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At least 181 records · Page 10

Role of motor unit structure in defining function

Motor units, defined as a motoneuron and all of its associated muscle fibers, are the basic functional units of skeletal muscle. Their activity represents the final output of the central nervous system, and their role in motor control has been widely studied. However, there has been relatively little work focused on the mechanical significance of recruiting variable numbers of motor units during different motor tasks. This review focuses on factors ranging from molecular to macroanatomical components that influence the mechanical output of a motor unit in the context of the whole muscle. These factors range from the mechanical properties of different muscle fiber types to the unique morphology of the muscle fibers constituting a motor unit of a given type and to the arrangement of those motor unit fibers in three dimensions within the muscle. We suggest that as a result of the integration of multiple levels of structural and physiological levels of organization, unique mechanical properties of motor units are likely to emerge. Copyright 2001 John Wiley & Sons, Inc.

Non-NASA Center↗

NIAC Phase-2 Final Report for Astrophysics and Technical Lab Studies of a Solar Neutrino Spacecraft Detector

The Sun provides all the energy that our planet needs for life and has been doing so for five billion years. Understanding our Sun and its interior is one of the major goals of the NASA Science program. Still this is a very difficult task because very little makes it directly out of the Sun’s interior. The energy we see today, that warms the Earth, was made 50,000 to 80,000 years ago and is only now coming to the surface to make light. However, neutrinos penetrate matter almost without interaction and make it to Earth in only eight minutes from creation. Since neutrinos interact only weakly they are hard to detect; never-the-less within the last ten years neutrino detectors on Earth have started to reliably detect neutrinos from the fusion reactions in the interior of the Sun and scientists have started to use this information to investigate the Sun’s nuclear furnace. Changes in solar neutrino flux make it advantageous to take a neutrino detector into space since the solar neutrino intensity changes dramatically as the inverse square of the distance from the Sun, by five orders of magnitude when going from the Earth to the Sun. Launch of a neutrino detector into space toward the Sun will: a) aim to significantly increase the neutrino flux 10,000x allowing for a smaller detector which improves detector energy resolution and performance, b) attempt to completely eliminate background terrestrial neutrino sources for improved measurement accuracy, and c) conduct unique science experiments near the Sun not achievable with much larger detectors on the Earth. NASA's interest in deep space exploration has been a key factor in its unmanned spacecraft development and launch of exploration science satellites and spacecraft. NASA has done exceptional experiments in space where science benefits from the unique platform of spacecraft that provides unprecedented views. For example, the Hubble Space Telescope is really a small and very common instrument, but when it is put into an orbit high above the Earth, it becomes one of the most powerful optical observatories man has ever made. Moving neutrino observations to space is the next obvious step. The concept of putting a neutrino detector in close orbit of the sun is completely unexplored and innovative. Its scientific return is to vastly enhance the understanding of the solar interior which is a NASA major goal as stated in the decadal survey. Preliminary calculations show that such a spacecraft if properly shielded, can operate in this environment both taking data of neutrino interactions which can be distinguished from random background rates of solar Electromagnetic emissions, Galactic charged cosmic-ray, and gamma-rays by using a double pulsed signature. The NIAC Phase-1 simulations have shown this idea to be very successful in eliminating background and identifying the neutrino interaction signal, hence this spacecraft detector concept once demonstrated to be Technical Readiness Level 7 and flight mission-ready would enable a whole new type of mission to explore and study our Sun, in details that could neither be done with the largest neutrino detectors on Earth nor other types of space-craft measurements that are not using neutrino detection. Our goal in this NIAC Phase-2 was to take the detector simulation ideas and construct a prototype for testing in the lab with tagged sources to evaluate and demonstrate that the performance in the simulations are borne out by a prototype.

Neutrino↗

Survey of lake flooding from ERTS-1: Lake Champlain

The author has identified the following significant results. ERTS-1 imagery showing seasonal lake-level conditions in Lake-Champlain can be used to assess shoreline change and flooding extent. MSS bands 6 and 7 provide maximum land-water contrasts and are the most useful for shoreline location. Shoreline changes observed between ERTS coverages of October 10 (low water) and April 7 and 25 (high water) are readily apparent and enlargement of specific scenes by a factor of four provides data which can be transferred to a map base. The unique synoptic view provided by ERTS-1 will make it possible to map shoreline positions occurring at a specific lake stage. Due to present government concerns over abnormally high lake levels, resource management questions have been raised regarding the extent, nature, and occurrence of inundation magnitude of shoreline change, and lake volume change.

Lind, A. O.↗

Gear crack propagation investigations

Analytical and experimental studies were performed to investigate the effect of gear rim thickness on crack propagation life. The FRANC (FRacture ANalysis Code) computer program was used to simulate crack propagation. The FRANC program used principles of linear elastic fracture mechanics, finite element modeling, and a unique re-meshing scheme to determine crack tip stress distributions, estimate stress intensity factors, and model crack propagation. Various fatigue crack growth models were used to estimate crack propagation life based on the calculated stress intensity factors. Experimental tests were performed in a gear fatigue rig to validate predicted crack propagation results. Test gears were installed with special crack propagation gages in the tooth fillet region to measure bending fatigue crack growth. Good correlation between predicted and measured crack growth was achieved when the fatigue crack closure concept was introduced into the analysis. As the gear rim thickness decreased, the compressive cyclic stress in the gear tooth fillet region increased. This retarded crack growth and increased the number of crack propagation cycles to failure.

Lewicki, David G.↗

Evidence for a Hematite Ore Body on Mars

The Mars Global Surveyor (MGS) spacecraft was launched from Cape Kennedy in November 1996. MGS was put into orbit around Mars in September of 1997 and has since been sending back data from a suite of instruments, including the Thermal Emission Spectrometer (TES). The TES instrument is an interferometric spectrometer designed to map the surface mineralogy of Mars by measuring the midinfrared emitted radiation over the spectral region of about 1600 to 200 cm(exp -1) (about 6 to 50 microns). This mineralogically sensitive technique utilizes the characteristic intra- and inter-molecular vibrations of minerals that are manifested in the midinfrared spectra. These spectral "fingerprints" are unique because they are dependent upon chemical composition, crystal structure, crystal orientation, and other factors. Midinfrared spectral data received from the MGS-TES instrument have indicated the presence of a large deposit of hematite (alpha-Fe2O3) in Sinus Meridiani, Mars. This hematite ore body, that is accompanied by basalt, is really extensive, encompassing an area about 350 by 500 km. To better understand the geologic context of this large deposit, a detailed laboratory spectroscopic investigation was conducted using more than 20 hematite samples so that their spectra could be compared to the martian spectra. The samples included red and gray polycrystaline hand samples, gray single-crystal hand samples, and red and gray fine- and coarse-grained particulates. The laboratory analyses provided thermal emissivity spectra that, when compared to the hematite emissivity spectra from Mars, suggest the Sinus Meridiani hematite is possibly an exposure of oriented hematite grains. These grains are likely coarser that 10 microns (and may be much larger) and gray in color. The characteristic of oriented grains is suggested by the apparent crystal axis-dependence of the energy emitted from the surface of Mars. The strong degree of crystal alignment exhibited in the emissivity spectra of Mars suggests that these oriented hematite crystals most likely occur as bedrock of aligned specular hematite grains (possibly schistose in texture) or as a secondary coating on bedrock, rather than as discrete particles. We are investigating the nature of this vast hematite deposit in order to understand better the geologic setting and infer past conditions and geological evolution on Mars.

Morris, Richard V.↗

Evidence for a Hematite Ore Body on Mars

The Mars Global Surveyor (MGS) spacecraft was launched from Cape Kennedy in November 1996. MGS was put into orbit around Mars in September of 1997 and has since been sending back data from a suite of instruments, including the Thermal Emission Spectrometer (TES). The TES instrument is an interferometric spectrometer designed to map the surface mineralogy of Mars by measuring the midinfrared emitted radiation over the spectral region of approximately 1600 to 200 per centimeter (appjroximately 6 to 50 microns). This mineralogically sensitive technique utilizes the characteristic intra- and inter-molecular vibrations of minerals that are manifested in the midinfrared spectra. These spectral "fingerprints" are unique because they are dependent upon chemical composition, crystal structure, crystal orientation, and other factors. Midinfrared spectral data received from the MGS-TES instrument have indicated the presence of a large deposit of hematite (alpha-Fe2O3) in Sinus Meridiani, Mars. This hematite ore body, that is accompanied by basalt, is areally extensive, encompassing and area approximately 350 by 500 km. To better understand the geologic context of this large deposit, a detailed laboratory spectroscopic investigation was conducted using more than 20 hematite samples so that their spectra could be compared to the martian spectra. The samples included red and gray polycrystaline hand samples, gray single-crystal hand samples, and red and gray fine- and coarse-grained particulates. The laboratory analyses provided thermal emissivity spectra that, when compared to the hematite emissivity spectra from Mars, suggest the Sinus Meridiani hematite is possibly an exposure of oriented hematite grains. These grains are likely coarser that 10 microns (and may be much larger) and gray in color The characteristic of oriented grains is suggested by the apparent crystal axis-dependence of the energy emitted from the surface of Mars. The strong degree of crystal alignment exhibited in the emissivity spectra of Mars suggests that these oriented hematite crystals most likely occur as bedrock of aligned specular hematite grains (possibly schistose in texture) or as a secondary coating on bedrock, rather than as discrete particles. We are investigating the nature of this vast hematite deposit in order to understand better the geologic setting and infer past conditions and geological evolution on Mars.

Lane, M. D.↗

Ionic signaling in plant responses to gravity and touch

Touch and gravity are two of the many stimuli that plants must integrate to generate an appropriate growth response. Due to the mechanical nature of both of these signals, shared signal transduction elements could well form the basis of the cross-talk between these two sensory systems. However, touch stimulation must elicit signaling events across the plasma membrane whereas gravity sensing is thought to represent transformation of an internal force, amyloplast sedimentation, to signal transduction events. In addition, factors such as turgor pressure and presence of the cell wall may also place unique constraints on these plant mechanosensory systems. Even so, the candidate signal transduction elements in both plant touch and gravity sensing, changes in Ca2+, pH and membrane potential, do mirror the known ionic basis of signaling in animal mechanosensory cells. Distinct spatial and temporal signatures of Ca2+ ions may encode information about the different mechanosignaling stimuli. Signals such as Ca2+ waves or action potentials may also rapidly transfer information perceived in one cell throughout a tissue or organ leading to the systemic reactions characteristic of plant touch and gravity responses. Longer-term growth responses are likely sustained via changes in gene expression and asymmetries in compounds such as inositol-1,4,5-triphosphate (IP3) and calmodulin. Thus, it seems likely that plant mechanoperception involves both spatial and temporal encoding of information at all levels, from the cell to the whole plant. Defining this patterning will be a critical step towards understanding how plants integrate information from multiple mechanical stimuli to an appropriate growth response.

Review↗

Human Research Program Human Health Countermeasures Element Nutrition Risk Standing Review Panel

The Nutrition Risk Standing Review Panel (SRP) reviewed and discussed the specific gaps and tasks for the Human Health Countermeasures (HHC) Element related to nutrition identified in the Human Research Program (HRP) Integrated Research Plan. There was general consensus that the described gaps and proposed tasks were critical to future NASA mission success. The SRP acknowledged the high scientific quality of the work currently being undertaken by the Nutritional Biochemistry group under the direction of Dr. Scott Smith. In review of the entire HRP, four new gaps were identified that complement the Element's existing research activities. Given the limitations of ground-based analogs for many of the unique physiological and metabolic alterations in space, future studies are needed to quantify nutritional factors that change during actual space flight. In addition, future tasks should seek to better evaluate the time course of physiological and metabolic alterations during flight to better predict alterations during longer duration missions. Finally, given the recent data suggesting a potential role for increased inflammatory responses during space flight, the role of inflammation needs to be explored in detail, including the development of potential countermeasures and new ground based analogs, if this possibility is confirmed.

Bistrian, Bruce↗

Programmable Ultra-Lightweight System Adaptable Radio

The programmable ultra-lightweight system adaptable radio (PULSAR) is a NASA Marshall Space Flight Center transceiver designed for the CubeSat market, but has the potential for other markets. The PULSAR project aims to reduce size, weight, and power while increasing telemetry data rate. The current version of the PULSAR has a mass of 2.2 kg and a footprint of 10.8 cm2. The height depends on the specific configuration. The PULSAR S-Band Communications Subsystem is an S- and X-band transponder system comprised of a receiver/detector (receiver) element, a transmitter element(s), and related power distribution, command, control, and telemetry element for operation and information interfaces. It is capable of receiving commands, encoding and transmitting telemetry, as well as providing tracking data in a manner compatible with Earthbased ground stations, near Earth network, and deep space network station resources. The software-defined radio's (SDR's) data format characteristics can be defined and reconfigured during spaceflight or prior to launch. The PULSAR team continues to evolve the SDR to improve the performance and form factor to meet the requirements that the CubeSat market space requires. One of the unique features is that the actual radio design can change (somewhat), but not require any hardware modifications due to the use of field programmable gate arrays.

Werkheiser, Arthur↗

An Examination of Heavy Ion-Induced Persistent Visual Error Signatures in an Electronic Display Driver Integrated Circuit

Given the ubiquity of electronic displays integration in human-based systems, the impending mission critical, space-based applications of electronic displays will necessitate SEE assessment of components unique to electronic displays. A commercially available DDIC designed to drive a small form factor organic light emitting diode (OLED) was visually monitored during heavy ion irradiation to catalogue radiation induced persistent visual error signatures that require manual intervention (i.e., power cycling) to return to nominal function. These error signatures were able to be reproduced via modification of configuration register values utilizing the instruction set intended for interfacing a microcontroller with the DDIC. This approach to emulation of heavy-ion induced errors on a table-top assists with human perception-based criticality analysis as well as development of mitigation techniques.

Electronic Displays↗

Human factors in Spacelab - Crew training

At NASA-Ames Research Center's Life Sciences Flight Experiments Project Office two payloads for the Shuttle Spacelab are currently in development. The first payload, Spacelab-3, will launch in November 1984. Unique life sciences hardware designed to support animals in 0-g will fly for the first time. Flight crew training sessions for the Spacelab-3 astronauts began in June 1982. Human factors involvement is extensive. A thorough understanding of both the 1-g and 0-g environments is necessary. The weightlessness of the space environment creates special conditions; e.g., the time required for a 1-g laboratory experiment significantly increases in 0-g. The transportation of objects in 0-g uses different techniques than on earth. These considerations, plus others, are incorporated into the design of the Spacelab-3 crew training program.

Junge, M. K.↗

Promoter-dependent and -independent activation of insulin-like growth factor binding protein-5 gene expression by prostaglandin E2 in primary rat osteoblasts

Insulin-like growth factor (IGF) action is mediated by high affinity cell surface IGF receptors and modulated by a family of secreted IGF binding proteins (IGFBPs). IGFBP-5, the most conserved of six IGFBPs characterized to date, uniquely potentiates the anabolic actions of IGF-I for skeletal cells. In osteoblasts, IGFBP-5 production is stimulated by prostaglandin E2 (PGE2), a local factor that mediates certain effects induced by parathyroid hormone, cytokines such as interleukin-1 and transforming growth factor-beta, and mechanical strain. In this study, we show that transcriptional and post-transcriptional events initiated by PGE2 collaborate to enhance IGFBP-5 gene expression in primary fetal rat osteoblast cultures. PGE2 treatment stimulated up to a 7-fold rise in steady-state levels of IGFBP-5 mRNA throughout 32 h of incubation. Analysis of nascent IGFBP-5 mRNA suggested that PGE2 had only a modest stimulatory effect on IGFBP-5 gene transcription, and transient transfection studies with IGFBP-5 promoter-reporter genes confirmed that PGE2 enhanced promoter activity by approximately 2-fold. Similar stimulatory effects were seen with forskolin. A DNA fragment with only 51 base pairs of the 5'-flanking sequence retained hormonal responsiveness, which may be mediated by a binding site for transcription factor AP-2 located at positions -44 to -36 in the proximal IGFBP-5 promoter. Incubation of osteoblasts with the mRNA transcriptional inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole demonstrated that PGE2 enhanced IGFBP-5 mRNA stability by 2-fold, increasing the t1/2 from 9 to 18 h. The effects of PGE2 on steady-state IGFBP-5 transcripts were abrogated by preincubating cells with cycloheximide, indicating that the effects of PGE2 on both gene transcription and mRNA stability required ongoing protein synthesis. Therefore, both promoter-dependent and -independent pathways converge to enhance IGFBP-5 gene expression in response to PGE2 in osteoblasts.

Non-NASA Center↗

Analysis and Experimental Tests of a High-Performance Evacuated Tubular Collector

A high-performance collector based on the use of all-glass, evacuated tubular collector elements is described and analyzed, and supporting experimental data presented. The collector operated with excellent efficiency at temperatures high enough to drive existing air conditioning units, and showed good performance under diffuse light and low insolation conditions. Collector efficiency was insensitive to operating temperature, ambient temperature, and wind speed. In addition, air, as well as liquid, can be used as the heat transfer fluid, with no significant performance penalty. While the equations governing the useful energy produced can be cast in a form similar to that for flat plate collectors, several important parameters were unique in a number of respects. The loss coefficient was unusually low, while the flow factor and effective insolation were unusually high.

Beekley, D. C.↗

Active thermal control for an advanced power platform

Effective use of the Shuttle Orbiter during the operational phase will require the provision of electrical power from free-flying power platforms which will interface with the Orbiter. Such platforms present unique requirements for active thermal control based upon the long life and high heat load requirements which will be necessary to provide 25 kW or more of electricity to the Orbiter and payloads. This paper will present key issues in the design of these active thermal control systems (ATCS) and will discuss potential solutions intended to ensure maximum effectiveness of advanced power platforms. Such issues include proper selection of coolant fluid for the power platform and payload loops; selection and development of thermal control surfaces for five-year life; the use of off-the-shelf hardware vs development of unique hardware, central vs decentralized control of the ATCS; system life and reliability as a factor in determining redundancy and the possibility of on-orbit EVA maintenance; and the interfaces between the power platform and the Orbiter and payloads.

Owen, J. W.↗

An analysis of human performance in simulated partial-gravity environments

Three unique partial gravity test environments; parabolic flight, water immersion and a mechanical-relief device provide the environment to evaluate human locomotion, reach sweeps, and posture in the reduced gravity levels of the moon (1/6) and Mars (3/8). The development of a motion analysis database for 1/6 and 3/8 gravity environments as well as an initial understanding of human motion in low gravity environments are the focus of these experiments. Each of the three partial-gravity simulations provided a unique environment with some specific limitations. Water immersion provides a continuous testing environment but must factor in the effects of water viscosity drag, subject weighting, and breathing apparatus. Parabolic flight provides the most realistic testing environment although the test must be interrupted every 40 seconds to execute a complete parabolic maneuver of the aircraft. Mechanical force relief systems also provide uninterrupted testing. However, the body support harness necessary for use of mechanical force relief systems can potentially hinder test subject movement. By using the test results generated from all three test arenas, the Man-Systems Division will create a database of human locomotion specific to the lunar and Mars gravity environments. The information gathered is being used to enhance the development and design of future human habitation elements.

Moore, Nathan R.↗

Mg II and Ly-alpha fluxes in M dwarfs - Evaluation of an acoustic model

Surface fluxes of Mg II and Ly-alpha from a sample of M dwarfs have been reported by Panagi and Mathioudakis (PM, 1992). In order to determine if acoustic effects can reproduce the fluxes in the least active ('basal') stars in the PM sample, we have constructed steady state models of plane-parallel atmospheres with T(eff) = 3000 and 4000 K including heating by shock dissipation. The models incorporate radiative losses in the chromosphere by solving the transfer equation for two strong lines (Mg II k and Ly-alpha). Predictions of standard weak shock theory are expected to overestimate the rate of energy deposition in the chromospheres of M dwarfs compared to the rate of deposition in F, G, or K dwarfs. In order to incorporate this effect in M dwarfs, we compute a series of atmospheric models in which, for a given T(eff), the standard weak shock dissipation rate is reduced by a series of factors F(r). Although the input acoustic flux F(mech) may in principle be determined uniquely by T(eff) and log g, the correct value to use in any particular case is not well known. We therefore use F(mech) and F(r) as parameters to construct a family of M dwarf models at various T(eff) and g. Comparing with the observed fluxes in the least active M dwarfs of the PM sample, we find that our models reproduce the observed fluxes of both Mg II and Ly-alpha best if F(mech) is close to the value predicted by Bohn (1984) and if F(r) is approximately equal to 10-20.

Mullan, D. J.↗

Perspectives from the Wearable Electronics and Applications Research (WEAR) Lab, NASA Johnson Space Center

As NASA moves beyond exploring low earth orbit and into deep space exploration, increased communication delays between astronauts and earth drive a need for crew to become more autonomous (earth-independent). Currently crew on board the International Space Station (ISS) have limited insight into specific vehicle system performance because of the dependency on monitoring and real-time communication with Mission Control. Wearable technology provides a method to bridge the gap between the human (astronaut) and the system (spacecraft) by providing mutual monitoring between the two. For example, vehicle or environmental information can be delivered to astronauts through on-body devices and in return wearables provide data to the spacecraft regarding crew health, location, etc. The Wearable Electronics and Applications Research (WEAR) Lab at the NASA Johnson Space Center utilizes a collaborative approach between engineering and human factors to investigate the use of wearables for spaceflight. Zero and partial gravity environments present unique challenges to wearables that require collaborative, user-centered, and iterative approaches to the problems. Examples of the WEAR Lab's recent wearable projects for spaceflight will be discussed.

Moses, Haifa R.↗

Perspectives from the Wearable Electronics and Applications Research (WEAR) Lab, NASA, Johnson Space Center

As NASA moves beyond exploring low earth orbit and into deep space exploration, increased communication delays between astronauts and earth drive a need for crew to become more autonomous (earth-independent). Currently crew on board the International Space Station (ISS) have limited insight into specific vehicle system performance because of the dependency on monitoring and real-time communication with Mission Control. Wearable technology provides a method to bridge the gap between the human (astronaut) and the system (spacecraft) by providing mutual monitoring between the two. For example, vehicle or environmental information can be delivered to astronauts through on-body devices and in return wearables provide data to the spacecraft regarding crew health, location, etc. The Wearable Electronics and Applications Research (WEAR) Lab at the NASA Johnson Space Center utilizes a collaborative approach between engineering and human factors to investigate the use of wearables for spaceflight. Zero and partial gravity environments present unique challenges to wearables that require collaborative, user-centered, and iterative approaches to the problems. Examples of the WEAR Lab's recent wearable projects for spaceflight will be discussed.

Moses, Haifa R.↗