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At least 199 records · Page 11

Unimodal Imaging of Monovalent Metal-Chelator Complexes and Lipids by MALDI Imaging Mass Spectrometry

Careful regulation of monovalent metal ions (M + ) is necessary to maintain a functional cellular system. Of these ions, appropriate sodium (Na + ) and potassium (K + ) concentrations are particularly integral for electrochemical signaling, as well as the secondary transport of nutrients and waste. Dysregulation of M + homeostasis can disrupt these mechanisms, potentially influencing the metabolism of downstream biomolecules such as lipids. Thus, the relationship between M + abundances and related biomolecular distributions must be elucidated to better understand the physiology of healthy and disordered tissues. Traditional techniques for imaging biological metal distributions include SIMS, LA-ICP-MS, and XRF; however, these capabilities are limited to elemental analysis or the analysis of molecular fragments and must be paired with other modalities to visualize distributions of more complex biomolecules within the same or similar samples. Conversely, matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a powerful tool often used for mapping such biomolecular distributions, but current methods are unable to detect metals within tissue. This study illustrates a novel methodology that adds metal detection to the MALDI IMS repertoire through which the simultaneous detection of M + metals and lipids is achievable. Using a robotic sprayer for homogeneous application, on-tissue deposition of the chelator deferiprone (DEF) enables subsequent detection of the ionizable metal-chelator complex by MALDI without hindering lipid detection. Our work provides proof-of-concept data for the simultaneous detection of K + , Na + , and intact lipids using MALDI IMS.

59 BASIC BIOLOGICAL SCIENCES↗

Multireference diffusion Monte Carlo reaches 2D materials

Abstract Quantum confinement in 2D materials strongly enhances electronic correlation effects. Therefore, predicting the properties of these unique materials, with both a high level of accuracy and computational efficiency, without relying on adjustable parameters or functionals, remains an outstanding theoretical challenge. The majority of theoretical studies are based on the approximations of density functional theory (DFT). The reliability of DFT predictions are heavily dependent on the choice of an approximated exchange-correlation functional. Here, we estimate the magnitude of impact of correlation on the total energy for the quintessential 2D material, graphene, by performing and comparing state-of-the-art selected CI and quantum Monte Carlo extrapolated calculations for a single unit cell at the$$\Gamma$$point. We demonstrate that Self-Healing Diffusion Monte Carlo (SHDMC) obtains a very compact, but high-quality wavefunction for this system that lacks the strong basis set dependence displayed by state of the art quantum chemistry methods. The SHDMC wavefunction is of higher quality compared to that obtained from sCI, in the same orbital basis, while being$$\sim$$ 1000 times smaller in terms of determinant count compared to sCI. We also demonstrate that extrapolating SHDMC results to the infinite determinant limit compares extremely well with complete basis set extrapolated sCI. Our work paves the way for future validation of SHDMC applied to challenging 2D materials.

Science & Technology - Other Topics↗

Uranium particle age dating, aggregation, and model age best estimators

We present important aspects of uranium particle age dating by Large-Geometry Secondary Ion Mass Spectrometry (LG-SIMS) that can introduce bias and increase model age uncertainties, especially for small, young, and/or low-enriched particles. This metrology is important for applications related to International Nuclear Safeguards. We explore influential factors related to model age estimation, including the effects of evolving surface chemistry on inter-element measurements of particles (e.g., Th and U), detector background, and aggregation methods using simulated and actual particle samples. We introduce a new model age estimator, called “mid68”, that supplements 95% confidence intervals, providing a “best estimate” and uncertainty about the most likely age. The mid68 estimator can be calculated using the Feldman and Cousins method or Bayesian methods and provides a value with a symmetric uncertainty that can be used for calculations and approximate aggregation of processed model age values when the raw data and correction factors are not available. For particles yielding low 230 Th counts amidst nonzero detector background, their underlying model age probability distributions are asymmetric, so the mid68 estimator provides additional robust information regarding the underlying model age likelihood. This study provides a comprehensive and timely examination of critical aspects of uranium particle age dating as more laboratories establish particle chronometry capabilities.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Advanced spectroscopic studies of (PPh 4 ) 2 [Co(N 3 ) 4 ], a field-induced single-ion magnet

The high-spin Co II complex (PPh 4 ) 2 [Co(N 3 ) 4 ] (Co-N 3 )has been investigated using advanced spectroscopic techniques [far-IR magneto-spectroscopy (FIRMS), high-frequency and high-field EPR (HFEPR), and inelastic neutron scattering (INS)] to study its zero-field-splitting (ZFS), giving spin-Hamiltonian (SH) parameters. The analysis of multi-frequency HFEPR reveals the easy-axis anisotropy with a D value of −10.39(5) cm −1 and a rhombic ratio (E/D) of 0.21(1). The magnetic properties have also been probed by direct-current (DC) magnetometry, suggesting minor differences in anisotropy from the previously reported polymorph (Co-N 3 ′). Ligand-field theory (LFT) analysis indicates that the structures of Co-N 3 and Co-N 3 ′ are closer to D 2d symmetry than other symmetries considered. Alternate-current (AC) susceptibility reveals slow magnetic relaxation under an applied field, indicating that Co-N 3 is a field-induced single-ion magnet (SIM). Here, while both Co-N 3 and Co-N 3 ′ were studied by DC magnetometry, one unusual aspect of the current work on Co-N 3 is that advanced spectroscopies HFEPR, FIRMS, and INS were used to directly observe transitions between ZFS split states, giving accurate SH parameters.

Hand, Adam T. [Univ. of Tennessee, Knoxville, TN (↗

The mechanism of hydroxyapatite coatings degradation at high substrate temperatures

Physical vapor deposition methods used for hydroxyapatite (HA) coatings typically require elevated substrate temperatures and post-deposition annealing to induce crystallization. However, such thermal treatments can degrade both the mechanical integrity and bioactivity of the coating, particularly when substrate temperatures exceed 500 °C. The mechanisms underlying these phenomena remain insufficiently understood. In this study, HA thin films were deposited on silicon and Ti6Al4V substrates using pulsed laser deposition and were systematically characterized to elucidate these mechanisms. XPS and SIMS analyses revealed a temperature-dependent loss of OH − and PO 4 3− groups, an increased Ca/P ratio, and the formation of interfacial oxides, all of which contribute to weakened adhesion. To clarify the temperature-dependent decline in bioactivity, protein adsorption behavior was analyzed using a Kramers-type kinetic framework; the fitted desorption kinetics indicate that coatings deposited near ∼500 °C provide the most stable protein attachment, whereas higher temperatures accelerate desorption due to dehydroxylation and carbonate substitution. Together, these findings provide mechanistic insight into the thermal degradation of HA coatings and offer a framework for optimizing deposition parameters to preserve stoichiometry, adhesion, and bioactivity for long-term biomedical applications.

Kylychbekov, Salizhan [Univ. of Oxford (United Kin↗

Non-classical ion-indiffusion processes in quasi-one-dimensional ionic conductor KTiOPO4

Developments in coercive field engineering and waveguide writing via ion-exchange in the ferroelectric ionic-conductor KTiOPO4 (KTP) have led to breakthroughs within the field of nonlinear optics and quantum photonics. However, the microscopic diffusion dynamics of ion-exchange in KTP are poorly understood and show signs of non-classical diffusion dynamics. The precise control of ion-exchange gradients is critical for developing KTP into a mature, integrated nonlinear optical material but requires a level of control that, in turn, demands a deeper understanding of the ion-exchange process. We employ direct ToF-SIMS mapping to untangle the complex diffusion dynamics of the commonly used ion-exchange dopant ions: Rb, Ba, and K. We map periodic diffusion gradients of two exchanges, one dominated by Rb-ions and the other by Ba-ions. For the first time, we show the interdependent nature of the Ba- and Rb ion in the ion-exchange diffusion gradient. The low incorporation of the Ba ion is mapped and quantified, and dopant–crystal interactions are identified. This work highlights the complex diffusion dynamics of dopants in the KTP structure and lays the foundation for deterministic control of diffusion gradients for the next generation of integrated nonlinear and quantum photonic devices.

Barrett, Laura [ORNL]↗

Axisymmetric hydrodynamics in numerical relativity: treating coordinate singularity, artificial heating and modeling MHD instabilities

Two-dimensional axisymmetric simulations of binary neutron star (BNS) merger remnant are a cheap alternative to 3D simulations. To maintain realism for secular timescales, simulations must avoid accumulated errors from drifts in conserved quantities and artificial heating, and they must model turbulent transport in a way that remains plausible throughout the evolution. It is also crucial to avoid numerical artifacts due to the polar coordinate axis singularity. Methods that behave well near the axis often break flux-conservative form of the hydrodynamic equations, resulting in significant drifts in conserved quantities. We present a flux-conservative scheme that maintains smoothness near the axis without sacrificing conservative formulation of the equations or incurring drifts in conserved global quantities. We compare the numerical performance of different treatments of the hydrodynamic equations when evolving a hypermassive neutron star resembling the remnant of a BNS merger. These simulations demonstrate that the new scheme combines the axis smoothness of non-conservative methods with the mass and angular momentum conservation of other conservative methods on $\sim 10^2$ ms timescales of viscous and neutrino-driven evolution. Because fluid profiles remain smooth in the remnant interior, it is possible to remove artificial heating by evolving the entropy density. We show how physical heating and cooling terms can be easily calculated from source terms of the conservative evolution variables and demonstrate our implementation. Finally, we discuss and implement improvements to the effective viscosity scheme to better model the effect of magnetohydrodynamic instabilities as the remnant evolves.

axisymmetry↗

Planar laser-induced fluorescence system for spatiotemporal ion velocity distribution function measurements

In this work, we present a planar laser-induced fluorescence (PLIF) system for measuring two-dimensional (2D), spatiotemporally resolved ion velocity distribution functions (IVDFs). A continuous-wave tunable diode laser produces a laser sheet that irradiates the plasma, and the resulting fluorescence is captured by an intensified CCD (ICCD) camera. Fluorescence images recorded at varying laser wavelengths are converted into 2D IVDFs using the Doppler shift principle. The developed diagnostic is implemented in an electron beam generated E × B plasma with a bulk plasma density of $\sim\!\!{10^{10}}{\text{c}}{{\text{m}}^{ - 3}}$ . The developed diagnostic is validated against a conventional single-point LIF method using photomultiplier tube-based detection, while significantly reducing the total measurement time by the number of spatial positions measured. The time-resolving capability of this diagnostic is tested by oscillating the plasma between two nominal operating modes with different density profiles and triggering the ICCD camera by the externally driven plasma oscillation. The measured 2D IVDF maps reveal several signatures of ion dynamics in this plasma source, including radially outflowing ions across the electric field and anomalous ion heating at the periphery, consistent with recent kinetic simulations and theoretical studies. A possible correlation between these ion kinetic features and rotating spoke structures is discussed.

E×B plasma↗

Observation of a cross-section enhancement near the production threshold in $\sqrt{s} = 13$ TeV pp collisions with the ATLAS detector

A measurement of $t\bar{t}$ production is presented in the invariant-mass region near the pair production threshold, $m_{t\bar{t}} \sim 345$ GeV, in final states with two charged leptons and multiple jets. The measurement is based on $140\,\mathrm{fb}^{-1}$ of proton–proton collision data collected at $\sqrt{s} = 13$ TeV with the ATLAS detector at the Large Hadron Collider. The data are compared to two models of $t\bar{t}$ production: a baseline model including only perturbative quantum chromodynamics (pQCD) predictions for the hard process at approximate next-to-next-to leading order accuracy in the strong coupling, and an extended model that, in addition, incorporates non-relativistic QCD simulations that also include the formation of colour-singlet quasi-bound-states near the $t\bar{t}$ threshold. The agreement between the data and the models is quantified via a profile-likelihood fit to the reconstructed $m_{t\bar{t}}$ distributions, in bins of two angular observables sensitive to spin-correlations in the $t\bar{t}$ system. An excess of events is observed over the baseline pQCD prediction, with an observed significance over 8 standard deviations. This excess is consistent with the formation of colour-singlet and spin-singlet S-wave quasi-bound $t\bar{t}$ states, as predicted by non-relativistic QCD, and corresponds to an observed cross-section of $9.3^{+1.4}_{-1.3}$ pb.

Large Hadron Collider↗

Investigations of atomic and molecular processes of NBI-heated discharges in the MAST Upgrade Super-X divertor with implications for reactors

This experimental study presents an in-depth investigation of the performance of the MAST-U Super-X divertor during NBI-heated operation (up to 2.5 MW) focussing on volumetric ion sources and sinks as well as power losses during detachment. The particle balance and power loss analysis revealed the crucial role of Molecular Activated Recombination and Dissociation (MAR and MAD) ion sinks in divertor particle and power balance, which remain pronounced in the change from ohmic to higher power (NBI heated) L-mode conditions. The importance of MAR and MAD remains with double the absorbed NBI heating. MAD results in significant power dissipation (up to ${\sim} 20\%$ of $P_\textrm{SOL}$), mostly in the cold ($T_e \lt 5$ eV) detached region. Theoretical and experimental evidence is found for the potential contribution of $D^-$ to MAR and MAD, which warrants further study. These results suggest that MAR and MAD can be relevant in higher power conditions than the ohmic conditions studied previously. Post-processing reactor-scale simulations suggests that MAR and MAD can play a significant role in divertor physics and synthetic diagnostic signals of reactor-scale devices, which are currently underestimated in exhaust simulations. This raises implications for the accuracy of reactor-scale divertor simulations of particularly tightly baffled (alternative) divertor configurations.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Dependence of ion-cyclotron range of frequencies instabilities on species mix and fast-ion distribution: III. Novel sub-cyclotron modes

Dedicated DIII-D experiments studied instabilities above and below the ion cyclotron frequency by injecting thirteen different neutral beam populations into L-mode plasmas with different thermal compositions of H, D, and 3 He at five different values of toroidal field. Two companion papers describe the results of these experiments in detail. This paper focuses on data and analysis of two instabilities that occur at ${\sim}0.6$ of the deuterium and hydrogen cyclotron frequencies $f_\mathrm {cD}$ and $f_\mathrm {cH}$ in mixed hydrogen and deuterium plasmas. The modes below $f_\mathrm {cD}$ are often driven unstable by deuterium beams but are rarely destabilized by hydrogen beams. The modes below $f_\mathrm {CD}$ are reported here for the first time in a fusion plasma. These $\mathrm{sub-}f_\mathrm {cH}$ modes are only driven by deuterium beams but, unlike the $\mathrm{sub-}f_\mathrm {cD}$ modes, they are only unstable in plasmas with deuterium concentrations that are ${\lesssim}20\%$; they also have a smaller amplitude than the sub-deuterium modes. Addition of fully-ionized 3 He to the plasma has little effect on the sub-cyclotron deuterium modes but is stabilizing for the sub-cyclotron hydrogen modes. The modes are excited in the core and have toroidal mode numbers around 20. These trends are compared with calculations of the growth rate in a simplified model. The theory successfully predicts global Alfvén eigenmode instability with frequencies and mode numbers close to experimental values, the stronger amplitude of the sub-deuterium modes, and the species-mix dependence of the sub-hydrogen modes. Increased damping associated with the ion-ion hybrid, cutoff, and crossover frequencies plausibly accounts for the stabilization of the $\mathrm{sub-}f_\mathrm {cH}$ modes when 3 He is puffed. However, the relative stability of $\mathrm{sub-}f_\mathrm {cH}$ modes during hydrogen injection remains unexplained.

electromagnetic ion cyclotron instability↗

Seismic and acoustic signals from the 2014 ‘interstellar meteor’

SUMMARY We conduct a thorough analysis of seismic and acoustic data purported to be from the so-called ‘interstellar meteor’ which entered the Earth’s atmosphere off the coast of Papua New Guinea on 2014 January 08. Previous work had suggested that this meteor may have been caused by an alien spacecraft burning up in the atmosphere. We conclude that both previously reported seismic signals are spurious—one has characteristics suggesting a local vehicular-traffic-based origin; whilst the other is statistically indistinguishable from the background noise. As such, previously reported localizations based on this data are unreliable. Analysis of acoustic data provides a best-fitting location estimate which is very far ($\sim$170 km) from the reported fireball location. Accordingly, we conclude that material recovered from the seafloor and purported to be from this event is almost certainly unrelated to it, and is likely of more mundane (non-interstellar) origin.

Geochemistry & Geophysics↗

The dark energy survey: detection of weak lensing magnification of supernovae and constraints on dark matter haloes

The residuals of the distance moduli of Type Ia supernovae (SNe Ia) relative to a Hubble diagram fit contain information about the inhomogeneity of the Universe, due to weak lensing magnification by foreground matter. By correlating the residuals of the Dark Energy Survey Year 5 SN Ia sample (DES-SN5YR) with extragalactic foregrounds from the DES Y3 Gold catalogue, we detect the presence of lensing at |$6.0 \sigma$| significance. This is the first detection with a significance level above |$5\sigma$|⁠. Constraints on the effective mass-to-light ratios and radial profiles of dark matter haloes surrounding individual galaxies are also obtained. We show that the scatter of SNe Ia around the Hubble diagram is reduced by modifying the standardization of the distance moduli to include an easily calculable de-lensing (i.e. environmental) term. We use the de-lensed distance moduli to recompute cosmological parameters derived from SN Ia, finding in Flat wcold dark matter a difference of |$\Delta \Omega _{\rm M} = +0.036$| and |$\Delta w = -0.056$| compared to the unmodified distance moduli, a change of |$\sim 0.3\sigma$|⁠. We argue that our modelling of SN Ia lensing will lower systematics on future surveys with higher statistical power. We use the observed dispersion of lensing in DES-SN5YR to constrain |$\sigma _8$|⁠, but caution that the fit is sensitive to uncertainties at small scales. Nevertheless, our detection of SN Ia lensing opens a new pathway to study matter inhomogeneity that complements galaxy–galaxy lensing surveys and has unrelated systematics.

79 ASTRONOMY AND ASTROPHYSICS↗

The three-dimensional structure of black hole accretion flows within the plunging region

ABSTRACT We analyse, using new analytical models and numerical general relativistic magnetohydrodynamic simulations, the three-dimensional properties of accretion flows inside the plunging region of black hole spacetimes (i.e. at radii smaller than the innermost stable circular orbit). These simulations are of thick discs, with aspect ratios of order unity $h/r \sim 1$, and with a magnetic field geometry given by the standard low-magnetization ‘SANE’ configuration. This work represents the first step in a wider analysis of this highly relativistic region. We show that analytical expressions derived in the ‘thin disc’ limit describe the numerical results remarkably well, despite the large aspect ratio of the flow. We further demonstrate that accretion within this region is typically mediated via spiral arms, and that the geometric properties of these spiral structures can be understood with a simple analytical model. These results highlight how accretion within the plunging region is fundamentally two-dimensional in character, which may have a number of observational implications. We derive a modified theoretical description of the pressure within the plunging region which accounts for turbulent heating and may be of use to black hole image modelling.

Astronomy & Astrophysics↗

Fate of supernova progenitors in massive binary systems

ABSTRACT How massive stars end their lives depends on the core mass, core angular momentum, and hydrogen envelopes at death. However, these key physical facets of stellar evolution can be severely affected by binary interactions. In turn, the effectiveness of binary interactions itself varies greatly depending on the initial conditions of the binaries, making the situation much more complex. We investigate systematically how binary interactions influence core–collapse progenitors and their fates. Binary evolution simulations are performed to survey the parameter space of supernova progenitors in solar metallicity binary systems and to delineate major evolutionary paths. We first study fixed binary mass ratios ($q=M_2/M_1$ = 0.5, 0.7, and 0.9) to elucidate the impacts of initial mass and initial separation on the outcomes, treating separately Type Ibc supernova, Type II supernova, accretion-induced collapse (AIC), rapidly rotating supernova (Ibc-R), black hole formation, and long gamma ray burst (long GRB). We then conduct 12 binary population synthesis model calculations, varying the initial condition distributions and binary evolution parameters, to estimate various supernova fractions. We obtain a Milky Way supernova rate $R_{\rm SN} = (1.78$–$2.47) \times 10^{-2} \, {\rm yr}^{-1}$ which is consistent with observations. We find the rates of AIC, Ibc-R, and long GRB to be $\sim 1/100$ the rate of regular supernovae. Our estimated long GRB rates are higher than the observed long GRB rate and close to the low luminosity GRB rate, although care must be taken considering our models are computed with solar metallicity. Furthering binary modelling and improving the inputs one by one will enable more detailed studies of these and other transients associated with massive stars.

Astronomy & Astrophysics↗

Automating galaxy morphology classification using k -nearest neighbours and non-parametric statistics

ABSTRACT Morphology is a fundamental property of any galaxy population. It is a major indicator of the physical processes that drive galaxy evolution and in turn the evolution of the entire Universe. Historically, galaxy images were visually classified by trained experts. However, in the era of big data, more efficient techniques are required. In this work, we present a k-nearest neighbours based approach that utilizes non-parametric morphological quantities to classify galaxy morphology in Sloan Digital Sky Survey images. Most previous studies used only a handful of morphological parameters to identify galaxy types. In contrast, we explore 1023 morphological spaces (defined by up to 10 non-parametric statistics) to find the best combination of morphological parameters. Additionally, while most previous studies broadly classified galaxies into early types and late types or ellipticals, spirals, and irregular galaxies, we classify galaxies into 11 morphological types with an average accuracy of ${\sim} 80\!-\!90 \, {{\rm per\, cent}}$ per T-type. Our method is simple, easy to implement, and is robust to varying sizes and compositions of the training and test samples. Preliminary results on the performance of our technique on deeper images from the Hyper Suprime-Cam Subaru Strategic Survey reveal that an extension of our method to modern surveys with better imaging capabilities might be possible.

Mukundan, Kavya↗

Short-period post-common envelope binaries with Balmer emission from SDSS and LAMOST based on ZTF photometric data

ABSTRACT We present here 55 short-period post-common envelope binaries (PCEBs) containing a hot white dwarf (WD) and a low-mass main sequence (MS). Based on the photometric data from Zwicky Transient Facility survey data Release 19 (ZTF DR19), the light curves are analysed for about 200 WDMS binaries with emission line(s) identified from the Sloan Digital Sky Survey (SDSS) or the Large Sky Area Multi-Object Fibre Spectroscopic Telescope (LAMOST) spectra, in which 55 WDMS binaries are found to exhibit variability in their luminosities with a short period and are thus short-period binaries (i.e. PCEBs). In addition, it is found that the orbital periods of these PCEBs locate in a range from 2.2643 to 81.1526 h. However, only six short-period PCEBs are newly discovered and the orbital periods of 19 PCEBs are improved in this work. Meanwhile, it is found that three objects are newly discovered eclipsing PCEBs, and a object (i.e. SDSS J1541) might be the short-period PCEB with a late M-type star or a brown dwarf companion based on the analysis of its spectral energy distribution. At last, the mechanism(s) being responsible for the emission features in the spectra of these PCEBs are discussed, the emission features arising in their optical spectra might be caused by the stellar activity or an irradiated component owing to a hot WD companion because most of them contain a WD with an effective temperature higher than $\sim$10 000 K.

Li, Lifang↗

Primeval very low-mass stars and brown dwarfs – VIII. The first age benchmark L subdwarf, a wide companion to a halo white dwarf

ABSTRACT We report the discovery of five white dwarf + ultracool dwarf systems identified as common proper motion wide binaries in the Gaia Catalogue of Nearby Stars. The discoveries include a white dwarf + L subdwarf binary, VVV 1256−62AB, a gravitationally bound system located 75.6$^{+1.9}_{-1.8}$ pc away with a projected separation of 1375$^{+35}_{-33}$ au. The primary is a cool DC white dwarf with a hydrogen dominated atmosphere, and has a total age of $10.5^{+3.3}_{-2.1}$ Gyr, based on white dwarf model fitting. The secondary is an L subdwarf with a metallicity of [M/H] = $-0.72^{+0.08}_{-0.10}$ (i.e. [Fe/H] = $-0.81\pm 0.10$) and $T_{\rm eff}$ = 2298$^{+45}_{-43}$ K based on atmospheric model fitting of its optical to near infrared spectrum, and likely has a mass just above the stellar/substellar boundary. The subsolar metallicity of the L subdwarf and the system’s total space velocity of 406 km s−1 indicates membership in the Galactic halo, and it has a flat eccentric Galactic orbit passing within 1 kpc of the centre of the Milky Way every $\sim$0.4 Gyr and extending to 15–31 kpc at apogal. VVV 1256−62B is the first L subdwarf to have a well-constrained age, making it an ideal benchmark of metal-poor ultracool dwarf atmospheres and evolution.

Zhang, Z. H. (ORCID:000000033047607X)↗