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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRS2022

A High-fidelity Performance and Sensitivity Analysis of X-ray Pulsar Navigation in Near-Earth and Cislunar Orbits

Millisecond X-ray pulsars are rapidly rotating neutron stars that emit broadband electromagnetic radiation, including X-rays. These emissions can appear as pulsations to distant observers with long-term stabilityrivaling laboratory atomic clocks. The concept of using X-ray pulsars for navigation, commonly referred to as XNAV, has a long history in the research literature. Notably, in 2017, NASA’s Station Explorer for X-ray Timing and Navigation (SEXTANT) mission,a technology enhancement to the Neutron Star Interior Composition Explorer, made a successful on-orbit demonstration of XNAV on the International Space Station (ISS) in Low-Earth-Orbit. This paper investigates the performance of XNAV in Earth and lunar regimes using a new high-fidelity XNAV analysis tool that builds on tools developed for SEXTANT and uses recent updates to the Goddard Enhanced Onboard Navigation System flight software. Specifically, we study the use of XNAV in an ISS-like orbit for comparison with SEXTANT results, in a highly-inclined geosynchronous orbit, and in an Earth-Moon L1 libration point Near Rectilinear Halo Orbit similar to that proposed for the planned lunar Gateway space station. This paper provides a high-level description of the XNAV analysis tool, baseline predicted performance results, selected sensitivity analyses, and conclusions.

Luke B Winternitz↗
NASA NTRSDate not supplied

Data Democratization: Challenges and Opportunities

Democratizing Earth data is one of the challenges many organizations around the world face in order to maximize the use of their Earth data for research, applications, education, and societal benefits. For example, at the NASA Goddard Earth Sciences (GES) Data and Information Services Center (DISC), over 1600 global and regional datasets in several NASA Earth science focus areas, including atmospheric composition, water and energy cycles, and climate variability, are archived and distributed to the public. Giovanni, the Geospatial Interactive Online Visualization and Analysis Infrastructure, was developed by GES DISC to facilitate data access and exploration, especially for novice users of Earth science. With Giovanni, users can analyze and visualize over 2000 Earth science variables (e.g., precipitation, aerosol, surface wind) without downloading data, software, the expert understanding of data formats and structures, and coding skills, lowering the barrier to data analysis/comparison by preprocessing and accessing to the data. Results of data analysis and visualization can be accessed in several popular formats (e.g., NetCDF, CSV). As a result of Giovanni's efforts, more than 3000 referral papers have been published in various fields. In spite of this, Giovanni is still difficult to use for some users. For instance, if one searches for "precipitation," it will return over 150 related variables. The question is, which one to use? Furthermore, variables from different data providers (e.g., satellites and models) are named differently with different units, further confusing users, especially those outside the communities. Data democratization is complex and multifaceted. Challenges include service and data discovery, user experiences, visualization, data quality, trustworthiness, and more. In this presentation, we will examine Giovanni as an example of challenges and opportunities in developing data democratization services.

data democratization↗
NASA NTRSDate not supplied

An Automated Meshing Framework for Progressive Damage Analysis of Fabrics Using CompDam

A meshing and model construction framework for progressive damage analysis of fabric composites is proposed. A mesoscale idealization is used such that the fiber tows are considered homogeneous and transversely isotropic continua, and the matrix is a homogeneous isotropic continuum. By using this idealization, relatively mature damage modeling techniques developed for laminates of unidirectional plies are transferrable to fabrics. Cohesive interface elements and a continuum damage mechanics (CDM) model implemented in the software CompDam are used to account for the key damage modes including cracking at the tow/matrix interface, transverse matrix cracking in the tows, and fiber breakage in the tows. Matrix degradation is accounted for by plasticity. The modeling approach is demonstrated for a 3D orthogonal woven fabric. The main novelty of the proposed model construction framework is in its flexibility resulting from a formulation that is agnostic to the fabric architecture and implementation using mesh based operations. The algorithm does not make any assumptions about the tow sizes, shape, path, or proximity to other tows, thus it is applicable to a broad range of fabric architectures. The matrix region mesh surrounding the tows is constructed from domain boundary and tow surface meshes (i.e. through a series of mesh-based operations) such that the model domain can be arbitrarily shaped.

Andrew Cole Bergan↗
NASA NTRS2001

Photochemical Phenomenology Model for the New Millennium

The "Photochemical Phenomenology Model for the New Millennium" project tackles the issue of reengineering and extension of validated physics-based modeling capabilities ("legacy" computer codes) to application-oriented software for use in science and science-support activities. While the design and architecture layouts are in terms of general particle distributions involved in scattering, impact, and reactive interactions, initial Photochemical Phenomenology Modeling Tool (PPMT) implementations are aimed at construction and evaluation of photochemical transport models with rapid execution for use in remote sensing data analysis activities in distributed systems. Current focus is on the Composite Infrared Spectrometer (CIRS) data acquired during the CASSINI flyby of Jupiter. Overall, the project has stayed on the development track outlined in the Year 1 annual report and most Year 2 goals have been met. The issues that have required the most attention are: implementation of the core photochemistry algorithms; implementation of a functional Java Graphical User Interface; completion of a functional CORBA Component Model framework; and assessment of performance issues. Specific accomplishments and the difficulties encountered are summarized in this report. Work to be carried out in the next year center on: completion of testing of the initial operational implementation; its application to analysis of the CASSINI/CIRS Jovian flyby data; extension of the PPMT to incorporate additional phenomenology algorithms; and delivery of a mature operational implementation.

Bishop, James↗
NASA NTRS2003

Efficient, Multi-Scale Designs Take Flight

Engineers can solve aerospace design problems faster and more efficiently with a versatile software product that performs automated structural analysis and sizing optimization. Collier Research Corporation's HyperSizer Structural Sizing Software is a design, analysis, and documentation tool that increases productivity and standardization for a design team. Based on established aerospace structural methods for strength, stability, and stiffness, HyperSizer can be used all the way from the conceptual design to in service support. The software originated from NASA s efforts to automate its capability to perform aircraft strength analyses, structural sizing, and weight prediction and reduction. With a strategy to combine finite element analysis with an automated design procedure, NASA s Langley Research Center led the development of a software code known as ST-SIZE from 1988 to 1995. Collier Research employees were principal developers of the code along with Langley researchers. The code evolved into one that could analyze the strength and stability of stiffened panels constructed of any material, including light-weight, fiber-reinforced composites.

Source record↗
NASA NTRSDate not supplied

Process Modeling of Woven Textiles

Woven polymer matrix composites offer numerous advantages over traditional unidirectional laminates. Processing conditions affect residual stress that builds up during manufacturing. This work proposes the analysis of three curing parameters on the local residual stress distribution of a plain weave textile architecture, including chemical shrinkage, the temperature cool down, and the evolution of matrix properties as a function of curing. Virtual curing is applied to the inter-tow matrix material of the plain weave Repeating Unit Cell (RUC) modeled in TexGen. Curing is implemented through user-written subroutines within the commercial software suite Abaqus. Results from process modeling are compared with a linear-elastic thermal cool down in Abaqus. A boundary conditions study is also conducted to compare the residual stress build up predicted by Flat(FBCs) and Periodic Boundary Conditions (PBCs). Preliminary results indicate that a thermal cool down over-estimates the end-of-cure stresses in the matrix. Process modeling is conducted with and without chemical shrinkage, then compared with a thermal cool down. Results show that 11.32% of the final stress state is due to chemical shrinkage. Material property evolution during curing also has a non-negligible effect on the end stress.

woven composites↗
NASA NTRS2006

Use of the JPL Electronic Nose to detect leaks and spills in an enclosed environment

An electronic nose to be used as an air quality monitor in human habitats in space has been developed at the Jet Propulsion Laboratory. This device is capable of detecting, identifying and quantifying several organic and inorganic chemical species which might be present as contaminants in spacecraft air. The complete portable device, including sensors, electronics, and software for data analysis, has been extensively tested.

environmental monitoring↗
NASA NTRS2011

NASA Tech Briefs, January 2011

The topics include: 1) Distributed Aerodynamic Sensing and Processing Toolbox; 2) Collaborative Supervised Learning for Sensor Networks; 3) Hazard Detection Software for Lunar Landing; 4) Onboard Nonlinear Engine Sensor and Component Fault Diagnosis and Isolation Scheme; 5) Network-Capable Application Process and Wireless Intelligent Sensors for ISHM; 6) Interface Supports Multiple Broadcast Transceivers for Flight Applications; 7) FPGA Sequencer for Radar Altimeter Applications; 8) Miniature Sapphire Acoustic Resonator - MSAR; 9) Process-Hardened, Multi-Analyte Sensor for Characterizing Rocket Plume Constituents; 10) SAD5 Stereo Correlation Line-Striping in an FPGA; 11) Hybrid Composite Cryogenic Tank Structure; 12) Nanoscale Deformable Optics; 13) Reliability-Based Design Optimization of a Composite Airframe Component; 14) Zinc Oxide Nanowire Interphase for Enhanced Lightweight Polymer Fiber Composites; 15) Plasma Igniter for Reliable Ignition of Combustion in Rocket Engines; 16) Wire Test Grip Fixture; 17) A Sub-Hertz, Low-Frequency Vibration Isolation Platform; 18) Carbon Nanofibers Synthesized on Selective Substrates for Nonvolatile Memory and 3D Electronics; 19) Nanoparticle/Polymer Nanocomposite Bond Coat or Coating; 20) High-Resolution Wind Measurements for Offshore Wind Energy Development; 21) Spring Tire; 22) Marsviewer 2008; 23) Mission Services Evolution Center Message Bus; 24) Major Constituents Analysis for the Vehicle Cabin Atmosphere Monitor; 25) Astronaut Health Participant Summary Application; 26) Adaption of the AMDIS Method to Flight Status on the VCAM Instrument; 27) Natural Language Interface for Safety Certification of Safety-Critical Software; 28) Cryogenic Caging for Science Instrumentation; 29) Wide-Range Neutron Detector for Space Nuclear Applications; 30) In Situ Guided Wave Structural Health Monitoring System; 31) Multiplexed Energy Coupler for Rotating Equipment; 32) Attitude Estimation in Fractionated Spacecraft Cluster Systems; 33) Full Piezoelectric Multilayer-Stacked Hybrid Actuation/Transduction Systems; 34) Active Flow Effectors for Noise and Separation Control; 35) Method and System for Temporal Filtering in Video Compression Systems; 36) Apparatus for Measuring Total Emissivity of Small, Low-Emissivity Samples; 37) Multiple-Zone Diffractive Optic Element for Laser Ranging Applications; 38) Simplified Architecture for Precise Aiming of a Deep-Space Communication Laser Transceiver; 39) Two-Photon-Absorption Scheme for Optical Beam Tracking; 40) High-Sensitivity, Broad-Range Vacuum Gauge Using Nanotubes for Micromachined Cavities; 41) Wide-Field Optic for Autonomous Acquisition of Laser Link; 42) Extracting Zero-Gravity Surface Figure of a Mirror; 43) Modeling Electromagnetic Scattering From Complex Inhomogeneous Objects; 44) Visual Object Recognition and Tracking of Tools; 45) Method for Implementing Optical Phase Adjustment; 46) Visual SLAM Using Variance Grid Maps; 47) Rapid Calculation of Spacecraft Trajectories Using Efficient Taylor Series Integration; 48) Efficient Kriging Algorithms; 49) Predicting Spacecraft Trajectories by the WeavEncke Method; 50) An Augmentation of G-Guidance Algorithms; 51) Comparison of Aircraft Icing Growth Assessment Software; 52) Silicon-Germanium Voltage-Controlled Oscillator at 105 GHz; 53) Estimation of Coriolis Force and Torque Acting on Ares-1; 54) Null Lens Assembly for X-Ray Mirror Segments; and 55) High-Precision Pulse Generator.

Source record↗
NASA NTRS1990

Use of a personal computer for the real-time reception and analysis of data from a sounding rocket experiment

In September 1988 the Earth and Planetary Atmospheres Group of the Space Sciences Laboratory of the University of California at Berkeley flew an experiment on a high-altitude sounding rocket launched from the NASA Wallops Flight Facility in Virginia. The experiment, BEARS (Berkeley EUV Airglow Rocket Spectrometer), was designed to obtain spectroscopic data on the composition and structure of the earth's upper atmosphere. Consideration is given to the objectives of the BEARS experiment; the computer interface and software; the use of remote data transmission; and calibration, integration, and flight operations.

Herrick, W. D.↗
NASA NTRS1998

Effect of the thickness variation and initial imperfection on buckling of composite cylindrical shells: Asymptotic analysis and numerical results by BOSOR4 and PANDA2

This study is an extension of a previous investigation of the combined effect of axisymmetric thickness variation and axisymmetric initial geometric imperfection on buckling of isotropic shells under uniform axial compression. Here the anisotropic cylindrical shells are investigated by means of Koiter's energy criterion. An asymptotic formula is derived which can be used to determine the critical buckling load for composite shells with combined initial geometric imperfection and thickness variation. Results are compared with those obtained by the software packages BOSOR4 and PANDA2.

Li, Yi-Wei↗
NASA NTRS1989

Computerized structural mechanics for 1990's: Advanced aircraft needs

The needs for computerized structural mechanics (CSM) as seen from the standpoint of the aircraft industry are discussed. These needs are projected into the 1990's with special focus on the new advanced materials. Preliminary design/analysis, research, and detail design/analysis are identified as major areas. The role of local/global analyses in these different areas is discussed. The lessons learned in the past are used as a basis for the design of a CSM framework that could modify and consolidate existing technology and include future developments in a rational and useful way. A philosophy is stated, and a set of analyses needs driven by the emerging advanced composites is enumerated. The roles of NASA, the universities, and the industry are identified. Finally, a set of rational research targets is recommended based on both the new types of computers and the increased complexity the industry faces. Computerized structural mechanics should be more than new methods in structural mechanics and numerical analyses. It should be a set of engineering applications software products that combines innovations in structural mechanics, numerical analysis, data processing, search and display features, and recent hardware advances and is organized in a framework that directly supports the design process.

Viswanathan, A. V.↗
NASA NTRS2008

Structural Design and Analysis of the Upper Pressure Shell Section of a Composite Crew Module

This paper presents the results of the structural design and analysis of the upper pressure shell section of a carbon composite demonstration structure for the Composite Crew Module (CCM) Project. The project is managed by the NASA Engineering and Safety Center with participants from eight NASA Centers, the Air Force Research Laboratory, and multiple aerospace contractors including ATK/Swales, Northrop Grumman, Lockheed Martin, Collier Research Corporation, Genesis Engineering, and Janicki Industries. The paper discusses details of the upper pressure shell section design of the CCM and presents the structural analysis results using the HyperSizer structural sizing software and the MSC Nastran finite element analysis software. The HyperSizer results showed that the controlling load case driving most of the sizing in the upper pressure shell section was the internal pressure load case. The regions around the cutouts were controlled by internal pressure and the main parachute load cases. The global finite element analysis results showed that the majority of the elements of the CCM had a positive margin of safety with the exception of a few hot spots around the cutouts. These hot spots are currently being investigated with a more detailed analysis. Local finite element models of the Low Impact Docking System (LIDS) interface ring and the forward bay gussets with greater mesh fidelity were created for local sizing and analysis. The sizing of the LIDS interface ring was driven by the drogue parachute loads, Trans-Lunar Insertion (TLI) loads, and internal pressure. The drogue parachute loads controlled the sizing of the gusset cap on the drogue gusset and TLI loads controlled the sizing of the other five gusset caps. The main parachute loads controlled the sizing of the lower ends of the gusset caps on the main parachute fittings. The results showed that the gusset web/pressure shell and gusset web/gusset cap interfaces bonded using Pi-preform joints had local hot spots in the Pi-preform termination regions. These regions require a detailed three-dimensional analysis, which is currently being performed, to accurately address the load distribution near the Pi-preform termination in the upper and lower gusset caps.

Sleight, David W.↗
NASA NTRS2001

Development of a Space Radiation Monte-Carlo Computer Simulation Based on the FLUKE and Root Codes

The radiation environment in space is a complex problem to model. Trying to extrapolate the projections of that environment into all areas of the internal spacecraft geometry is even more daunting. With the support of our CERN colleagues, our research group in Houston is embarking on a project to develop a radiation transport tool that is tailored to the problem of taking the external radiation flux incident on any particular spacecraft and simulating the evolution of that flux through a geometrically accurate model of the spacecraft material. The output will be a prediction of the detailed nature of the resulting internal radiation environment within the spacecraft as well as its secondary albedo. Beyond doing the physics transport of the incident flux, the software tool we are developing will provide a self-contained stand-alone object-oriented analysis and visualization infrastructure. It will also include a graphical user interface and a set of input tools to facilitate the simulation of space missions in terms of nominal radiation models and mission trajectory profiles. The goal of this project is to produce a code that is considerably more accurate and user-friendly than existing Monte-Carlo-based tools for the evaluation of the space radiation environment. Furthermore, the code will be an essential complement to the currently existing analytic codes in the BRYNTRN/HZETRN family for the evaluation of radiation shielding. The code will be directly applicable to the simulation of environments in low earth orbit, on the lunar surface, on planetary surfaces (including the Earth) and in the interplanetary medium such as on a transit to Mars (and even in the interstellar medium). The software will include modules whose underlying physics base can continue to be enhanced and updated for physics content, as future data become available beyond the timeframe of the initial development now foreseen. This future maintenance will be available from the authors of FLUKA as part of their continuing efforts to support the users of the FLUKA code within the particle physics community. In keeping with the spirit of developing an evolving physics code, we are planning as part of this project, to participate in the efforts to validate the core FLUKA physics in ground-based accelerator test runs. The emphasis of these test runs will be the physics of greatest interest in the simulation of the space radiation environment. Such a tool will be of great value to planners, designers and operators of future space missions, as well as for the design of the vehicles and habitats to be used on such missions. It will also be of aid to future experiments of various kinds that may be affected at some level by the ambient radiation environment, or in the analysis of hybrid experiment designs that have been discussed for space-based astronomy and astrophysics. The tool will be of value to the Life Sciences personnel involved in the prediction and measurement of radiation doses experienced by the crewmembers on such missions. In addition, the tool will be of great use to the planners of experiments to measure and evaluate the space radiation environment itself. It can likewise be useful in the analysis of safe havens, hazard migration plans, and NASA's call for new research in composites and to NASA engineers modeling the radiation exposure of electronic circuits. This code will provide an important complimentary check on the predictions of analytic codes such as BRYNTRN/HZETRN that are presently used for many similar applications, and which have shortcomings that are more easily overcome with Monte Carlo type simulations. Finally, it is acknowledged that there are similar efforts based around the use of the GEANT4 Monte-Carlo transport code currently under development at CERN. It is our intention to make our software modular and sufficiently flexible to allow the parallel use of either FLUKA or GEANT4 as the physics transport engine.

Pinsky, L. S.↗
NASA NTRS2009

Modern Material Analysis Instruments Add a New Dimension to Materials Characterization and Failure Analysis

Modern analytical tools can yield invaluable results during materials characterization and failure analysis. Scanning electron microscopes (SEMs) provide significant analytical capabilities, including angstrom-level resolution. These systems can be equipped with a silicon drift detector (SDD) for very fast yet precise analytical mapping of phases, as well as electron back-scattered diffraction (EBSD) units to map grain orientations, chambers that admit large samples, variable pressure for wet samples, and quantitative analysis software to examine phases. Advanced solid-state electronics have also improved surface and bulk analysis instruments: Secondary ion mass spectroscopy (SIMS) can quantitatively determine and map light elements such as hydrogen, lithium, and boron - with their isotopes. Its high sensitivity detects impurities at parts per billion (ppb) levels. X-ray photo-electron spectroscopy (XPS) can determine oxidation states of elements, as well as identifying polymers and measuring film thicknesses on coated composites. This technique is also known as electron spectroscopy for chemical analysis (ESCA). Scanning Auger electron spectroscopy (SAM) combines surface sensitivity, spatial lateral resolution (10 nm), and depth profiling capabilities to describe elemental compositions of near and below surface regions down to the chemical state of an atom.

Panda, Binayak↗
NASA NTRS2012

VESGEN Software for Mapping and Quantification of Vascular Regulators

VESsel GENeration (VESGEN) Analysis is an automated software that maps and quantifies effects of vascular regulators on vascular morphology by analyzing important vessel parameters. Quantification parameters include vessel diameter, length, branch points, density, and fractal dimension. For vascular trees, measurements are reported as dependent functions of vessel branching generation. VESGEN maps and quantifies vascular morphological events according to fractal-based vascular branching generation. It also relies on careful imaging of branching and networked vascular form. It was developed as a plug-in for ImageJ (National Institutes of Health, USA). VESGEN uses image-processing concepts of 8-neighbor pixel connectivity, skeleton, and distance map to analyze 2D, black-and-white (binary) images of vascular trees, networks, and tree-network composites. VESGEN maps typically 5 to 12 (or more) generations of vascular branching, starting from a single parent vessel. These generations are tracked and measured for critical vascular parameters that include vessel diameter, length, density and number, and tortuosity per branching generation. The effects of vascular therapeutics and regulators on vascular morphology and branching tested in human clinical or laboratory animal experimental studies are quantified by comparing vascular parameters with control groups. VESGEN provides a user interface to both guide and allow control over the users vascular analysis process. An option is provided to select a morphological tissue type of vascular trees, network or tree-network composites, which determines the general collections of algorithms, intermediate images, and output images and measurements that will be produced.

Parsons-Wingerter, Patricia A.↗
NASA NTRS2008

Geologic Evolution of the Martian Highlands: MTMs -20002, -20007, -25002, and -25007

As part of a continuing study to understand the relationship between valleys and highland resurfacing through geologic mapping, the authors are continuing to map seven 1:500,000-scale MTM quads in portions of the Margaritifer, Arabia, and Noachis Terrae. Results from this mapping will also help constrain the role and extent of past water in the region. The MTMs are grouped in two different areas within the region and compliment previous mapping in adjacent areas. Three western quads focus on Jones crater and the Himera, Samara, and Loire Valles systems. This abstract focuses on the four eastern quads wherein a large, ancient impact structure, Noachis basin, is flanked on its south and east by a series of valley networks. A solitary valley drains this basin and stretches north-northeast for approximately 450 km, transporting materials into Arabia Terra. Pertinent raster and vector data have been imported and registered using ESRI's ArcMap GIS software. To inspect and quantify stratigraphic relations, crater counts are being compiled in ESRI's ArcView GIS software to make use of crater counting tools specifically developed for planetary mappers. New datasets from the Mars Reconnaissance Orbiter including 4 CTX images, 31 CRISM multi-spectral pushbroom images, and 4 HiRISE images were incorporated into the project during the third year. The CRISM dataset uses summary parameters with thresholds to select targets for the high-resolution datasets. The befit for mappers is the extensive coverage and general compositional information. Results of a cursory analysis show strong mafic absorptions on the floors of Peta crater and Noachis basin. LCP absorptions occur more often than olivine, however, olivine tends to be denser than both pyroxenes. Olivine and HCP mat indicate relatively younger rocks, which is supported by the occurrence of wrinkle ridges associated with high olivine and HCP absorptions in the Peta crater and Noachis basin floors.

Fortezzo, C. M.↗
NASA NTRS2010

Mapping and Quantification of Vascular Branching in Plants, Animals and Humans by VESGEN Software

Humans face daunting challenges in the successful exploration and colonization of space, including adverse alterations in gravity and radiation. The Earth-determined biology of humans, animals and plants is significantly modified in such extraterrestrial environments. One physiological requirement shared by humans with larger plants and animals is a complex, highly branching vascular system that is dynamically responsive to cellular metabolism, immunological protection and specialized cellular/tissue function. The VESsel GENeration (VESGEN) Analysis has been developed as a mature beta version, pre-release research software for mapping and quantification of the fractal-based complexity of vascular branching. Alterations in vascular branching pattern can provide informative read-outs of altered vascular regulation. Originally developed for biomedical applications in angiogenesis, VESGEN 2D has provided novel insights into the cytokine, transgenic and therapeutic regulation of angiogenesis, lymphangiogenesis and other microvascular remodeling phenomena. Vascular trees, networks and tree-network composites are mapped and quantified. Applications include disease progression from clinical ophthalmic images of the human retina; experimental regulation of vascular remodeling in the mouse retina; avian and mouse coronary vasculature, and other experimental models in vivo. We envision that altered branching in the leaves of plants studied on ISS such as Arabidopsis thaliana cans also be analyzed.

Parsons-Wingerter, Patricia A.↗
NASA NTRS2010

Mapping and Quantification of Vascular Branching in Plants, Animals and Humans by VESGEN Software

Humans face daunting challenges in the successful exploration and colonization of space, including adverse alterations in gravity and radiation. The Earth-determined biology of plants, animals and humans is significantly modified in such extraterrestrial environments. One physiological requirement shared by larger plants and animals with humans is a complex, highly branching vascular system that is dynamically responsive to cellular metabolism, immunological protection and specialized cellular/tissue function. VESsel GENeration (VESGEN) Analysis has been developed as a mature beta version, pre-release research software for mapping and quantification of the fractal-based complexity of vascular branching. Alterations in vascular branching pattern can provide informative read-outs of altered vascular regulation. Originally developed for biomedical applications in angiogenesis, VESGEN 2D has provided novel insights into the cytokine, transgenic and therapeutic regulation of angiogenesis, lymphangiogenesis and other microvascular remodeling phenomena. Vascular trees, networks and tree-network composites are mapped and quantified. Applications include disease progression from clinical ophthalmic images of the human retina; experimental regulation of vascular remodeling in the mouse retina; avian and mouse coronary vasculature, and other experimental models in vivo. We envision that altered branching in the leaves of plants studied on ISS such as Arabidopsis thaliana cans also be analyzed.

Parsons-Wingerter, P. A.↗