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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRS1998

Protein Kinases Possibly Mediate Hypergravity-Induced Changes in F-Actin Expression by Endothelial Cells

Basic cellular functions such as electrolyte concentration, cell growth rate, glucose utilization, bone formation, response to growth stimulation, and exocytosis are modified in microgravity. These studies indicate that microgravity affects a number of physiological systems and included in this are cell signaling mechanisms. Rijken and coworkers performed growth factor studies that showed PKC signaling and actin microfilament organization appears to be sensitive to microgravity, suggesting that the inhibition of signal transduction by microgravity may be related to alterations in actin microfilament organization. However, similar studies have not been done for vascular cells. Vascular endothelial cells play critical roles in providing nutrients to organ and tissues and in wound repair. The major deterrent to ground-based microgravity studies is that it is impossible to achieved true microgravity for longer than a few minutes on earth. Hence, it has not been possible to conduct prolonged microgravity studies except for two models that simulate certain aspects of microgravity. However, hypergravity is quite easily achieved. Several researchers have shown that hypergravity will increase the proliferation of several different cell lines while decreasing cell motility and slowing liver regeneration following partial hepatectomy, These studies indicate the hypergravity also alters the behavior of most cells. Several investigators have shown that hypergravity affects the activation of several protein kinases (PKs) in cells. In this study, we investigated whether hypergravity alters the expression of f-actin by bovine aortic endothelial cells (BAECs) and the role of PK's (calmodulin 11 dependent, PKA and PKC) as mediators of these effects.

Love, Felisha D.↗
NASA NTRS2000

Constraints on Particles and Fields from X-Ray Data

We review emission processes for the handful of extragalactic radio sources which produce X-rays from hotspots and knots in radio jets. In almost all cases, the emitting feature shows a large gradient in radio brightness, indicative of the presence of a strong shock. Since both thermal and synchrotron self Compton models face severe difficulties (except for the hotspots of Cygnus A and 3C 295), the most likely explanation is the presence of gamma = 10(exp 7) electrons producing X-ray synchrotron emission. The major problems remaining are why so few features have been detected so far and why has no optical emission been detected in some cases. While a somewhat unique situation exists for 3C 390.3, serious problems remain for Pictor A, 3C 120, and the quasar jets in 3C 273 and PKS 0637.

Harris, D. E.↗
NASA NTRS2000

High-Frequency Observations of Blazars

We report on the results of high-frequency VLBA observations of 42 gamma-ray bright blazars monitored at 22 and 43 GHz between 1993.9 and 1997.6. In 1997 the observations included polarization-sensitive imaging. The cores of gamma-ray blazars are only weakly polarized, with EVPAs (electric-vector position angles) usually within 40 deg of the local direction of the jet. The EVPAs of the jet components are usually within 20 deg of the local jet direction. The apparent speeds of the gamma-ray bright blazars are considerably faster than in the general population of bright compact radio sources. Two X-ray flares (observed with RXTE) of the quasar PKS 1510-089 appear to be related to radio flares, but with the radio leading the X-ray variations by about 2 weeks. This can be explained either by synchrotron self-Compton emission in a component whose variations are limited by light travel time or by the Mirror Compton model.

Marscher, A. P.↗
NASA NTRS2001

Frequency Stratification of the Nonthermal Emission in Blazars

Research supported by this grant involved theoretical investigations of the multifrequency nonthermal emission from the relativistic jets in blazars, which are quasars and related objects with highly variable brightness. In the initial stage of the project, one-dimensional, conical (i.e., spherical symmetry between the jet axis and surface is assumed) jet models were used to explain the multi-waveband spectra and variability of blazars. The results were applied to two flares observed in the object PKS 2155-304, leading to the conclusion that the distinct differences in the observed characteristics of the two flares can be explained with the same jet model if two different physical parameters (the magnetic field in the first flare and the efficiency of acceleration of electrons to high energies in the second) varied.

Marscher, Alan P.↗
NASA NTRS1998

A Viewing Angle-Kinetic Luminosity Scheme for BL Lacertae Objects

We propose a unified classification for BL Lacertae objects (BLs), focusing on the synchrotron peak frequency of the spectral energy distribution. The unification scheme is based on the angle theta that describes the orientation of the relativistic jet and on the electron kinetic luminosity Lamba(sub kin) of the jet. We assume that Lamba(sub kin) scales with the size of the jet (r) in a self-similar fashion (Lamba(sub kin) is proportional to r(exp 2)), as supported by observational data. The jets are self-similar in geometry and have the same pressure and median magnetic field at the inlet, independent of size. The self-similarity is broken for the highest energy electrons, which radiate mainly at high frequencies, since for large sources they suffer more severe radiative energy losses over a given fraction of the jet length. We calculate the optically thin synchrotron spectrum using an accelerating inner jet model based on simple relativistic gas dynamics and show that it can fit the observed infrared-to-X-ray spectrum of PKS 2155-304. We couple the accelerating jet model to the unification scheme and compare the results to complete samples of BLs. The negative apparent evolution of X-ray-selected BLs is explained as a result of positive evolution of the jet electron kinetic luminosity Lamba(sub kin). We review observational arguments in favor of the existence of scaled-down accretion disks and broad emission-line regions in BLs. The proposed unification scheme can explain the lack of observed broad emission lines in X-ray-selected BLs as well as the existence of those lines preferentially in luminous radio-selected BLs. Finally, we review observational arguments that suggest the extension of this unification scheme to all blazars.

Georganopoulos, Markos↗
NASA NTRS2001

STIS Observations of the Low-z Ly-Alpha Forest

The Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope has brought a new era in studying the low-redshift Lyman-alpha Forest. The advantages of STIS over previous HST spectrographs include: (1) a high spectral resolution (7 km/s) comparable to Keck/HIRES spectra of the high-z Lyman-alpha forest; and (2) a high observing efficiency brought about by an imaging detector able to span the full far-UV wavelength range (1150-1700 A, or equivalently, z=0.0-0.4) in a single exposure. The STIS Investigation Definition Team is therefore conducting an observational program to determine the properties of the low-z intergalactic medium as manifested by the Lyman-alpha forest. The team has made observations of the quasars: 3C 273, 3C 351, and PKS 0405. We shall present preliminary results based on the sightline to 3C 273, the brightest of these sources.

Heap, Sara R.↗
NASA NTRS2001

HST/STIS Spectroscopy of the Local Lyman-Alpha Forest

The Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope has brought a new era in studying the low-redshift Lyman-alpha Forest. The advantages of STIS over previous HST spectrographs include:(l) a high spectral resolution (7 km/s) comparable to Keck/HIRES spectra of the high-redshift Lyman-alpha forest; (2) a high observing efficiency brought about by an imaging detector able to span the full fares wavelength range (1150-1700 A, or equivalently, z=0.0-0.4) in a single exposure. The STIS Investigation Definition Team is therefore conducting an observational program to determine the properties of the low-redshift intergalactic medium as manifested by the Lyman-alpha forest. The team has made observations of the quasars: 3C 273, 3C 351, and PKS 0405. We shall present results based on the sightline to 3C 273, the brightest of these sources.

Heap, Sara R.↗
NASA NTRS2000

High-Frequency Observations of Blazars

We report on the results of high-frequency VLBA observations of 42 gamma ray bright blazars monitored at 22 and 43 GHz between 1993.9 and 1997-6. In 1997 the observations included polarization-sensitive imaging. The cores of gamma ray blazars are only weakly polarized, with EVPAs (electric-vector position angles) usually within 40 degrees of the local direction of the jet. The EVPAs of the jet components are usually within 20 degrees of the local jet direction. The apparent speeds of the gamma ray bright blazars are considerably faster than in the general population of bright compact radio sources. Two X-ray flares (observed with RXTE) of the quasar PKS 1510-089 appear to be related to radio flares, but with the radio leading the X-ray variations by about 2 weeks. This can be explained either by synchrotron self-Compton emission in a component whose variations are limited by light travel time or by the Mirror Compton model.

Marscher, A. P.↗
NASA NTRS2004

Frequency-Dependent Time Lags in Three Blazars

The work completed includes the analysis of observations obtained during Cycle 6 of the Rossi X-ray Timing Explorer (RXTE). The project is part of a longer-term, continuing program to study the X-ray emission process in blazars in collaboration with Dr. Ian McHardy (U. of Southampton, UK). The goals of the program are to study the X-ray emission mechanism in blazars and the relation of the X-ray emission to changes in the relativistic jet. The program includes contemporaneous brightness and linear polarization monitoring at radio and optical wavelengths, total and polarized intensity imaging at 43 GHz with a resolution of 0.1 milliarcseconds with the VLBA, and well-sampled X-ray light curves obtained from a series of approved RXTE programs. During RXTE cycle 6, the project was awarded RXTE time to monitor three quasars: PKS 1510-089 two times per week, and 3C 273 and 3C 279 three times per week each. The X-ray data, including those from earlier cycles, were compared with radio measurements obtained 2-3 times per week in the centimeter-wave band with the Michigan radio telescope, monthly imaging observations with the VLBA at 43 GHz, and optical observations obtained at several telescopes around the world. Since it is the long-term X-ray light curve that is of greatest value, this report includes discussion of all the data collected through August 2003 rather than just the Cycle 6 data.

Marscher, Alan P.↗
NASA NTRS2004

Bulk Comptonization of the Cosmic Microwave Background by Extragalactic Jets as a Probe of their Matter Content

We propose a method for estimating the composition, i.e. the relative amounts of leptons and protons, of extragalactic jets which exhibit Chandra - detected knots in their kpc scale jets. The method relies on measuring, or setting upper limits on, the component of the Cosmic Microwave Background (CMB) radiation that is bulk-Comptonized by the cold electrons in the relativistically flowing jet. These measurements, along with modeling of the broadband knot emission that constrain the bulk Lorentz factor GAMMA of the jets, can yield estimates of the jet power carried by protons and leptons. We provide an explicit calculation of the spectrum of the bulk-Comptonized (BC) CMB component and apply these results to PKS 0637 - 752 and 3C 273, two superluminal quasars with Chandra - detected large scale jets. What makes these sources particularly suited for such a procedure is the absence of significant non-thermal jet emission in the 'bridge', the region between the core and the first bright jet knot, which guarantees that most of the electrons are cold there, leaving the BC scattered CMB radiation as the only significant source of photons in this region. At lambda = 3.6 - 8.0 microns, the most likely band to observe the BC scattered CMB emission, the Spitzer angular resolution (approximately 1" - 3") is considerably smaller than the the 'bridges' of these jets (approximately 10"), making it possible to both measure and resolve this emission.

Georganopoulos, Markos↗
NASA NTRS2006

Extragalactic Backgrounds in the Far UV and Exploring Star Formation at High Redshifts with Gamma-ray Observations

The determination of the intergalactic photon densities from the FIR to the UV which is produced by stellar emission and dust reradiation at various redshifts can provide an independent measure of the star formation history of the universe. Using recent Spitzer and GALEX data in conjunction with other observational inputs, Stecker, Malkan and Scully have calculated the intergalactic photon density as a function of both energy and redshift for 0 < zeta < 6 for photon energies from 0.003 eV to the Lyman limit cutoff at 13.6 eV in a ACDM universe with Omega(sub Lambda) = 0.7 and Omega(sub m) = 0.3. Their results are based on backwards evolution models for galaxies which were developed by Malkan and Stecker previously. The calculated background SEDs at zeta = 0 are in good agreement with the present observational data and limits. The calculated intergalactic photon densities as a function of redshift were used to predict to extend the absorption of high energy 7-rays in intergalactic space from sources such as blazars and quasars, this absorption being produced by interactions the y-rays with the intergalactic FIR-UV photons having the calculated densities. The results are in excellent agreement with absorption features found in the low gamma-ray spectra of Mkn 421, Mkn 501 at, zeta = 0.03 and PKS

Stecker, Floyd W.↗
NASA NTRS2006

Intergalactic Photon Spectra from the Far-IR to the UV Lyman Limit for 0 < z < 6 and the Optical Depth of the Universe to High-Energy Gamma Rays

We calculate the intergalactic photon density as a function of both energy and redshift for 0<z<6 for photon energies from.003 eV to the Lyman limit cutoff at 13.6 eV in a (Omega)CDM universe with (Omega)(Lambda)=0.7 and (Omega)m=0.3. The basic features of our backward-evolution model for galaxies were developed in earlier papers by Malkan & Stecker. With a few improvements, we find that this evolutionary model gives predictions of new deep number counts from Spitzer, as well as a calculation of the spectral energy distribution of the diffuse infrared background, which are in good agreement with the data. We then use our calculated intergalactic photon densities to extend previous work on the absorption of high-energy Gamma-rays in intergalactic space owing to interactions with low-energy photons and the 2.7 K cosmic microwave background radiation. We calculate the optical depth of the universe, Tau , for Gamma-rays having energies from 4 GeV to 100 TeV emitted by sources at redshifts from 0 to 5. We also give an analytic fit with numerical coefficients for approximating (E(Gamma), z). As an example of the application of our results, we calculate the absorbed spectrum of the blazar PKS 2155-304 at z=0.117 and compare it with the spectrum observed by the HESS air Cerenkov Gamma-ray telescope array.

Stecker, F. W.↗
NASA NTRS2007

An Intriguing Convex Break in the EGRET SED of Mrk 421

Based upon analysis of the entire EGRET data from Mrk 421, it is found that the time-averaged spectra are inconsistent with the predictions of current theoretical models that have had success in describing simultaneous X-ray/TeV observations, and suggest additional components in the GeV band, as well as complex time variability. Current theoretical pictures explain the GeV emission as comptonization of the synchrotron photons in the jet, and predict hard spectra that should join smoothly with the TeV emission. Our analysis shows that the situation is more complex. The spectrum ranges from hard to soft during individual epochs, and shows a convext break in the aggregated data. We also present the mission-averaged EGRET spectrum for PKS 2155-304, which shows a similar (but not as pronounced) convex curvature. We discuss a series of possible explanations for the 10(exp 22) - 10(exp 23) HZ declining part of the EGRET nu F(sub nu), spectrum for Mrk 421, and suggest that it is synchrotron emission from the high energy tail of the electron population that produces the X-rays during the highest X-ray states. Such multi-MeV photons are produced by electrons accelerated close to the limit of diffusive shock acceleration. Simultaneous GLAST and X-ray observations of high X-ray states will address the issue of the convex curvature in the future.

Nandikotkur, Giridhar↗
NASA NTRS1997

Multiwavelength Observations of a Dramatic High Energy Flare in the Blazar 3C 279

Multiwavelength observation of blazars in conjuction with EGRET points have been obtained at several epochs. However, either the monitoring was to sparse or the source was not active during the campaign, so that detections of correlated mulitwavelentgh variabiltiy on short times scales are tentaive (3C 279, Maraschi et al. 1994; Hartman et al. 1996; OJ 287, Webb et al. 1996; PKS 0537-441, Pian et al. 1997).

gamma↗
NASA NTRS2018

Marginal protein stability drives subcellular proteome isoelectric point

There exists a positive correlation between the pH of subcellular compartments and the median isoelectric point (pI) for the associated proteomes. Proteins in the human lysosome—a highly acidic compartment in the cell—have a median pI of ∼6.5, whereas proteins in the more basic mitochondria have a median pI of ∼8.0. Proposed mechanisms reflect potential adaptations to pH. For example, enzyme active site general acid/base residue pKs are likely evolved to match environmental pH. However, such effects would be limited to a few residues on specific proteins, and might not affect the proteome at large. A protein model that considers residue burial upon folding recapitulates the correlation between proteome pI and environmental pH. This correlation can be fully described by a neutral evolution process; no functional selection is included in the model. Proteins in acidic environments incur a lower energetic penalty for burying acidic residues than basic residues, resulting in a net accumulation of acidic residues in the protein core. The inverse is true under alkaline conditions. The pI distributions of subcellular proteomes are likely not a direct result of functional adaptations to pH, but a molecular spandrel stemming from marginal stability.

Kaiser Loell↗