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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 199 records · Page 11
All sourcesNASA NTRSDOE OSTI
NASA NTRS1996

Consumption, supply and transport: self-organization without direct communication

Swimming bacteria of the species Bacillus subtilis require and consume oxygen. In static liquid cultures the cells' swimming behaviour leads them to accumulate up oxygen concentration gradients generated by consumption and supply. Since the density of bacterial cells exceeds that of the fluid in which they live, fluid regions where cells have accumulated are denser than depleted regions. These density variations cause convection. The fluid motion is dynamically maintained by the swimming of the cells toward regions of attraction: the air-fluid interface and the fluctuating advecting attractors, gradients of oxygen concentration that are embedded in the convecting fluid. Because of the fluid dynamical conservation laws, these complex physical and biological factors generate patterns ordered over distances > 10000 bacterial cell diameters. The convection enhances long-range transport and mixing of oxygen, cells and extracellular products by orders of magnitude. Thus, through the interplay of physical and biological factors, a population of undifferentiated selfish cells creates functional dynamic patterns. Populations of bacteria that have organised themselves into regularly patterned regions of vigorous convection and varying cell concentration interact with their environment as if they were one purposeful, coherent multicellular individual. The mathematical and experimental ingredients of these remarkable phenomena are presented here.

Non-NASA Center↗
NASA NTRS1993

Time-resolved tryptophan fluorescence in photosynthetic reaction centers from Rhodobacter sphaeroides

Tryptophan fluorescence of reaction centers isolated from Rhodobacter sphaeroides, both stationary and time-resolved, was studied. Fluorescence kinetics were found to fit best a sum of four discrete exponential components. Half of the initial amplitude was due to a component with a lifetime of congruent to 60 ps, belonging to Trp residues, capable of efficient transfer of excitation energy to bacteriochlorophyll molecules of the reaction center. The three other components seem to be emitted by Trp ground-state conformers, unable to participate in such a transfer. Under the influence of intense actinic light, photooxidizing the reaction centers, the yield of stationary fluorescence diminished by congruent to 1.5 times, while the number of the kinetic components and their life times remained practically unchanged. Possible implications of the observed effects for the primary photosynthesis events are considered.

NASA Program Exobiology↗
NASA NTRS2005

Extracting trends from two decades of microgravity macromolecular crystallization history

Since the 1980s hundreds of macromolecular crystal growth experiments have been performed in the reduced acceleration environment of an orbiting spacecraft. Significant enhancements in structural knowledge have resulted from X-ray diffraction of the crystals grown. Similarly, many samples have shown no improvement or degradation in comparison to those grown on the ground. A complex series of interrelated factors affect these experiments and by building a comprehensive archive of the results it was aimed to identify factors that result in success and those that result in failure. Specifically, it was found that dedicated microgravity missions increase the chance of success when compared with those where crystallization took place as a parasitic aspect of the mission. It was also found that the chance of success could not be predicted based on any discernible property of the macromolecule available to us.

Review↗
NASA NTRS2006

Generalized Orbital Projections of a Sublimating Ice Particle

The issue of orbital debris resulting from human activities in space is a growing concern for the space users' community. Waste generated in Low Earth Orbit (LEO) can stay in orbit for a long time, creating significant hazards for other spacecraft flying at lower intercepting orbits. Many spacecraft, especially crewed vehicles, are required to vent fluids into space. These fluids include propellant, wastewater, excess condensate, and others. It is important to analyze the behavior of particles that result from these activities, since each individual particle is capable of damaging or destroying a spacecraft in a lower, crossing orbit, and such particles are invisible to tracking radar systems on the ground. The deorbit trajectory of an ice particle is complex. It depends on factors including attitude of the vehicle during vent, initial velocities of particles, altitude at which the vent occurred, and numerous evaporation and sublimation factors. These include contamination within the vented water, evolution of bubbles within the clear water, and sun flux factors such as time of the year and current beta angle. The purpose of this study is to examine the influences of these factors on the trajectories of ice particles resulting from condensate water dumps, and to bound the safe trajectories of spacecraft that lie below the venting spacecraft.

Menkin, Evgeny↗
NASA NTRS2007

The Effects of Radiation on Imagery Sensors in Space

Recent experience using high definition video on the International Space Station reveals camera pixel degradation due to particle radiation to be a much more significant problem with high definition cameras than with standard definition video. Although it may at first appear that increased pixel density on the imager is the logical explanation for this, the ISS implementations of high definition suggest a more complex causal and mediating factor mix. The degree of damage seems to vary from one type of camera to another, and this variation prompts a reconsideration of the possible factors in pixel loss, such as imager size, number of pixels, pixel aperture ratio, imager type (CCD or CMOS), method of error correction/concealment, and the method of compression used for recording or transmission. The problem of imager pixel loss due to particle radiation is not limited to out-of-atmosphere applications. Since particle radiation increases with altitude, it is not surprising to find anecdotal evidence that video cameras subject to many hours of airline travel show an increased incidence of pixel loss. This is even evident in some standard definition video applications, and pixel loss due to particle radiation only stands to become a more salient issue considering the continued diffusion of high definition video cameras in the marketplace.

Mathis, Dylan↗
NASA NTRS2010

NASA Tech Briefs, March 2010

Topics covered include: Software Tool Integrating Data Flow Diagrams and Petri Nets; Adaptive Nulling for Interferometric Detection of Planets; Reducing the Volume of NASA Earth-Science Data; Reception of Multiple Telemetry Signals via One Dish Antenna; Space-Qualified Traveling-Wave Tube; Smart Power Supply for Battery-Powered Systems; Parallel Processing of Broad-Band PPM Signals; Inexpensive Implementation of Many Strain Gauges; Constant-Differential-Pressure Two-Fluid Accumulator; Inflatable Tubular Structures Rigidized with Foams; Power Generator with Thermo-Differential Modules; Mechanical Extraction of Power From Ocean Currents and Tides; Nitrous Oxide/Paraffin Hybrid Rocket Engines; Optimized Li-Ion Electrolytes Containing Fluorinated Ester Co-Solvents; Probabilistic Multi-Factor Interaction Model for Complex Material Behavior; Foldable Instrumented Bits for Ultrasonic/Sonic Penetrators; Compact Rare Earth Emitter Hollow Cathode; High-Precision Shape Control of In-Space Deployable Large Membrane/Thin-Shell Reflectors; Rapid Active Sampling Package; Miniature Lightweight Ion Pump; Cryogenic Transport of High-Pressure-System Recharge Gas; Water-Vapor Raman Lidar System Reaches Higher Altitude; Compact Ku-Band T/R Module for High-Resolution Radar Imaging of Cold Land Processes; Wide-Field-of-View, High-Resolution, Stereoscopic Imager; Electrical Capacitance Volume Tomography with High-Contrast Dielectrics; Wavefront Control and Image Restoration with Less Computing; Polarization Imaging Apparatus; Stereoscopic Machine-Vision System Using Projected Circles; Metal Vapor Arcing Risk Assessment Tool; Performance Bounds on Two Concatenated, Interleaved Codes; Parameterizing Coefficients of a POD-Based Dynamical System; Confidence-Based Feature Acquisition; Algorithm for Lossless Compression of Calibrated Hyperspectral Imagery; Universal Decoder for PPM of any Order; Algorithm for Stabilizing a POD-Based Dynamical System; Mission Reliability Estimation for Repairable Robot Teams; Processing AIRS Scientific Data Through Level 3; Web-Based Requesting and Scheduling Use of Facilities; AutoGen Version 5.0; Time-Tag Generation Script; PPM Receiver Implemented in Software; Tropospheric Emission Spectrometer Product File Readers; Reporting Differences Between Spacecraft Sequence Files; Coordinating "Execute" Data for ISS and Space Shuttle; Database for Safety-Oriented Tracking of Chemicals; Apparatus for Cold, Pressurized Biogeochemical Experiments; Growing B Lymphocytes in a Three-Dimensional Culture System; Tissue-like 3D Assemblies of Human Broncho-Epithelial Cells; Isolation of Resistance-Bearing Microorganisms; Oscillating Cell Culture Bioreactor; and Liquid Cooling/Warming Garment.

Source record↗
NASA NTRS2014

Some Challenges in the Design of Human-Automation Interaction for Safety-Critical Systems

Increasing amounts of automation are being introduced to safety-critical domains. While the introduction of automation has led to an overall increase in reliability and improved safety, it has also introduced a class of failure modes, and new challenges in risk assessment for the new systems, particularly in the assessment of rare events resulting from complex inter-related factors. Designing successful human-automation systems is challenging, and the challenges go beyond good interface development (e.g., Roth, Malin, & Schreckenghost 1997; Christoffersen & Woods, 2002). Human-automation design is particularly challenging when the underlying automation technology generates behavior that is difficult for the user to anticipate or understand. These challenges have been recognized in several safety-critical domains, and have resulted in increased efforts to develop training, procedures, regulations and guidance material (CAST, 2008, IAEA, 2001, FAA, 2013, ICAO, 2012). This paper points to the continuing need for new methods to describe and characterize the operational environment within which new automation concepts are being presented. We will describe challenges to the successful development and evaluation of human-automation systems in safety-critical domains, and describe some approaches that could be used to address these challenges. We will draw from experience with the aviation, spaceflight and nuclear power domains.

systems engineering↗
NASA NTRS2018

GeneLab: Omics Data System for Space Biology Research

During spaceflight, a complex set of detrimental factors impinge upon astronauts and other biological systems. To help understand this dynamic, NASA is developing GeneLab, an open access data system to encourage widespread analysis of spaceflight relevant omics data.

Omics↗
NASA NTRSDate not supplied

Using Controlled Impact Experiments to Understand the Effects of Cohesive Blocks on the Cratering Process

When considering large-scale impact events that occur in the gravity-regime, smallscale target heterogeneities (on order of the projectile diameter) are anticipated to have a minimal effect on the cratering process and are therefore not considered in scaling relations [1-3]. Such heterogeneities and other details of the target's strength and structure, however, become increasingly influential as the magnitude of the impact decreases [4]. At the scale of craters forming mostly in regolith on the Moon (< a few meters), for example, target properties such as cohesive strength, density, porosity, and friction have more leverage than gravity to influence the resultant crater dimensions [5]. Further complications beyond just target properties can manifest in many forms, such as subsurface layers [6]; the presence of random, competent blocks [7]; buried lenses of impact melt; and/or pockets of regolith compacted or indurated to varying degrees by previous impacts. Summing the total effect of target properties and any additional heterogeneities for integration into scaling relations is not straightforward, as each individual parameter will have unequal, and so far, unquantified, effects on the final crater. Even when craters are produced under a best-case scenario of controlled laboratory conditions, understanding the entire relevant parameter space can be a formidable task, and deconvolution of all the contributing factors can be a complex undertaking. To begin the process of quantifying such effects, we are conducting an extensive series of impact experiments to build a framework for the interpretation of craters observed on the characteristically complex surfaces throughout the solar system. Here we present the first, and simplest, configuration to be examined in this multi-year experimental campaign: one in which solitary, cohesive blocks are placed in the path of the projectile’s trajectory at different burial depths in granular, sand targets. Among the variables to be investigated in this configuration are the influence of block size, compressive strength, and burial depth.

impact crater↗
NASA NTRSDate not supplied

Statistical Wind-Tunnel Experimentation Advancements for eVTOL Aircraft Aero-Propulsive Model Development

Compared to many conventional aircraft, electric vertical takeoff and landing (eVTOL) vehicle designs present greater aero-propulsive complexity and many interacting factors requiring development of novel testing and model development strategies. This paper describes several advances in statistically-rigorous experiment design methods for wind-tunnel testing of eVTOL aircraft enabling accurate aero-propulsive model development. The techniques are applied to a subscale tilt-rotor eVTOL aircraft configuration built at NASA Langley Research Center that has 24 independent control effectors. The general testing approach, leveraging design of experiments and response surface methodology, is outlined and followed by a detailed description of the experiment design and modeling approach employed for different phases of the wind-tunnel testing. A new approach for gravitational tare modeling is developed and validated, which reduces the required wind-tunnel test time by nearly 50%. A mostly automated trim envelope determination approach is formulated to rapidly determine the aircraft flight envelope to inform transition testing for aero-propulsive model development. Efficient powered-airframe characterization tests are conducted using a nested I-optimal design approach formulated in previous simulation-based testing. The collective wind-tunnel testing approach facilitates rapid characterization of eVTOL aircraft configurations and produces accurate aero-propulsive models that can be used in flight dynamics simulations.

design of experiments↗
NASA NTRS2000

Time- and dose-related interactions between glucocorticoid and cyclic adenosine 3',5'-monophosphate on CCAAT/enhancer-binding protein-dependent insulin-like growth factor I expression by osteoblasts

Glucocorticoid has complex effects on osteoblasts. Several of these changes appear to be related to steroid concentration, duration of exposure, or specific effects on growth factor expression or activity within bone. One important bone growth factor, insulin-like growth factor I (IGF-I), is induced in osteoblasts by hormones such as PGE2 that increase intracellular cAMP levels. In this way, PGE2 activates transcription factor CCAAT/enhancer-binding protein-delta (C/EBPdelta) and enhances its binding to a specific control element found in exon 1 in the IGF-I gene. Our current studies show that preexposure to glucocorticoid enhanced C/EBPdelta and C/EBPbeta expression by osteoblasts and thereby potentiated IGF-I gene promoter activation in response to PGE2. Importantly, this directly contrasts with inhibitory effects on IGF-I expression that result from sustained or pharmacologically high levels of glucocorticoid exposure. Consistent with the stimulatory effect of IGF-I on bone protein synthesis, pretreatment with glucocorticoid sensitized osteoblasts to PGE2, and in this context significantly enhanced new collagen and noncollagen protein synthesis. Therefore, pharmacological levels of glucocorticoid may reduce IGF-I expression by osteoblasts and cause osteopenic disease, whereas physiological transient increases in glucocorticoid may permit or amplify the effectiveness of hormones that regulate skeletal tissue integrity. These events appear to converge on the important role of C/EBPdelta and C/EBPbeta on IGF-I expression by osteoblasts.

NASA Program Biomedical Research and Countermeasur↗
NASA NTRS1999

Miniature Time-of-Flight Mass Spectrometer

Major advances must occur to protect astronauts from prolonged periods in near-zero gravity and high radiation associated with extended space travel. The dangers of living in space must be thoroughly understood and methods developed to reverse those effects that cannot be avoided. Six of the seven research teams established by the National Space Biomedical Research Institute (NSBRI) are studying biomedical factors for prolonged space travel to deliver effective countermeasures. To develop effective countermeasures, each of these teams require identification of and quantitation of complex pharmacological, hormonal, and growth factor compounds (biomarkers) in humans and in experimental animals to develop an in-depth knowledge of the physiological changes associated with space travel. At present, identification of each biomarker requires a separate protocol. Many of these procedures are complicated and the identification of each biomarker requires a separate protocol and associated laboratory equipment. To carry all of this equipment and chemicals on a spacecraft would require a complex clinical laboratory; and it would occupy much of the astronauts time. What is needed is a small, efficient, broadband medical diagnostic instrument to rapidly identify important biomarkers for human space exploration. The Miniature Time-Of- Flight Mass Spectrometer Project in the Technology Development Team is developing a small, high resolution, time-of-flight mass spectrometer (TOFMS) to quantitatively measure biomarkers for human space exploration. Virtues of the JHU/APL TOFMS technologies reside in the promise for a small (less than one cubic ft), lightweight (less than 5 kg), low-power (less than 50 watts), rugged device that can be used continuously with advanced signal processing diagnostics. To date, the JHU/APL program has demonstrated mass capability from under 100 to beyond 10,000 atomic mass units (amu) in a very small, low power prototype for biological analysis. Further, the electronic nature of the TOFMS output makes it ideal for rapid telemetry to earth for in-depth analysis by ground support teams.

Potember, Richard S.↗
DOE OSTI2025

Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25

The Mediator complex facilitates interactions between transcription factors and RNA polymerase II, a process that is required for host gene transcription, including in response to viral infections. Among the many subunits in the Mediator complex, the MED25 subunit has been shown to be a target for viral activators during infection. Here we provide the molecular basis for the interaction between human respiratory syncytial virus (hRSV) nonstructural 1 protein (NS1) and the activator interaction domain (ACID) of MED25. The X-ray crystal structure of the complex revealed that NS1 straddles and binds two faces of MED25 ACID. This interaction is distinct from previously known viral activators. Importantly, our data support the conformational flexibility of viral transcriptional regulators. Furthermore, ChIP-seq and RNA-seq analysis identified the ATF3 transcription factor and a role for NS1/Mediator/ATF3 interaction in host gene regulation in hRSV infections. Our findings provide a molecular basis for hRSV NS1-based regulation of host gene transcription and reveal how viruses exploit the conformational heterogeneity at fuzzy transcription activator interfaces.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1984

Report of the Panel on Human Factors

Human error in the operation of complex systems is the largest single cause of incidents, accidents, and the loss of lives and dollars. Therefore, it is understandable that the focus of human factors research and engineering is on increasing our understanding of the basic mechanisms of human error and on developing techniques for reducing or eliminating the various causes of human error.

Rouse, William B.↗
NASA NTRS1990

Identification challenges for large space structures

The paper examines the on-orbit modal identification of large space structures, stressing the importance of planning and experience, in preparation for the Space Station Structural Characterization Experiment (SSSCE) for the Space Station Freedom. The necessary information to foresee and overcome practical difficulties is considered in connection with seven key factors, including test objectives, dynamic complexity of the structure, data quality, extent of exploratory studies, availability and understanding of software tools, experience with similar problems, and pretest analytical conditions. These factors affect identification success in ground tests. Comparisons with similar ground tests of assembled systems are discussed, showing that the constraints of space tests make these factors more significant. The absence of data and experiences relating to on-orbit modal identification testing is shown to make identification a uniquely mathematical problem, although all spacecraft are constructed and verified by proven engineering methods.

Pappa, Richard S.↗
DOE OSTI2024

SISGR: The regulation of carbon fixation in plant and green algae: Rubisco activase and the origin of heat inactivation of CO 2 assimilation

Rubisco activase (Rca) is a critical AAA+ ATPase protein complex that remodels and promotes the Rubisco enzyme, a key player in photosynthetic performance and carbon fixation. The assembly and function of the Rca protein complex are regulated by a range of factors, including subunit concentration, nucleotide-binding states, thermal conditions, metal-ion coordination, and post-translational modifications, such as phosphorylation. Despite its importance in photosynthesis, the detailed molecular mechanisms underlying the regulation of plant Rca and how it activates Rubisco remain elusive. This project aims to bridge this knowledge gap by integrating sophisticated enzymology tools with single-molecule methods and high-resolution electron microscopy to elucidate the structure and function of plant Rca. Through these multiple approaches, we have systematically investigated how the activity of plant Rca is impacted by various factors, such as phosphorylation and metal-ion coordination. The Rca complex assembly/disassembly dynamics were captured using anti-Brownian electrokinetic (ABEL) trap-based measurements, providing unprecedented insight into its structural flexibility and diverse assembly states. Furthermore, the structural analysis of Rca through electron crystallography and single-particle cryogenic electron microscopy (cryo-EM) reveals novel assembly states of the spinach Rca, providing insight into the mechanistic action for Rubisco remodeling. By combining cutting-edge tools and approaches, this work uncovers critical aspects of Rca’s regulation and assembly, paving the way for a deeper understanding of its role in photosynthetic efficiency and the potential for enhancing carbon fixation in crops.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

Primer: Physical Factors of Agricultural Production & Climate Change

This white paper is a primer on physical factors that influence agricultural production and associated touchpoints to climate change. Agricultural production (which includes both crop and livestock production) is critical for food security and supports other economic products, such as textiles and generation of fuels for energy. Various physical factors influence agricultural production, including the crop types being cultivated and livestock being raised; land area and quality; water access and control; fertilizers, pesticides, and antibiotics; labor; and infrastructure associated with processing, storage, and transportation. These factors are impacted by climate change in both chronic and acute ways, from changing temperatures and precipitation patterns to increased prevalence of extreme events and diseases. We draw on examples from around the world to show the complex ways that agricultural production factors and climate interact with local capacities to influence regions around the world.

54 ENVIRONMENTAL SCIENCES↗