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At least 181 records · Page 10

Monte Carlo predictions of DNA fragment-size distributions for large sizes after HZE particle irradiation

DSBs (double-strand breaks) produced by densely ionizing space radiation are not located randomly in the genome: recent data indicate DSB clustering along chromosomes. DSB clustering at large scales, from >100 Mbp down to approximately 2 kbp, is modeled using a Monte-Carlo algorithm. A random-walk model of chromatin is combined with a track model, that predicts the radial distribution of energy from an ion, and the RLC (randomly-located-clusters) formalism, in software called DNAbreak. This model generalizes the random-breakage model, whose broken-stick fragment-size distribution is applicable to low-LET radiation. DSB induction due to track interaction with the DNA volume depends on the radiation quality parameter Q. This dose-independent parameter depends only weakly on LET. Multi-track, high-dose effects depend on the cluster intensity parameter lambda, proportional to fluence as defined by the RLC formalism. After lambda is determined by a numerical experiment, the model reduces to one adjustable parameter Q. The best numerical fits to the experimental data, determining Q, are obtained. The knowledge of lambda and Q allows us to give biophysically based extrapolations of high-dose DNA fragment-size data to low doses or to high LETs.

NASA Center JSC↗

Generalized Levy-walk model for DNA nucleotide sequences

We propose a generalized Levy walk to model fractal landscapes observed in noncoding DNA sequences. We find that this model provides a very close approximation to the empirical data and explains a number of statistical properties of genomic DNA sequences such as the distribution of strand-biased regions (those with an excess of one type of nucleotide) as well as local changes in the slope of the correlation exponent alpha. The generalized Levy-walk model simultaneously accounts for the long-range correlations in noncoding DNA sequences and for the apparently paradoxical finding of long subregions of biased random walks (length lj) within these correlated sequences. In the generalized Levy-walk model, the lj are chosen from a power-law distribution P(lj) varies as lj(-mu). The correlation exponent alpha is related to mu through alpha = 2-mu/2 if 2 < mu < 3. The model is consistent with the finding of "repetitive elements" of variable length interspersed within noncoding DNA.

NASA Discipline Number 14-10↗

Stochastic models for atomic clocks

For the atomic clocks used in the National Bureau of Standards Time Scales, an adequate model is the superposition of white FM, random walk FM, and linear frequency drift for times longer than about one minute. The model was tested on several clocks using maximum likelihood techniques for parameter estimation and the residuals were acceptably random. Conventional diagnostics indicate that additional model elements contribute no significant improvement to the model even at the expense of the added model complexity.

Barnes, J. A.↗

Channeled propagation of solar particles

Bartley (1966) and McCracken and Ness (1966) identified bundles of interplanetary magnetic field (IMF) lines that differed in direction from the interplanetary field lines in which they were imbedded. These bundles, called filaments differed in direction by as much as several tens of degrees from the surrounding field. The filaments werre first noticed due to the large and sudden change in flow direction of highly anisotropic solar flare protons in the energy range 1 to 13 MeV. Passage of the filaments over the spacecraft required a few hours, implying a diameter for the filaments of approximately 3 x 10 to the 6th power km at a distance of 1 AU from the Sun. In 1968, Jakipii and Parker used Leighton's hypothesis of random walk of magnetic field lines associated with granules and supergranules (1964) to develop a picture of an interplanetary medium composed of a tangle of field lines frozen into the solar wind, but whose feet were carried about by the random motions at the solar surface. Jakipii and Parker noted that using a correlation length of 15,000 km - about the radius of a supergranule - the magnetic structure would be 3 x 10 to the 6th power km in size of the filaments as determined by Bartley and McCracken and Ness. These workers did not find changes in the solar particle intensity, anisotropy ratio or energy spectrum as the spacecraft entered the filament.

Anderson, K. A.↗

The color of magnetic monopole noise

We relate the anomaly in the noise color of spin ice to the emergent nature of its magnetic monopoles and their random walk. Monopoles are quasi-particles, and the spin vacuum in which they wander is not structureless. Rather, the underlying spin ensemble filters the thermal white noise, leading to non-trivial coevolution. Thus, monopoles can be considered as "dressed" random walkers, activated by a non-trivial stochastic noise that subsumes mutual interactions and the coevolution of their spin vacuum. From this, we suggest that recent experimental results are interpretable in terms of monopole subdiffusion. Furthermore, we then conjecture relations between the color of the noise and other observables, such as relaxation time, monopole density, the dynamic exponent, and the order of the annihilation reaction, which suggests to us the introduction of spin-ice-specific critical exponents in a neighborhood of the ice manifold criticality.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Maximum Kolmogorov-Sinai Entropy Versus Minimum Mixing Time in Markov Chains

We establish a link between the maximization of Kolmogorov Sinai entropy (KSE) and the minimization of the mixing time for general Markov chains. Since the maximisation of KSE is analytical and easier to compute in general than mixing time, this link provides a new faster method to approximate the minimum mixing time dynamics. It could be interesting in computer sciences and statistical physics, for computations that use random walks on graphs that can be represented as Markov chains.

97 MATHEMATICS AND COMPUTING↗

Localization in Fractonic Random Circuits

We study the spreading of initially local operators under unitary time evolution in a one-dimensional random quantum circuit model that is constrained to conserve a U ( 1 ) charge and also the dipole moment of this charge. These constraints are motivated by the quantum dynamics of fracton phases. We discover that the charge remains localized at its initial position, providing a crisp example of a nonergodic dynamical phase of random circuit dynamics. This localization can be understood as a consequence of the return properties of low-dimensional random walks, through a mechanism reminiscent of weak localization, but insensitive to dephasing. The charge dynamics is well described by a system of coupled hydrodynamic equations, which makes several nontrivial predictions that are all in good agreement with numerics in one dimension. Importantly, these equations also predict localization in two-dimensional fractonic random circuits. We further find that the immobile fractonic charge emits nonconserved operators, whose spreading is governed by exponents that are distinct from those observed in nonfractonic circuits. These nonstandard exponents are also explained by our coupled hydrodynamic equations. Where entanglement properties are concerned, we find that fractonic operators exhibit a short time linear growth of observable entanglement with saturation to an area law, as well as a subthermal volume law for operator entanglement. The entanglement spectrum is found to follow semi-Poisson statistics, similar to eigenstates of many-body localized systems. The nonergodic phenomenology is found to persist to initial conditions containing nonzero density of dipolar or fractonic charge, including states near the sector of maximal charge. Our work implies that low-dimensional fracton systems should preserve forever a memory of their initial conditions in local observables under noisy quantum dynamics, thereby constituting ideal memories. It also implies that one- and two-dimensional fracton systems should realize true many-body localization (MBL) under Hamiltonian dynamics, even in the absence of disorder, with the obstructions to MBL in translation-invariant systems and in spatial dimensions greater than one being evaded by the nature of the mechanism responsible for localization. We also suggest a possible route to new nonergodic phases in high dimensions.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Near Critical Preferential Attachment Networks have Small Giant Components

Preferential attachment networks with power law exponent τ>3 are known to exhibit a phase transition. There is a value ρ{sub c}>0 such that, for small edge densities ρ≤ρ{sub c} every component of the graph comprises an asymptotically vanishing proportion of vertices, while for large edge densities ρ>ρ{sub c} there is a unique giant component comprising an asymptotically positive proportion of vertices. In this paper we study the decay in the size of the giant component as the critical edge density is approached from above. We show that the size decays very rapidly, like exp (−c/√(ρ−ρ{sub c})) for an explicit constant c>0 depending on the model implementation. This result is in contrast to the behaviour of the class of rank-one models of scale-free networks, including the configuration model, where the decay is polynomial. Our proofs rely on the local neighbourhood approximations of Dereich and Mörters (Ann Probab 41(1):329–384, 2013) and recent progress in the theory of branching random walks (Gantert et al. in Ann Inst Henri Poincaré Probab Stat 47(1):111–129, 2011).

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Stabilization of the 81-channel coherent beam combination using machine learning

We develop a rapidly converging algorithm for stabilizing a large channel-count diffractive optical coherent beam combination. An 81-beam combiner is controlled by a novel, machine-learning based, iterative method to correct the optical phases, operating on an experimentally calibrated numerical model. A neural-network is trained to detect phase errors based on interference pattern recognition of uncombined beams adjacent to the combined one. Due to the non-uniqueness of solutions in the full space of possible phases, the network is trained within a limited phase perturbation/error range. This also reduces the number of samples needed for training. Simulations have proven that the network can converge in one step for small phase perturbations. When the trained neural-network is applied to a realistic case of 360 degree full range, an iterative scheme exploits random walking at the beginning, with the accuracy of prediction on phase feedback direction, to allow the neural-network to step into the training range for fast convergence. This neural-network-based iterative method of phase detection works tens of times faster than the commonly used stochastic parallel gradient descent approach (SPGD) using a single-detector and random dither when both are tested with random phase perturbations.

Wang, Dan↗

Phase noise in pulsed Doppler lidar and limitations on achievable single-shot velocity accuracy

The smaller sampling volumes afforded by Doppler lidars compared to radars allows for spatial resolutions at and below some sheer and turbulence wind structure scale sizes. This has brought new emphasis on achieving the optimum product of wind velocity and range resolutions. Several recent studies have considered the effects of amplitude noise, reduction algorithms, and possible hardware related signal artifacts on obtainable velocity accuracy. We discuss here the limitation on this accuracy resulting from the incoherent nature and finite temporal extent of backscatter from aerosols. For a lidar return from a hard (or slab) target, the phase of the intermediate frequency (IF) signal is random and the total return energy fluctuates from shot to shot due to speckle; however, the offset from the transmitted frequency is determinable with an accuracy subject only to instrumental effects and the signal to noise ratio (SNR), the noise being determined by the LO power in the shot noise limited regime. This is not the case for a return from a media extending over a range on the order of or greater than the spatial extent of the transmitted pulse, such as from atmospheric aerosols. In this case, the phase of the IF signal will exhibit a temporal random walk like behavior. It will be uncorrelated over times greater than the pulse duration as the transmitted pulse samples non-overlapping volumes of scattering centers. Frequency analysis of the IF signal in a window similar to the transmitted pulse envelope will therefore show shot-to-shot frequency deviations on the order of the inverse pulse duration reflecting the random phase rate variations. Like speckle, these deviations arise from the incoherent nature of the scattering process and diminish if the IF signal is averaged over times greater than a single range resolution cell (here the pulse duration). Apart from limiting the high SNR performance of a Doppler lidar, this shot-to-shot variance in velocity estimates has a practical impact on lidar design parameters. In high SNR operation, for example, a lidar's efficiency in obtaining mean wind measurements is determined by its repetition rate and not pulse energy or average power. In addition, this variance puts a practical limit on the shot-to-shot hard target performance required of a lidar.

Mcnicholl, P.↗

Extrapolation of the dna fragment-size distribution after high-dose irradiation to predict effects at low doses

The patterns of DSBs induced in the genome are different for sparsely and densely ionizing radiations: In the former case, the patterns are well described by a random-breakage model; in the latter, a more sophisticated tool is needed. We used a Monte Carlo algorithm with a random-walk geometry of chromatin, and a track structure defined by the radial distribution of energy deposition from an incident ion, to fit the PFGE data for fragment-size distribution after high-dose irradiation. These fits determined the unknown parameters of the model, enabling the extrapolation of data for high-dose irradiation to the low doses that are relevant for NASA space radiation research. The randomly-located-clusters formalism was used to speed the simulations. It was shown that only one adjustable parameter, Q, the track efficiency parameter, was necessary to predict DNA fragment sizes for wide ranges of doses. This parameter was determined for a variety of radiations and LETs and was used to predict the DSB patterns at the HPRT locus of the human X chromosome after low-dose irradiation. It was found that high-LET radiation would be more likely than low-LET radiation to induce additional DSBs within the HPRT gene if this gene already contained one DSB.

NASA Discipline Radiation Health↗

Numerical Simulation of the Anomalous Transport of High-Energy Cosmic Rays in Galactic Superbubble

A continuous-time random-walk (CTRW) model to simulate the transport and acceleration of high-energy cosmic rays in galactic superbubbles has recently been put forward (Barghouty & Schnee 2102). The new model has been developed to simulate and highlight signatures of anomalous transport on particles' evolution and their spectra in a multi-shock, collective acceleration context. The superbubble is idealized as a heterogeneous region of particle sources and sinks bounded by a random surface. This work concentrates on the effects of the bubble's assumed astrophysical characteristics (cf. geometry and roughness) on the particles' spectra.

Barghouty, A. F.↗

Calculation of Dose Deposition in 3D Voxels by Heavy Ions and Simulation of gamma-H2AX Experiments

The biological response to high-LET radiation is different from low-LET radiation due to several factors, notably difference in energy deposition and formation of radiolytic species. Of particular importance in radiobiology is the formation of double-strand breaks (DSB), which can be detected by -H2AX foci experiments. These experiments has revealed important differences in the spatial distribution of DSB induced by low- and high-LET radiations [1,2]. To simulate -H2AX experiments, models based on amorphous track with radial dose are often combined with random walk chromosome models [3,4]. In this work, a new approach using the Monte-Carlo track structure code RITRACKS [5] and chromosome models have been used to simulate DSB formation. At first, RITRACKS have been used to simulate the irradiation of a cubic volume of 5 m by 1) 450 1H+ ions of 300 MeV (LET 0.3 keV/ m) and 2) by 1 56Fe26+ ion of 1 GeV/amu (LET 150 keV/ m). All energy deposition events are recorded to calculate dose in voxels of 20 m. The dose voxels are distributed randomly and scattered uniformly within the volume irradiated by low-LET radiation. Many differences are found in the spatial distribution of dose voxels for the 56Fe26+ ion. The track structure can be distinguished, and voxels with very high dose are found in the region corresponding to the track "core". These high-dose voxels are not found in the low-LET irradiation simulation and indicate clustered energy deposition, which may be responsible for complex DSB. In the second step, assuming that DSB will be found only in voxels where energy is deposited by the radiation, the intersection points between voxels with dose > 0 and simulated chromosomes were obtained. The spatial distribution of the intersection points is similar to -H2AX foci experiments. These preliminary results suggest that combining stochastic track structure and chromosome models could be a good approach to understand radiation-induced DSB and chromosome aberrations.

Plante, I.↗

On a Local Version of the Bak–Sneppen Model

A major difficulty in studying the Bak–Sneppen model is in effectively comparing it with well-understood models. This stems from the use of two geometries: complete graph geometry to locate the global fitness minimizer, and graph geometry to replace the species in the neighborhood of the minimizer. Over the years a number of models inspired by Bak–Sneppen were studied, usually by introducing different or new features (e.g. discretizing fitness, randomized neighbors or population size). We present a variant that only uses features present in Bak–Sneppen, and whose difference from the Bak–Sneppen is that only the graph geometry is used for the evolution. This allows to obtain the stationary distribution through random walk dynamics while preserving the geometric nature of the model. We use this to show that for constant-degree graphs, the stationary fitness distribution converges to an IID law as the number of vertices tends to infinity. We also discuss exponential ergodicity through coupling, and avalanches for the model.

97 MATHEMATICS AND COMPUTING↗

Grassmannian Diffusion Maps--Based Dimension Reduction and Classification for High-Dimensional Data

This work introduces the Grassmannian diffusion maps (GDMaps), a novel nonlinear dimensionality reduction technique that defines the affinity between points through their representation as low-dimensional subspaces corresponding to points on the Grassmann manifold. Here, the method is designed for applications, such as image recognition and data-based classification of constrained high-dimensional data where each data point itself is a high-dimensional object (i.e., a large matrix) that can be compactly represented in a lower-dimensional subspace. The GDMaps is composed of two stages. The first is a pointwise linear dimensionality reduction wherein each high-dimensional object is mapped onto the Grassmann manifold representing the low-dimensional subspace on which it resides. The second stage is a multipoint nonlinear kernel-based dimension reduction using diffusion maps to identify the subspace structure of the points on the Grassmann manifold. To this end, an appropriate Grassmannian kernel is used to construct the transition matrix of a random walk on a graph connecting points on the Grassmann manifold. Spectral analysis of the transition matrix yields low-dimensional Grassmannian diffusion coordinates embedding the data into a low-dimensional reproducing kernel Hilbert space. Further, a novel data classification/recognition technique is developed based on the construction of an overcomplete dictionary of reduced dimension whose atoms are given by the Grassmannian diffusion coordinates. Three examples are considered. First, a "toy" example shows that the GDMaps can identify an appropriate parametrization of structured points on the unit sphere. The second example demonstrates the ability of the GDMaps to revealing the intrinsic subspace structure of high-dimensional random field data. In the last ex- ample, a face recognition problem is solved considering face images subject to varying illumination conditions, changes in face expressions, and occurrence of occlusions. The technique presented high recognition rates (i.e., 95% in the best case) using a fraction of the data required by conventional methods.

42 ENGINEERING↗

On an asymptotic viscosity solution property of solutions of discrete Hamilton–Jacobi–Bellman equations

In this paper, we show that a proper limit of solutions of discrete Hamilton–Jacobi–Bellman (dHJB) equations in a random walk model becomes a viscosity solution of a Hamilton–Jacobi–Bellman (HJB) variational inequality in a continuous-time geometric Brownian model. HJB variational inequalities are used to analyze singular stochastic control problems in mathematical finance. By our result, with the help of dHJB equations, we can obtain viscosity solutions of HJB variational inequalities which are usually identified with the value functions of the singular stochastic control problems.

97 MATHEMATICS AND COMPUTING↗

Construction of distinct discrete time scattering quantum walk formulations on the honeycomb lattice

Here we address the scattering construction of discrete time quantum walks on the honeycomb lattice. We write the system general (unitary) one step time evolution operator in terms of: (i) complete arbitrary scattering matrices Γ{sup (j,k)}, defined on the sites (j,k) of the lattice and; and (ii) topological directional functions Φ, which represent the distinct ways we can keep track of the propagation directions along the three bonds attached to each (j,k). By imposing the Φ’s to comply with all the honeycomb translational and point group symmetries (in the case of Γ{sup (j,k)}=Γ), we obtain in total ten independent model versions, presenting different dynamical features. To study some of their traits, we consider the idea of ‘characteristic paths’ CPs (closely related to classical random walks), determining the CPs for each one of the ten formulations. We then discuss many numerical examples of time evolution dynamics for our scattering quantum walks. For the calculations we use few Γ’s, as the Discrete Fourier Transform (DFT) and Grover matrices.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗