore rings were compared with inflight spore rings. Factors that are related to space flight recovery and reentry into earth gravity may have effected these alterations.

Rogers, T. D.↗

Lower body negative pressure - The second manned Skylab mission

Results of orthostatic evaluations of the crew of Skylab 3 with lower body negative pressure (LBNP) stress tests during their 59-d mission are reported. Except for an inflight increase (rather than a decrease) in resting heart rates, results were essentially parallel to those observed in crewmen of the shorter Skylab 2 mission. Exaggerated elevations in heart rate and decreases in pulse pressure during LBNP stress inflight and immediately postflight corresponded to lowered orthostatic tolerance. Large decrements is resting calf size inflight and in total leg volume postflight indicated significant headward fluid shifts as had already been seen in the Skylab 2 crewmen. In addition, decreases in calf circumference gave no certain indication of a plateau over the 59 d inflight. Percentage volume increase in calf size during LBNP stress inflight was greater than those in either preflight or postflight tests.

Johnson, R. L.↗

Determination of cardiac size following space missions of different durations - The second manned Skylab mission

A simple method to estimate cardiac size from single frontal plane chest roentgenograms has been described. Pre- and postflight chest X-rays from Apollo 17, and Skylab 2 and 3 have been analyzed for changes in the cardiac silhouette size. The data obtained from the computed cardiothoracic areal ratios compared well with the clinical cardiothoracic diametral ratios (r = .86). Though an overall postflight decrease in cardiac size is evident, the mean difference was not statistically significant (n = 8). The individual decreases in the cardiac silhouette size postflight are thought to be due to decrements in intracardiac chamber volumes rather than in myocardial muscle mass.

Nicogossian, A.↗

Measurement of a single tendon reflex in conjunction with a myogram - The second manned Skylab mission

A generalized hyperreflexia was observed in Skylab 2 crew members immediately postflight. Duration of the Achilles reflex was significantly shortened. Further shortening was observed on the fourth day after recovery. At the 16th and 29th postrecovery days a lengthening of the reflex was observed in two of the three crew members. The muscle potential intervals were shortened immediately postflight and remained shortened throughout the 29 day postflight evaluation period.

Baker, J. T.↗

The Apollo-Soyuz Test Project: Medical report

The results of the clinical aspects as well as the preflight and postflight research studies that were performed on the astronauts are presented. Because of the compromised postflight crew health status, not all postflight research procedures could be accomplished. This compromise was the result of the anomalous entrance of toxic gas into the spacecraft cabin during the earth landing sequence. Despite the exposure, the medical data collected are of sufficient interest to warrant inclusion in this official ASTP Medical Report.

Nicogossian, A. E.↗

Evaluation of the electromechanical properties of the cardiovascular system after prolonged weightlessness

Devices and techniques for measuring and analyzing systolic time intervals and quantitative phonocardiograms were initiated during Apollo 17. The data show that the systolic time interval from Apollo 17 crewmen remained elevated longer postflight than the response criteria of heart rate, blood pressure, and percent change in leg volume all of which had returned to preflight levels by the second day postflight. Although the systolic time interval values were only slightly outside the preflight fiducial limits, this finding suggested that: the analysis of systolic time intervals may help to identify the mechanisms of postflight orthostatic intolerance by virtue of measuring ventricular function more directly and, the noninvasive technique may prove useful in determining the extent and duration of cardiovascular instability after long duration space flight. The systolic time intervals obtained on the Apollo 17 crewmen during lower body negative pressure were similar to those noted in patients with significant heart disease.

Bergman, S. A., Jr.↗

Investigation of the effect of space flight factors on chromosomes in seeds

Frequency of mutations in postflight air-dry Crepis capillaris seeds, kept for five days aboard an artificial satellite was 36.0 + or - 1.9%, vs. 19.01 + or - 1.2% for seeds in a similar ground experiment. Both groups of seeds were prepared in identical concentrations and were treated by the same mutagen. The spectrum of mutations in postflight Crepis capillaris seeds contained a large number of chromosome-type mutations and some cells showed multiple alterations. Postflight seeds not treated with mutagens had a slightly higher level of mutability.

Dubinina, L. G.↗

STS-1 orbital trajectory reconstruction using unmodelled acceleration estimation

A postflight trajectory reconstruction and analysis were conducted in order to determine the effects of unmodeled thrusting on the Space Shuttle Orbiter, to generate representative thrusting uncertainties for input to error analyses, and to evaluate the accuracy of the Ancillary trajectory data product and real-time vectors. The methods of selecting appropriate data arcs, time placement of compensation forces, limitations of the orbit determination process, and methods of evaluating solutions obtained from various force combinations are presented. It is shown that the estimation of forces to compensate for uncoupled attitude maneuvers and attitude hold maintenance thrusting significantly improves the postflight reconstruction of Space Shuttle Orbiter trajectories. A reduction of measurement residual statistics due to dynamic model uncertainties yields improved accuracy for postflight orbit determination.

Lacarna, R. J.↗

LDEF thermal measurements system (P0003)

Many of the passive experiments flying on LDEF will be significantly enhanced if data are available postflight to indicate the temperature time histories of test materials and other specimens exposed in the experiments. The baseline LDEF approach was to provide postflight calculated temperature histories of experiment boundaries and solar flux data for the mission, which can in turn be used by each investigator to calculate the temperature time histories for critical experiment components. Without in-flight temperature measurements, a substantial uncertainty will exist in the calculated temperatures. The data measured by the themal measurement system (THERM) will significantly improve postflight knowledge of temperatures experienced by LDEF experiments. The THERM data will also be valuable in validating the LDEF thermal design concept and in providing better design data for experimenters on future LDEF missions. The objectives of this experiment are to determine the history of the interior average temperatures of the LDEF for the total orbital mission and to measure the temperatures of selected components and thermal boundary conditions.

Robert F. Greene, Jr.↗

Capture and real-time display of selected Space Shuttle reentry data

Because the flight planning for the orbital flight test (OFT) flights of the NASA Space Shuttle required several months, there was very little time to analyze data from one flight before it was necessary to start final planning for the next flight. Real-time and selected immediate postflight data display of the reentry data minimized the postflight computer analysis time required so that the rigid time restraints imposed by the program could be met. This paper describes the methods used to decommutate and provide real-time and immediate postflight data display of selected Space Shuttle reentry data.

Chiles, H. R.↗

Otolith tilt-translation reinterpretation following prolonged weightlessness - Implications for preflight training

Observations with three astronauts yielded two major findings. First, perceived self-motion during sinusoidal roll differed immediately postflight from preflight. Between 70 and 150 min after landing, roll was perceived primarily as linear translation. Secondly, more horizontal eye movement was elicited by roll simulation immediately postflight relative to both preflight and later postflight observations. These results support an 'otolith tilt-translation reinterpretation' hypothesis, which has clear implications for understanding astronaut reports of space motion sickness during the early period of orbital flight. A proposal for 'prophylactic adaptation training' which may provide preflight adaptation to weightlessness, derives from this reearch.

Parker, D. E.↗

Research opportunities on immunocompetence in space

The most significant of the available data on the effects of space flight on immunocompetences and the potential operational and clinical significance of reported changes are as follows: (1) reduced postflight blastogenic response of peripheral lymphocytes from space crew members; (2) postflight neutrophilia persisting up to 7 days; (3) gingival inflammation of the Skylab astronauts; (4) postflight lymphocytopenia, eosinopenia, and monocytopenia; (5) modifications and shifts in the microflora of space crews and spacecraft; and (6) microbial contamination of cabin air and drinking water. These responses and data disclose numerous gaps in the knowledge that is essential for an adequate understanding of space-related changes in immunocompetence.

Beisel, W. R.↗

The human cardiovascular system in the absence of gravity

The data collected from a Space Shuttle crew to investigate cardiovascular changes due to microgravity are presented. The experimental procedures which involved preflight, immediate postflight, and one week following postflight echocardiograms of 13 individuals are described. The immediate postflight results reveal a 20 percent decrease in stroke volume, a 16 percent decrease in left ventricular diastolic volume index (LVDVI), no change in systolic volume, blood pressure, or cardiac index, and a 24 percent increase in heart rate. One week later a 17 percent stroke volume increase, a 29 percent increase in cardiac index, and normal blood pressure, and LVDVI were observed. It is concluded that upon reexposure to gravity a readaptation process for the cardiovascular system occurs.

Bungo, M. W.↗

Fluid shifts in weightlessness

Studies of leg volumes in space by multiple girth measurements showed reductions of 1.9 l (12.8 percent of leg volume), with 1.1 l from the nondominant leg, on Skylab 4. On landing, 65 percent of postflight leg volume increase was complete at 1.5 h. Measurement of the dominant leg during the equivalent period on Shuttle showed a mean loss of 0.9 l which was 90-percent complete at 150 min. Postflight increases were 87-percent complete at 1.5 h postlanding. Mass measurements during and after Skylab 4 showed a loss of 2.5 kg over the first 4 d on orbit, with a gain of 2.7 kg over the first 4 d of recovery. These changes are assumed to be tissue fluids secondary to changes in hydrostatic pressures and are much greater than those seen in bed rest. Rate and magnitude of inflight and postflight changes have significant operational impact.

Thornton, William E.↗

Cholesterol in serum lipoprotein fractions after spaceflight

Results are reported from blood-lipid measurements obtained from 125 Space Shuttle crew members before and after space flight. The data are presented in tables and discussed in detail. The main differences noted between preflight and postflight values are a 12.8-percent decrease in high-density lipoproteins on postflight day 1 and significant decreases in total cholesterol and both high- and low-density lipoproteins later in the 23-day postflight period.

Leach, Carolyn S.↗

The US Experiments Flown on the Soviet Biosatellite Cosmos 1887

Cosmos 1887, a biosatellite containing biological and radiation experiments from the Soviet Union, the United States and seven other countries, was launched on September 29, 1987. One Rhesus monkey's feeder stopped working two days into the flight and a decision was made to terminate the mission after 12 1/2 days. The biosatellite returned to Earth on October 12, 1987. A system malfunction, during the reentry procedure, caused the Cosmos 1887 spacecraft to land approximately 1800 miles beyond the intended landing site and delayed the start of the postflight procedures by approximately 44 hours. Further information on the conditions at landing and postflight activities is included in the Mission Operations portion of this document. U.S. and U.S.S.R. specialists jointly conducted 26 experiments on this mission, including the postflight transfer of data, hardware and biosamples to the U.S.

Connolly, James P.↗

Use of the Long Duration Exposure Facility's thermal measurement system for the verification of thermal models

Results are presented of the comparison between the Long Duration Exposure Facility (LDEF) Thermal Measurements Systems (THERM) recorded temperature data and the predicted values as calculated prior to the LDEF deployment. The postflight thermal model was verified and calculated temperature uncertainties were reduced to under + or - 18 F from the preflight uncertainties of + or - 40 F. The THERM consisted of 8 temperature sensors, a shared tape recorder, a standard LDEF flight battery, and an electronics control box. The temperatures were measured at selected locations on the LDEF structure interior during the first 490 days of flight and recorded for postflight analysis. After the recorder was recovered from space, the tape recorder was recovered and the data reduced for comparison to the LDEF predicted temperatures. By comparing the calculated values to the measured data, a verified thermal model that presents the best agreement with the THERM data was obtained. The THERM experiment provided an economical way of performing a postflight verification of the LDEF Thermal Model by recording a limited number of flight temperatures on typical locations of the LDEF structure.

Berrios, William M.↗