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NASA NTRS2012

Microgravity Science Glovebox (MSG) Space Science's Past, Present, and Future on the International Space Station (ISS)

The Microgravity Science Glovebox (MSG) is a double rack facility designed for microgravity investigation handling aboard the International Space Station (ISS). The unique design of the facility allows it to accommodate science and technology investigations in a "workbench" type environment. MSG facility provides an enclosed working area for investigation manipulation and observation in the ISS. Provides two levels of containment via physical barrier, negative pressure, and air filtration. The MSG team and facilities provide quick access to space for exploratory and National Lab type investigations to gain an understanding of the role of gravity in the physics associated research areas. The MSG is a very versatile and capable research facility on the ISS. The Microgravity Science Glovebox (MSG) on the International Space Station (ISS) has been used for a large body or research in material science, heat transfer, crystal growth, life sciences, smoke detection, combustion, plant growth, human health, and technology demonstration. MSG is an ideal platform for gravity-dependent phenomena related research. Moreover, the MSG provides engineers and scientists a platform for research in an environment similar to the one that spacecraft and crew members will actually experience during space travel and exploration. The MSG facility is ideally suited to provide quick, relatively inexpensive access to space for National Lab type investigations.

Spivey, Reggie A.↗

NASA NTRS2013

Nanoscale Surface Plasmonics Sensor With Nanofluidic Control

Conventional quantitative protein assays of bodily fluids typically involve multiple steps to obtain desired measurements. Such methods are not well suited for fast and accurate assay measurements in austere environments such as spaceflight and in the aftermath of disasters. Consequently, there is a need for a protein assay technology capable of routinely monitoring proteins in austere environments. For example, there is an immediate need for a urine protein assay to assess astronaut renal health during spaceflight. The disclosed nanoscale surface plasmonics sensor provides a core detection method that can be integrated to a lab-on-chip device that satisfies the unmet need for such a protein assay technology. Assays based upon combinations of nanoholes, nanorings, and nanoslits with transmission surface plasmon resonance (SPR) are used for assays requiring extreme sensitivity, and are capable of detecting specific analytes at concentrations as low as picomole to femtomole level in well-controlled environments. The device operates in a transmission mode configuration in which light is directed at one planar surface of the array, which functions as an optical aperture. The incident light induces surface plasmon light transmission from the opposite surface of the array. The presence of a target analyte is detected by changes in the spectrum of light transmitted by the array when a target analyte induces a change in the refractive index of the fluid within the nanochannels. This occurs, for example, when a target analyte binds to a receptor fixed to the walls of the nanochannels in the array. Independent fluid handling capability for individual nanoarrays on a nanofluidic chip containing a plurality of nanochannel arrays allows each array to be used to sense a different target analyte and/or for paired arrays to analyze control and test samples simultaneously in parallel. The present invention incorporates transmission mode nanoplasmonics and nanofluidics into a single, microfluidically controlled device. The device comprises one or more arrays of aligned nanochannels that are in fluid communication with inflowing and outflowing fluid handling manifolds that control the flow of fluid through the arrays. The array acts as an aperture in a plasmonic sensor. Fluid, in the form of a liquid or a gas and comprising a sample for analysis, is moved from an inlet manifold through the nanochannel array, and out through an exit manifold. The fluid may also contain a reagent used to modify the interior surfaces of the nanochannels, and/or a reagent required for the detection of an analyte.

Wei, Jianjun↗

NASA NTRS1989

Channel simulator upgrade to use field propagation data

The JPL Channel Simulator lab was modified to allow full duplex links and to allow the use of field propagation data for link fading. This capability will be used to test equipment for the joint AUSSAT/NASA mobile satellite experiment in July 1989.

Berner, Jeff B.↗

NASA NTRS2012

From Extremophiles to Star Trek, The Use of Synthetic Biology in Astrobiology

Synthetic biology – the design and construction of new biological parts and systems and the redesign of existing ones for useful purposes – has the potential to transform fields from pharmaceuticals to fuels. Our lab has focused on the potential of synthetic biology to revolutionize all three major parts of astrobiology: Where do we come from? Where are we going? and Are we alone? For the first and third, synthetic biology is allowing us to answer whether the evolutionary narrative that has played out on planet earth is likely to have been unique or universal. For example, in our lab we are re-evolving biotic functions using only the most thermodynamically stable amino acids in order to understand potential capabilities of an early organism with a limited repertoire of amino acids. In the future synthetic biology will play an increasing role in human activities both on earth, in fields as diverse as bio-mining, human health and the industrial production of novel bio-composites. Beyond earth, we will rely increasingly on biologically-provided life support, as we have throughout our evolutionary history. In order to do this, the field will build on two of the great contributions of astrobiology: studies of the origin of life and life in extreme environments.

Life in Extreme Environments↗

NASA NTRSDate not supplied

Next Generation Exercise Device (NGED): Advancing Exercise Capabilities for Future Space Missions Through Biomechanical Modeling

BACKGROUND As space exploration extends to long-duration missions on the Moon and Mars, maintaining astronaut health and fitness becomes increasingly critical. The Next Generation Exercise Device (NGED), developed and tested by the HumanWorks Lab in NASA Johnson Space Center's (JSC) Software, Robotics, and Simulation Division, aims to address this challenge through innovative approaches. This study presents the development and evaluation of an NGED system, focusing on its adaptability to various mission scenarios, including prospective use in a Lunar Pressurized Rover (LPR). Central to this project is the application of biomechanical modeling to optimize exercise efficacy and safety in microgravity and partial gravity environments. The project is a collaborative effort with the Human Health and Performance group at Johnson Space Center, ensuring a comprehensive approach to astronaut well-being that integrates biomechanical principles with practical exercise solutions. The NGED represents the next generation of exercise capabilities for missions in space, on the Moon and Mars, with a specific focus on applications such as the LPR. METHODS AND RESULTS Data collection for NGED development was conducted with two motor-driven Beyond Power Voltra I [1] systems and a custom test structure to allow placement of the cable-based devices on the ground, at shoulder height, and overhead. The collection was performed in JSC’s Prototype Immersive Technology (PIT) Lab, utilizing an OptiTrack motion capture system and AMTI force platform, to enable detailed biomechanical analysis via OpenSim [2,3]. Motion capture data were collected for three subjects representing different body types and statures. The marker set used was an enhanced version of the full-body Plug-in Gait marker set [4], with additional markers strategically placed for the primary objective of informing exercise volume requirements. Subjects performed a series of 17 exercises, carefully selected to engage various muscle groups, including novel spaceflight exercises such as skiing (ergometer style), lateral pulldowns, wood chops, triceps extensions, and flies, with load variations ranging from 10 to 90 pounds to maintain kinematic form. This comprehensive approach allowed for a thorough evaluation of the NGED's performance across a wide range of motions and loads. The biomechanical modeling and analysis were conducted using a modified OpenSim Full Body Rajagopal Model [4,5] and also scaled to the maximum and minimum anthropometry provided in NASA-STD-3001 [6]. Volumetric convex hulls were generated based on model marker trajectories and aggregated into geometric assemblies. These can be placed in models of vehicle designs to assess fit to protect for exercise as well as to adapt NGED exercise to fit available space. Preliminary findings from the collection indicate that the NGED prototype demonstrates significant adaptability across varying user anthropometrics and exercise types. The device showed consistent performance in load-bearing exercises, with subjects able to perform exercises effectively while maintaining proper biomechanical form. CONCLUSION NGED represents a forward-looking advancement in exercise capabilities for future space missions. In the future, this system can be used to capture valuable metrics (e.g., isometric mid-thigh pull for force output measurements, assessments of postural muscle strength, overall isometric strength). Its versatility in accommodating various exercises and user physiques, coupled with the ability to provide targeted biomechanical loading, makes it a promising approach for maintaining astronaut health during long-duration missions to the Moon and Mars. Future work will focus on refining the NGED based on initial biomechanical findings, leveraging the detailed insights provided by motion capture and analysis techniques. Particular emphasis will be placed on optimizing its use within the confined spaces of a LPR and other space habitats. This work contributes significantly to NASA's goals of supporting human health and performance in deep space exploration, paving the way for sustainable long-term presence beyond Low Earth Orbit through advanced, biomechanically-informed exercise solutions.

C Wang↗

NASA NTRS1994

Customizing the JPL Multimission Ground Data System: Lessons learned

The Multimission Ground Data System (MGDS) at NASA's Jet Propulsion Laboratory has brought improvements and new technologies to mission operations. It was designed as a generic data system to meet the needs of multiple missions and avoid re-inventing capabilities for each new mission and thus reduce costs. It is based on adaptable tools that can be customized to support different missions and operations scenarios. The MGDS is based on a distributed client/server architecture, with powerful Unix workstations, incorporating standards and open system architectures. The distributed architecture allows remote operations and user science data exchange, while also providing capabilities for centralized ground system monitor and control. The MGDS has proved its capabilities in supporting multiple large-class missions simultaneously, including the Voyager, Galileo, Magellan, Ulysses, and Mars Observer missions. The Operations Engineering Lab (OEL) at JPL has been leading Customer Adaptation Training (CAT) teams for adapting and customizing MGDS for the various operations and engineering teams. These CAT teams have typically consisted of only a few engineers who are familiar with operations and with the MGDS software and architecture. Our experience has provided a unique opportunity to work directly with the spacecraft and instrument operations teams and understand their requirements and how the MGDS can be adapted and customized to minimize their operations costs. As part of this work, we have developed workstation configurations, automation tools, and integrated user interfaces at minimal cost that have significantly improved productivity. We have also proved that these customized data systems are most successful if they are focused on the people and the tasks they perform and if they are based upon user confidence in the development team resulting from daily interactions. This paper will describe lessons learned in adapting JPL's MGDS to fly the Voyager, Galileo, and Mars Observer missions. We will explain how powerful, existing ground data systems can be adapted and packaged in a cost effective way for operations of small and large planetary missions. We will also describe how the MGDS was adapted to support operations within the Galileo Spacecraft Testbed. The Galileo testbed provided a unique opportunity to adapt MGDS to support command and control operations for a small autonomous operations team of a handful of engineers flying the Galileo Spacecraft flight system model.

Murphy, Susan C.↗

NASA NTRS1997

Remote Sensing of Surficial Process Responses to Extreme Meteorological Events

Changes in the frequency and magnitude of extreme meteorological events are associated with changing environmental means. Such events are important in human affairs, and can also be investigated by orbital remote sensing. During the course of this project, we applied ERS-1, ERS-2, Radarsat, and an airborne sensor (AIRSAR-TOPSAR) to measure flood extents, flood water surface profiles, and flood depths. We established a World Wide Web site (the Dartmouth Flood Observatory) for publishing remote sensing-based maps of contemporary floods worldwide; this is also an online "active archive" that presently constitutes the only global compilation of extreme flood events. We prepared an article for EOS concerning SAR imaging of the Mississippi Valley flood; an article for the International Journal of Remote Sensing on measurement of a river flood wave using ERS-2, began work on an article (since completed and published) on the Flood Observatory for a Geoscience Information Society Proceedings volume, and presented lectures at several Geol. Soc. of America Natl. Meetings, an Assoc. of Amer. Geographers Natl. Meeting, and a Binghamton Geomorphology Symposium (all on SAR remote sensing of the Mississippi Valley flood). We expanded in-house modeling capabilities by installing the latest version of the Army Corps of Engineers RMA two-dimensional hydraulics software and BYU Engineering Graphics Lab's Surface Water Modeling System (finite elements based pre- and post-processors for RMA work) and also added watershed modeling software. We are presently comparing the results of the 2-d flow models with SAR image data. The grant also supported several important upgrades of pc-based remote sensing infrastructure at Dartmouth. During work on this grant, we collaborated with several workers at the U.S. Army Corps of Engineers, Remote Sensing/GIS laboratory (for flood inundation mapping and modeling; particularly of the Illinois River using the AIRSAR/TOPSAR/ERS-2 combined data), with Dr. Karen Prestegaard at the University of Maryland (geomorphological responses to the extreme 1993 flood along the Raccoon drainage in central Iowa), and with Mr Tim Scrom of the Albany National Weather Service River Forecast Center (initial planning for the use of Radarsat and ERS-2 for flood warning). The work thus initiated with this proposal is continuing.

Brakenridge, G. Robert↗

NASA NTRSDate not supplied

Studying Microbial Adaptation in the Laboratory: Sensor & Control Upgrades for an Experimental Evolution Biofluidics System

Experimental evolution (EE) involves iteratively exposing a microbial community to specific stressors to study its response to changes in environment over time. EE work is commonly done manually in the laboratory, but, when there are many environmental variables to measure and adjust, it is highly labor intensive, prone to human error, and challenging to scale. Single-purpose automated continuous culturing chambers exist, but implement only limited stressor types. A more general-purpose design is desirable. The BeING Lab at Ames Research Center created the prototype Automated Adaptive Directed Evolution Chamber (AADEC) to address these problems, beginning with Escherichia coli tolerance of short-wave ultraviolet (UV-C) radiation and of temperature. In newer versions, AADEC monitors microbial activity and can adjust the UV-C and temperature levels automatically. An optical density measurement is used to determine how many cells are present in the growth medium—over time, this corresponds to how many survive and reproduce. Oxidation-reduction potential provides information on consumed metabolic energy, and pH and electrical conductivity on metabolic products. Dissolved oxygen content is used to determine aerobic vs anaerobic growth. A Raspberry Pi computer processes all this data to set the UV-C stressor level. AADEC’s auxiliary systems include peristaltic pumps to change media and agitation to counteract cell settling. These actuators can also act as additional stressors. With the Raspberry Pi monitoring sensors and adjusting actuators in real time, AADEC takes measurements and controls the environment much more accurately than can be done with a manual EE implementation. The third and latest AADEC iteration is the first to simplify design and usage with circuits on PCBs and the ability to pre-program experimental protocols. Still planned is expansion to a multi-well design for the study of varying cell cultures in parallel, which will enable researchers to retain and re-inoculate cultures exhibiting the desired trait most strongly while flushing out others. AADEC’s special capabilities make it a valuable tool for studying life under multiple stressors, enabling scientists to replicate changes in climate on microbes for study in a lab setting.

Microbial Adaptation↗

NASA NTRS1974

Computer and display systems for large physiological models

This paper describes the computer and display systems which were developed for physiological models at NASA's Environmental Physiology Lab, Johnson Space Center. The systems involve hardware and software for remote communications, computation, and display. Also described is the development of a capability to proceed from a physiologist's hypothesis to meaningful presentations of model and laboratory data. Two large hardware and software computer configurations and their graphic display systems are discussed. One system is for dedicated use in the laboratory, and the other system is for remote use on a time-sharing basis. It is concluded that these techniques can add a new dimension to physiological data analysis tasks.

Hassell, R. F.↗

NASA NTRS2005

Observations in the 1.3 and 1.5 THz atmospheric windows with the Receiver Lab Telescope

The Receiver Lab Telescope (RLT) is a groundbased terahertz telescope; it is currently the only instrument producing astronomical data between 1 and 2 THz. The capabilities of the RLT have been expanding since observations began in late 2002. Initial observations were limited to the 850 GHz and 1.03 THz windows due to the availability of solid state local oscillators. In the last year we have begun observations with new local oscillators for the 1.3 and 1.5 THz atmospheric windows.

ground based observations↗

NASA NTRS2014

Design of a K/Q-band Beacon Receiver for the Alphasat TDP#5 Experiment

This paper describes the design and performance of a coherent K/Q-band (20/40GHz) beacon receiver developed at NASA Glenn Research Center (GRC) that will be installed at the Politecnico di Milano (POLIMI) for use in the Alphasat Technology Demonstration Payload #5 (TDP#5) beacon experiment. The goal of this experiment is to characterize rain fade attenuation at 40GHz to improve the performance of existing statistical rain attenuation models in the Q-band. The ground terminal developed by NASA GRC utilizes an FFT-based frequency estimation receiver capable of characterizing total path attenuation effects due to gaseous absorption, clouds, rain, and scintillation. The receiver system has been characterized in the lab and demonstrates a system dynamic range performance of better than 58dB at 1Hz and better than 48dB at 10Hz rates.

beacon receiver↗

NASA NTRS2013

Altitude-Limiting Airbrake System for Small to Medium Scale Rockets

The goal of the overall internship opportunity this semester was to learn and practice the elements of engineering design through direct exposure to real engineering problems. The primary exposure was to design and manufacture an airbrake device for use with small-medium scale rocket applications. The idea was to take the presented concept of a solution and transform said concept into a reliable fully-functioning and reusable mechanism. The mechanism was to be designed as an insurance feature so that the overall altitude of a rocket with relatively undetermined engine capabilities does not unexpectedly exceed the imposed 10,000 foot ceiling, per range requirements. The airbrake concept was introduced to the Prototype Development Lab as a rotation-driven four tiered offset track pin mechanism, i.e. the airbrake was deployed by rotating a central shaft attached directly to the bottom plate. The individual airbrake fins were subsequently deployed using multiple plates with tracks of offset curvature. The fins were created with guide pins to follow the tracks in each of the offset plates, thus allowing the simultaneous rotational deployment of all fins by only rotating one plate. The concept of this solution was great; though it did not function in application. The rotating plates alone brought up problems like the entire back half of the rocket rotating according to the motion of the aforementioned base plate. Subsequently, the solution currently under development became a static linear actuator-driven spring-loaded fin release system. This solution is almost instantaneously triggered electronically when the avionics detect that the rocket has reached the calculated altitude of deceleration. This altitude will allow enough time remaining to the overall ceiling to adequately decelerate the rocket prior to reaching the ceiling.

Rocket University↗

NASA NTRS2014

Design of a K/Q-Band Beacon Receiver for the Alphasat Technology Demonstration Payload (TDP) #5 Experiment

This paper describes the design and performance of a coherent KQ-band (2040 GHz) beacon receiver developed at NASA Glenn Research Center (GRC) that will be installed at the Politecnico di Milano (POLIMI) for use in the Alphasat Technology Demonstration Payload 5 (TDP5) beacon experiment. The goal of this experiment is to characterize rain fade attenuation at 40 GHz to improve the performance of existing statistical rain attenuation models in the Q-band. The ground terminal developed by NASA GRC utilizes an FFT-based frequency estimation receiver capable of characterizing total path attenuation effects due to gaseous absorption, clouds, rain, and scintillation. The receiver system has been characterized in the lab and demonstrates a system dynamic range performance of better than 58 dB at 1 Hz and better than 48 dB at 10 Hz rates.

rain fade↗

NASA NTRS2014

Design of a K/Q-Band Beacon Receiver for the Alphasat TDP#5 Experiment

beacon receiver↗

NASA NTRSDate not supplied

Astrobee Operations on the Iss: Gui’S Impact on the Operators’ Cognitive Load

The Astrobee free-flying robots have completed their fifth successful year of operations housed in the Japanese Experimental Module (JEM) on the International Space Station (ISS). In this paper, we introduce two Graphical User Interfaces (GUI) used to operate and monitor in real-time the Astrobee free-flying robots onboard the ISS and report on the impact these GUIs have in the operator’s cognitive load. A review of the state-of-the-art GUI design for remotely teleoperated scenarios with minimal time delay is presented and the study’s conclusion used to determine the elements and recommendations to create an interface that minimizes its impact on the overall performance of an operator during an activity at the ISS. The Ground Data System (GDS) is one of the two GUIs in the study: it contains several tabs, each of which displays a different set of controls for specific tasks e.g. Overview, Run Plan, Teleoperate, Guest Science; some also display video and a three-dimensional (3D) representation of the ISS and robot based on the Astrobee’s telemetry. Most tabs enable a single operator-robot connection, however some of its tabs are capable to monitor and control up to three Astrobees simultaneously. The GDS Helper is a text-based user interface created to facilitate commanding and monitoring of an Astrobee robot directly from an SSH session. In full interactive mode it displays a maximum of 5 sections: general commanding, feedback/ack, telemetry, guest science commanding, and data, all in one view. In batch mode, it enables complex command scripting while retaining some interactive capabilities. A comparative analysis between these GUIs is carried out at an analogous ISS environment at the NASA Ames Research Center’s Granite Lab and its results presented. While GDS is able to provide an operator with control and situational awareness via its video and 3D displays, its several tabs may introduce an overwhelming amount of information confusing and delaying the operator especially during time-sensitive maneuvers where the operator may need to switch back and forth between them. GDS helper in the other hand does not provide video or 3D displays thus not allowing an operator to attain situational awareness, however it provides the operator with a design displaying commonly used data in a single window, enabling the operator to understand the state of the robot at a glance and control it through a commands entered via keyboard instead of a combination of mouse clicks and keyboard input. The results of the experiments measure the cognitive load across several operators maneuvering Astrobee to accomplish tasks ranging from fully manual to supervised activities. A GUI combining a single window displaying data along video and a 3D display is expected to reduce the operator’s cognitive load.

Astrobee↗

NASA NTRSDate not supplied

Overview of Predictive Simulation Capability Development for Crater Evolution and Ejecta in Continuum/Rarefied Flows

As part of the Game Changing Development (GCD) Program, funded by NASA’s Space Technology Mission Directorate (STMD), the development of simulation capability for the prediction of extra-terrestrial Plume Surface Interaction (PSI) environments has been undertaken by the Fluid Dynamics Branch at NASA/MSFC. The Predictive Simulation Capability (PSC) Element is focused on creating simulation capability for the reliable and accurate prediction of PSI in Martian (~650 Pa) and Lunar (vacuum) ambient environments. In addition to the predictive simulation capability, the GCD Program also contains a companion Ground Testing Element for development of focused datasets for validation of predictive capability as well as a Flight-focused Instrumentation Element. The focus of this paper is to provide an overview and a brief status on one area of capability development through this GCD PSI project - capturing the effects of mixed continuum/rarefied flow on crater development and ejecta sheets. This includes both capability enhancements and maturation of the predictive tool, Loci/GGFS, into a production capable tool as well as validation of the tool against PSI data in Martian and Lunar environments. There are six newly developed capabilities that will be production ready by the end of the fiscal year. Newly developed capabilities must first be verified prior to being production ready, and this process includes capability demonstration, solution verification, and performance evaluation. An overview of the newly developed capabilities with respect to several test cases, including cratering simulations of the Apollo Lunar Module, will be presented. Several validation analyses have been performed to validate in Martian and more Lunar-like environments, including simulations of cratering from a subsonic flow test at Planetary Aeolian Lab (PAL) conducted in a Martian-like environment and pre-test cratering predictions of Physics Focused Ground Test (PFGT) tests planned to be performed in Martian-like and more Lunar-like environments. An overview of these validation analyses as it pertains to the capability development will be presented.

Andrew Weaver↗

NASA NTRS1979

Holographic flow visualization at NASA Langley

Holographic flow visualization systems at two NASA Langley facilities, a hypersonic blow-down tunnel using CF4 gas and an expansion tube with very short test time, are described. A pulsed ruby laser is used at a CF4 tunnel for single pulse holography, double pulse with several minutes between exposures, and dual plate holographic interferometry. Shadowgraph, schlieren, and interferograms are reconstructed from the holograms in a separate reconstruction lab. At the expansion tube the short run time of 200 microseconds requires precise triggering of its double pulsed ruby laser. With double pulse capability of 20 to 1200 microseconds pulse separation, one pulse can occur before and one later after flow is established to obtain fringe free background interferograms (perfect infinite fringe) or both pulses can occur during flow in order to study flow instabilities. Holograms are reconstructed at the expansion tube with an in-place setup which makes use of a high power CW Argon laser and common optics for both recording and reconstructing the holograms. The holographic systems at the CF4 tunnel and expansion tube are operated routinely for flow visualization by tunnel technicians. Typical flow visualization photographs from both facilities are presented.

Burner, A. W.↗

NASA NTRS1992

Materials dispersion and biodynamics project research

The Materials Dispersion and Biodynamics Project (MDBP) focuses on dispersion and mixing of various biological materials and the dynamics of cell-to-cell communication and intracellular molecular trafficking in microgravity. Research activities encompass biomedical applications, basic cell biology, biotechnology (products from cells), protein crystal development, ecological life support systems (involving algae and bacteria), drug delivery (microencapsulation), biofilm deposition by living organisms, and hardware development to support living cells on Space Station Freedom (SSF). Project goals are to expand the existing microgravity science database through experiments on sounding rockets, the Shuttle, and COMET program orbiters and to evolve,through current database acquisition and feasibility testing, to more mature and larger-scale commercial operations on SSF. Maximized utilization of SSF for these science applications will mean that service companies will have a role in providing equipment for use by a number of different customers. An example of a potential forerunner of such a service for SSF is the Materials Dispersion Apparatus (MDA) 'mini lab' of Instrumentation Technology Associates, Inc. (ITA) in use on the Shuttle for the Commercial MDAITA Experiments (CMIX) Project. The MDA wells provide the capability for a number of investigators to perform mixing and bioprocessing experiments in space. In the area of human adaptation to microgravity, a significant database has been obtained over the past three decades. Some low-g effects are similar to Earth-based disorders (anemia, osteoporosis, neuromuscular diseases, and immune system disorders). As new information targets potential profit-making processes, services and products from microgravity, commercial space ventures are expected to expand accordingly. Cooperative CCDS research in the above mentioned areas is essential for maturing SSF biotechnology and to ensure U.S. leadership in space technology. Currently, the MDBP conducts collaborative research with investigators at the Rockefeller University, National Cancer Institute, and the Universities of California, Arizona, and Alabama in Birmingham. The growing database from these collaborations provides fundamental information applicable to development of cell products, manipulation of immune cell response, bone cell growth and mineralization, and other processes altered by low-gravity. Contacts with biotechnology and biopharmaceutical companies are being increased to reach uninformed potential SSF users, provide access through the CMDS to interested users for feasibility studies, and to continue active involvement of current participants. We encourage and actively seek participation of private sector companies, and university and government researchers interested in biopharmaceuticals, hardware development and fundamental research in microgravity.

Lewis, Marian L.↗