Search NASA⌕ Search

SEARCH · Search NASA

Results for “BONE MARROW”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 199 records · Page 11
All sourcesNASA NTRSDOE OSTI
NASA NTRS1992

Human exposure to large solar particle events in space

Whenever energetic solar protons produced by solar particle events traverse bulk matter, they undergo various nuclear and atomic collision processes which significantly alter the physical characteristics and biologically important properties of their transported radiation fields. These physical interactions and their effect on the resulting radiation field within matter are described within the context of a recently developed deterministic, coupled neutron-proton space radiation transport computer code (BRYNTRN). Using this computer code, estimates of human exposure in interplanetary space, behind nominal (2 g/sq cm) and storm shelter (20 g/sq cm) thicknesses of aluminum shielding, are made for the large solar proton event of August 1972. Included in these calculations are estimates of cumulative exposures to the skin, ocular lens, and bone marrow as a function of time during the event. Risk assessment in terms of absorbed dose and dose equivalent is discussed for these organs. Also presented are estimates of organ exposures for hypothetical, worst-case flare scenarios. The rate of dose equivalent accumulation places this situation in an interesting region of dose rate between the very low values of usual concern in terrestrial radiation environments and the high-dose-rate values prevalent in radiation therapy.

Townsend, L. W.↗
NASA NTRS1992

Risk analyses for the solar particle events of August through December 1989

The solar particle events of August through December 1989, among the largest ever recorded, are analyzed to assess the potential hazards to humans on interplanetary missions from events of these types. Using the coupled neutron-proton space radiation transport computer code BRYNTRN, risk estimates for the effects of exposures to the skin, ocular lens, and bone marrow are made for nominal thicknesses of the spacecraft aluminum shielding. Risk assessment in terms of absorbed dose is made for each event. Also presented are estimates of organ absorbed dose and dose equivalent for pairs of events which occurred within 30-day periods, and for the cumulative August through December 1989 period.

Townsend, Lawrence W.↗
NASA NTRS1992

Effect of spaceflight on natural killer cell activity

The effects of spaceflight on immune cell function were determined in rats flown on Cosmos 2044. Control groups included vivarium, synchronous, and antiorthostatically suspended rats. The ability of natural killer cells to lyse two different target cell lines was determined. Spleen and bone marrow cells obtained from flight rats showed significantly inhibited cytotoxicity for YAC-1 target cells compared with cells from synchronous control rats. This could have been due to exposure of the rats to microgravity. Antiorthostatic suspension did not affect the level of cytotoxicity from spleen cells of suspended rats for YAC-1 cells. On the other hand, cells from rats flown in space showed no significant differences from vivarium and synchronous control rats in cytotoxicity for K-562 target cells. Binding of natural killer cells to K-562 target cells was unaffected by spaceflight. Antiorthostatic suspension resulted in higher levels of cytotoxicity from spleen cells for Cr-51-labeled K-562 cells. The results indicate differential effects of spaceflight on function of natural killer cells. This shows that spaceflight has selective effects on the immune response.

Rykova, Marina P.↗
NASA NTRS1992

Interplanetary crew exposure estimates for galactic cosmic rays

Using the Langley Research Center galactic cosmic-ray transport computer code and the Computerized Anatomical Man model, initial estimates of interplanetary exposure of astronauts to galactic cosmic rays, during periods of solar minimum activity, are made for a realistic human geometry shielded by various thicknesses of spacecraft aluminum shielding. Conventional dose assessment in terms of total absorbed dose and dose equivalent is made for the skin, ocular lens, and bone marrow. Included in the analyses are separate evaluations of the contributions from the incident primary ions, from subsequent-generation fragmentation products, and from target fragments. In all cases considered, the equivalent sphere approximation yielded conservative overestimates for the actual organ exposures.

Townsend, Lawrence W.↗
NASA NTRS1992

Human exposure to galactic cosmic rays in space

The Langley Research Center GCR (galactic cosmic rays) code (HZETRN) and the computerized Anatomical Man (CAM) model are used to estimate astronaut exposures, from GCR particles, for missions beyond earth's magnetosphere. Conventional risk assessments in terms of total absorbed dose and dose equivalent are made for skin, ocular lens, and bone marrow. For each organ, evaluations are made of relative contributions from incident protons, iron nuclei, and their secondary reaction products.

Townsend, L. W.↗
NASA NTRS1993

Toxicity study of dimethylethoxysilane (DMSES), the waterproofing agent for the Orbiter heat protective system

DMES, a volatile liquid, is used by NASA to waterproof the Orbiter thermal protective system. During waterproofing operations at the Oribter Processing Facility at KSC, workers could be exposed to DMES vapor. To assess the toxicity of DMES, acute and subchronic (2-week and 13-week) inhalation studies were conducted with rats. Studies were also conducted to assess the potential of DMES. Inhalation exposure concentrations ranged from 40 ppm to 4000 ppm. No mortality was observed during the studies. Exposures to 2100 ppm produced narcosis and ataxia. Post-exposure recovery from these CNS effects was rapid (less than 1 hr). These effects were concentration-dependent and relatively independent of exposure length. Exposure to 3000 ppm for 2 weeks (5 h/d, 5 d/wk) produced testicular toxicity. The 13-week study yielded similar results. Results from the genotoxicity assays (in vivo/in vitro unscheduled DNA synthesis in rat primary heptaocytes, chromosomal aberrations in rat bone marrow cells; reverse gene mutation in Salmonella typhimurium; and forward mutation in Chinese hamster culture cells) were negative. These studies indicated that DMES is mildly to moderately toxic but not a multagen.

Lam, Chiu-Wing↗
NASA NTRS1993

Magnetic resonance imaging after exposure to microgravity

A number of physiological changes were demonstrated in bone, muscle, and blood from exposure of humans and animals to microgravity. Determining mechanisms and the development of effective countermeasures for long-duration space missions is an important NASA goal. Historically, NASA has had to rely on tape measures, x-ray, and metabolic balance studies with collection of excreta and blood specimens to obtain this information. The development of magnetic resonance imaging (MRI) offers the possibility of greatly extending these early studies in ways not previously possible; MRI is also non-invasive and safe; i.e., no radiation exposure. MRI provides both superb anatomical images for volume measurements of individual structures and quantification of chemical/physical changes induced in the examined tissues. This investigation will apply MRI technology to measure muscle, intervertebral disc, and bone marrow changes resulting from exposure to microgravity.

Leblanc, Adrian↗
NASA NTRS1995

The influence of space flight on erythrokinetics in man. Space Life Sciences Missions 1 and 2. Experiment E261

The purpose of this contract was to design and conduct experiments that would increase our understanding of the influence of space flight on erythrokinetics and the rapid change that occurs in the red blood cell mass during spaceflight. The experiment designated E261, was flown on Space Life Science missions SLS-1 and SLS-2 (STS 40 and STS 58). Unique features of this experiment included radionuclide tracer studies during flight and frequent in-flight blood samples specifically for the first three or four days of the mission. Plasma volume measurements were made early and late in the missions. Radioactive iron kinetics studies were initiated after one or three days in microgravity since the magnitude of the red blood cell mass decrease dictated that bone marrow production must be decreased very early in the flight. The schedule was designed to study the time course of the changes that occur during spaceflight and to possibly define a mechanism for the rapid reduction in red blood cell mass.

Alfrey, Clarence P.↗
NASA NTRS1994

Production and action of cytokines in space

B6MP102 cells, a continuously cultured murine bone marrow macrophage cell line, were tested for secretion of tumor necrosis factor-alpha and Interleukin-1 during space flight. We found that B6MP102 cells secreted more tumor necrosis factor-alpha and interleukin-1 when stimulated in space with lipopolysaccharide than controls similarly stimulated on earth. This compared to increased secretion of interferon-beta and -gamma by lymphocytes that was measured on the same shuttle flights. Although space flight enhanced B6MP102 secretion of tumor necrosis factor-alpha, an experiment on a subsequent space flight (STS-50) found that cellular cytotoxicity, mediated by tumor necrosis factor-alpha, was inhibited.

Chapes, Stephen K.↗
NASA NTRS1994

Interleukin-2 therapy reverses some immunosuppressive effects of skeletal unloading

Using antiorthostatic suspension, we characterized hematopoietic changes that may be responsible for the detrimental effect of skeletal unloading on macrophage development. Skeletally unloaded mice had suppressed macrophage development in unloaded and loaded bones, which indicated a systemic effect. Bone marrow cells from unloaded mice secreted less macrophage colony-stimulating factor and interleukin-6 than control mice. Additionally, T-lymphocyte proliferation was reduced after skeletal unloading. We show that polyethylene glycol-interleukin-2 therapy reversed the effects of skeletal unloading on macrophage development and cell proliferation.

Armstrong, Jason W.↗
NASA NTRS1997

Plant and Animal Gravitational Biology

Session WA2 includes short reports concerning: (1) The Asymmetrical Growth of Otoliths in Fish Affected by Altered Gravity and Causes Kinetosis; (2) Neurobiological Responses of Fish to Altered Gravity conditions: A Review; (3) An Age-Dependent Sensitivity of the Roll-Induced Vestibulocular Reflex to Hypergravity Exposure of Several Days in an Amphibian (Xenopus Laevis); (4) Mechanically-Induced Membrane Wounding During Parabolic Flight; and (5) Erythropoietin Stimulates Increased F Cell Numbers in Bone Marrow Cultures Established in Gravity and Microgravity Conditions.

Source record↗
NASA NTRS1997

Body Fluid Regulation and Hemopoiesis in Space Flight

In this session, Session JA2, the discussion focuses on the following topics: Bodymass and Fluid Distribution During Longterm Spaceflight with and without Countermeasures; Plasma Volume, Extracellular Fluid Volume, and Regulatory Hormones During Long-Term Space Flight; Effect of Microgravity and its Ground-Based Models on Fluid Volumes and Hemocirculatory Volumes; Seventeen Weeks of Horizontal Bed Rest, Lower Body Negative Pressure Testing, and the Associated Plasma Volume Response; Evaporative Waterloss in Space Theoretical and Experimental Studies; Erythropoietin Under Real and Simulated Micro-G Conditions in Humans; and Vertebral Bone Marrow Changes Following Space Flight.

Source record↗
NASA NTRS1997

Poster Session

In this session, Poster Session, the discussion focuses on the following topics: Development of correlative measures for the assessment of attention and memory; Biodynamical Responses of the Crewmember Head/Neck System During Emergence Ejection; Fecundation in the Sky, a Ten Years Old Experiment in Microgravity; A Modified Botex Incubator as a Transport System For Developing Crickets into Space; Chromosomal Aberrations in Peripheral Lymphocytes of Cosmonauts and Astronauts after Space Flights; Method for Establishing Long term Bone Marrow; Cultures Under Microgravity Conditions Reproduction Under Simulated Weightlessness --Mammalian in vivo Experiments Under Suspension; Towards Human Movement Analysis Without the Use of Markers; Habitability Requirements For a Cogent Mars Mission; The Saucer Concept for Space Habitats; New Way In Modeling the Growth of the Organism; The Fractionation of Hydrogen and Oxygen Stable Isotopes By Life Support Systems of Space Station "MIR"; and Effect of Space Flight on Neutrophil Function.

Source record↗
NASA NTRS1981

Skeletal Alterations in Rats During Space Flight

Male Wistar rats were placed in orbit for an 18.5 day period aboard the Soviet Cosmos 1129 biological satellite. The skeletal changes which occurred during space flight were a reduced rate of periosteal bone formation in the tibial and humeral diaphyses, a decreased trabecular bone volume, and an increased fat content of the bone marrow in the proximal tibial metaphysis.

Wronski, T. J.↗
NASA NTRS1998

STS-90 Day 02 Highlights

On this second day of the STS-90 mission, the flight crew, Cmdr. Richard A. Searfoss, Pilot Scott D. Altman, and Mission Specialists Richard M. Linnehan, Dafydd Rhys Williams and Kathryn P. Hire, and Payload Specialists Jay C. Buckey and James A. Pawelczyk activate the Bioreactor Demonstration Experiment, an investigation that grows cell tissue cultures in weightlessness. The device, making its fourth shuttle flight, has the capability to grow more perfect tissue samples in weightlessness than can be achieved on Earth. Cell samples in the bioreactor experiment aboard Columbia include renal tissue and bone marrow, both samples being evaluated for the ability to produce substances useful in a variety of medical treatments on Earth.

Source record↗
NASA NTRS1998

STS-95 Day 07 Highlights

On this seventh day of the STS-95 mission, the flight crew, Cmdr. Curtis L. Brown, Pilot Steven W. Lindsey, Mission Specialists Scott E. Parazynski, Stephen K. Robinson, and Pedro Duque, and Payload Specialists Chiaki Mukai and John H. Glenn, again test the Orbiter Space Vision System. OSVS uses special markings on Spartan and the shuttle cargo bay to provide an alignment aid for the arm's operator using shuttle television images. It will be used extensively on the next Space Shuttle flight in December as an aid in using the arm to join together the first two modules of the International Space Station. Specialist John Glenn will complete a daily back-pain questionnaire by as part of a study of how the muscle, intervertebral discs and bone marrow change after exposure to microgravity.

Source record↗
NASA NTRS1998

STS-95 Day 08 Highlights

On this eighth day of the STS-95 mission, the flight crew, Cmdr. Curtis L. Brown, Pilot Steven W. Lindsey, Mission Specialists Scott E. Parazynski, Stephen K. Robinson, and Pedro Duque, and Payload Specialists Chiaki Mukai and John H. Glenn, continue to perform microgravity experiments. Specialist John Glenn completes a back-pain questionnaire as part of a study of how the muscle, intervertebral discs and bone marrow change due to microgravity. The results will then be compared with data provided by astronauts during previous missions. Glenn continues blood sample analysis and blood processing that are part of the Protein Turnover (PTO) experiment, which is studying the muscle loss that occurs during space flight.

Source record↗
NASA NTRS2003

In Vitro Studies on Space Radiation-Induced Delayed Genetic Responses: Shielding Effects

Understanding the radiation risks involved in spaceflight is of considerable importance, especially with the long-term occupation of ISS and the planned crewed exploration missions. Several independent causes may contribute to the overall risk to astronauts exposed to the complex space environment, such as exposure to GCR as well as SPES. Protons and high-Z energetic particles comprise the GCR spectrum and may exert considerable biological effects even at low fluence. There are also considerable uncertainties associated with secondary particle effects (e.g. HZE fragments, neutrons etc.). The interaction of protons and high-LET particles with biological materials at all levels of biological organization needs to be investigated fully in order to establish a scientific basis for risk assessment. The results of these types of investigation will foster the development of appropriately directed countermeasures. In this study, we compared the biological responses to proton irradiation presented to the target cells as a monoenergetic beam of particles of complex composition delivered to cells outside or inside a tissue phantom head placed in the United States EVA space suit helmet. Measurements of chromosome aberrations, apoptosis, and the induction of key proteins were made in bone marrow from CBA/CaJ and C57BL/6 mice at early and late times post exposure to radiation at 0, 0.5, 1 and 2 Gy while inside or outside of the helmet. The data showed that proton irradiation induced transmissible chromosomal/genomic instability in haematopoietic stem cells in both strains of mice under both irradiation conditions and especially at low doses. Although differences were noted between the mouse strains in the degree and kinetics of transforming growth factor-beta 1 and tumor necrosis factor-alpha secretion, there were no significant differences observed in the level of the induced instability under either radiation condition, or for both strains of mice. Consequently, when normalized to physical dose, the monoenergetic proton field present inside the helmet-protected phantom produced equivalent biological responses, when compared to unshielded cells, as measured by the induction of delayed genetic effects in murine haematopoietic stem cells.

Kadhim, Munira A.↗