Search NASA⌕ Search

SEARCH · Search NASA

Results for “performance decline”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Mechanisms of electromagnetic field control on mineral scaling in brackish water reverse osmosis: Combined homogenous and heterogeneous nucleation

Electromagnetic field (EMF) treatment has emerged as a promising approach for scaling control due to its cost-effectiveness, simplicity, and low energy consumption. However, there is a limited understanding of the mechanisms by which applied EMF impacts mineral scaling in reverse osmosis (RO) systems. This has led to inconclusive and varied results and uncertainties regarding its effectiveness. This study elucidates the impacts of EMF on homogenous and heterogeneous nucleation and membrane performance during RO desalination of different feedwaters. Our results reveal that EMF exhibits greater efficacy in treating near-saturated water (SI∼0), especially when coupled with extended hydraulic flushing (HF). For saturated brackish water desalination, heterogeneous scaling predominantly occurs on membrane surfaces, with the effectiveness of EMF in inhibiting scaling primarily attributed to the hydration effect. In supersaturated solutions, EMF promotes bulk precipitation due to the magnetohydrodynamic effect, quickly blocking membrane pores. Thus, when the saturation reaches a certain high level during RO desalination, magnetohydrodynamic EMF effects can accelerate flux decline caused by homogeneous scaling. In conclusion, this work provides an efficient method for predicting EMF efficiency, emphasizing the importance of saturation conditions and HF cleaning duration in determining membrane performance, suggesting these show promise for improving undersaturated or near-saturated feedwater desalination via RO.

42 ENGINEERING↗
NASA NTRS1998

Interplanetary Mission Design Handbook: Earth-to-Mars Mission Opportunities and Mars-to-Earth Return Opportunities 2009-2024

This paper provides information for trajectory designers and mission planners to determine Earth-Mars and Mars-Earth mission opportunities for the years 2009-2024. These studies were performed in support of a human Mars mission scenario that will consist of two cargo launches followed by a piloted mission during the next opportunity approximately 2 years later. "Porkchop" plots defining all of these mission opportunities are provided which include departure energy, departure excess speed, departure declination arrival excess speed, and arrival declinations for the mission space surrounding each opportunity. These plots are intended to be directly applicable for the human Mars mission scenario described briefly herein. In addition, specific trajectories and several alternate trajectories are recommended for each cargo and piloted opportunity. Finally, additional studies were performed to evaluate the effect of various thrust-to-weight ratios on gravity losses and total time-of-flight tradeoff, and the resultant propellant savings and are briefly summarized.

George, L. E.↗
DOE OSTI2025

Volcano‐like Activity Trends in Au@Pd Catalysts: The Role of Pd Loading and Nanoparticle Size

The addition of palladium (Pd) to preformed gold nanoparticles (Au NPs) enables the formation of core‐shell structures with enhanced catalytic performance in oxidation reactions. However, predicting the precise palladium content required to achieve maximum catalytic activity remains difficult based on current understanding. Herein, Pd was systematically introduced onto titania‐supported Au NPs (2, 6, and 10 nm) to evaluate their performance in benzyl alcohol oxidation. A volcano‐like trend in catalytic activity was observed, where activity increased with Pd addition, peaked, and then declined. The Pd loading required for maximum activity depended on Au NP size: ≈40 at% Pd/Au for 2.6 nm, ≈20 at% Pd/Au for 6.4 nm, and ≈12.5 at% Pd/Au for 10.6 nm. For Au NPs > 6 nm, peak activity aligned with monolayer Pd coverage, while for smaller NPs (2–3 nm), optimal Pd content was below monolayer predictions. X‐ray absorption spectroscopy revealed a core‐shell structure at low Pd content, but higher Pd loadings led to Pd diffusion into the Au core. This structural transformation likely caused activity decline, indicating that AuPd alloying negatively impacts catalysis. These results highlight that core‐shell Au@Pd catalysts outperform AuPd alloys and provide crucial insights for designing highly active bimetallic catalysts.

X-ray absorption spectroscopy↗
NASA NTRS1976

Performance of a recoverable tug for planetary missions including use of perigee propulsion and corrections for nodal regression

Mathematical equations are derived by using the Maximum Principle to obtain the maximum payload capability of a reusable tug for planetary missions. The mathematical formulation includes correction for nodal precession of the space shuttle orbit. The tug performs this nodal correction in returning to this precessed orbit. The sample case analyzed represents an inner planet mission as defined by the declination (fixed) and right ascension of the outgoing asymptote and the mission energy. Payload capability is derived for a typical cryogenic tug and the sample case with and without perigee propulsion. Optimal trajectory profiles and some important orbital elements are also discussed.

Borsody, J.↗
NASA NTRS1976

Performance of a recoverable Tug for planetary missions including use of perigee propulsion and corrections for nodal regression

Mathematical equations are derived by using the Maximum Principle to obtain the maximum payload capability of a reusable Tug for planetary missions. The mathematical formulation includes correction for nodal precession of the Space Shuttle orbit. The Tug performs this nodal correction in returning to this precessed orbit. The sample case analyzed represents an inner planet mission as defined by the declination (fixed) and right ascension of the outgoing asymptote and the mission energy. Payload capability is derived for a typical cryogenic Tug and the sample case with and without perigee propulsion. Optimal trajectory profiles and some important orbital elements are also discussed.

Borsody, J.↗
NASA NTRS1994

A comparison of several GPS data reduction methods

For several years, discussions have been ongoing about how to analyze GPS time information in order to get the most accurate and precise time comparison between two locations. Many similar studies were done several years ago before the constellation was dominated by Block II satellites. With the Block II satellites and the use of Selective Availability (S/A), time comparisons have lost some precision and accuracy. This paper presents the results of research that was performed to find not only the best of several time comparison methods, but also to determine to what degree precision and accuracy have declined due to S/A.

Chadsey, H.↗
DOE OSTI2021

Baseline [ 18 F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer’s disease

Background: The role and implementation of tau PET imaging for predicting subsequent cognitive decline in Alzheimer’s disease (AD) remains uncertain. This study was designed to evaluate the relationship between baseline [ 18 F]GTP1 tau PET and subsequent longitudinal change across multiple cognitive measures over 18 months. Methods: Our analyses incorporated data from 67 participants, including cognitively normal controls (n = 10) and β-amyloid (Aβ)-positive individuals ([ 18 F] florbetapir Aβ PET) with prodromal (n = 26), mild (n = 16), or moderate (n = 15) AD. Baseline measurements included cortical volume (MRI), tau burden ([ 18 F]GTP1 tau PET), and cognitive assessments [Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), 13-item version of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog13), and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)]. Cognitive assessments were repeated at 6-month intervals over an 18-month period. Associations between baseline [ 18 F]GTP1 tau PET indices and longitudinal cognitive performance were assessed via univariate (Spearman correlations) and multivariate (linear mixed effects models) approaches. The utility of potential prognostic tau PET cut points was assessed with ROC curves. Results: Univariate analyses indicated that greater baseline [ 18 F]GTP1 tau PET signal was associated with faster rates of subsequent decline on the MMSE, CDR, and ADAS-Cog13 across regions of interest (ROIs). In multivariate analyses adjusted for baseline age, cognitive performance, cortical volume, and Aβ PET SUVR, the prognostic performance of [ 18 F]GTP1 SUVR was most robust in the whole cortical gray ROI. When AD participants were dichotomized into low versus high tau subgroups based on baseline [ 18 F]GTP1 PET standardized uptake value ratios (SUVR) in the temporal (cutoff = 1.325) or whole cortical gray (cutoff = 1.245) ROIs, high tau subgroups demonstrated significantly more decline on the MMSE, CDR, and ADAS-Cog13. Conclusions: Our results suggest that [ 18 F]GTP1 tau PET represents a prognostic biomarker in AD and are consistent with data from other tau PET tracers. Tau PET imaging may have utility for identifying AD patients at risk for more rapid cognitive decline and for stratification and/or enrichment of participant selection in AD clinical trials.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2010

Decline in Aerobic Fitness After Long-Term Stays on the International Space Station

U.S. and non-Russian International Partner astronauts who participate in long-term International Space Station (ISS) expeditions perform submaximal cycle exercise tests before, during, and after space flight. The heart rate (HR) and oxygen uptake (VO2) responses to exercise are used to estimate peak VO2 (EVO2pk). Purpose: To determine if the following factors are associated with the preflight-to-post flight change in EVO2pk: gender, age, body weight (BW), number of aerobic exercise sessions/wk- during flight, length of flight, EVO2pk measured before and late during the flight, ISS Expedition number and time between landing and the first post flight test. Methods: Records of 37 ISS astronauts (30 male, BW=81.6 plus or minus 8.6 kg; 7 female BW=66.1 plus or minus 4.9 kg [mean plus or minus SD]), age 46 plus or minus 4 years, were retrospectively examined. Peak HR and VO2 were measured approximately 9 months before flight to establish the test protocol. The submaximal cycle test consisted of three 5-minute stages designed to elicit 25, 50, and 75% of VO2pk. EVO2pk was calculated using linear least-squares extrapolation of average HR and VO2 during the last minute of each stage to predict VO2 at maximal HR. VO2 was not measured during flight and was assumed to not be different from preflight. Testing was performed 45 days before launch, late during flight, and during the week after landing. A random-intercept multivariate model was used to determine which characteristics significantly contributed to post flight EVO2pk. Results: In-flight aerobic exercise averaged 5.4 plus or minus 1.2 sessions/wk. ISS flight duration averaged 163 plus or minus 39 d. Mean EVO2pk values were 3.41 plus or minus 0.64 L (raised dot) per minute before flight, 3.09 plus or minus 0.57 L (raised dot) per minute late in flight, and 3.02 plus or minus 0.65 L (raised dot) per minute after flight. Late- and after-flight values were lower (p less than 0.05) than preflight values and did not differ from each other. Time between landing and post flight testing was 4.5 plus or minus 1.6 days. The only factor significantly associated with the post flight EVO2pk value was the late-flight EVO2pk score. Conclusion: Testing performed late during a mission provides a prediction of EVO2pk after landing. This approach may be implemented during longer missions.

Lynn, Peggy A.↗
DOE OSTI2026

Size-related decline in dryland shrubs is related to reductions in hydraulic efficiency and carbon assimilation and not nonstructural carbohydrate depletion

Plant growth and survival are fundamentally constrained by water transport from roots to leaves, impacting carbon assimilation and associated labile carbon pools. However, physiological constraints on growth and survival vary with plant age, due to changes in metabolic sinks, and increases in hydraulic path length from rhizosphere to canopy. We investigated crown dieback, growth, hydraulics, carbon assimilation and carbohydrate storage in relation to increasing basal diameter of two dominant shrub species (Caragana korshinskii and Artemisia ordosica) at the southeastern edge of the Tengger Desert, China. The aim was to identify mechanisms of decreased performance with plant size in dryland shrubs. Clear contrasts in stomatal regulation of leaf water potentials were detected between species. Despite these contrasts, radial growth, hydraulic transport efficiency (Ks), and photosynthetic efficiency similarly declined in both species with increasing plant size, while non-structural carbohydrate (NSC) reserves remained unchanged. Xylem embolism (PLC) increased with plant size, resulting in significant reductions in carbon assimilation in both species. Results indicate that hydraulic, and potentially carbon assimilation constraints, rather than reductions in carbohydrate storage, govern growth-related dryland shrub decline. These findings improve our understanding of how population demography impacts dryland forest response to climate change.

Zhang, Hongxia↗
DOE OSTI2022

Finding quadruply imaged quasars with machine learning – I. Methods

ABSTRACT Strongly lensed quadruply imaged quasars (quads) are extraordinary objects. They are very rare in the sky and yet they provide unique information about a wide range of topics, including the expansion history and the composition of the Universe, the distribution of stars and dark matter in galaxies, the host galaxies of quasars, and the stellar initial mass function. Finding them in astronomical images is a classic ‘needle in a haystack’ problem, as they are outnumbered by other (contaminant) sources by many orders of magnitude. To solve this problem, we develop state-of-the-art deep learning methods and train them on realistic simulated quads based on real images of galaxies taken from the Dark Energy Survey, with realistic source and deflector models, including the chromatic effects of microlensing. The performance of the best methods on a mixture of simulated and real objects is excellent, yielding area under the receiver operating curve in the range of 0.86–0.89. Recall is close to 100 per cent down to total magnitude i ∼ 21 indicating high completeness, while precision declines from 85 per cent to 70 per cent in the range i ∼ 17–21. The methods are extremely fast: training on 2 million samples takes 20 h on a GPU machine, and 108 multiband cut-outs can be evaluated per GPU-hour. The speed and performance of the method pave the way to apply it to large samples of astronomical sources, bypassing the need for photometric pre-selection that is likely to be a major cause of incompleteness in current samples of known quads.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS2020

SAGE III ISS Contamination Monitoring Package: Observations in Orbit

The Stratospheric Aerosol and Gas Experiment III (SAGE III) telescope and instrument assembly employ the methods of solar occultation and lunar occultation to retrieve near-global vertical profiles of atmospheric ozone, water vapor, nitrogen dioxide, aerosol extinctions, and other gaseous species and atmospheric state parameters. The SAGE III grating spectrometer measures light within the spectral range of 280 nm to 1037 nm at approximately 1 nm resolution, but retrievals in the Ultraviolet (UV) are particularly sensitive to contamination of the optical train. Therefore, a contamination door that contains a quartz optical window can be closed over the telescope aperture during periods of enhanced external contaminant flux. This optically transparent window permits continued science event acquisition at an acceptably diminished signal-to-noise ratio, which is expected to decline with ongoing accretion of contaminant material. To date, this impact has been short term, and science quality through the window returns to baseline performance after a contamination source is removed and spontaneous desorption removes material from the low-affinity quartz surface. Two Contamination Monitoring Packages (CMPs) consisting of eight Thermoelectric Quartz Crystal Microbalances (TQCMs) from QCM Research provide characterization and redundant monitoring of contaminant deposition from the 2π steradian solid angle on the payload side of the Expedite the Processing of Experiments to the Space Station (ExPRESS) Payload Adapter. CMP data are closely examined by the SAGE III team to determine when the contamination door should remain closed during science events and in what direction the instrument assembly scan head should stow when not acquiring science measurements. Additionally, should the CMPs indicate an unacceptable accretion rate, the ight computer will close the contamination door as part of the automatic fault detection system. Along with spectrometer measurements of the quartz window's transmission, the payload CMPs enable auditing of the mission contamination budget. The process of Thermogravimetric Analysis (TGA) can be used to help identify chemical constituents accreted on the CMP sensors. To be presented here along with an explanation of the CMP systems are the first two and a half years of observations of the contaminant deposition environment around the payload in quiescence and during special events like docking vehicles.

Tyler T Dawson↗
NASA NTRS2020

SAGE III/ISS Contamination Monitoring Package: Observations in Orbit

The Stratospheric Aerosol and Gas Experiment III (SAGE III) telescope and instrument assembly employ the methods of solar occultation and lunar occultation to retrieve near-global vertical profiles of atmospheric ozone, water vapor, nitrogen dioxide, aerosol extinctions, and other gaseous species and atmospheric state parameters. The SAGE III grating spectrometer measures light within the spectral range of 280 nm to 1037 nm at approximately 1 nm resolution, but retrievals in the Ultraviolet (UV) are particularly sensitive to contamination of the optical train. Therefore, a contamination door that contains a quartz optical window can be closed over the telescope aperture during periods of enhanced external contaminant flux. This optically transparent window permits continued science event acquisition at an acceptably diminished signal-to-noise ratio, which is expected to decline with ongoing accretion of contaminant material. To date, this impact has been short term, and science quality through the window returns to baseline performance after a contamination source is removed and spontaneous desorption removes material from the low-affinity quartz surface. Two Contamination Monitoring Packages (CMPs) consisting of eight Thermoelectric Quartz Crystal Microbalances (TQCMs) from QCM Research provide characterization and redundant monitoring of contaminant deposition from the 2pi steradian solid angle on the payload side of the Expedite the Processing of Experiments to the Space Station (ExPRESS) Payload Adapter. CMP data are closely examined by the SAGE III team to determine when the contamination door should remain closed during science events and in what direction the instrument assembly scan head should stow when not acquiring science measurements. Additionally, should the CMPs indicate an unacceptable accretion rate, the flight computer will close the contamination door as part of the automatic fault detection system. Along with spectrometer measurements of the quartz window's transmission, the payload CMPs enable auditing of the mission contamination budget. The process of Thermogravimetric Analysis (TGA) can be used to help identify chemical constituents accreted on the CMP sensors. To be presented here along with an explanation of the CMP systems are the first two and a half years of observations of the contaminant deposition environment around the payload in quiescence and during special events like docking vehicles.

Tyler T Dawson↗
NASA NTRS2012

Performance and Environmental Assessment of an Advanced Aircraft with Open Rotor Propulsion

Application of high speed, advanced turboprops, or "propfans," to transonic transport aircraft received significant attention during the 1970s and 1980s when fuel efficiency was the driving focus of aeronautical research. Unfortunately, after fuel prices declined sharply there was no longer sufficient motivation to continue maturing this technology. Recent volatility in fuel prices and increasing concern for aviation s environmental impact, however, have renewed interest in unducted, open rotor propulsion. Because of the renewed interest in open rotor propulsion, the lack of publicly available up-to-date studies assessing its benefits, and NASA s focus on reducing fuel consumption, a preliminary aircraft system level study on open rotor propulsion was initiated to inform decisions concerning research in this area. New analysis processes were established to assess the characteristics of open rotor aircraft. These processes were then used to assess the performance, noise, and emissions characteristics of an advanced, single-aisle aircraft using open rotor propulsion. The results of this initial study indicate open rotor engines have the potential to provide significant reductions in fuel consumption and landing-takeoff cycle NOX emissions. Noise analysis of the study configuration indicates that an open rotor aircraft in the single-aisle class would be able to meet current noise regulations with margin.

Guynn, Mark D.↗
NASA NTRS2008

CME Interaction with Coronal Holes and Their Interplanetary Consequences

A significant number of interplanetary (IP) shocks (-17%) during cycle 23 were not followed by drivers. The number of such "driverless" shocks steadily increased with the solar cycle with 15%, 33%, and 52% occurring in the rise, maximum, and declining phase of the solar cycle. The solar sources of 15% of the driverless shocks were very close the central meridian of the Sun (within approx.15deg), which is quite unexpected. More interestingly, all the driverless shocks with their solar sources near the solar disk center occurred during the declining phase of solar cycle 23. When we investigated the coronal environment of the source regions of driverless shocks, we found that in each case there was at least one coronal hole nearby suggesting that the coronal holes might have deflected the associated coronal mass ejections (CMEs) away from the Sun-Earth line. The presence of abundant low-latitude coronal holes during the declining phase further explains why CMEs originating close to the disk center mimic the limb CMEs, which normally lead to driverless shocks due to purely geometrical reasons. We also examined the solar source regions of shocks with drivers. For these, the coronal holes were located such that they either had no influence on the CME trajectories. or they deflected the CMEs towards the Sun-Earth line. We also obtained the open magnetic field distribution on the Sun by performing a potential field source surface extrapolation to the corona. It was found that the CMEs generally move away from the open magnetic field regions. The CME-coronal hole interaction must be widespread in the declining phase, and may have a significant impact on the geoeffectiveness of CMEs.

Gopalswamy, N.↗
NASA NTRS1976

Cerebellar pressor response in the dog

A fastigial pressor response has been elicited in the anesthetized mongrel dog. Stimulation within the rostral portions of this nucleus results in mean arterial pressure rises up to 150 mmHg above control. A proportional tachycardia is simultaneously evoked which may rapidly attain heart rates of 190 beats/min above control levels. Peak tachycardias immediately subside and often the heart rate declines below control values during stimulation while arterial pressure remains elevated. When either the carotid sinuses were isolated by ligation or a bilateral vagotomy was performed, the fastigial tachycardia was sustained. The response could still be attained when submaximal doses of alpha-chloralose anesthesia or high levels of barbiturates (30-40 mg/kg) were given. Both portions of the response result from widespread sympathetic activation; however, buffering of the response through the baroreceptor reflexes is only demonstrated in the cardiac segment of the response.

Dormer, K. J.↗
NASA NTRS2018

Multidecadal Changes in Lower Stratospheric Ozone: Variability Vs. Trends

As upper stratospheric ozone appears to be recovering as a result of decreasing chlorine loading following the implementation of the Montreal Protocol and its amendments and in agreement with model projections, several recent studies report an apparent decline of ozone concentrations in the lower stratosphere in the last two decades, particularly in the extratropics. Our previous work as well as at least two other studies provide evidence that this decline results from transport changes rather than an intensification of chemical depletion. It remains unclear whether these changes represent long-term internal variability or are a consequence of a climate forcing. Here we perform free-running ensembles of the recent past (1980-2016) using the Goddard Earth Observing System Model (GEOS) at the cubed sphere C180 (approximately half degree) resolution. Two suites of 10-member ensembles are performed, one in which observed sea surface temperature (SSTs) are fully prescribed, and the other in which the linear SST trend over the recent past is removed so as to only retain internal variability. We evaluate the trends in both ozone as well as two idealized tracers with prescribed uniform loss that are used to isolate the role of transport from chemistry and emissions. Probability-distribution-functions of the trends in both ozone and idealized tracers are compared among ensemble members and with observed trends in order to evaluate the likelihood of recent observed declines in lower stratospheric ozone, relative to large internal variability. Moreover, comparisons among simulations with and without imposed SST trends indicate the extent to which dynamically-driven ozone trends reflect forced trends or internal variability in lower stratospheric dynamics.

Wargan, Krzysztof↗
DOE OSTI2020

Residence time determines invasiveness and performance of garlic mustard ( Alliaria petiolata ) in North America

Abstract While biological invasions have the potential for large negative impacts on local communities and ecological interactions, increasing evidence suggests that species once considered major problems can decline over time. Declines often appear driven by natural enemies, diseases or evolutionary adaptations that selectively reduce populations of naturalised species and their impacts. Using permanent long‐term monitoring locations, we document declines of Alliaria petiolata (garlic mustard) in eastern North America with distinct local and regional dynamics as a function of patch residence time. Projected site‐specific population growth rates initially indicated expanding populations, but projected population growth rates significantly decreased over time and at the majority of sites fell below 1, indicating declining populations. Negative soil feedback provides a potential mechanism for the reported disappearance of ecological dominance of A. petiolata in eastern North America.

Blossey, Bernd↗
DOE OSTI2023

Editorial: Neuroscience, computing, performance, and benchmarks: Why it matters to neuroscience how fast we can compute

At the turn of the millennium the computational neuroscience community realized that neuroscience was in a software crisis: software development was no longer progressing as expected and reproducibility declined. The International Neuroinformatics Coordinating Facility (INCF) was inaugurated in 2007 as an initiative to improve this situation. The INCF has since pursued its mission to help the development of standards and best practices. In a community paper published this very same year, Brette et al. tried to assess the state of the field and to establish a scientific approach to simulation technology, addressing foundational topics, such as which simulation schemes are best suited for the types of models we see in neuroscience. In 2015, a Frontiers Research Topic “Python in neuroscience” by Muller et al. triggered and documented a revolution in the neuroscience community, namely in the usage of the scripting language Python as a common language for interfacing with simulation codes and connecting between applications. The review by Einevoll et al. documented that simulation tools have since further matured and become reliable research instruments used by many scientific groups for their respective questions. Open source and community standard simulators today allow research groups to focus on their scientific questions and leave the details of the computational work to the community of simulator developers. A parallel development has occurred, which has been barely visible in neuroscientific circles beyond the community of simulator developers: Supercomputers used for large and complex scientific calculations have increased their performance from ~10 TeraFLOPS (10 13 floating point operations per second) in the early 2000s to above 1 ExaFLOPS (10 18 floating point operations per second) in the year 2022. This represents a 100,000-fold increase in our computational capabilities, or almost 17 doublings of computational capability in 22 years. Moore's law (the observation that it is economically viable to double the number of transistors in an integrated circuit every other 18–24 months) explains a part of this; our ability and willingness to build and operate physically larger computers, explains another part. It should be clear, however, that such a technological advancement requires software adaptations and under the hood, simulators had to reinvent themselves and change substantially to embrace this technological opportunity. It actually is quite remarkable that—apart from the change in semantics for the parallelization—this has mostly happened without the users knowing. The current Research Topic was motivated by the wish to assemble an update on the state of neuroscientific software (mostly simulators) in 2022, to assess whether we can see more clearly which scientific questions can (or cannot) be asked due to our increased capability of simulation, and also to anticipate whether and for how long we can expect this increase of computational capabilities to continue.

biophysically detailed models↗