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This is an abstract for an invited paper at the AIAA Aviation Conference, June 2021. The work described here is part of an effort of coordinated experiments in the Unitary Plan Wind Tunnel (UPWT) facility at the NASA Langley Research Center (LaRC) and matching CFD simulations. The primary goal of the work is to assess the productivity and true predictive accuracy of CFD, absent any guidance from experiment, in the high supersonic speed range as compared to experiments performed at the NASA LaRC’s UPWT facility. This report concerns CFD simulation of the primary flow-path in the empty wind tunnel, including the settling chamber, nozzle, test section, and some of the tunnel downstream of the test section. The Mach number in the test section ranges from M~2.4 to M~4.6, and the required area ratio variation is achieved by translation of a nozzle block which constricts the area of a loosely S-shaped throat. Flow past protuberances in the settling chamber and into this S-bend throat are predicted by CFD to generate streamwise vorticity that may, or may not, persist through the throat and into the test section as coherent vortices. Some flow conditions are notably unsteady at frequencies well below those of turbulence, due to unsteady separated flow ahead of the nozzle block. The bulk flow moves at velocities ranging from 'walking speed' in the settling chamber to M~4.6 in the test section. Heat transfer to the settling chamber walls and buoyancy are significant at high Mach number. Subtle variations in surface curvature in the nozzle generate Mach waves that propagate into the test section. CFD of the empty tunnel serves two purposes. Firstly, the full-tunnel simulations are used to provide upstream boundary conditions for CFD of vehicle aerodynamics which are generally performed in a domain confined to the wind tunnel test section; these companion studies are addressed in other papers. Secondly, it is a challenging test for CFD to resolve all of the empty tunnel flow phenomena relevant to flow in the test section. It requires a more complete definition of geometry than was originally anticipated. In addition, it requires good spatial and temporal accuracy, and turbulence modeling that performs well on specific phenomena such as corner flows. The boundary conditions and solution algorithms must perform well from incompressible to almost hypersonic speeds. The final state of the pre-test CFD was a product of an iterative self-improvement process. The initial simulations of the empty tunnel were deficient in many respects, but hints to those deficiencies were recognized in the solutions, and remedies were implemented. Possible further improvements will be studied in the post-test phase when comparisons with experimental data are possible. The CFD was performed by five separate collaborative teams using four different flow solvers: FUN3D, Overflow, Star-CCM+ and USM3D. The level of effort of these teams varied significantly, but each made important contributions to the goals of the work. A concerted effort to use uncertainty quantification methods (UQ) in CFD is also a goal of this work. To this end, variations in CFD results due to grid refinement, turbulence modeling, and boundary conditions have been characterized. Code-to-code variation is another means of assessing CFD uncertainty. All CFD solvers predict similarity among the primary flow features; these include the variation of Mach number due to changes in Reynolds number, and the bulk flow angularity due to tunnel-wall curvature. All CFD solvers also predict similar trends in secondary flows, such as the downwash in the side-wall boundary layers. Three of the high-spatial resolution simulations give similar predictions of a complex secondary flow phenomena, streamwise vortices generated in the S-bend throat that persist into the side-wall boundary layers of the test section. Two of the highest-resolution simulations, run with the same turbulence model in different CFD solvers, gave encouragingly similar predictions of a complex tertiary flow phenomenon, small transient "sprites" of upwash flows, resulting from vortices that presumably originate in the separated flow near the leading edge of the nozzle block. While the CFD was done in a "blind pre-test" mode, requests from the experimental team for CFD results pertaining to unsteadiness and total temperature variations in the test section resulted in CFD runs that included a cooled wall in settling chamber. This then led to a change in the standard practice for running the Overflow results, which would not have occurred without this "release" of this experimental information. CFD was also used to guide some measurements. The paper will focus on establishing the consensus among CFD results and understanding differences among those results. Initial findings from the efforts to characterize CFD uncertainty have been done and will be included in the paper.