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NASA NTRSDate not supplied

A Human-In-The-Loop Simulation for Urban Air Mobility in the Terminal Area

In this paper researchers propose a human-in-the-loop experiment to study human performance when tasked with tactical deconfliction in terminal area air taxi operations. The air taxi operations being considered herein are an advanced air transportation concept called Urban Air Mobility (UAM). The UAM concept aims to support not only air taxi operations, but also package delivery and emergency response among other use cases. The key innovation over current air transportation lies with the introduction of highly automated aircraft and air traffic management systems. Development of the UAM system will include transitional midterm phases where some operational services will be provided by a mixture of automation and human actors. Midterm operations present a unique challenge, since the scope of responsibility of automated systems is largely undefined, suggesting the need for direct human participation with little to inform how much human intervention is necessary. Here it is assumed that traffic management responsibilities require coordination between human actors and automated systems and focus on arrival flows for midterm operations. In the proposed human-in-the-loop simulation, virtual UAM traffic is strategically deconflicted by a Provider of Services for UAM at departure, then tactically managed by a human at the arrival facility. Generated traffic consists of UAM participants flying in UAM exclusive airspace structures, thus isolated from traditional traffic. The human operator is tasked with managing spacing of arrival traffic and executing speed adjustments as deemed necessary. Researchers propose the investigation of three levels of automation assistance: 1) no assistance; 2) spacing violation detection; 3) spacing violation detection and speed adjustment recommendations. Quantitative measures like throughput and delay are used to assess the human's capacity for accommodating airborne delays. Qualitative evaluations such as surveys and open-ended feedback are used to gain insight into human factors. These factors could introduce additional capacity constraints on traffic, independent of physical or technical constraints. Although findings for this study will not be reported as the study has not yet been executed, the authors conclude with potential outcomes informed by previous simulations in the literature and suggestions for the structure and procedures of midterm human-automation air traffic management.

UAM↗

NASA NTRSDate not supplied

A Human-In-The-Loop Simulation for Urban Air Mobility in the Terminal Area

In this presentation we propose a human-in-the-loop experiment to study the potential impact of human engagement in tactical mitigation of delay in terminal area air taxi operations. The air taxi operations being considered herein is an advanced air transportation concept called Urban Air Mobility (UAM). The UAM concept aims to support not only air taxi operations, but also package delivery and emergency response among other use cases. The key innovation over current air transportation lies with the introduction of autonomous aircraft and autonomous air traffic management systems. Development of the UAM system will include transitional midterm phases where some operational services will be provided by a mixture of automation and human actors. Midterm operations present a unique challenge, since the scope of responsibility of automated systems is largely undefined, suggesting the need for direct human participation with little to inform how much human intervention is necessary. Here we assume that traffic management responsibilities require coordination between human actors and automated systems and focus on arrival flows for midterm operations. In the proposed human-in-the-loop simulation, virtual UAM traffic is strategically deconflicted by a Provider of Services for UAM at departure, then tactically managed by a human at the arrival facility. Generated traffic consists of UAM participants flying in UAM exclusive airspace structures, thus isolated from traditional traffic. The human operator is tasked with managing spacing of arrival traffic and executing speed adjustments as deemed necessary. We propose the investigation of three levels of automation assistance: 1) no assistance; 2) spacing violation detection; 3) spacing violation detection and speed adjustment recommendations. Quantitative measures like throughput and delay are used to assess the human's capacity for accommodating airborne delays. Qualitative evaluations such as surveys and open-ended feedback are used to gain insight into human factors. These factors could introduce additional capacity constraints on traffic, independent of physical or technical constraints. Although findings for this study will not be reported as the study has not yet been executed, we conclude with potential outcomes informed by previous simulations in the literature and suggestions for the structure and procedures of midterm human-automation air traffic management.

UAM↗

NASA NTRS2026

Designing a Propylene-Glycol Coolant Servicer System for Gateway’s Internal Active Thermal Control System

A human spacecraft ATCS—especially one using single-phase coolant loops exposed to cabin atmospheric conditions—requires periodic degassing and refilling to support long-duration missions of 15 to 30 years. During initial fill operations, system maintenance, gas permeation, and quick-disconnect mating or de-mating, small amounts of gas can gradually enter the coolant system over time. This can lead to degraded heat transfer performance, pump cavitation, and potentially pump vapor lock if a significant gas volume accumulates over time. Additionally, system leaks and routine fluid sampling can gradually reduce accumulator volumes to unacceptable levels, requiring periodic refills. In more severe cases, catastrophic changes in fluid composition may necessitate emergency draining, refilling, and degassing to ensure continued system functionality. These risks were identified and mitigated on the ISS ITCS through the development of a dual-membrane degasser ORU and a Fluid Servicer System ORU for coolant refilling. These systems were developed for the fully water-based ISS ITCS Coolant[1]. The Gateway space station, the first permanent human habitat in lunar orbit, uses a propylene-glycol/water coolant mixture, which has significantly different fluid properties compared to pure water. Because microgravity degassing technologies are sensitive to fluid surface tension and viscosity, existing ISS hardware is not suitable for servicing a propylene-glycol-based TCS. Unlike the ISS, the Gateway will operate in a higher-radiation environment and must meet stricter mass constraints due to its location outside of low earth orbit. This Government Furnished Equipment (GFE) flight hardware project aims to develop a lightweight, radiation-resistant Coolant Servicer System (CSS) capable of degassing and refilling Gateway’s propylene-glycol water-based IATCS.

Propylene Glycol Water↗

NASA NTRS2026

Designing a Propylene-Glycol Coolant Servicer System for Gateway’s Internal Active Thermal Control System

Propylene Glycol Water↗

NASA NTRS2003

Metrics for in-space telescope assembly techniques

Reliable metrics are not yet available for choosing among human and robotic assets for space-based construction and servicing of large space telescopes. Using FAIR-DART as a reference design, we generated example event sequences for telescope assembly scenarios in enough detail to identify infrastructure assumptions and technology requirements. A systems trade among human and robotic techniques (human EVA, on-site telerobotic, ground-in-the- loop robotic, commanded or sequenced robotic, and autonomous/decision-making robotic) helped us to define key metrics in the human-robotic trade space, including quality, time, cost, and risk. Our methodology included examining representative end-member scenarios. Case A treated each step in the assembly sequence as if all other steps have no on-site human involvement, and Case B treated each step as if human EVA is already involved in all other steps. With this trade, we identified key enabling technologies and infrastructure for space-based assembly and servicing of large space telescopes.

space telescopes human and robotic in-space assemb↗

NASA NTRS2014

Industry Initiated Core Safety Attributes for Human Spaceflight for the 7th IAASS Conference

Now that the NASA Commercial Crew Program (CCP) is beginning its full certification contract for crew transportation to the International Space Station (ISS), is it time for industry to embrace a minimum set of core safety attributes? Those attributes can then be evolved into an industry-led set of basic safety standards and requirements. After 50 years of human space travel sponsored by governments, there are two basic conditions that now exist within the international space industry. The first, there is enough of a space-faring history to encourage the space industry to design, develop and operate human spaceflight systems without government contracts for anything other than services. Second, industry is capable of defining and enforcing a set of industry-based safety attributes and standards for human spaceflight to low-Earth orbit (LEO). This paper will explore both of these basic conditions with a focus on the safety attributes and standards. In the United States, the Federal Aviation Administration (FAA) is now starting to dialogue with industry about the basic safety principles and attributes needed for potential future regulatory oversight. This process is not yet formalized and will take a number of years once approval is given to move forward. Therefore, throughout the next few years, it is an excellent time and opportunity for industry to collaborate together and develop the core set of attributes and standards. As industry engages and embraces a common set of safety attributes, then government agencies, like the FAA and NASA can use that industry-based product to strengthen their efforts on a safe commercial spaceflight foundation for the future. As the commercial space industry takes the lead role in establishing core safety attributes, and then enforcing those attributes, the entire planet can move away from governmental control of design and development and let industry expand safe and successful space operations in LEO. At that point the governmental agencies can focus on oversight of the industries' defined standards and enforcement for common welfare of the space-faring populous and overall public safety.

crew transportation↗

DOE OSTI2026

Human Factors and Technologies Design to Improve User Acceptance of Pooled Rideshare for Increasing Transportation System Energy Efficiency

This multi-year project delivered a comprehensive, human-factors-driven framework to understand, model, and improve pooled rideshare (PR) adoption in the United States. Through three large-scale national survey studies involving more than 16,000 participants across multiple cities and demographic groups, the research established one of the most extensive datasets to date on user perceptions, behavioral barriers, and service expectations related to pooled rideshare. These data revealed key human factors barriers of user acceptance of PR and suggested potential actionable experience optimizations that could lead to increased PR usage. This foundational knowledge guided the development of novel human-factors models and behavioral choice models that quantify how psychological, demographic, and trip-level factors influence willingness to pool. Building on these empirical insights, the project developed advanced behavioral modeling tools, including mixed logit and integrated choice and latent variable models, to capture both observable and latent influences on PR adoption. These models significantly improved the ability to predict riders’ acceptance of pooled trips, explaining choice heterogeneity through latent constructs such as safety, service experience, privacy concerns, time sensitivity, and environmental attitudes. Together, these models provide a robust analytical foundation for designing PR systems that more effectively meet user needs. The project translated human-factors insights and behavioral models into actionable technology innovations by extending POLARIS—an agent-based, activity-based travel simulation platform—into a fully functional pooled rideshare simulation environment. New PR modules, acceptance models, and regional scenarios were implemented for Greenville, SC and Austin, TX, enabling high-fidelity validation of algorithmic strategies under realistic demand and traffic conditions. The simulation platform supported the development and evaluation of adaptive discount-based assignment algorithms, enhanced willingness-to-pay formulations, demographic-aware incentive mechanisms, and a proactive joint assignment and repositioning strategy. Simulation results demonstrated substantial gains in pooling uptake, average vehicle occupancy, energy efficiency, and fleet profitability. In Greenville, pooling adoption more than doubled, while reductions in vehicle-miles traveled and energy consumption were significant. In Austin, pooling improvements were achieved with minimal service-quality trade-offs, and profitability increased across all fleet sizes. Through this research, we developed a comprehensive understanding of the human factors barriers that limit user acceptance of pooled rideshare services. These insights enabled the design of human-factors-aware pooled rideshare technologies that more effectively address user concerns and improve adoption rates. By integrating these models into an advanced agent-based simulation framework, we demonstrated that higher adoption of pooled rideshare can lead to measurable improvements in energy efficiency and system performance. Together, these contributions establish a validated pathway from human-centered analysis to technology development and energy-saving outcomes, supporting national goals for more sustainable and efficient mobility systems.

Jia, Yunyi↗

DOE OSTI2025

User Acceptance of Shared Autonomous Vehicles

A dissertation is proposed to explore user acceptance of shared autonomous vehicles (SAVs). SAVs are facing limited user acceptance. To systematically tackle the user acceptance barriers of SAVs, the main problem can be disintegrated into two sub-problems of user acceptance of autonomous vehicles (AVs) and ridesharing. The comfort of the ride experience in AVs is a determinant of user acceptance. Understanding the influential factors and developing methodologies to quantify human comfort in AVs are essential to facilitating future research to improve human comfort in AVs. The current pooled rideshare (PR) service closely resembles the anticipated future of SAVs. Understanding why users prefer or refuse to use PR at the current stage prepares SAVs for broader acceptance in the future. Until now, a series of peer-reviewed publications have been published to achieve the technical goals. Two simulator-based user studies were conducted to instrument the research on human comfort in AVs. Statistical analysis was performed to identify the crucial vehicular behavioral factors of human comfort in AVs. The influential factors of human comfort in AVs and methodologies to quantify and detect human comfort in AVs were investigated. Two survey-based studies were deployed to facilitate the investigation of user acceptance of rideshare services. The influential factors of users' willingness to consider PR were explored and identified, and the choice behaviors in ridesharing services were comprehensively modeled and analyzed. The proposed research answers a series of fundamental questions regarding the user acceptance of SAVs. For the branch of user acceptance of AVs, the research generated guidelines for improving passenger comfort in AVs by identifying a series of autonomous driving factors of passenger comfort. The research also provides fundamental tools to estimate human comfort levels for future research and in-AV applications. For the branch of user acceptance of PR, the research provided user acceptance-aware vehicle, service, and policy design insights that can promote the usage of PR.

Su, Haotian↗

NASA NTRSDate not supplied

Space Transformation -- Localizing the Remote and Connecting the Isolated

In motivating the Space Transformation theme for this year’s 4S symposium, the organizers provided the following context, “Transformation of economies are driven by a change in values and accelerated by new technologies.” These words rang particularly true when I read them at the beginning of the holiday season. Like so many others, I was in the early phases of my Christmas shopping procrastination campaign, and I’d just been reflecting on how Amazon Prime was the transformational tool I’d been waiting for. Basic limiting principles of time and space, supply and demand, were all but erased by the Amazon Prime phenomenon. Coupled with emerging 3D printing and other adaptive manufacturing technologies, a transformation from deliberate planning to “think it … have it” had occurred, empowering me to procrastinate longer than I’d ever dreamed possible. The organizers went on to ponder, “Will space transformation also affect society?”, just as our team at the Air Force Research Lab’s (AFRL) Center for Rapid Innovation (CRI) were working alongside partners within our larger Integrated Capabilities Directorate, NASA’s Flight Opportunities and Small Spacecraft Technology programs, and DARPA’s Luna-10 program to develop technologies and execute demonstration missions that leverage the space domain to genuinely connect even the most remote and austere domains on the timeline of need. Picking apart the miracle that is Amazon prime, where does the model fail, and why? More relevantly to the theme of this year’s symposium, how can the space domain be used to overcome its limitations and minimize its weaknesses? Perhaps it is best assessed in the context of Use Cases. What are the Amazon delivery cost, schedule, and cargo limiters to the Amundsen-Scott South Pole Research Station, or the Lunar South Pole Research Station? This paper will explore enabling infrastructure that allows Amazon prime to thrive and assess the transformational enabling technologies that would be necessary to extend that miracle to the truly remote or the truly austere. Localizing the Remote • First, it will evaluate the ability of the on-going AFRL Rocket Cargo and Space Initiatives Ringside Seats systems, coupled with Astrobotic’s Xodiak and Xogdor capabilities, developed to support the NASA Flight Opportunities Program (FOP), to supply orbital/suborbital delivery to both improved and austere sites on the Earth and Moon. • Then, it will add the surface terminal distribution leg, with an examination of Lunar Outpost’s Mobile Autonomous Prospecting Platform (MAPP), equipped with Mobile Autonomous Robotic Swarm (MARS) software, and Intuitive Machine’s Hopper, developed with support of AFRL and NASA’s Commercial Lunar Payload Services (CLPS) program. Connecting the Isolated From there, it will focus on the destination, asking what implied destination services are required to support highly assured autonomous delivery. • Specifically, it will highlight Astrobotic’s Skymage mesh-networked publish and subscribe communication and navigation service, as well as AFRL’s on-going developments of radioisotope and reactor nuclear-sourced thermoelectric power generation and distribution systems under development under the Joint Emergent Technology Supplying On-orbit Nuclear Power (JETSON) program by Lockheed Martin, Westinghouse, Intuitive Machines, and Zeno Power, to provide the power service to locations well off the grid. • Finally, the paper will connect to the “human machine”. What connects the remote or in-situ human consumer to the remote domain? What connects the diverse international government and commercial services to each other? The former will focus on AFRL’s OraCloud feeding their Space Defense Control and Characterization System (SDCCS) and Lunar Station’s MoonHacker systems, while the latter will focus on the BlueHalo/Tensor LunX Technology Platform for the Cislunar Commodity Marketplace. In 1984, Krafft Ehricke famously remarked that, “If God wanted man to become a spacefaring species, He would have given man a Moon.” This paper is not about the Moon, but is about humans as a spacefaring species, shedding the pesky land/air limitations of the Amazon Prime model … so that we can all live a procrastinator’s “think it … have it” existence.

Charles Finley↗

NASA NTRS2004

EVA Performance Prediction

Astronaut physical performance capabilities in micro gravity EV A or on planetary surfaces when encumbered by a life support suit and debilitated by a long exposure to micro gravity will be less than unencumbered pre flight capabilities. The big question addressed by human factors engineers is: what can the astronaut be expected to do on EVA or when we arrive at a planetary surface? A second question is: what aids to performance will be needed to enhance the human physical capability? These questions are important for a number of reasons. First it is necessary to carry out accurate planning of human physical demands to ensure that time and energy critical tasks can be carried out with confidence. Second it is important that the crew members (and their ground or planetary base monitors) have a realistic picture of their own capabilities, as excessive fatigue can lead to catastrophic failure. Third it is important to design appropriate equipment to enhance human sensory capabilities, locomotion, materials handling and manipulation. The evidence from physiological research points to musculoskeletal, cardiovascular and neurovestibular degradation during long duration exposure to micro gravity . The evidence from the biomechanics laboratory (and the Neutral Buoyancy Laboratory) points to a reduction in range of motion, strength and stamina when encumbered by a pressurized suit. The evidence from a long history of EVAs is that crewmembers are indeed restricted in their physical capabilities. There is a wealth of evidence in the literature on the causes and effects of degraded human performance in the laboratory, in sports and athletics, in industry and in other physically demanding jobs. One approach to this challenge is through biomechanical and performance modeling. Such models must be based on thorough task analysis, reliable human performance data from controlled studies, and functional extrapolations validated in analog contexts. The task analyses currently carried out for EVA activities are based more on extensive domain experience than any formal analytic structure. Conversely, physical task analysis for industrial and structured evidence from training and EV A contexts. Again on earth there is considerable evidence of human performance degradation due to encumbrance and fatigue. These industrial models generally take the form of a discounting equation. The development of performance estimates for space operations, such as timeline predictions for EVA is generally based on specific input from training activity, for example in the NBL or KC135. uniformed services tasks on earth are much more formalized. Human performance data in the space context has two sources: first there is the micro analysis of performance in structured tasks by the space physiology community and second there is the less structured evidence from training and EV A contexts.

Peacock, Brian↗

NASA NTRS2018

Design Optimisation and Mass Saving of the Structure of the Orion-MPCV European Service Module

This paper presents an overview of the design optimisation measures that have been proposed and analysed in order to reduce the mass of the structure, including the MMOD (Micro-Meteoroid and Orbital Debris) protection system, of the ESM (European Service Module) for the “Orion” MPCV (Multi-Purpose Crew Vehicle). Under an agreement between NASA and ESA, the NASA Orion MPCV for human space exploration missions will be powered by a European Service Module, based on the design and experience of the ATV (Automated Transfer Vehicle). The development and qualification of the European Service Module is managed and implemented by ESA. The ESM prime contractor and system design responsible is Airbus Defence and Space. Thales Alenia Space Italia is responsible for the design and integration of the ESM Structure and MMOD protection system in addition to the Thermal Control System and the Consumable Storage System. The Orion Multi-Purpose Crew Vehicle is a pressurized, crewed spacecraft that transports up to four crew members from the Earth’s surface to a nearby destination or staging point. Orion then brings the crew members safely back to the Earth’s surface at the end of the mission. Orion provides all services necessary to support the crew members while on-board for short duration missions (up to 21 days) or until they are transferred to another orbiting habitat. The ESM supports the crew module from launch through separation prior to re-entry by providing: in-space propulsion capability for orbital transfer, attitude control, and high altitude ascent aborts; water and oxygen/nitrogen needed for a habitable environment; and electrical power generation. In addition, it maintains the temperature of the vehicle's systems and components and offers space for unpressurized cargo and scientific payloads. The ESM has been designed for the first 2 Lunar orbit missions, EM-1 (Exploration mission 1) is an un-crewed flight planned around mid-2020, and EM-2, the first crewed flight, is planned in 2022. At the time where the first ESM is about to be weighted, the predicted mass lies slightly above the initial requirement. For future builds, mass reduction of the Service Module has been considered necessary. This is being investigated, together with other design improvements, in order to consolidate the ESM design and increase possible future missions beyond the first two Orion MPCV missions. The mass saving study has introduced new optimised structural concepts, optimisation of the MMOD protection shields, and optimised redesign of parts for manufacturing through AM (Additive Manufacturing).

Micro-Meteroids and Orbital Debris Protection Syst↗

DOE OSTI2022

MultiSector Dynamics: Advancing the Science of Complex Adaptive Human-Earth Systems

The field of MultiSector Dynamics (MSD) explores the dynamics and co-evolutionary pathways of human and Earth systems with a focus on critical goods, services, and amenities delivered to people through interdependent sectors. This commentary lays out core definitions and concepts, identifies MSD science questions in the context of the current state of knowledge, and describes ongoing activities to expand capacities for open science, leverage revolutions in data and computing, and grow and diversify the MSD workforce. Central to our vision is the ambition of advancing the next generation of complex adaptive human-Earth systems science to better address interconnected risks, increase resilience, and improve sustainability. This will require convergent research and the integration of ideas and methods from multiple disciplines. Understanding the tradeoffs, synergies, and complexities that exist in coupled human-Earth systems is particularly important in the context of energy transitions and increased future shocks.

Reed, Patrick↗

DOE OSTI2023

Rapidly Changing Range Limits in a Warming World: Critical Data Limitations and Knowledge Gaps for Advancing Understanding of Mangrove Range Dynamics in the Southeastern USA

Climate change is altering species’ range limits and transforming ecosystems. For example, warming temperatures are leading to the range expansion of tropical, cold-sensitive species at the expense of their cold-tolerant counterparts. In some temperate and subtropical coastal wetlands, warming winters are enabling mangrove forest encroachment into salt marsh, which is a major regime shift that has significant ecological and societal ramifications. Here, we synthesized existing data and expert knowledge to assess the distribution of mangroves near rapidly changing range limits in the southeastern USA. We used expert elicitation to identify data limitations and highlight knowledge gaps for advancing understanding of past, current, and future range dynamics. Mangroves near poleward range limits are often shorter, wider, and more shrublike compared to their tropical counterparts that grow as tall forests in freeze-free, resource-rich environments. The northern range limits of mangroves in the southeastern USA are particularly dynamic and climate sensitive due to abundance of suitable coastal wetland habitat and the exposure of mangroves to winter temperature extremes that are much colder than comparable range limits on other continents. Thus, there is need for methodological refinements and improved spatiotemporal data regarding changes in mangrove structure and abundance near northern range limits in the southeastern USA. Advancing understanding of rapidly changing range limits is critical for foundation plant species such as mangroves, as it provides a basis for anticipating and preparing for the cascading effects of climate-induced species redistribution on ecosystems and the human communities that depend on their ecosystem services.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2021

Scat Detection Dog Surveys for the San Joaquin Kit Fox on the Lawrence Livermore National Laboratory's Experimental Test Site (Site 300) and the Corral Hollow Ecological Reserve: 2020 Deployment

The San Joaquin kit fox (Vulpes macrotis mutica) historically occupied an extensive range in the San Joaquin Valley, California; however, their populations and habitat have since been significantly reduced by human impacts (United States Fish and Wildlife Service [USFWS] 1998). More than 95% of the potential habitat for kit foxes on the San Joaquin Valley floor has been converted to irrigated agriculture, urbanized, or industrialized lands. The San Joaquin kit fox was listed as endangered by the USFWS in 1967 and as threatened by the State of California in 1971. Records from local surveys, research projects, and incidental sightings indicate the present distribution of kit foxes extends from 1) southern Kern County north to Contra Costa, Alameda, and San Joaquin counties on the west side of the valley and to Stanislaus County on the east side; 2) into some of the larger, uncultivated valley-floor land parcels in Kern, Tulare, Kings, Fresno, Madera, and Merced counties; and 3) westward within 5 counties in the interior coastal range (USFWS 1998). Kit foxes have been denoted to occur in 3 geographically distinct core and several satellite populations in a heavily fragmented landscape, with the largest extant populations concentrated in the southern part of the range and smaller populations and isolated sightings in the central and northern portions (USFWS 1998, 2010).

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2021

Federal Fleet Resilience Planning

Federal fleet operations span the diverse geography of the country as the vehicles provide services in support of equally diverse agency missions. Fleets face the potential for disruption of services from natural disasters, infrastructure failures, and human threats. This report reviews some of the hazards, threats, and disruptions that fleets may face, describes an approach to fleet management that incorporates resilience, and provides an overview of fleet resilience considerations. While this report is not comprehensive, it describes considerations for integrating resilience into fleet management organizational priorities.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

DOE OSTI2021

Federal Fleet Resilience Planning

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

DOE OSTI2025

G2PDeep-v2: A Web-Based Deep-Learning Framework for Phenotype Prediction and Biomarker Discovery for All Organisms Using Multi-Omics Data

Multi-omics data offers rich insights into complex traits across organisms, yet integrating and analyzing these datasets for phenotype prediction and marker discovery remains challenging. Researchers need accessible tools that combine deep learning, hyperparameter optimization, visualization, and downstream analysis in a unified web platform. To address this, we developed G2PDeep-v2, a web-based platform powered by deep learning for phenotype prediction and marker discovery from multi-omics data across a wide range of organisms, including humans and plants. The server provides multiple services for researchers to create deep-learning models through an interactive interface and train these models using an automated hyperparameter tuning algorithm on high-performance computing resources. Users can visualize the results of phenotype and markers predictions and perform Gene Set Enrichment Analysis for the significant markers to provide insights into the molecular mechanisms underlying complex diseases, conditions and other biological phenotypes being studied.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1994

A look into the crystal ball: The next 25 years

The PTTI Planning Meeting was born at about the same time as the atomic definition of the unit of time, the second. This use of the cesium resonance was made possible by advances in quantum electronics during the preceding decade which resulted in commercial availability of cesium, rubidium, and hydrogen clocks and frequency standards. Twenty-five years later these types of clocks still are the backbone of time and frequency applications; together with a variety of crystal oscillators, transmitters, and receivers, as well as signal distribution, conditioning and switching systems, atomic clocks are an essential part of the infrastructure of modern navigation and communication technology. The next 25 years undoubtedly will see a pervasive expansion of PTTI into the infrastructure that supports and leverages industrial, social, environmental, defense, and even individual human activities. Speculation as to what capabilities, services, and personal conveniences may become available will be limited by two factors: the degree to which existing device concepts can be made more affordable and reliable, and the ability to miniaturize for purposes of compatibility with electronic integration. With regard to the latter, history teaches us that the required technological breakthrough is unlikely to originate in existing technology; thus, we may expect a paradigm shift in PTTI device concepts not unlike the shift in the 1960s from vacuum tubes to semiconductors.

Hellwig, Helmut↗