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At least 181 records · Page 10

The space station assembly phase: Flight telerobotic servicer feasibility, volume 1

The question is addressed which was raised by the Critical Evaluation Task Force (CETF) analysis of the space station: if a Flight Telerobotic Servicer (FTS) of a given technical risk could be built for use during space station assembly, could it save significant extravehicular (EVA) resources. Key issues and trade-offs associated with using an FTS to aid in space station assembly phase tasks such as construction and servicing are identified. A methodology is presented that incorporates assessment of candidate assembly phase tasks, telerobotics performance capabilities, development costs, operational constraints (STS and proximity operations), maintenance, attached payloads, and polar platforms. A discussion of the issues is presented with focus on potential FTS roles: (1) as a research-oriented test bed to learn more about space usage of telerobotics; (2) as a research-based test bed with an experimental demonstration orientation and limited assembly and servicing applications; or (3) as an operational system to augment EVA, to aid the construction of the space station, and to reduce the programmatic (schedule) risk by increasing the flexibility of mission operations. During the course of the study, the baseline configuration was modified into Phase 1 (a station assembled in 12 flights), and Phase 2 (a station assembled over a 30 flight period) configuration.

Smith, Jeffrey H.↗

Elementary Particle Physics

The UT Dallas High Energy Physics group collaborates on the ATLAS experiment which observes the world’s high energy proton-proton collisions. The UTD group utilized ATLAS 8 TeV Run 1 data to search for evidence of a “dark photon”, a gauge boson outside the “Standard Model of Particle Physics” that theorist hypothesize could mediate a force felt only by the dark matter particles that dominate out universe. The observable signature is a pair of prompt lepton jets. The results of this search were published in 2013. More recently, we have improved the sensitivity of the analysis using machine learning techniques, and we are extending the search to higher and lower mass dark photons using the ATLAS 13 TeV data set. Detection of a new fifth force would represent an important advance beyond the 4 known forces that influence baryonic matter. The LHC Long Shutdown 1 from 2013-2014 was a period of intense work on refurbishment and upgrades for the ATLAS Pixel community and the UTD group. The service quarter panels of the original Pixel detector were replaced, and the Insertable B Layer (IBL) detector was integrated. During IBL integration, UTD participated on the Stave Task Force that solved corrosion problems with IBL wire bonds. We developed a relative humidity sensor that was used during integration and transport to the beamline when detector was unpowered. The sensors were repurposed to monitor relative humidity inside the ID endplates until the built-in sensors were recommissioned. The UTD group worked on the connection of the Pixel and IBL at Point 1 and we were in charge of electric service testing. The IBL wire bond corrosion was the instigation for developing a new conformal coating method using an atomizing spray and Cellpack polyurethane. It is being considered for use in the ITk tracker upgrade. We have demonstrated its tolerance both of a 9 MGy ionizing dose and thermal expansion. Two UTD students are completing authorship qualification projects. One is helping understand variations in impact parameter resolution across different running periods. The second is developing a data-driven method to monitor the fraction of fake tracks in dense jets.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

History of wildland fires on Vandenberg Air Force Base, California

The fire history of the past 50 years for Vandenberg AFB, California was determined using aerial photography, field investigation, and historical and current written records. This constitutes a record of the vegetation age classes for the entire base. The location, cause, and fuel type for sixty fires from this time period were determined. The fires were mapped and entered into a geographic infomation system (GIS) for Vandenberg. Fire history maps derived from this GIS were printed at 1:9600 scale and are on deposit at the Vandenberg Environmental Task Force Office. Although some ecologically significant plant communities on Vandenberg are adapted to fire, no natural fire frequency could be determined, since only one fire possibly caused by lightning occurred in the area now within the base since 1937. Observations made during this study suggest that burning may encourage the invasion of exotic species into chaparral, in particular Burton Mesa or sandhill chaparral, an unusual and geographically limited form of chaparral found on the base.

Hickson, Diana E.↗

Space Station Freedom engineering prototype development

The content of the Advance Development Program and subsequent Engineering Prototype Development activity has been guided by a series of focused studies. These studies started with the report of the Advance Development Task Force. An outline of issues relating to Automation, Data Systems, and Telerobotics was projected for the Space Station. Subsequent studies built upon and reaffirmed a focus on development and prototyping of Automation Technology for subsystem monitoring and problem diagnosis, Data System growth to accommodate more sophisticated automation, and use of Telerobotics technology to assist in the reduction ot required ExtraVehicular Activity (EVA) and IntraVehicular Activity (IVA) task time.

Fernquist, Alan↗

Telerobotic capabilities for space operations

This paper presents a summary of tests involving either pure telerobotics, or telerobots in conjunction with extravehicular activity, applied to some of the servicing tasks of the Hubble Space Telescope (HST). This research was conducted in a neutral buoyancy environment, using the high fidelity mockup used for astronaut crew training, along with two telerobots developed in the Space Systems Laboratory. These tests showed that current telerobots are capable of a limited subset of tasks required for EVA servicing of HST, and that specific developments in robotic capability are required, particularly in high torque output and positioning in constrained volumes, before the telerobotic systems are capable replacements to EVA. A more immediately promising application is the use of telerobots to enhance and extend the EVA capabilities, by acting as 'assistants' to the EVA crewmen performing the dexterous and high-force tasks.

Akin, David L.↗

Proposed Products to Support Shelter-Evacuation Decision Making in the Event of a Nuclear Detonation

Response strategies implemented in the first few hours to days after a nuclear detonation on the US homeland may save more than 100,000 lives. Effective planning and pre-event capability development can increase the response efficacy and so the number of lives saved. During such an event, the US Department of Defense, Joint Task Force Civil Support (DoD JTF-CS) provides command and control for the DoD forces supporting civil authority response operations. Among other activities, JTF-CS expects to support FEMA as well as State and local agencies in shelter and evacuation response activities. JTF-CS currently uses a manual method to generate evacuation decision making products. This method compares the dose that would be (a) acquired remaining at a given location to that (b) acquired during evacuation along a small number of routes. In these products, evacuation may be warranted when the projected “remain” dose is greater than the “evacuate” dose. This method only provides a limited consideration of the protection buildings provide their occupants. To inform the JTF-CS nuclear detonation response, the DoD Defense Threat Reduction Agency (DTRA) has tasked Lawrence Livermore National Laboratory (LLNL) to design a set of planning and response products to support shelter-evacuation activities. This report documents these products to facilitate DTRA and JTF-CS planning efforts. To provide context, we also provide appendices that summarize US planning guidance response zones, early (<72 h) response strategies, and other key topics.

61 RADIATION PROTECTION AND DOSIMETRY↗

ENSO-Induced Teleconnection: Process-Oriented Diagnostics to Assess Rossby Wave Sources and Ambient Flow Properties in Climate Models

Climate model fidelity in representing ENSO-induced teleconnection is assessed with process-oriented diagnostics that examine a chain of processes, from equatorial Pacific precipitation to the midlatitude circulation pattern over the Pacific–North American regions. Such processes are rarely addressed during model development. Using an upper-tropospheric divergent level, local vorticity gradient of the ambient zonal flow (∂ 2 U¯/∂y 2 ) and a restoring force for Rossby waves (β * ) are estimated, the equivalent barotropic vorticity equation is solved, and an anomalous Rossby wave source (RWS') quantified. The analysis is applied to AMIP5 and AMIP6 simulations. For a realistic circulation response representation, the hypothesis that models accurately represent the strength and location of RWS', and spatial variations in β * is tested. Compared to AMIP5, in AMIP6 there are clear improvements in representing RWS' and β * . To validate the hypothesis, the analysis identifies two metrics: spatially coherent RWS' in the subtropical North Pacific, and longitudes of negative β * over the western-central North Pacific. By projecting these metrics in two and three-dimensional views, improvements or degradations in model versions are apparent. If a model’s fidelity in representing ∂ 2 U¯/∂y 2 and RWS' are compromised, then radiated Rossby waves are reflected more equatorward, resulting in zonally elongated circulation anomalies over the central North Pacific. Thus, during climate model development, applying this analysis frequently will keep a regular check on the fidelity of the modeled response to anomalous El Niño convection in conjunction with changing model ambient flow dependencies. As a result, this analysis is intended to form a process-oriented diagnostics package, a community contribution to the NOAA Model Diagnostics Task Force.

54 ENVIRONMENTAL SCIENCES↗

Stratospheric aerosol forcing for CMIP7 – Part 1: optical properties for pre-industrial, historical, and scenario simulations

Stratospheric aerosols, most of which originate from explosive volcanic sulfur emissions into the stratosphere, are a key natural driver of climate variability. They are thus a forcing provided by the Coupled Model Intercomparison Project (CMIP) Climate Forcings Task Team to climate modelling groups participating in phase 7 of CMIP. For the historical period, we provide two datasets covering 1750–2023: (i) a volcanic upper tropospheric-stratospheric sulfur emission dataset, documented in a companion paper; and (ii) a stratospheric sulfate aerosol optical property dataset, documented in this paper. For the satellite era (from 1979 onwards), stratospheric aerosol optical properties are derived from the Global Space-based Stratospheric Aerosol Climatology (GloSSAC) dataset. For the pre-satellite era (1750–1978), optical properties are derived from our volcanic SO 2 emission dataset using a new version of the reduced-complexity volcanic aerosol model Easy Volcanic Aerosol (Height) (EVA_H v2). A background, non-volcanic stratospheric aerosol climatology is derived from the 1998–2001 period with a trend over 1850–1978 accounting for increasing anthropogenic aerosols. A monthly stratospheric aerosol climatology is derived from the 1850–2021 average for both pre-industrial and scenario (future) simulations, with a 9-year ramp over 2022–2030 for scenario simulations to ensure a smooth transition from the historical period. CMIP7 simulations should use version 2.2.1 of our pre-industrial and historical datasets, and version 2.2.2 of our scenario dataset. Our methodology to produce historical aerosol optical properties significantly differs from CMIP6 for the pre-satellite era, and the resulting forcings in turn largely differ. In particular, the CMIP6 dataset was mostly based on the sparse and uncertain pyrheliometer record, which resulted in strongly underrepresented emissions from small-to-moderate magnitude eruptions. The resulting bias is addressed in CMIP7, which is entirely emission-derived in the pre-satellite era and uses more recent ice-core-based volcanic sulfur emission inventories than CMIP6. Our approach results in an overall larger volcanic aerosol forcing for CMIP7, with the 1850–2014 mean mid-visible global mean stratospheric aerosol optical depth (SAOD) in CMIP7 (0.0138) being 29 % higher than in CMIP6 (0.0107). The pre-industrial mean of the same variable is 26 % higher in CMIP7 (0.0135, derived from the historical 1850–2021) than CMIP6 (0.0107, derived from the historical 1850–2014 mean). Using a reduced-complexity climate model, we simulate a global mean surface temperature that is 0.07 °C colder for 1850–1900 when using the CMIP7 dataset instead of CMIP6, whereas 2000–2014 is 0.03 °C warmer in CMIP7. Our dataset also exhibits lower forcing for 1960–1980, resulting in temperatures 0.06 °C warmer when averaged over 1960–1990, a period for which CMIP6 climate models exhibit a cold bias. Given the large uncertainties characterizing the dataset, in particular for the pre-satellite era, we advise against treating the CMIP7 or CMIP6 dataset as uniquely superior for any specific year and highlight the need for further evaluation. We conclude the study by discussing sources of uncertainty for the dataset, future research avenues to improve it, as well as requirements to operationalize the production of the dataset, i.e. extend it and update it on an annual basis instead of every 5–7 years following CMIP cycles.

Aubry, Thomas J. [Univ. of Exeter, Devon (United K↗

Standoff Over the LRSO: Assessing the long-range stand-off missile's impact on strategic stability.

Mutual vulnerability to strategic forces seems to remain the de facto foundation for strategic stability across the U.S.-Russia and U.S.-China dyadic relationships; This work has suggested the bomber force tasked with delivering the LRSO is characterized by relatively long flight times and rich signature sets which make its use inconsistent with the requirements for a disarming first-strike. Therefore, the LRSO would not be expected to disrupt mutual vulnerability by making a disarming strike more possible or attractive; Even if a stealthy air-launched cruise missile is paired with a stealth bomber aircraft, the signatures associated with bomber generation and aerial refueling from non-stealth tanker aircraft make it unlikely the LRSO could be launched against a peer or near-peer nation-state without advance warning; To the extent a nuclear armed air-launched cruise missile deters would-be U.S. adversaries from nuclear use, maintaining a survivable weapon system is crucial for maintaining that stable deterrent effect. A modern stand-off weapon and stealth delivery platform increase the probability this capability will be maintained in the future against other nations' increasingly capable A2/AD systems; The LRSO has been touted as a flexible option to deter, or conduct should deterrence fail, limited nuclear strikes pursuant to Russia's reported "escalate-to-deescalate" doctrine. The concept of limited nuclear use is still intensely debated, and there is no guarantee that escalation could be controlled even with tailored LRSO employment; The challenge of warhead discrimination has not historically led to a nuclear response to a cruise missile launch, but there is no guarantee that cannot change. Having accurate military intelligence coupled with discerning analysis of the context in which cruise missiles are employed (e.g., how escalated is the conflict, how many missiles have been launched, have there been signatures of strategic force mobilization, or has the nuclear threshold been crossed?) will likely be essential for reducing the danger of misperception. Developing norms and/or communication channels in the aforementioned dyadic relationships may also further these ends. In sum, this work has identified and analyzed many of the major arguments in the debate regarding the LRSO's impact on strategic stability. During this study and survey of other nation's conceptions of strategic stability, it became clear that the LRSO is neither inherently stabilizing or destabilizing; rather, it is one instrument in addition to unambiguous U.S. policy, clear messaging, and signaling of intent that may promote stability by reducing the risk of miscalculation and unintended escalation.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗

Research priorities for managing invasive wild pigs in North America

ABSTRACT With recent increases in distribution and numbers of feral pigs ( Sus scrofa ; invasive wild pigs) in North America, there has been a concurrent increase in the ecological and economic effects they have had on native and anthropogenic ecosystems. Despite the amplified interest in invasive wild pig research, there remains a significant knowledge gap regarding their basic biology and ecology, the scope of the damage they cause, and the efficacy of many control strategies. Such information is important to support the successful management of invasive wild pigs throughout North America and other areas. In 2016, members of the National Wild Pig Task Force met and developed a set of research priorities to aid in effective management of invasive wild pigs. These research priorities identify 4 topical areas where increased effort and science is most needed to manage invasive wild pigs: biology and ecology, economic and ecological damages, control strategies, and education and human dimensions, with particular emphasis on areas where specific data gaps remain within each topical area. Resolution of such knowledge deficits would advance the understanding of invasive wild pig ecology, enabling more efficient and effective management of this species. © 2018 The Wildlife Society.

Beasley, James C.↗

U.S. Commercial Building Stock Analysis of COVID-19 Mitigation Strategies

The COVID-19 pandemic highlights the importance of improving building indoor air quality to reduce occupants' chances of contracting airborne illness. The ASHRAE Epidemic Task Force (ASHRAE-ETF) released several COVID-19 mitigation strategies at the onset of the pandemic. This study explores four of those recommendations for reducing transmission of COVID-19 inside buildings: (1) 100% outdoor air ventilation, (2) MERV-13 or better filters, (3) demand control ventilation removal, and (4) HVAC flushing mode. These recommendations were simulated and assessed using ComStock, a model of the U.S. commercial building stock. The study showed the 100% outdoor air ventilation recommendation had the largest impact on energy consumption, noncoincident peak demand, and thermostat violations. Removing demand control ventilation had the smallest national aggregate impact, installing MERV-13 filters led to slight increases in energy use and peak demand, and HVAC outdoor air flushing led to modest energy use and peak demand increases.

building energy modelling↗

MJO simulation in CMIP5 climate models: MJO skill metrics and process-oriented diagnosis

The Madden-Julian Oscillation (MJO) simulation diagnostics developed by MJO Working Group and the process-oriented MJO simulation diagnostics developed by MJO Task Force are applied to 37 Coupled Model Intercomparison Project phase 5 (CMIP5) models in order to assess model skill in representing amplitude, period, and coherent eastward propagation of the MJO, and to establish a link between MJO simulation skill and parameterized physical processes. Process-oriented diagnostics include the Relative Humidity Composite based on Precipitation (RHCP), Normalized Gross Moist Stability (NGMS), and the Greenhouse Enhancement Factor (GEF). Numerous scalar metrics are developed to quantify the results. Most CMIP5 models underestimate MJO amplitude, especially when outgoing longwave radiation (OLR) is used in the evaluation, and exhibit too fast phase speed while lacking coherence between eastward propagation of precipitation/convection and the wind field. The RHCP-metric, indicative of the sensitivity of simulated convection to low-level environmental moisture, and the NGMS-metric, indicative of the efficiency of a convective atmosphere for exporting moist static energy out of the column, show robust correlations with a large number of MJO skill metrics. The GEF-metric, indicative of the strength of the column-integrated longwave radiative heating due to cloud-radiation interaction, is also correlated with the MJO skill metrics, but shows relatively lower correlations compared to the RHCP- and NGMS-metrics. Our results suggest that modifications to processes associated with moisture-convection coupling and the gross moist stability might be the most fruitful for improving simulations of the MJO. Though the GEF-metric exhibits lower correlations with the MJO skill metrics, the longwave radiation feedback is highly relevant for simulating the weak precipitation anomaly regime that may be important for the establishment of shallow convection and the transition to deep convection.

54 ENVIRONMENTAL SCIENCES↗

Guidelines in review: Comparison of ESC and AHA guidance for the diagnosis and management of infective endocarditis in adults

Over recent years, new evidence has led a rethinking of the available guidance on the diagnosis and management of infective endocarditis (IE). This review compares the most recently available guidance provided by the American Heart Association (AHA) IE Writing Committee, and the Task Force for the management of IE of the European Society of Cardiology (ESC). This represents the sixth of a new series of comparative guidelines review published in the Journal.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Spectroscopic Needs for Imaging Dark Energy Experiments

Ongoing and near-future imaging-based dark energy experiments are critically dependent upon photometric redshifts (a.k.a. photo-z’s): i.e., estimates of the redshifts of objects based only on flux information obtained through broad filters. Higher-quality, lower-scatter photo-z’s will result in smaller random errors on cosmological parameters; while systematic errors in photometric redshift estimates, if not constrained, may dominate all other uncertainties from these experiments. The desired optimization and calibration is dependent upon spectroscopic measurements for secure redshift information; this is the key application of galaxy spectroscopy for imaging-based dark energy experiments. Hence, to achieve their full potential, imaging-based experiments will require large sets of objects with spectroscopically-determined redshifts, for two purposes: Training: Objects with known redshift are needed to map out the relationship between object color and z (or, equivalently, to determine empirically-calibrated templates describing the rest-frame spectra of the full range of galaxies, which may be used to predict the color-z relation). The ultimate goal of training is to minimize each moment of the distribution of differences between photometric redshift estimates and the true redshifts of objects, making the relationship between them as tight as possible. The larger and more complete our “training set” of spectroscopic redshifts is, the smaller the RMS photo-z errors should be, increasing the constraining power of imaging experiments; Requirements: Spectroscopic redshift measurements for ~30,000 objects over >~15 widely-separated regions, each at least ~20 arcmin in diameter, and reaching the faintest objects used in a given experiment, will likely be necessary if photometric redshifts are to be trained and calibrated with conventional techniques. Larger, more complete samples (i.e., with longer exposure times) can improve photo-z algorithms and reduce scatter further, enhancing the science return from planned experiments greatly (increasing the Dark Energy Task Force figure of merit by up to ~50%); Options: This spectroscopy will most efficiently be done by covering as much of the optical and near-infrared spectrum as possible at modestly high spectral resolution (λ/Δλ > ~3000), while maximizing the telescope collecting area, field of view on the sky, and multiplexing of simultaneous spectra. The most efficient instrument for this would likely be either the proposed GMACS/MANIFEST spectrograph for the Giant Magellan Telescope or the OPTIMOS spectrograph for the European Extremely Large Telescope, depending on actual properties when built. The PFS spectrograph at Subaru would be next best and available considerably earlier, c. 2018; the proposed ngCFHT and SSST telescopes would have similar capabilities but start later. Other key options, in order of increasing total time required, are the WFOS spectrograph at TMT, MOONS at the VLT, and DESI at the Mayall 4 m telescope (or the similar 4MOST and WEAVE projects); of these, only DESI, MOONS, and PFS are expected to be available before 2020. Table 2-3 of this white paper summarizes the observation time required at each facility for strawman training samples. To attain secure redshift measurements for a high fraction of targeted objects and cover the full redshift span of future experiments, additional near-infrared spectroscopy will also be required; this is best done from space, particularly with WFIRST-2.4 and JWST; Calibration: The first several moments of redshift distributions (the mean, RMS redshift dispersion, etc.), must be known to high accuracy for cosmological constraints not to be systematics-dominated (equivalently, the moments of the distribution of differences between photometric and true redshifts could be determined instead). The ultimate goal of calibration is to characterize these moments for every subsample used in analyses - i.e., to minimize the uncertainty in their mean redshift, RMS dispersion, etc. – rather than to make the moments themselves small. Calibration may be done with the same spectroscopic dataset used for training if that dataset is extremely high in redshift completeness (i.e., no populations of galaxies to be used in analyses are systematically missed). Accurate photo-z calibration is necessary for all imaging experiments; Requirements: If extremely low levels of systematic incompleteness (<~0.1%) are attained in training samples, the same datasets described above should be sufficient for calibration. However, existing deep spectroscopic surveys have failed to yield secure redshifts for 30–60% of targets, so that would require very large improvements over past experience. This incompleteness would be a limiting factor for training, but catastrophic for calibration. If <~0.1% incompleteness is not attainable, the best known option for calibration of photometric redshifts is to utilize cross-correlation statistics in some form. The most direct method for this uses cross-correlations between positions on the sky of bright objects of known spectroscopic redshift with the sample of objects that we wish to calibrate the redshift distribution for, measured as a function of spectroscopic z. For such a calibration, redshifts of ~100,000 objects over at least several hundred square degrees, spanning the full redshift range of the samples used for dark energy, would be necessary; and Options: The proposed BAO experiment eBOSS would provide sufficient spectroscopy for basic calibrations, particularly for ongoing and near-future imaging experiments. The planned DESI experiment would provide excellent calibration with redundant cross-checks, but will start after the conclusion of some imaging projects. An extension of DESI to the Southern hemisphere would provide the best possible calibration from cross-correlation methods for DES and LSST. We thus anticipate that our two primary needs for spectroscopy – training and calibration of photometric redshifts – will require two separate solutions. For ongoing and future projects to reach their full potential, new spectroscopic samples of faint objects will be needed for training; those new samples may be suitable for calibration, but the latter possibility is uncertain. In contrast, wide-area samples of bright objects are poorly suited for training, but can provide high-precision calibrations via cross-correlation techniques. Additional training/calibration redshifts and/or host galaxy spectroscopy would enhance the use of supernovae and galaxy clusters for cosmology. We also summarize additional work on photometric redshift techniques that will be needed to prepare for data from ongoing and future dark energy experiments.

79 ASTRONOMY AND ASTROPHYSICS↗

Dosimetric Inhomogeneity Predicts for Long-Term Breast Pain After Breast-Conserving Therapy

Purpose: The objective of this cross-sectional study was to characterize long-term breast pain in patients undergoing breast-conserving surgery and radiation (BCT) and to identify predictors of this pain. Methods and Materials: We identified 355 eligible patients with Tis-T2N0M0 breast cancer who underwent BCT in 2007 to 2011, without recurrent disease. A questionnaire derived from the Late Effects Normal Tissue Task Force (LENT) Subjective, Objective, Management, Analytic (SOMA) scale was mailed with 7 items detailing the severity, frequency, duration, and impact of ipsilateral breast pain over the previous 2 weeks. A logistic regression model identified predictors of long-term breast pain based on questionnaire responses and patient, disease, and treatment characteristics. Results: The questionnaire response rate was 80% (n=285). One hundred thirty-five patients (47%) reported pain in the treated breast, with 19 (14%) having pain constantly or at least daily; 15 (11%) had intense pain. The pain interfered with daily activities in 11 patients (8%). Six patients (4%) took analgesics for breast pain. Fourteen (10%) thought that the pain affected their quality of life. On univariable analysis, volume of breast tissue treated to ≥105% of the prescribed dose (odds ratio [OR] 1.001 per cc, 95% confidence interval [CI] 1.000-1.002; P=.045), volume treated to ≥110% (OR 1.009 per cc, 95% CI 1.002-1.016; P=.012), hormone therapy use (OR 1.95, 95% CI 1.12-3.39; P=.02), and other sites of pain (OR 1.79, 95% CI 1.05-3.07; P=.03) predicted for long-term breast pain. On multivariable analysis, volume ≥110% (OR 1.01 per cc, 95% CI 1.003-1.017; P=.007), shorter time since treatment (OR 0.98 per month, 95% CI 0.96-0.998; P=.03), and hormone therapy (OR 1.84, 95% CI 1.05-3.25; P=.03) were independent predictors of pain. Conclusion: Long-term breast pain was common after BCT. Although nearly half of patients had pain, most considered it tolerable. Dosimetric inhomogeneity independently predicted for pain and should be minimized to the greatest extent possible.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

PDB-IHM: A System for Deposition, Curation, Validation, and Dissemination of Integrative Structures

Structures of many large biomolecular assemblies are now being determined using integrative approaches. In these approaches, information derived from multiple experimental and computational methods is combined to compute three-dimensional structures of multi-protein complexes and other macromolecular machines. A standalone prototype data resource for integrative structures called PDB-Dev was built, based on recommendations of the Integrative and Hybrid Methods (IHM) Task Force of the Worldwide Protein Data Bank (wwPDB). This effort included developing data standards and software tools for collecting, curating, validating, visualizing, archiving, and disseminating integrative structures that span diverse spatiotemporal scales and conformational states. Mechanisms have been created to validate integrative structures based on the experimental data underpinning them. Building upon this foundational framework, PDB-Dev has been further expanded to handle large dynamic macromolecular systems and integrative structures that combine, for example, experimental restraints with atomic coordinates computed by machine learning algorithms. Data standards and supporting tools have also been extended to capture information about biomolecular dynamics, such as conformational transitions and related kinetic data derived from biophysical methods. Recently, PDB-Dev was unified with the PDB archive and rebranded as PDB-IHM (pdb-ihm.org), further promoting FAIR (Findable, Accessible, Interoperable, and Reusable) principles of data stewardship for integrative structural biology.

IHMCIF↗

Resonances in QCD

We report on the EMMI Rapid Reaction Task Force meeting 'Resonances in QCD', which took place at GSI October 12-14, 2015 (Fig.~1). A group of 26 people met to discuss the physics of resonances in QCD. The aim of the meeting was defined by the following three key questions; what is needed to understand the physics of resonances in QCD?; where does QCD lead us to expect resonances with exotic quantum numbers?; and what experimental efforts are required to arrive at a coherent picture? For light mesons and baryons only those with up, down and strange quark content were considered. For heavy-light and heavy-heavy meson systems, those with charm quarks were the focus.This document summarizes the discussions by the participants, which in turn led to the coherent conclusions we present here.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗