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During aerospace vehicle conceptual and preliminary design, empirical non-optimum factors are typically applied to predicted structural component weights to account for undefined manufacturing and design details. Non-optimum factors are developed here for 32 aluminum-lithium 2195 orthogrid panels comprising the liquid hydrogen tank barrel of the Space Shuttle External Tank using measured panel weights and manufacturing drawings. Minimum values for skin thickness, axial and circumferential blade stiffener thickness and spacing, and overall panel thickness are used to estimate individual panel weights. Panel non-optimum factors computed using a coarse weights model range from 1.21 to 1.77, and a refined weights model (including weld lands and skin and stiffener transition details) yields non-optimum factors of between 1.02 and 1.54. Acreage panels have an average 1.24 non-optimum factor using the coarse model, and 1.03 with the refined version. Non-optimum factors are also calculated for the aluminum-alloy gores that compose the ogive and ellipsoidal bulkheads of the Space Shuttle Super-Lightweight Tank propellant tanks. Minimum values for actual gore skin thicknesses and weld land dimensions are extracted from component production drawings, and are used to predict reference gore weights. These actual skin thicknesses are also compared to skin thicknesses predicted using classical structural mechanics and tank proof-test pressures. Both coarse and refined weights models are developed for the gores. The coarse model is based on the proof-test skin thicknesses, and the refined model uses the actual skin thicknesses and weld land details. Both models include manufacturing tolerance weight estimates. To determine the gore non-optimum factors, these reference weights are then compared to flight hardware weights reported in a mass properties database. The gore non-optimum factors computed using the coarse weights model range from 1.18 to 2.36, with an average non-optimum factor of 1.68. Application of the refined weights model yields non-optimum factors between 1.00 and 1.45, with an average non-optimum factor of 1.13. To demonstrate their utility, these calculated non-optimum factors are then used to predict more realistic (i.e., heavier) gore weights for a proposed heavy-lift launch vehicle's propellant tank bulkheads.