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At least 181 records · Page 10

Combustion Module 1: Spacelab Racks Integrated at the Lewis Research Center for the First Time

The Combustion Module-1 (CM-1), NASA's largest (over 1800 lb) and one of the most sophisticated combustion experiments ever to fly on the Spacelab, will be carried on the first Microgravity Science Laboratory (MSL-1) mission aboard the space shuttle flight STS-84 in April 1997. The CM-1 project is a stepping stone to the space station era, because the hardware can support multiple investigators on the same mission and can be integrated at user locations and shipped to the launch site. CM-1 is being developed to accommodate microgravity combustion experiments that are designed to help explain and predict the behavior of combustion processes. Although the two principal investigators for CM-1 are both studying combustion processes, their investigations are quite different. Professor Paul D. Ronney of the University of Southern California will examine the Structures of Flame Balls at Low Lewis Numbers (SOFBALL), in which a variety of fuel-lean gaseous mixtures fill the combustion chamber and are ignited. Professor Gerard M. Faeth of the University of Michigan will investigate Laminar Soot Processes (LSP) by studying the key properties of burning gas jets of fuel, employing different fuels and nozzle sizes.

Source record↗

Enabling Biological Discovery Through Biospecimen Sharing: The Nasa Biological Institutional Scientific Collection

Understanding biological impacts from spaceflight hazards and the subsequent development of countermeasures are a high priority to enable humanity to venture back to the Moon, and then to Mars and beyond. Experiments have been conducted with model organisms flown to space and analogous investigations terrestrially, to identify biological mechanistic impacts from spaceflight hazards and to develop mitigation countermeasures, thus contributing towards basic and applied science goals. However, sending organisms into space is a costly endeavor. To maximize scientific return, all biospecimens not required by spaceflight-relevant Principal Investigators are harvested, preserved, and archived in the NASA Biological Institutional Scientific Collection (NBISC). Biospecimens are collected and preserved according to well-established standard operating procedures to maintain scientific quality and are available on-request by the international scientific community. NBISC currently stores over 32,000 biospecimens from Shuttle, International Space Station, and ground-based space analog investigations. Tissue sharing has resulted in at least 33 publications since 2011 and 51 requests since 2016. Many requests for NBISC biospecimens come from first-time investigators who subsequently submit grants as their point-of-entry into the field of spaceflight biology and health. The NBISC biorepository is part of the NASA ‘Open Science for Life in Space’ collaborative group of projects, which includes NASA Genelab, the Space Biology Program’s Biospecimen Sharing Program, Physical Sciences Informatics, and the Ames Life Sciences Data Archive. NBISC biospecimens have been awarded to NASA Genelab, who then generated various open access science ‘omics datasets through the GeneLab Sample Processing laboratory, with resulting data widely used for biological study. Other NBISC biospecimen awards have led to studies on fecal microbiome analysis, DNA damage analysis using single-cell DNA sequencing, enzymatic-pathway identification involved in spaceflight muscle atrophy, and characterization of ocular morphological changes. Of note, NBISC is expanded to include a new Space Microbial Culture Collection (SMCC) for the collection, identification, documentation, long-term preservation, and distribution of space-related microbial isolates.

Biospecimens↗

The preliminary Long Duration Exposure Facility (LDEF) materials data base

A preliminary Long Duration Exposure Facility (LDEF) Materials Data Base was developed by the LDEF Materials Special Investigation Group (MSIG). The LDEF Materials Data Base is envisioned to eventually contain the wide variety and vast quantity of materials data generated for LDEF. The data is searchable by optical, thermal, and mechanical properties, exposure parameters (such as atomic oxygen flux), and author(s) or principal investigator(s). The LDEF Materials Data Base was incorporated into the Materials and Processes Technical Information System (MAPTIS). MAPTIS is a collection of materials data which was computerized and is available to engineers, designers, and researchers in the aerospace community involved in the design and development of spacecraft and related hardware. This paper describes the LDEF Materials Data Base and includes step-by-step example searches using the data base. Information on how to become an authorized user of the system is included.

Funk, Joan G.↗

Materials And Processes Technical Information System (MAPTIS) LDEF materials data base

A preliminary Long Duration Exposure Facility (LDEF) Materials Data Base was developed by the LDEF Materials Special Investigation Group (MSIG). The LDEF Materials Data Base is envisioned to eventually contain the wide variety and vast quantity of materials data generated from LDEF. The data is searchable by optical, thermal, and mechanical properties, exposure parameters (such as atomic oxygen flux) and author(s) or principal investigator(s). Tne LDEF Materials Data Base was incorporated into the Materials and Processes Technical Information System (MAPTIS). MAPTIS is a collection of materials data which has been computerized and is available to engineers, designers, and researchers in the aerospace community involved in the design and development of spacecraft and related hardware. The LDEF Materials Data Base is described and step-by-step example searches using the data base are included. Information on how to become an authorized user of the system is included.

Funk, Joan G.↗

Second International Microgravity Laboratory (IML-2)

This report highlights the scientific and engineering accomplishments achieved during the 14-day Second International Microgravity Laboratory (IML-2) mission. The mission, managed by the National Aeronautics and Space Administration's Marshall Space Flight Center in Huntsville, Alabama, laid the groundwork for broader international partnerships and scientific alliances. Five other space agencies joined NASA on the mission: the Canadian Space Agency (CSA), the European Space Agency (ESA), the French Space Agency (CNES), the German Space Agency (DARA), and the National Space Development Agency of Japan (NASDA). For the mission, microgravity and life sciences investigations were completed inside Spacelab by a crew working around the clock. The report foreword and introduction describe the mission and the facilities used for IML-2. By the end of the mission, hundreds of primary and secondary experiments were completed. With the help of the principal investigators, most of the primary investigations and some of the co-investigations are described in this document. The lead report authors are cited at the beginning of each experiment description The remainder of the description includes the experiment objectives, flight activities postflight analysis, conclusions, illustrations, and references for further research. The major scientific accomplishments of each investigation are highlighted.

Snyder, Robert S.↗

NASA/ESA CT-990 Spacelab simulation. Appendix A: The experiment operator

A joint NASA/ESA endeavor was established to conduct an extensive spacelab simulation using the NASA CV-990 airborne laboratory. The scientific payload was selected to perform studies in upper atmospheric physics and infrared astronomy with principal investigators from France, the Netherlands, England, and several groups from the United States. Two experiment operators from Europe and two from the U.S. were selected to live aboard the aircraft along with a mission manager for a six-day period and operate the experiments in behalf of the principal scientists. This appendix discusses the experiment operators and their relationship to the joint mission under the following general headings: selection criteria, training programs, and performance. The performance of the proxy operators was assessed in terms of adequacy of training, amount of scientific data obtained, quality of data obtained, and reactions to problems that arose in experiment operation.

Reller, J. O., Jr.↗

NASA FACTS: E. coli AntiMicrobial Satellite (EcAMSat)

The E. coli AntiMicrobial Satellite(EcAMSat) mission will investigate space microgravity affects on the antibiotic resistance of E. coli, a bacterial pathogen responsible for urinary tract infection in humans and animals. EcAMSat is being developed through a partnership between NASAs Ames Research Center and the Stanford University School of Medicine. Dr. A.C. Matin is the Stanford University Principal Investigator. EcAMSat will investigate spaceflight effects on bacterial antibiotic resistance and its genetic basis. Bacterial antibiotic resistance may pose a danger to astronauts in microgravity, where the immune response is weakened. Scientists believe that the results of this experiment could help design effective countermeasures to protect astronauts health during long duration human space missions.

Spremo, Stevan↗

UNAVCO facility support of NASA Dynamics of the Solid Earth (DOSE) GPS investigation for years 1995-1996

This report consists of the following sections: a list of the NASA DOSE (Dynamics of the Solid Earth) Program Global Positioning System (GPS)-based campaigns supported by the UNAVCO (University Navstar Consortium) Boulder Facility; a list of NASA DOSE GPS permanent site installations supported by the UNAVCO Boulder Facility; and example science snapshots indicating the research projects supported with equipment and technical support available to DOSE Principal Investigators via the UNAVCO Boulder Facility.

Ware, Randolph↗

Open Science for Life in Space: Data Sharing and Tools for Knowledge Discovery

The next era in human space exploration is rapidly approaching and will require the use of countermeasures to deep space health hazards. The development of countermeasures (or, the re-purposing of existing agents) will be highly dependent on our understanding of basic biological responses to space stressors (e.g. ionizing radiation, altered gravitational fields, altered day-night cycles, confinement, isolation, hostile-closed environments, distance-duration from Earth, exposure to celestial regolith, etc.). The fast-growing array of space biological data, which in the past was simply archived after minimal analysis, holds great potential if it can be reorganized and formatted for Open Science. Organizing the data for such analysis is a challenge because of its diverse nature (molecular, cellular, tissue, imaging, whole organism and behavior). We will discuss here several strategies that NASA’s Biological and Physical Science Division has put in place to maximize the return on investment for spaceflight bioscience data. Open Science, as a scientific philosophy, is the concept that the more people who have access to the data, the more knowledge will be gained from it. This guiding principle led NASA to develop GeneLab in 2015. GeneLab houses spaceflight and relevant ground-based multi-omics data, and has grown to ~400 transcriptomic, proteomic, metabolomic and epigenomic datasets from plant, rodent, small animal, and microbial space experiments. GeneLab provides users with various tools for data analysis and a visualization portal that allows users to interact with gene expression data from space-related ‘omics experiments. Open Science is also about building scientific communities, and with this spirit in mind, GeneLab has spawned several Analysis Working Groups (AWGs), comprised of more than 200 volunteer scientists. The AWGs initially provided feedback on the processing pipeline and metadata ‘omics standards for GeneLab. Over the last few years, they have become a community-driven science enterprise, engaging in large meta-analysis of GeneLab datasets, resulting in 10 publications (beyond the originally submitted research). Overall, the Open Science nature of GeneLab has resulted in a high degree of data re-use, resulting in 38 additional publications derived from the original 67 publication over the past four years. The enormous success and knowledge gained from GeneLab has led to a collection of sister NASA “Open Science Data Repositories (OSDR)” and research support groups. These include the NASA Ames Life Sciences Data Archive (ALSDA), the NASA Biological Institutional Scientific Collection (NBISC), and the Biospecimen Sharing Program (BSP). All are adopting the GeneLab data architecture system to maximize open-access, find-ability, accessibility, interoperability, and reusability (FAIR). ALSDA collects and curates phenotypic-physiological bioimaging-behavioral data from space and space-relevant non-human experiments, oftentimes coming from the same omics-associated experimental datasets found in GeneLab. Since 2021, a community of ~100 researchers have rallied around ALSDA, to provide feedback in a new ALSDA AWG focused on phenotypic-physiological investigation-sample-assay metadata standards (e.g., Micro-Computed Tomography, Light/Fluorescence Microscopy, Western Blot, Flow Cytometry, Novel Object Recognition, Elevated Plus Maze, etc. of ~50 assays collected). These standards are part of a new single point-of-entry data submission portal for all non-human Space Biology and Human Research Program principal investigators, to submit, curate, and share their research data. With open-access space biological data now collected and curated together with rich metadata, and with the potential for linkage to “big data” from the international biological and medical communities (NIH, EBI, etc.), the artificial intelligence and machine learning (AI/ML) era has started for Space Biology. Several other talks will cover these topics in this conference.

life sciences↗

Open Science for Life in Space: Data Sharing and Tools for Knowledge Discovery

The next era in human space exploration is rapidly approaching and will require the use of countermeasures to deep space health hazards. The development of countermeasures (or, there-purposing of existing agents) will be highly dependent on our understanding of basic biological responses to space stressors (e.g. ionizing radiation, altered gravitational fields, altered day-night cycles, confinement, isolation, hostile-closed environments, distance-duration from Earth, exposure to celestial regolith, etc.). The fast-growing array of space biological data, which in the past was simply archived after minimal analysis, holds great potential if it can be reorganized and formatted for Open Science. Organizing the data for such analysis is a challenge because of its diverse nature (molecular, cellular, tissue, imaging, whole organism and behavior). We will discuss here several strategies that NASA's Biological and Physical Science Division has put in place to maximize the return on investment for spaceflight bioscience data. Open Science, as a scientific philosophy, is the concept that the more people who have access to the data, the more knowledge will be gained from it. This guiding principle led NASA to develop GeneLab in 2015. GeneLab houses spaceflight and relevant ground-based multi-omics data, and has grown to ~400 transcriptomatic, proteomic, metabolomic and epigenomic datasets from plant, rodent, small animal, and microbial space experiments. GeneLab provides users with various tools for data analysis and a visualization portal that allows users to interact with gene expression data from space-related 'omics experiments. Open Science is also about building scientific communities, and with this spirit in mind, GeneLab has spawned several Analysis Working Groups (AWGs), comprised of more than 200 volunteer scientists. The AWGs initially provided feedback on the processing pipeline and metadata 'omics standards for GeneLab. Over the last few years, they have become a community-driven science enterprise, engaging in large meta-analysis of GeneLab datasets, resulting in 10 publications (beyond the originally submitted research). Overall, the Open Science nature of GeneLab has resulted in a high degree of data-use, resulting in 40 enabled publications by open data. The enormous success and knowledge gained from GeneLab has led to a collection of sister NASA "Open Science Data Repositories (OSDR)" and research support groups. These include the NASA Ames Life Sciences Data Archive (ALSDA), the NASA Biological Institutional Scientific Collection (NBISC), and the Biospecimen Sharing Program (BSP). All are adopting the GeneLab data architecture system to maximize open-access, find-ability, accessibility, interoperability, and reusability (FAIR). ALSDA collects and curates phenotypic-physiological bioimaging-behavioral data from space and space-relevant non-human experiments, oftentimes coming from the same omics-associated experimental datasets found in GeneLab. Since 2021, a community of ~100 researchers have rallied around ALSDA, to provide feedback in a new ALSDA AWG focused on phenotypic-physiological investigation-sample-assay metadata standards (e.g., Micro-Computed Tomography, Light/Flourescence Microscopy, Western Blot, Flow Cytometry, Novel Object Recognition, Elevated Plus Maze, etc. of ~50 assays collected). These standards are part of a new single point-of-entry data submission portal for all non-human Space Biology and Human Research Program principal investigators, to submit, curate, and share their research data. With open-access space biological data now collected and curated together with rich metadata, and with the potential for linkage to "big data" from the international biological and medical communities (NIH, EBI, etc.), the artificial intelligence and machine learning (AI/ML) era has started for Space Biology.

omics↗

NASA selects scientific investigations for Earth dynamics studies

Forty two domestic investigators affiliated with U.S. universities, governmental agencies, or private concerns and 14 investigators from France, West Germany, the Netherlands, Switzerland, Spain, Sweden, Australia, New Zealand, Venezuela, and Canada were selected to use precise geodetic data obtained by laser ranging and very long base interferometry in a study of the Earth's tectonic plate movement, crustal deformation, and rotational dynamics. The studies to be made and the principal investigators for each are listed.

Source record↗

LDEF materials overview

The flight and retrieval of the National Aeronautics and Space Administration's Long Duration Exposure Facility (LDEF) provided an opportunity for the study of the low-Earth orbit (LEO) environment and long-duration space environmental effects (SEE) on materials that is unparalleled in the history of the U.S. Space Program. The 5-year, 9-month flight of LDEF greatly enhanced the potential value of all materials on LDEF to the international SEE community, compared to that of the original 1-year flight plan. The remarkable flight attitude stability of LDEF enables specific analyses of individual and combined effects of LEO environmental parameters on identical materials on the same space vehicle. NASA recognized this potential by forming the LDEF Space Environmental Effects on Materials Special Investigation Group (MSIG) to address the greatly expanded materials and LEO space environment analysis opportunities available in the LDEF structure, experiment trays, and corollary measurements so that the combined value of all LDEF materials data to current and future space missions will be addressed and documented. An overview of the interim LDEF materials findings of the principal investigators and the Materials Special Investigation Group is provided. These revelations are based on observations of LEO environmental effects on materials made in space during LDEF retrieval and during LDEF tray deintegration at the Kennedy Space Center, and on findings of approximately 1.5 years of laboratory analyses of LDEF materials by the LDEF materials scientists. These findings were extensively reviewed and discussed at the MSIG-sponsored LDEF Materials Workshop '91. The results are presented in a format that categorizes the revelations as 'clear findings' or 'obscure preliminary findings' (and progress toward their resolution), plus resultant needs for new space materials developments and ground simulation testing/analytical modeling, in seven categories: materials/environmental parameters and data bases; LDEF contamination; thermal control coatings and protective treatments; polymers and films; polymer-matrix composites; metals, ceramics, and optical materials; and systems-related materials. The utilization of LDEF materials data for future low-Earth orbit missions is also discussed, concentrating on Space Station Freedom. In general, the LDEF data is remarkably consistent; LDEF will provide a 'benchmark' for materials design data bases for satellites in low-Earth orbit. Some materials were identified to be encouragingly resistant to LEO SEE for 5.8-years; other 'space qualified' materials displayed significant environmental degradation. General contamination levels on LDEF were low, but molecular contamination was widespread; LDEF offers an unprecedented opportunity to provide a unified perspective of unmanned LEO spacecraft contamination mechanisms. New material development requirements for long-term LEO missions were identified and current ground simulation testing methods/data for new, durable materials concepts can be validated with LDEF results. LDEF findings are already being integrated into the design of Space Station Freedom.

Stein, Bland A.↗

12 Inch Fan Acoustic Research

There were three general purposes of this research; first, to investigate fundamental fan acoustic processes, second, to produce high quality data for the validation of aeroacoustic codes and, third, to investigate candidate noise control concepts. These were all to be investigated using the NASA built and supplied 12 inch fan which is a 0.1 scale model of a modem ultra high bypass fan. NASA also supplied the test environments, wind tunnel entries in the 14 by 22 Foot Subsonic Wind Tunnel and the Anechoic Noise Research Facility. To fulfill the purposes of the grant, investigations were performed in several general topics. In the area of fundamental fan studies, some of the topics involved were azimuthal directivity and tip clearance effects. In the area of high quality validation data significant parameter studies in the wind tunnel tests were performed. And in the area of noise control concepts, heated air injection was studied. The principal investigator performed the work on this grant by leading the concept development, design, planning, data analysis and reporting of the areas studied. The final report for this grant consists of a listing, which follows, of all reports, presentations, and publications that were made for the work done during the performance period.

Thomas, R. H.↗

Scientist-Stakeholder Relationships Drive Carbon Data Product Transfer Effectiveness within NASA Program

Carbon cycle science is at the heart of research on global climate change and its long-term impacts, as it examines the exchange of carbon between the atmosphere, oceans, land, and the impact of fossil fuel emissions on this cycling. Given the urgency of the climate challenge, NASA's Carbon Monitoring System (CMS) requires all funded investigators to identify and work with stakeholder organizations at project inception to accelerate the transfer of the products developed by funded research into decision making systems. In this study, we contribute to the literature through the implementation of a quantitative analysis of 908 unique survey responses from funded investigators to explore the maturity of the scientist-stakeholder engagement. The paper employs multiple correspondence analysis to provide evidence to support policy options to increase stakeholder integration into research programs. Despite limitations of the dataset used, we demonstrated that multiple funding rounds, long-standing relationships between the stakeholder and scientist, and the scientific productivity of the Principal Investigator, including the ability to produce datasets and research papers on these datasets, all contribute to carbon products moving from research to operational use. The maturity of relationships between scientists and stakeholders was shown to result improved stakeholder engagement. The use of carbon products should be identified in every stage of the program, and that capacity building is needed to support both existing and newly identified stakeholders better understand and use CMS products. As federal, state, and local policy on climate adaptation and mitigation matures, the need for information on carbon will expand. Building of stakeholder-scientist relationships in CMS results in an effective generation and use of datasets to support this need and prototype ways that improved information needed for decision making can be created.

Molly E Brown↗

Energy Augmentation for Vehicle Electric Systems (EAVES)

This preliminary study evaluated eight concepts for augmenting the energy state of electric Vertical Take-Off and Landing vehicles. Advanced Air Mobility electric vehicles could need additional charge due to depleted batteries (e.g., strong winds along the way) while approaching their destination. There are five direct charging and three indirect charging concepts presented in this paper. The concepts are in the preliminary research stage and are being refined. Considering the concepts are for the year 2045 timeframe, there is sufficient time to evolve them, along with the designs of these electric air vehicles. This Technical Memorandum describes more detail and provides a discussion on the desirability, viability, feasibility, and wickedness of these energy augmentation concepts. A discussion of barriers and initial investigation approach for the concepts is presented as well. One intent for the presentation of this Technical Memorandum is to capture the work done from March through September 2022 within NASA’s Convergent Aeronautics Solutions (CAS) Project, in the Transformative Aeronautics Concepts Program. At the end of the effort, it was decided that only one concept would be further investigated. The rest of the concepts for energy augmentation would be described in this document and could be picked up later if NASA chose to further investigate them. This document is a collection of input from the authors regarding the concepts they worked on. It is not intended to be a conference or journal publication, but a record of research conducted on the concepts considered by the Energy Augmentation for Vehicle Electric Systems (EAVES) team consisting of the authors. Mr. Todd Stinchfield was the Principal Investigator.

Kapil Sheth↗

LDEF materials overview

The flight and retrieval of the LDEF provided an opportunity for the study of the low earth orbit (LEO) environment and long-duration space environmental effects (SEE) on materials that is unparalleled in the history of the US space program. The 5-year, 9-month flight of the LDEF greatly enhanced the potential value of all materials on the LDEF to the international SEE community, compared to that of the original 1-year flight plan. The remarkable flight attitude stability of the LDEF enables specific analyses of various individual and combined effects of LEO environmental parameters on identical materials on the same vehicle. NASA recognized this potential by forming the LDEF Space Environmental Effects on Materials Special Investigation Group (MSIG) to address the greatly expanded materials and LEO space environment parameter analysis opportunities available in the LDEF structure, experiment trays, and corollary measurements, so that the combined value of all LDEF materials data to current and future space missions are addressed and documented. This presentation provides an overview of the interim LDEF materials findings of the principal investigators and the MSIG.

Stein, Bland A.↗

LDEF materials: An overview of the interim findings

The flight and retrieval of the National Aeronautics and Space Administration's Long Duration Exposure Facility (LDEF) provided an opportunity for the study of the low-Earth orbit (LEO) environment and long-duration space environmental effect (SEE) on materials that are unparalleled in the history of the U.S. space program. The 5.8-year flight of LDEF greatly enhanced the potential value of materials data from LDEF to the international SEE community, compared to that of the original 1-year flight plan. The remarkable flight attitude stability of LDEF enables specific analyses of various individual and combined effects of LEO environmental parameters on identical materials of the same space vehicle. NASA recognized the potential by forming the LDEF Space Environmental Effects on Materials Special Investigation Group (MSIG) to address the greatly expanded materials and LEO space environment parameter analysis opportunities available in the LDEF structure, experiment trays, and corollary measurements, so that the combined value of all LDEF materials data to current and future space missions will be assessed and documented. This paper provides an overview of the interim LDEF materials findings of the Principal Investigators and the Materials Special Investigation Group. These revelations are based on observations of LEO environmental effects on materials made in-space during LDEF retrieval and during LDEF tray deintegration at the Kennedy Space Center, and on findings of approximately 1.5 years of laboratory analyses of LDEF materials by the LDEF materials scientists. These findings were extensively reviewed and discussed at the MSIG-sponsored LDEF Materials Workshop '91. The results are presented in a format which categorizes the revelations as 'clear findings' or 'confusing/unexplained findings' and resultant needs for new space materials developments and ground simulation testing/analytical modeling in seven categories: environmental parameters and data bases; LDEF contamination; thermal control coatings and protective treatments; polymers and films; polymer-matrix composites; metals, ceramics, and optical materials; and systems-related materials. General outlines of findings of the other LDEF Special Investigation Groups (Ionizing Radiation, Meteoroid and Debris, and Systems) are also included. The utilization of LDEF materials data for future low-earth orbit missions is also discussed, concentrating on Space Station Freedom. Some directions for continuing studies of LDEF materials are outlined. In general, the LDEF data is remarkable consistent; LDEF will provide a 'benchmark' for materials design data bases for satellites in low-Earth orbit. Some materials were identified to be encouragingly resistant to LEO SEE for 5.8-years; other 'space qualified' materials displayed significant environmental degradation. Molecular contamination was widespread; LDEF offers an unprecedented opportunity to provide a unified perspective of unmanned LEO spacecraft contamination mechanisms. New material development requirements for long-term LEO missions have been identified and current ground simulation testing methods/data for new, durable materials concepts can be validated with LDEF results. LDEF findings are already being integrated into the design of Space Station Freedom.

Stein, Bland A.↗

Five biomedical experiments flown in an Earth orbiting laboratory: Lessons learned from developing these experiments on the first international microgravity mission from concept to landing

There are numerous problems associated with accommodating complex biological systems in microgravity in the flexible laboratory systems installed in the Orbiter cargo bay. This presentation will focus upon some of the lessons learned along the way from the University laboratory to the IML-1 Microgravity Laboratory. The First International Microgravity Laboratory (IML-1) mission contained a large number of specimens, including: 72 million nematodes, US-1; 3 billion yeast cells, US-2; 32 million mouse limb-bud cells, US-3; and 540 oat seeds (96 planted), FOTRAN. All five of the experiments had to undergo significant redevelopment effort in order to allow the investigator's ideas and objectives to be accommodated within the constraints of the IML-1 mission. Each of these experiments were proposed as unique entities rather than part of the mission, and many procedures had to be modified from the laboratory practice to meet IML-1 constraints. After a proposal is accepted by NASA for definition, an interactive process is begun between the Principal Investigator and the developer to ensure a maximum science return. The success of the five SLSPO-managed experiments was the result of successful completion of all preflight biological testing and hardware verification finalized at the KSC Life Sciences Support Facility housed in Hangar L. The ESTEC Biorack facility housed three U.S. experiments (US-1, US-2, and US-3). The U.S. Gravitational Plant Physiology Facility housed GTHRES and FOTRAN. The IML-1 mission (launched from KSC on 22 Jan. 1992, and landed at Dryden Flight Research Facility on 30 Jan. 1992) was an outstanding success--close to 100 percent of the prelaunch anticipated science return was achieved and, in some cases, greater than 100 percent was achieved (because of an extra mission day).

Winget, C. M.↗