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At least 181 records · Page 10

Persistence of Space Radiation Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts

Cytogenetic damage in astronaut's peripheral blood lymphocytes is a useful in vivo marker of space radiation induced damage. Moreover, if radiation induced chromosome translocations persist in peripheral blood lymphocytes for many years, as has been assumed, they could potentially be used to measure retrospective doses or prolonged low dose rate exposures. However, as more data becomes available, evidence suggests that the yield of translocations may decline with time after exposure, at least in the case of space radiation exposures. We present our latest follow-up measurements of chromosome aberrations in astronauts blood lymphocytes assessed by FISH painting and collected a various times beginning directly after return from space to several years after flight. For most individuals the analysis of individual time-courses for translocations revealed a temporal decline of yields with different half-lives. Since the level of stable aberrations depends on the interplay between natural loss of circulating T-lymphocytes and replenishment from the stem or progenitor cells, the differences in the rates of decay could be explained by inter-individual variation in lymphocyte turn over. Biodosimetry estimates derived from cytogenetic analysis of samples collected a few days after return to earth lie within the range expected from physical dosimetry. However, a temporal decline in yields may indicate complications with the use of stable aberrations for retrospective dose reconstruction, and the differences in the decay time may reflect individual variability in risk from space radiation exposure. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from one crewmember who has participated in two separate long-duration space missions and has been followed up for over 10 years provides limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.

George, Kerry↗

Presence Personalization and Persistence: A New Approach to Building Archives to Support Collaborative Research

We discuss approaches to building archives that support the way most science is done. Today research is done in formal teams and informal groups. However our on-line services are designed to work with a single user. We have begun prototyping a new approach to building archives in which support for collaborative research is built in from the start. We organize the discussion along three elements that we believe to be necessary for effective support: We must enable user presence in the archive environment; users must be able to interact. Users must be able to personalize the environment, adding data and capabilities useful to themselves and their team. These changes must be persistent: subsequent sessions must be able to build upon previous sessions. In building the archive we see the large multi-player interactive games as a paradigm of how this approach can work. These three 'P's are essential in gaming as well and we shall use insights from the gaming world and virtual reality systems like Second Life in our prototype.

McGlynn, Thomas A.↗

Basic Diagnosis and Prediction of Persistent Contrail Occurrence using High-resolution Numerical Weather Analyses/Forecasts and Logistic Regression. Part I: Effects of Random Error

Straightforward application of the Schmidt-Appleman contrail formation criteria to diagnose persistent contrail occurrence from numerical weather prediction data is hindered by significant bias errors in the upper tropospheric humidity. Logistic models of contrail occurrence have been proposed to overcome this problem, but basic questions remain about how random measurement error may affect their accuracy. A set of 5000 synthetic contrail observations is created to study the effects of random error in these probabilistic models. The simulated observations are based on distributions of temperature, humidity, and vertical velocity derived from Advanced Regional Prediction System (ARPS) weather analyses. The logistic models created from the simulated observations were evaluated using two common statistical measures of model accuracy, the percent correct (PC) and the Hanssen-Kuipers discriminant (HKD). To convert the probabilistic results of the logistic models into a dichotomous yes/no choice suitable for the statistical measures, two critical probability thresholds are considered. The HKD scores are higher when the climatological frequency of contrail occurrence is used as the critical threshold, while the PC scores are higher when the critical probability threshold is 0.5. For both thresholds, typical random errors in temperature, relative humidity, and vertical velocity are found to be small enough to allow for accurate logistic models of contrail occurrence. The accuracy of the models developed from synthetic data is over 85 percent for both the prediction of contrail occurrence and non-occurrence, although in practice, larger errors would be anticipated.

Duda, David P.↗

An Fe XXVI Absorption Line in the Persistent Spectrum of the Dipping Low Mass X-ray Binary 1A 1744-361

We report on Chandra X-ray Observatory (CXO) High-Energy Transmission Grating (HETG) spectra of the dipping Low Mass X-ray Binary (LMXB) 1A 1744-361 during its July 2008 outburst. We find that its persistent emission is well modeled by a blackbody (kT approx. 1.0 keV) plus power-law (Gamma approx. 1.7) with an absorption edge at 7.6 keV. In the residuals of the combined spectrum we find a significant absorption line at 6.961+/-0.002 keV, consistent with the Fe XXVI (hydrogen-like Fe) 2 - 1 transition. We place an upper limit on the velocity of a redshifted flow of v < 221 km/s. We find an equivalent width for the line of 27+2/-3 eV, from which we determine a column density of 7+/-1 x 10(exp 17)/sq cm via a curve-of-growth analysis. Using XSTAR simulations, we place a lower limit on the ionization parameter of > 10(exp 3.6) erg cm/s. The properties of this line are consistent with those observed in other dipping LMXBs. Using Rossi X-ray Timing Explorer (RXTE) data accumulated during this latest outburst we present an updated color-color diagram which clearly shows that IA 1744-361 is an "atoll" source. Finally, using additional dips found in the RXTE and CXO data we provide an updated orbital period estimate of 52+/-5 minutes.

Gavriil, Fotis P.↗

Monitoring Coastal Marshes for Persistent Saltwater Intrusion

Primary goal: Provide resource managers with remote sensing products that support ecosystem forecasting models requiring salinity and inundation data. Work supports the habitat-switching modules in the Coastal Louisiana Ecosystem Assessment and Restoration (CLEAR) model, which provides scientific evaluation for restoration management (Visser et al., 2008). Ongoing work to validate flooding with radar (NWRC/USGS) and enhance persistence estimates through "fusion" of MODIS and Landsat time series (ROSES A.28 Gulf of Mexico). Additional work will also investigate relationship between saltwater dielectric constant and radar returns (Radarsat) (ROSES A.28 Gulf of Mexico).

Kalcic, Maria↗

Monitoring Coastal Marshes for Persistent Flooding and Salinity Stress

Our objective is to provide NASA remote sensing products that provide inundation and salinity information on an ecosystem level to support habitat switching models. Project born out of need by the Coastal Restoration Monitoring System (CRMS), joint effort by Louisiana Department of Natural Resources and the U.S. Geological Survey, for information on persistence of flooding by storm surge and other flood waters. The results of the this work support the habitat-switching modules in the Coastal Louisiana Ecosystem Assessment and Restoration (CLEAR) model, which provides scientific evaluation for restoration management. CLEAR is a collaborative effort between the Louisiana Board of Regents, the Louisiana Department of Natural Resources (LDNR), the U.S. Geological Survey (USGS), and the U.S. Army Corps of Engineers (USACE). Anticipated results will use: a) Resolution enhanced time series data combining spatial resolution of Landsat with temporal resolution of MODIS for inundation estimates. b) Potential salinity products from radar and multispectral modeling. c) Combined inundation and salinity inputs to habitat switching module to produce habitat switching maps (shown at left)

Kalcic, Maria↗

Persistent Longitudinal Variations of Plasma Density and DC Electric Fields in the Low Latitude Ionosphere Observed with Probes on the C/NOFS Satellite

Continuous measurements using in situ probes on consecutive orbits of the C/N0FS satellite reveal that the plasma density is persistently organized by longitude, in both day and night conditions and at all locations within the satellite orbit, defined by its perigee and apogee of 401 km and 867 km, respectively, and its inclination of 13 degrees. Typical variations are a factor of 2 or 3 compared to mean values. Furthermore, simultaneous observations of DC electric fields and their associated E x B drifts in the low latitude ionosphere also reveal that their amplitudes are also strongly organized by longitude in a similar fashion. The drift variations with longitude are particularly pronounced in the meridional component perpendicular to the magnetic field although they are also present in the zonal component as well. The longitudes of the peak meridional drift and density values are significantly out of phase with respect to each other. Time constants for the plasma accumulation at higher altitudes with respect to the vertical drift velocity must be taken into account in order to properly interpret the detailed comparisons of the phase relationship of the plasma density and plasma velocity variations. Although for a given period corresponding to that of several days, typically one longitude region dominates the structuring of the plasma density and plasma drift data, there is also evidence for variations organized about multiple longitudes at the same time. Statistical averages will be shown that suggest a tidal "wave 4" structuring is present in both the plasma drift and plasma density data. We interpret the apparent association of the modulation of the E x B drifts with longitude as well as that of the ambient plasma density as a manifestation of tidal forces at work in the low latitude upper atmosphere. The observations demonstrate how the high duty cycle of the C/NOFS observations and its unique orbit expose fundamental processes at work in the low latitude, inner regions of geospace.

Pfaff, R.↗

The Long Range Persistence of Wakes Behind a Row of Roughness Elements

We consider a periodic array of relatively small roughness elements whose spanwise separation is of the order of the local boundary-layer thickness and construct a local asymptotic high-Reynolds-number solution that is valid in the vicinity of the roughness. The resulting flow decays on the very short streamwise length scale of the roughness, but the solution eventually becomes invalid at large downstream distances and a new solution has to be constructed in the downstream region. This latter result shows that the roughness-generated wakes can persist over very long streamwise distances, which are much longer than the distance between the roughness elements and the leading edge. Detailed numerical results are given for the far wake structure.

Goldstein, M. E.↗

Atmospheric Circulation Anomalies During Two Persistent North American Droughts: 1932-1939 and 1948-1957

We use an early twentieth century (1908-1958) atmospheric reanalysis, based on assimilation of surface and sea level pressure observations, to contrast atmospheric circulation during two periods of persistent drought in North America: 1932-1939 (the Dust Bowl) and 1948-1957. Primary forcing for both droughts is believed to come from anomalous sea surface temperatures (SSTs): a warm Atlantic and a cool eastern tropical Pacific. For boreal winter (October-March) in the 1950s, a stationary wave pattern originating from the tropical Pacific is present, with positive centers over the north Pacific and north Atlantic ocean basins and a negative center positioned over northwest North America and the tropical/subtropical Pacific. This wave train is largely absent for the 1930s drought; boreal winter height anomalies are organized much more zonally, with positive heights extending across northern North America. For boreal summer (April-September) during the 1930s, a strong upper level ridge is centered over the Great Plains; this feature is absent during the 1950s and appears to be linked to a weakening of the Great Plains low-level jet (GPLLJ). Subsidence anomalies are co-located over the centers of each drought: in the central Great Plains for the 1930s and in a band extending from the southwest to the southeastern United States for the 1950s. The location and intensity of this subsidence during the 1948-1957 drought is a typical response to a cold eastern tropical Pacific, but for 1932-1939 deviates in terms of the expected intensity, location, and spatial extent. Overall, circulation anomalies during the 1950s drought appear consistent with the expected response to the observed SST forcing. This is not the case for the 1930s, implying some other causal factor may be needed to explain the Dust Bowl drought anomalies. In addition to SST forcing, the 1930s were also characterized by massive alterations to the land surface, including regional-scale devegetation from crop failures and intensive wind erosion and dust storms. Incorporation of these land surface factors into a general circulation model greatly improves the simulation of precipitation and subsidence anomalies during this drought, relative to simulations with SST forcing alone. Even with additional forcing from the land surface, however, the model still has difficulty reproducing some of the other circulation anomalies, including weakening of the GPLLJ and strengthening of the upper level ridge during AMJJAS. This may be due to either weaknesses in the model or uncertainties in the boundary condition estimates. Still, analysis of the circulation anomalies supports the conclusion of an earlier paper (Cook et al. in Proc Natl Acad Sci 106:4997, 2009), demonstrating that land degradation factors are consistent with the anomalous nature of the Dust Bowl drought.

Cook, Benjamin↗

Directional Limits on Persistent Gravitational Waves Using LIGO S5 Science Data

The gravitational-wave (GW) sky may include nearby pointlike sources as well as astrophysical and cosmological stochastic backgrounds. Since the relative strength and angular distribution of the many possible sources of GWs are not well constrained, searches for GW signals must be performed in a model-independent way. To that end we perform two directional searches for persistent GWs using data from the LIGO S5 science run: one optimized for pointlike sources and one for arbitrary extended sources. The latter result is the first of its kind. Finding no evidence to support the detection of GWs, we present 90% confidence level (CL) upper-limit maps of GW strain power with typical values between 2 - 20 X 10 (exp -50) strain2Hz(exp -1) and 5 - 35 X 10 (exp -49) strain2Hz(exp -1)/sr for pointlike and extended sources respectively. The limits on pointlike sources constitute a factor of 30 improvement over the previous best limits. We also set 90% CL limits on the narrow-band root-mean-square GW strain from interesting targets including Sco X-1, SN1987A and the Galactic Center as low as approximately equal 7 X 10(exp -25) in the most sensitive frequency range near 160Hz. These limits are the most constraining to date and constitute a factor of 5 improvement over the previous best limits.

Abadie, J.↗

3D Normal Human Neural Progenitor Tissue-Like Assemblies: A Model of Persistent VZV Infection

Varicella-zoster virus (VZV) is a neurotropic human alphaherpesvirus that causes varicella upon primary infection, establishes latency in multiple ganglionic neurons, and can reactivate to cause zoster. Live attenuated VZV vaccines are available; however, they can also establish latent infections and reactivate. Studies of VZV latency have been limited to the analyses of human ganglia removed at autopsy, as the virus is strictly a human pathogen. Recently, terminally differentiated human neurons have received much attention as a means to study the interaction between VZV and human neurons; however, the short life-span of these cells in culture has limited their application. Herein, we describe the construction of a model of normal human neural progenitor cells (NHNP) in tissue-like assemblies (TLAs), which can be successfully maintained for at least 180 days in three-dimensional (3D) culture, and exhibit an expression profile similar to that of human trigeminal ganglia. Infection of NHNP TLAs with cell-free VZV resulted in a persistent infection that was maintained for three months, during which the virus genome remained stable. Immediate-early, early and late VZV genes were transcribed, and low-levels of infectious VZV were recurrently detected in the culture supernatant. Our data suggest that NHNP TLAs are an effective system to investigate long-term interactions of VZV with complex assemblies of human neuronal cells.

Goodwin, Thomas J.↗

An Fe XXIV Absorption Line in the Persistent Spectrum of the Dipping Low-Mass X-Ray Binary 1A 1744-361

We report on Chandra X-ray Observatory (Chandra) High Energy Transmission Grating spectra of the dipping low-mass X-ray binary 1A 1744−361 during its 2008 July outburst. We find that its persistent emission is well modeled by a blackbody (kT approx. 1.0 keV) plus power law (Gamma approx. 1.7) with an absorption edge. In the residuals of the combined spectrum, we find a significant absorption line at 6.961 +/- 0.002 keV, consistent with the Fe xxvi (hydrogen-like Fe) 2-1 transition.We place an upper limit on the velocity of a redshifted flow of nu < 221 km/s. We find an equivalent width for the line of 27+2/−3 eV, from which we determine a column density of (7 +/- 1)×10(exp 17) /sq. cm via a curve-of-growth analysis. Using XSTAR simulations, we place a lower limit on the ionization parameter of >103.6 erg cm/s. We discuss what implications the feature has on the system and its geometry. We also present Rossi X-ray Timing Explorer data accumulated during this latest outburst and, via an updated color-color diagram, clearly show that 1A 1744−361 is an "atoll" source

stars↗

Evolving Systems: Nonlinear Adaptive Key Component Control with Persistent Disturbance Rejection

This paper presents an introduction to Evolving Systems, which are autonomously controlled subsystems that self-assemble into a new Evolved System with a higher purpose. Evolving Systems of aerospace structures often require additional control when assembling to maintain stability during the entire evolution process. This is the concept of Adaptive Key Component Control which operates through one specific component to maintain stability during the evolution. In addition this control must overcome persistent disturbances that occur while the evolution is in progress. We present theoretical results for the successful operation of Nonlinear Adaptive Key Component control in the presence of such disturbances and an illustrative example.

adaptive control↗

Persistent Doppler Shift Oscillations Observed with HINODE-EIS in the Solar Corona: Spectroscopic Signatures of Alfvenic Waves and Recurring Upflows

Using data obtained by the EUV Imaging Spectrometer on board Hinode, we have performed a survey of obvious and persistent (without significant damping) Doppler shift oscillations in the corona. We have found mainly two types of oscillations from February to April in 2007. One type is found at loop footpoint regions, with a dominant period around 10 minutes. They are characterized by coherent behavior of all line parameters (line intensity, Doppler shift, line width, and profile asymmetry), and apparent blueshift and blueward asymmetry throughout almost the entire duration. Such oscillations are likely to be signatures of quasi-periodic upflows (small-scale jets, or coronal counterpart of type-II spicules), which may play an important role in the supply of mass and energy to the hot corona. The other type of oscillation is usually associated with the upper part of loops. They are most clearly seen in the Doppler shift of coronal lines with formation temperatures between one and two million degrees. The global wavelets of these oscillations usually peak sharply around a period in the range of three to six minutes. No obvious profile asymmetry is found and the variation of the line width is typically very small. The intensity variation is often less than 2%. These oscillations are more likely to be signatures of kink/Alfv´en waves rather than flows. In a few cases, there seems to be a π/2 phase shift between the intensity and Doppler shift oscillations, which may suggest the presence of slow-mode standing waves according to wave theories. However, we demonstrate that such a phase shift could also be produced by loops moving into and out of a spatial pixel as a result of Alfv´enic oscillations. In this scenario, the intensity oscillations associated with Alfv´enic waves are caused by loop displacement rather than density change. These coronal waves may be used to investigate properties of the coronal plasma and magnetic field.

Solar Corona↗

Persistent Expression Changes of Fibrosis-Related Genes in the Lung Tissues of Rats Exposed to Lunar Dust Particles

The Moon's surface is covered by a layer of fine, potential reactive dust. Lunar dust contain about 1‐2% of very fine respirable dust (less than 3 micrometers). The habitable area of any lunar landing vehicle and outpost would inevitably be contaminated with lunar dust that could pose a health risk. The purpose of the study is to evaluate the toxicity of Apollo moon dust in rodents to assess the health risk of dust exposures to humans. One of the particular interests in the study is to evaluate dust‐induced changes of the expression of fibrosis‐related genes, and to identify specific signaling pathways involved in lunar dustinduced toxicity. F344 rats were exposed for 4 weeks (6h/d; 5d/wk) in nose‐only inhalation chambers to concentrations of 0 (control air), 2.1, 6.8, 21, and 61 milligrams per cubic meters of lunar dust. Five rats per group were euthanized at 1 day, 1 week, 1 month, and 3 months after the last inhalation exposure. The bronchoalveolar lavage fluid (BALF) was collected by lavaging with phosphate‐buffered saline (PBS). A zymosan‐induced luminolbased chemiluminescence assay was used to assess the activity of BAL cells. The lavaged lung tissue was snap frozen in LN2 and total RNA was isolated using the Qigen RNeasy kit. The expression of 84 fibrosisrelated genes were analyzed using the RT2 Profiler PCR Array technique. The expression of 18 genes of interest were further measured using real‐time PCR technique in all the samples. 10 out of 18 genes of interest showed persistently significant expression changes in the local lung tissue exposed to lunar dust, indicating a prolonged proinflammatory response. The expressions of several of these genes were dose‐ and time‐dependent and were significantly correlated with other pathological parameters. The potential signaling pathways and upstream regulators were further analyzed using IPA pathway analysis tool based on the gene expression data. The data presented in this study, for the first time, explore the molecular mechanisms of lunar dust induced toxicity, contributing not only the risk assessment for future space exploration, but also understandings of the dust‐induced toxicity in humans on earth.

Zhang, Ye↗

Antarctic-Wide Array of High-Resolution Ice Core Records Reveals Pervasive Lead Pollution Began in 1889 and Persists Today

Interior Antarctica is among the most remote places on Earth and was thought to be beyond the reach of human impacts when Amundsen and Scott raced to the South Pole in 1911. Here we show detailed measurements from an extensive array of 16 ice cores quantifying substantial toxic heavy metal lead pollution at South Pole and throughout Antarctica by 1889 - beating polar explorers by more than 22 years. Unlike the Arctic where lead pollution peaked in the 1970s, lead pollution in Antarctica was as high in the early 20th century as at any time since industrialization. The similar timing and magnitude of changes in lead deposition across Antarctica, as well as the characteristic isotopic signature of Broken Hill lead found throughout the continent, suggest that this single emission source in southern Australia was responsible for the introduction of lead pollution into Antarctica at the end of the 19th century and remains a significant source today. An estimated 660 t of industrial lead have been deposited over Antarctica during the past 130 years as a result of mid-latitude industrial emissions, with regional-to-global scale circulation likely modulating aerosol concentrations. Despite abatement efforts, significant lead pollution in Antarctica persists into the 21st century.

pollution↗

Simulation Study of Landau Damping Near the Persisting to Arrested Transition

A one-dimensional electrostatic filtered Vlasov-Poisson simulation study is discussed. The transition from persisting to arrested Landau damping that is produced by increasing the strength of a sinusoidal perturbation on a background Vlasov-Poisson equilibrium is explored. Emphasis is placed on observed features of the electron phase-space distribution when the perturbation strength is near the transition value. A single ubiquitous waveform is found perturbing the space-averaged phase-space distribution at almost any time in all of the simulations; the sole exception is the saturation stage that can occur at the end of the arrested damping scenario. This waveform contains relatively strong, very narrow structures in velocity bracketing (plus or minus velocity (sub res)) - the velocities at which electrons must move to traverse the dominant field mode wavelength in one of its oscillation periods - and propagating with (plus or minus velocity (sub res)) respectively. Local streams of electrons are found in these structures crossing the resonant velocities from low speed to high speed during Landau damping and from high speed to low speed during Landau growth. At the arrest time, when the field strength is briefly constant, these streams vanish. It is conjectured that the expected transfer of energy between electrons and field during Landau growth or damping has been visualized for the first time. No evidence is found in the phase-space distribution to support recent well-established discoveries of a second-order phase transition in the electric field evolution. While trapping is known to play a role for larger perturbation strengths, it is shown that trapping plays no role at any time in any of the simulations near the transition perturbation strength.

plasma simulation↗

WindBots: A Concept for Persistent In-Situ Science Explorers for Gas Giants

This report summarizes the study of a mission concept to Jupiter with one or multiple Wind Robots able to operate in the Jovian atmosphere, above and below the clouds - down to 10 bar, for long durations and using energy obtained from local sources. This concept would be a step towards persistent exploration of gas giants by robots performing in-situ atmospheric science, powered by locally harvested energy. The Wind Robots, referred in this report as WindBots (WBs), would ride the planetary winds and transform aeolian energy into kinetic energy of flight, and electrical energy for on-board equipment. Small shape adjustments modify the aerodynamic characteristics of their surfaces, allowing for changes in direction and a high movement autonomy. Specifically, we sought solutions to increase survivability to strong/turbulent winds, and mobility and autonomy compared to passive balloons.

WindBots↗