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At least 181 records · Page 10

Proteomic Profiling of Intra-Islet Features Reveals Substructure-Specific Protein Signatures

Despite their diminutive size, islets of Langerhans play a large role in maintaining systemic energy balance in the body. New technologies have enabled us to go from studying the whole pancreas, to isolated whole islets, to partial islet sections, and now to islet substructures isolated from within the islet. Using a microfluidic nanodroplet-based proteomics platform coupled with laser capture microdissection (LCM), we present an in-depth investigation of protein profiles specific to regions within the islet. These regions studied include the vascular tissue containing interface boundary, micro-vascular tissue internal to the islet, isolated endocrine cells, islet sections with vasculature intact, and finally acinar tissue from around the islet. Unique protein signatures observed in the inner vasculature potentially indicate increased innervation and intra-islet neuron-like crosstalk compared to external vasculature. We also demonstrate the utility of these data for isolating localized structure-specific drug-target interactions using existing protein/drug binding databases.

59 BASIC BIOLOGICAL SCIENCES↗

Estimating nucleon substructure properties in a unified model of p-Pb and Pb-Pb collisions

We apply a well tested hybrid transport model, which couples viscous hydrodynamics to a hadronic afterburner, to describe bulk observables in proton-lead and lead-lead collisions at $\sqrt{s}$$_ {NN}$ = 5.02 TeV. The quark-gluon plasma (QGP) initial conditions are modeled using the parametric TRENTo model with additional nucleon substructure parameters to vary the number and size of hot spots inside each nucleon, followed by a pre-equilibrium free streaming stage to match the full energy-momentum tensor of the initial state onto viscous hydrodynamics. Initial condition and QGP medium parameters, such as the temperature dependence of the QGP shear and bulk viscosities, are then calibrated using Bayesian parameter estimation to describe charged particle yields, mean p T and anisotropic flow harmonics of both collision systems in a single self-consistent framework. We find that the hybrid model provides a compelling, simultaneous description of both collision systems using appropriately chosen model parameters, and present new posterior estimates for the size and shape of the nucleon and temperature dependence of QGP shear and bulk viscosities.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Photometric metallicity for 694 233 Galactic giant stars from Gaia DR3 synthetic Strömgren photometry: Metallicity distribution functions of halo substructures

We used two previous calibrations and the standardised synthetic photometry in the v, b, and y Strömgren passbands from Gaia DR3 BP/RP spectra to obtain photometric metallicities for a selected sample of 694 233 old Galactic giant stars having |b|> 20.0° and parallax uncertainties lower than 10%. The zero point of both sets of photometric metallicities has been shifted to ensure an optimal match with the spectroscopic [Fe/H] values for 44 785 stars in common with APOGEE DR17, focusing on the metallicity range where they provide the highest accuracy. The metallicities derived in this way from one calibration display a typical accuracy of ≲0.1 dex and 1σ precision ≲0.2 dex in the range -2.2 ≲ [Fe/H] ≲ - 0.4, while they show a systematic trend with [Fe/H] at higher metallicity, beyond the applicability range of the relation. Those derived from the other calibration display, in general, reduced precision, and lower accuracy in the metal-poor regime, but have a median accuracy < 0.05 dex for [Fe/H] ≥ - 0.8. These results are confirmed and, consequently, the metallicities are validated, by comparison with large sets of spectroscopic metallicities from various surveys. The newly obtained metallicities are used to derive metallicity distributions for several previously identified substructures in the Galactic halo with an unprecedented number of stars. The catalogue including the two sets of metallicities and the associated uncertainties is made publicly available.

79 ASTRONOMY AND ASTROPHYSICS↗

KINEMATICS AND CHEMISTRY OF HALO SUBSTRUCTURES: THE VICINITY OF THE VIRGO OVERDENSITY

We present observations obtained with the Anglo-Australian Telescope's 2dF wide field spectrograph AAOmega of K-type stars located within a region of the sky which contains the Virgo Overdensity and the leading arm of the Sagittarius Stream. On the basis of the resulting velocity histogram, we isolate halo substructures in these overlapping regions including Sagittarius and previously discovered Virgo groups. Through comparisons with N-body models of the Galaxy-Sagittarius interaction, we find a tri-axial dark matter halo is favored and we exclude a prolate shape. This result is contradictory with other observations along the Sagittarius leading arm, which typically favor prolate models. We have also uncovered K-giant members of Sagittarius that are notably more metal-poor (([Fe/H]) = -1.7 {+-} 0.3 dex) than previous studies. This suggests a significantly wider metallicity distribution exists in the Sagittarius Stream than formerly considered. We also present data on five carbon stars which were discovered in our sample.

79 ASTRONOMY AND ASTROPHYSICS↗

THE PHOTOMETRIC PROPERTIES OF A VAST STELLAR SUBSTRUCTURE IN THE OUTSKIRTS OF M33

We have surveyed approximately 40 deg{sup 2} surrounding M33 with Canada-France-Hawaii Telescope MegaCam/MegaPrime in the g and i filters out to a maximum projected radius from this galaxy of 50 kpc, as part of the Pan-Andromeda Archaeological Survey (PAndAS). Our observations are deep enough to resolve the top {approx}4 mag of the red giant branch population in this galaxy. We have previously shown that the disk of M33 is surrounded by a large, irregular, low surface brightness substructure. Here, we quantify the stellar populations and structure of this feature using the PAndAS data. We show that the stellar populations of this feature are consistent with an old population with ([Fe/H]) {approx} -1.6 dex and an interquartile range in metallicity of {approx}0.5 dex. We construct a surface brightness map of M33 that traces this feature to {mu}{sub V} {approx_equal} 33 mag arcsec{sup -2}. At these low surface brightness levels, the structure extends to projected radii of {approx}40 kpc from the center of M33 in both the northwest and southeast quadrants of the galaxy. Overall, the structure has an 'S-shaped' appearance that broadly aligns with the orientation of the H I disk warp. We calculate a lower limit to the integrated luminosity of the structure of -12.7 {+-} 0.5 mag, comparable to a bright dwarf galaxy such as Fornax or Andromeda II and slightly less than 1% of the total luminosity of M33. Further, we show that there is tentative evidence for a distortion in the distribution of young stars near the edge of the H I disk that occurs at similar azimuth to the warp in H I. The data also hint at a low-level, extended stellar component at larger radius that may be an M33 halo component. We revisit studies of M33 and its stellar populations in light of these new results and discuss possible formation scenarios for the vast stellar structure. Our favored model is that of the tidal disruption of M33 in its orbit around M31.

79 ASTRONOMY AND ASTROPHYSICS↗

A HIGH-RESOLUTION MASS MAP OF GALAXY CLUSTER SUBSTRUCTURE: LensPerfect ANALYSIS OF A1689

We present a strong lensing (SL) mass model of A1689 which resolves substructures an estimated 25 kpc across within the central {approx}400 kpc diameter. We achieve this resolution by perfectly reproducing the observed (strongly lensed) input positions of 168 multiple images of 55 knots residing within 135 images of 42 galaxies. Our model makes no assumptions about light tracing mass, yet we reproduce the brightest visible structures with some slight deviations. A1689 remains one of the strongest known lenses on the sky, with an Einstein radius of R{sub E} = 47.''0 {+-} 1.''2 (143{sup +3}{sub -4} kpc) for a lensed source at z{sub s} = 2. We find that a single Navarro-Frenk-White (NFW) or Sersic profile yields a good fit simultaneously (with only slight tension) to both our SL mass model and published weak lensing (WL) measurements at larger radius (out to the virial radius). According to this NFW fit, A1689 has a mass of M{sub vir} = 2.0{sup +0.5}{sub -0.3} x 10{sup 15} M{sub sun} h {sup -1}{sub 70} (M{sub 200} = 1.8{sup +0.4}{sub -0.3} x 10{sup 15} M{sub sun} h {sup -1}{sub 70}) within the virial radius r{sub vir} = 3.0 {+-} 0.2 Mpc h {sup -1}{sub 70} (r{sub 200} = 2.4{sup +0.1}{sub -0.2} Mpc h {sup -1}{sub 70}), and a central concentration c{sub vir} = 11.5{sup +1.5}{sub -1.4} (c{sub 200} = 9.2 {+-} 1.2). Our SL model prefers slightly higher concentrations than previous SL models, bringing our SL + WL constraints in line with other recent derivations. Our results support those of previous studies which find A1689 has either an anomalously large concentration or significant extra mass along the line of sight (perhaps in part due to triaxiality). If clusters are generally found to have higher concentrations than realized in simulations, this could indicate that they formed earlier, perhaps as a result of early dark energy.

79 ASTRONOMY AND ASTROPHYSICS↗

INSIGHT INTO THE FORMATION OF THE MILKY WAY THROUGH COLD HALO SUBSTRUCTURE. III. STATISTICAL CHEMICAL TAGGING IN THE SMOOTH HALO

We find that the relative contribution of satellite galaxies accreted at high redshift to the stellar population of the Milky Way's smooth halo increases with distance, becoming observable relative to the classical smooth halo about 15 kpc from the Galactic center. In particular, we determine line-of-sight-averaged [Fe/H] and [{alpha}/Fe] in the metal-poor main-sequence turnoff (MPMSTO) population along every Sloan Extension for Galactic Understanding and Exploration (SEGUE) spectroscopic line of sight. Restricting our sample to those lines of sight along which we do not detect elements of cold halo substructure (ECHOS), we compile the largest spectroscopic sample of stars in the smooth component of the halo ever observed in situ beyond 10 kpc. We find significant spatial autocorrelation in [Fe/H] in the MPMSTO population in the distant half of our sample beyond about 15 kpc from the Galactic center. Inside of 15 kpc however, we find no significant spatial autocorrelation in [Fe/H]. At the same time, we perform SEGUE-like observations of N-body simulations of Milky Way analog formation. While we find that halos formed entirely by accreted satellite galaxies provide a poor match to our observations of the halo within 15 kpc of the Galactic center, we do observe spatial autocorrelation in [Fe/H] in the simulations at larger distances. This observation is an example of statistical chemical tagging and indicates that spatial autocorrelation in metallicity is a generic feature of stellar halos formed from accreted satellite galaxies.

79 ASTRONOMY AND ASTROPHYSICS↗

SEXTANS' COLD SUBSTRUCTURES AS A DYNAMICAL JUDGE: CORE, CUSP, OR MOND?

The cold dark matter model predicts cuspy dark matter (DM) halos. However, it has been found that in some low-mass galaxies, cored dark halos provide a better description of their internal dynamics. Here we give constraints on the dark halo profile in the Sextans dwarf spheroidal galaxy by studying the longevity of two cold kinematic substructures detected in this galaxy. We perform N-body simulations of a stellar clump in the Sextans dwarf galaxy, including a live DM halo and the main stellar component. We find that if the dark halo is cuspy, stellar clumps orbiting with semi-major axis ≈400 pc are disrupted in ∼5 Gyr, even if the clump is initially as compact stellar cluster with a radius of r{sub c} = 5 pc. Stellar clusters in an initial orbit with semi-major axis ≤250 pc may survive to dissolution, but their orbits decay toward the center by dynamical friction. In contrast, the stellar clumps can persist for a Hubble time within a cored DM halo, even if the initial clump's radius is as extended as r{sub c} = 80 pc. We also study the evolution of the clump in the MONDian context. In this scenario, we find that even an extended stellar clump with radius r{sub c} = 80 pc survives for a Hubble time, but an unrealistic value for the stellar mass-to-light ratio of 9.2 is needed.

79 ASTRONOMY AND ASTROPHYSICS↗

Hubble space telescope/advanced camera for surveys confirmation of the dark substructure in A520

We present a weak-lensing study of the cluster A520 based on Advanced Camera for Surveys (ACS) data. The excellent data quality provides a mean source density of ∼109 arcmin{sup –2}, which improves both resolution and significance of the mass reconstruction compared to a previous study based on Wide Field Planetary Camera 2 (WFPC2) images. We take care in removing instrumental effects such as the charge trailing due to radiation damage of the detector and the position-dependent point-spread function. This new ACS analysis confirms the previous claims that a substantial amount of dark mass is present between two luminous subclusters where we observe very little light. The centroid of the dark peak in the current ACS analysis is offset to the southwest by ∼1' with respect to the centroid from the WFPC2 analysis. Interestingly, this new centroid is in better agreement with the location where the X-ray emission is strongest, and the mass-to-light ratio estimated with this centroid is much higher (813 ± 78 M {sub ☉}/L {sub R☉}) than the previous value; the aperture mass with the WFPC2 centroid provides a consistent mass. Although we cannot provide a definite explanation for the dark peak, we discuss a revised scenario, wherein dark matter with a more conventional range (σ{sub DM}/m {sub DM} < 1 cm{sup 2} g{sup –1}) of self-interacting cross-section can lead to the detection of this dark substructure. If supported by detailed numerical simulations, this hypothesis opens up the possibility that the A520 system can be used to establish a lower limit of the self-interacting cross-section of dark matter.

79 ASTRONOMY AND ASTROPHYSICS↗

The effects of varying cosmological parameters on halo substructure

We investigate how different cosmological parameters, such as those delivered by the WMAP and Planck missions, affect the nature and evolution of the dark matter halo substructure. We use a series of flat Λ cold dark matter cosmological N-body simulations of structure formation, each with a different power spectrum but with the same initial white noise field. Our fiducial simulation is based on parameters from the WMAP seventh year cosmology. We then systematically vary the spectral index, n{sub s} ; matter density, Ω {sub M}; and normalization of the power spectrum, σ{sub 8}, for seven unique simulations. Across these, we study variations in the subhalo mass function, mass fraction, maximum circular velocity function, spatial distribution, concentration, formation times, accretion times, and peak mass. We eliminate dependence of subhalo properties on host halo mass and average the values over many hosts to reduce variance. While the 'same' subhalos from identical initial overdensity peaks in higher σ{sub 8}, n{sub s} , and Ω {sub m} simulations accrete earlier and end up less massive and closer to the halo center at z = 0, the process of continuous subhalo accretion and destruction leads to a steady state distribution of these properties across all subhalos in a given host. This steady state mechanism eliminates cosmological dependence on all of the properties listed above except for subhalo concentration and V {sub max}, which remain greater for higher σ{sub 8}, n{sub s} , and Ω {sub m} simulations, and subhalo formation time, which remains earlier. We also find that the numerical technique for computing the scale radius and the halo finder that were used can significantly affect the concentration-mass relationship as computed for a simulation.

79 ASTRONOMY AND ASTROPHYSICS↗

More pieces of the puzzle: chemistry and substructures in the galactic thick disk

We present a study of the chemical abundances of solar neighborhood stars associated with dynamical structures in the Milky Way's (thick) disk. These stars were identified as an overdensity in the eccentricity range 0.3 < ε < 0.5 in the Copenhagen-Geneva Survey by Helmi et al. We find that stars with these dynamical characteristics do not constitute a homogeneous population. A relatively sharp transition in dynamical and chemical properties appears to occur at a metallicity of [Fe/H] ∼ –0.4. Stars with [Fe/H] > –0.4 have mostly lower eccentricities, smaller vertical velocity dispersions, are α-enhanced, and define a rather narrow sequence in [α/Fe] versus [Fe/H], clearly distinct from that of the thin disk. Stars with [Fe/H] < –0.4 have a range of eccentricities, are hotter vertically, and depict a larger spread in [α/Fe]. We also found tentative evidence of a substructure possibly associated with the disruption of a metal-rich star cluster. The differences between these populations of stars is also present in, e.g., [Zn/Fe], [Ni/Fe], and [SmII/Fe], suggesting a real physical distinction.

79 ASTRONOMY AND ASTROPHYSICS↗

RESONANT CLUMPING AND SUBSTRUCTURE IN GALACTIC DISKS

We describe a method to extract resonant orbits from N-body simulations, exploiting the fact that they close in frames rotating with a constant pattern speed. Our method is applied to the N-body simulation of the Milky Way by Shen et al. This simulation hosts a massive bar, which drives strong resonances and persistent angular momentum exchange. Resonant orbits are found throughout the disk, both close to the bar and out to the very edges of the disk. Using Fourier spectrograms, we demonstrate that the bar is driving kinematic substructure even in the very outer parts of the disk. We identify two major orbit families in the outskirts of the disk, one of which makes significant contributions to the kinematic landscape, namely, the m:l = 3:−2 family, resonating with the bar. A mechanism is described that produces bimodal distributions of Galactocentric radial velocities at selected azimuths in the outer disk. It occurs as a result of the temporal coherence of particles on the 3:−2 resonant orbits, which causes them to arrive simultaneously at pericenter or apocenter. This resonant clumping, due to the in-phase motion of the particles through their epicycle, leads to both inward and outward moving groups that belong to the same orbital family and consequently produce bimodal radial velocity distributions. This is a possible explanation of the bimodal velocity distributions observed toward the Galactic anticenter by Liu et al. Another consequence is that transient overdensities appear and dissipate (in a symmetric fashion), resulting in a periodic pulsing of the disk’s surface density.

79 ASTRONOMY AND ASTROPHYSICS↗

SPECTROSCOPIC OBSERVATIONS OF AN EVOLVING FLARE RIBBON SUBSTRUCTURE SUGGESTING ORIGIN IN CURRENT SHEET WAVES

We present imaging and spectroscopic observations from the Interface Region Imaging Spectrograph of the evolution of the flare ribbon in the SOL2014-04-18T13:03 M-class flare event, at high spatial resolution and time cadence. These observations reveal small-scale substructure within the ribbon, which manifests as coherent quasi-periodic oscillations in both position and Doppler velocities. We consider various alternative explanations for these oscillations, including modulation of chromospheric evaporation flows. Among these, we find the best support for some form of wave localized to the coronal current sheet, such as a tearing mode or Kelvin–Helmholtz instability.

79 ASTRONOMY AND ASTROPHYSICS↗

Structure formation in a mixed dark matter model with decaying sterile neutrino: the 3.5 keV X-ray line and the Galactic substructure

We perform a set of cosmological simulations of structure formation in a mixed dark matter (MDM) model. Our model is motivated by the recently identified 3.5 keV X-ray line, which can be explained by the decay of non-resonantly produced sterile neutrinos accounting for 20–60% of the dark matter in the Universe. These non-resonantly produced sterile neutrinos have a sizable free-streaming length and hence behave effectively as warm dark matter (WDM). Assuming the rest of dark matter is composed of some cold dark matter (CDM) particles, we follow the coevolution of a mixed WDM plus CDM cosmology. Specifically, we consider the models with the warm component fraction of r{sub warm}=0.25 and 0.50. Our MDM models predict that the comoving Jeans length at the matter-radiation equality is close to that of the thermally produced warm dark matter model with particle mass m{sub WDM}=2.4 keV, but the suppression in the fluctuation power spectrum is weaker. We perform large N-body simulations to study the structure of non-linear dark halos in the MDM models. The abundance of substructure is significantly reduced in the MDM models, and hence the so-called small-scale crisis is mitigated. The cumulative maximum circular velocity function (CVF) of at least one halo in the MDM models is in good agreement with the CVFs of the observed satellites in the Milky Way and the Andromeda galaxy. We argue that the MDM models open an interesting possibility to reconcile the reported 3.5 keV line and the internal structure of galaxies.

79 ASTRONOMY AND ASTROPHYSICS↗

Measuring the power spectrum of dark matter substructure using strong gravitational lensing

In recent years, it has become possible to detect individual dark matter subhalos near images of strongly lensed extended background galaxies. Typically, only the most massive subhalos in the strong lensing region may be detected this way. In this work, we show that strong lenses may also be used to constrain the much more numerous population of lower mass subhalos that are too small to be detected individually. In particular, we show that the power spectrum of projected density fluctuations in galaxy halos can be measured using strong gravitational lensing. We develop the mathematical framework of power spectrum estimation, and test our method on mock observations. We use our results to determine the types of observations required to measure the substructure power spectrum with high significance. We predict that deep observations (∼10 hours on a single target) with current facilities can measure this power spectrum at the 3σ level, with no apparent degeneracy with unknown clumpiness in the background source structure or fluctuations from detector noise. Upcoming ALMA measurements of strong lenses are capable of placing strong constraints on the abundance of dark matter subhalos and the underlying particle nature of dark matter.

79 ASTRONOMY AND ASTROPHYSICS↗

Bayesian forecasts for dark matter substructure searches with mock pulsar timing data

Dark matter substructure, such as primordial black holes (PBHs) and axion miniclusters, can induce phase shifts in pulsar timing arrays (PTAs) measurements due to gravitational effects. In order to gain a more realistic forecast for the detectability of such models of dark matter with PTAs, we propose a Bayesian inference framework to search for phase shifts generated by PBHs and perform the analysis on mock PTA data. Furthermore, for most PBH masses the constraints on the dark matter abundance agree with previous (frequentist) analyses (without mock data) to $\mathcal{O}$(1) factors. This further motivates a dedicated search for PBHs (and dense small scale structures) in the mass range from 10 -8 M ⊙ to well above 10 2 M ⊙ with the Square Kilometer Array. Moreover, with a more optimistic set of timing parameters, future PTAs are predicted to constrain PBHs down to 10 -11 M ⊙ . Lastly, we discuss the impact of backgrounds, such as Supermassive Black Hole Mergers, on detection prospects, suggesting a future program to separate a dark matter signal from other astrophysical sources.

79 ASTRONOMY AND ASTROPHYSICS↗

Robust clustering of the local Milky Way stellar kinematic substructures with Gaia eDR3

Understanding local stellar kinematic substructures in the solar neighbourhood helps build a complete picture of the formation of the Milky Way, as well as an empirical phase space distribution of dark matter that would inform detection experiments. We apply the clustering algorithm HDBSCAN on the Gaia early third data release to identify a list of stable clusters in velocity space and action-angle space by taking into account the measurement uncertainties and studying the stability of the clustering results. We find 1405 (497) stars in 23 (6) robust clusters in velocity space (action-angle space) that are consistently not associated with noise. We discuss the kinematic properties of these structures and study whether many of the small clusters belong to a similar larger cluster based on their chemical abundances. They are attributed to the known structures: the Gaia Sausage-Enceladus, the Helmi Stream, and globular cluster NGC 3201 are found in both spaces, while NGC 104 and the thick disc (Sequoia) are identified in velocity space (action-angle space). Although we do not identify any new structures, we find that the HDBSCAN member selection of already known structures is unstable to input kinematics of the stars when resampled within their uncertainties. We therefore present the stable subset of local kinematic structures, which are consistently identified by the clustering algorithm, and emphasize the need to take into account error propagation during both the manual and automated identification of stellar structures, both for existing ones as well as future discoveries.

79 ASTRONOMY AND ASTROPHYSICS↗

Quantifying substructures in Hubble Frontier Field clusters: comparison with ΛCDM simulations

The Hubble Frontier Fields (HFF) are six clusters of galaxies, all showing indications of recent mergers, which have recently been observed for lensed images. As such they are the natural laboratories to study the merging history of galaxy clusters. In this work, we explore the 2D power spectrum of the mass distribution $P_{\rm M}(k)$ as a measure of substructure. We compare $P_{\rm M}(k)$ of these clusters (obtained using strong gravitational lensing) to that of $\Lambda$CDM simulated clusters of similar mass. In order to compute lensing $P_{\rm M}(k)$, we produced free-form lensing mass reconstructions of HFF clusters, without any light traces mass (LTM) assumption. Moreover, the inferred power at small scales tends to be larger if (i)~the cluster is at lower redshift, and/or (ii)~there are deeper observations and hence more lensed images. In contrast, lens reconstructions assuming LTM show higher power at small scales even with fewer lensed images; it appears the small scale power in the LTM reconstructions is dominated by light information, rather than the lensing data. The average lensing derived $P_{\rm M}(k)$ shows lower power at small scales as compared to that of simulated clusters at redshift zero, both dark-matter only and hydrodynamical. The possible reasons are: (i)~the available strong lensing data are limited in their effective spatial resolution on the mass distribution, (ii)~HFF clusters have yet to build the small scale power they would have at $z\sim 0$, or (iii)~simulations are somehow overestimating the small scale power.

79 ASTRONOMY AND ASTROPHYSICS↗