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NASA NTRS2002

SEARCH Workshop on Large-Scale Atmosphere/Cryosphere Observations

The purpose of the workshop held in Seattle during 27-29 November 2001 was to review existing land, sea ice, and atmospheric observations and the prospect for an Arctic System Reanalysis, through white papers, invited speakers, and panels. A major task for SEARCH was to determine how existing observation systems can be best used and enhanced to understand and anticipate the course of the ongoing changes in the Arctic. The primary workshop conclusion is that there is no cohesion among various Arctic disciplines and data types to form a complete observation set of Arctic change; a second workshop conclusion is that present data sets are vastly underutilized in understanding Arctic change; a third conclusion is that a distributed observing system must accommodate a wide range of spatial patterns of variability.

Source record↗
NASA NTRS2006

NASA's Lunar Robotic Architecture Study

This report documents the findings and analysis of a 60-day agency-wide Lunar Robotic Architecture Study (LRAS) conducted by the National Aeronautics and Space Administration (NASA). Work on this study began in January 2006. Its purpose was to: Define a lunar robotics architecture by addressing the following issues: 1) Do we need robotic missions at all? If so, why and under what conditions? 2) How would they be accomplished and at what cost? Are they within budget? 3) What are the minimum requirements? What is the minimum mission set? 4) Integrate these elements together to show a viable robotic architecture. 5) Establish a strategic framework for a lunar robotics program. The LRAS Final Report presents analysis and recommendations concerning potential approaches related to NASA s implementation of the President's Vision for Space Exploration. Project and contract requirements will likely be derived in part from the LRAS analysis and recommendations contained herein, but these do not represent a set of project or contract requirements and are not binding on the U.S. Government unless and until they are formally and expressly adopted as such. Details of any recommendations offered by the LRAS Final Report will be translated into implementation requirements. Moreover, the report represents the assessments and projects of the report s authors at the time it was prepared; it is anticipated that the concepts in this report will be analyzed further and refined. By the time some of the activities addressed in this report are implemented, certain assumptions on which the report s conclusions are based will likely evolve as a result of this analysis. Accordingly, NASA, and any entity under contract with NASA, should not use the information in this report for final project direction. Since the conclusion of this study, there have been various changes to the Agency's current portfolio of lunar robotic precursor activities. First, the Robotic Lunar Exploration Program (RLEP) has been renamed the Lunar Precursor and Robotic Program (LPRP). On May 17, 2006, the Lunar Reconnaissance Orbiter (LRO) was confirmed to enter its implementation phase. Last, a new low-cost secondary payload known as the Lunar Crater Observation and Sensing Satellite (LCROSS) was co-manifested to launch with LRO in 2008. These changes are consistent with the conclusions and recommendations of this study, but came too late to be specifically reflected in this report.

Mulville, Daniel R.↗
NASA NTRS2007

Integrating Human Factors into Crew Exploration Vehicle (CEV) Design

The purpose of this design process is to apply Human Engineering (HE) requirements and guidelines to hardware/software and to provide HE design, analysis and evaluation of crew interfaces. The topics include: 1) Background/Purpose; 2) HE Activities; 3) CASE STUDY: Net Habitable Volume (NHV) Study; 4) CASE STUDY: Human Modeling Approach; 5) CASE STUDY: Human Modeling Results; 6) CASE STUDY: Human Modeling Conclusions; 7) CASE STUDY: Human-in-the-Loop Evaluation Approach; 8) CASE STUDY: Unsuited Evaluation Results; 9) CASE STUDY: Suited Evaluation Results; 10) CASE STUDY: Human-in-the-Loop Evaluation Conclusions; 11) Near-Term Plan; and 12) In Conclusion

Mihriban Whitmore↗
NASA NTRS2007

GRAS NRT Precise Orbit Determination: Operational Experience

EUMETSAT launched the meteorological satellite MetOp-A in October 2006; it is the first of the three satellites that constitute the EUMETSAT Polar System (EPS) space segment. This satellite carries a challenging and innovative instrument, the GNSS Receiver for Atmospheric Sounding (GRAS). The goal of the GRAS instrument is to support the production of atmospheric profiles of temperature and humidity with high accuracy, in an operational context, based on the bending of the GPS signals traversing the atmosphere during the so-called occultation periods. One of the key aspects associated to the data processing of the GRAS instrument is the necessity to describe the satellite motion and GPS receiver clock behaviour with high accuracy and within very strict timeliness limitations. In addition to these severe requirements, the GRAS Product Processing Facility (PPF) must be integrated in the EPS core ground segment, which introduces additional complexity from the data integration and operational procedure points of view. This paper sets out the rationale for algorithm selection and the conclusions from operational experience. It describes in detail the rationale and conclusions derived from the selection and implementation of the algorithms leading to the final orbit determination requirements (0.1 mm/s in velocity and 1 ns in receiver clock error at 1 Hz). Then it describes the operational approach and extracts the ideas and conclusions derived from the operational experience.

MartinezFadrique, Francisco M.↗
NASA NTRS2004

Habitat Utilization Assessment - Building in Behaviors

Habitability, and the associated architectural and design attributes of an environment, is a powerful performance shaping factor. By identifying how inhabitants use an area, we can draw conclusions about what design or architectural attributes cause what behaviors and systematically design in desired human performance. We are analyzing how a crew uses a long duration habitat and work environment during a four-day underwater mission and identifying certain architectural and design attributes that are related to, and potential enablers of, certain crew behaviors. By identifying how inhabitants use the habitat, we can draw conclusions about what habitability attributes cause what behaviors and systematically design in desired human performance (applicable to NASA's Bioastronautics Human Behavior and Performance Critical Path Roadmap question 6.12). This assessment replicates a methodology reported in a chapter titled "Sociokinetic Analysis as a Tool for Optimization of Environmental Design" by C. Adams.' That study collected video imagery of certain areas of a closed habitat during a 91 day test and from that data calculated time spent in different volumes during the mission, and characterized the behaviors occurring in certain habitat volumes thus concluding various rules for design of such habitats. This study assesses the utilization of the Aquarius Habitat, an underwater station, which will support six Aquanauts for a fourteen-day mission during which the crew will perform specific scientific and engineering studies. Video is recorded for long uninterrupted periods of time during the mission and from that data the time spent in each area is calculated. In addition, qualitative and descriptive analysis of the types of behaviors in each area is performed with the purpose of identifying any behaviors that are not typical of a certain area. If a participant uses an area in a way different from expected, a subsequent analysis of the features of that area may result in conclusions of performance shaping factors. With the addition of this study, we can make comparisons between the two different habitats and begin drawing correlation judgments about design features and behavior. Ideally, this methodology should be repeated in additional Aquarius missions and other analog environments because the real information will come from comparisons between habitats.

Whitmore, Mihriban↗
NASA NTRS2011

What Dominates the Coronal Emission Spectrum During the Cycle of Impulsive Heating and Cooling?

The smoking gun of small-scale, impulsive events heating the solar corona is expected to be the presence of a hot ( > 5 MK) plasma component. Evidence for this has been scarce, but has gradually begun to accumulate due to recent studies designed to constrain the high temperature part of the emission measure distribution. However, the detected hot component is often weaker than models predict and this is due in part to the common modeling assumption that the ionization balance remains in equilibrium. The launch of the latest generation of space-based observing instrumentation aboard Hinode and the Solar Dynamics Observatory (SDO) has brought the matter of the ionization state of the plasma firmly to the forefront. It is timely to consider exactly what emission current instruments would detect when observing a corona heated impulsively on small-scales by nanoflares. Only after we understand the full effects of nonequilibrium ionization can we draw meaningful conclusions about the plasma that is (or is not) present. We have therefore performed a series of hydrodynamic simulations for a variety of different nanoflare properties and initial conditions. Our study has led to several key conclusions. 1. Deviations from equilibrium are greatest for short-duration nanoflares at low initial coronal densities. 2. Hot emission lines are the most affected and are suppressed sometimes to the point of being invisible. 3. The emission detected in all of the SDO-AIA channels is generally dominated by warm, over-dense, cooling plasma. 4. It is difficult not to create coronal loops that emit strongly at 1.5 MK and in the range 2 to 5 MK, which are the most commonly observed kind, for a broad range of nanoflare scenarios. 5. The Fe XV (284.16 ) emission in most of our models is about 10 times brighter than the Ca XVII (192.82 ) emission, consistent with observations. Our overarching conclusion is that small-scale, impulsive heating inducing a nonequilibrium ionization state leads to predictions for observable quantities that are entirely consistent with what is actually observed.

Bradshaw, Stephen J.↗
NASA NTRS2005

Simulations of Evaporating Multicomponent Fuel Drops

A paper presents additional information on the subject matter of Model of Mixing Layer With Multicomponent Evaporating Drops (NPO-30505), NASA Tech Briefs, Vol. 28, No. 3 (March 2004), page 55. To recapitulate: A mathematical model of a three-dimensional mixing layer laden with evaporating fuel drops composed of many chemical species has been derived. The model is used to perform direct numerical simulations in continuing studies directed toward understanding the behaviors of sprays of liquid petroleum fuels in furnaces, industrial combustors, and engines. The model includes governing equations formulated in an Eulerian and a Lagrangian reference frame for the gas and drops, respectively, and incorporates a concept of continuous thermodynamics, according to which the chemical composition of a fuel is described by use of a distribution function. In this investigation, the distribution function depends solely on the species molar weight. The present paper reiterates the description of the model and discusses further in-depth analysis of the previous results as well as results of additional numerical simulations assessing the effect of the mass loading. The paper reiterates the conclusions reported in the cited previous article, and states some new conclusions. Some new conclusions are: 1. The slower evaporation and the evaporation/ condensation process for multicomponent-fuel drops resulted in a reduced drop-size polydispersity compared to their single-component counterpart. 2. The inhomogeneity in the spatial distribution of the species in the layer increases with the initial mass loading. 3. As evaporation becomes faster, the assumed invariant form of the molecular- weight distribution during evaporation becomes inaccurate.

Bellan, Josette↗
NASA NTRS2015

Re-Evaluation of HSE DATA in Light of High P-T Partitioning Data: Late Chondritic Addition to Inner Solar System Bodies Not Always Required for HSE

Studies of terrestrial peridotite and martian and achondritic meteorites have led to the conclusion that addition of chondritic material to growing planets or planetesimals, after core formation, occurred on Earth, Moon, Mars, asteroid 4 Vesta, and the parent body of the angritic meteorites. One study even proposed that this was a common process in the final stages of growth. These conclusions are based al-most entirely on the 8 highly siderophile elements (HSE; Re, Au, Pt, Pd, Rh, Ru, Ir, Os), which have been used to argue for late accretion of chondritic material to the Earth after core formation was complete. This idea was originally proposed because the D(metal/silicate) values for the HSE are very high (greater than 10,000), yet their concentration in the terrestrial mantle is too high to be consistent with such high Ds. The HSE in the terrestrial mantle also are present in chondritic relative abundances and hence require similar Ds if this was the result of core-mantle equilibration. The conclusion that late chondritic additions are required for all five of these bodies is based on the chondritic relative abundances of the HSE, as well as their elevated concentrations in the samples. An easy solution is to call upon addition of chondritic material to the mantle of each body, just after core formation; however, in practice this means similar additions of chondritic materials to each body just after core formation which ranges from approximately 4-5 Ma after T(sub 0) for 4 Vesta and the angrites, to 10-25 Ma for Mars, to 35 to 60 Ma for Moon and perhaps the Earth. Since the work of there has been a realization that high PT conditions can lower the partition coefficients of many siderophile elements, indicating that high PT conditions (magma ocean stage) can potentially explain elevated siderophile element abundances. However, detailed high PT partitioning data have been lacking for many of the HSE to evaluate whether such ideas are viable for all four bodies. Re-cent partitioning studies have covered P, T, fO2, and compositional ranges that allow values to be predicted at conditions relevant to these five inner solar system bodies. Because the D(HSE) metal/silicate are lowered substantially at higher PT conditions and natural com-positions (FeNi metallic liquids and peridotites) it is natural to re-examine the role of core formation on the HSE patterns in a variety of inner solar system bodies. Here I will discuss other processes (including high PT core formation for Mars, Moon and Earth) that can produce the observed HSE patterns, and demonstrate that there are viable hypotheses other than the "one size fits all" hypothesis of late chondritic additions.

Righter, K.↗
NASA NTRS2016

Method of Heat Treating Aluminum-Lithium Alloy to Improve Formability

A method is provided for heat treating aluminum-lithium alloys to improve their formability. The alloy is heated to a first temperature, maintained at the first temperature for a first time period, heated at the conclusion of the first time period to a second temperature, maintained at the second temperature for a second time period, actively cooled at the conclusion of the second time period to a third temperature, maintained at the third temperature for a third time period, and then passively cooled at the conclusion of the third time period to room temperature.

Chen, Po-Shou↗
NASA NTRS2017

Characterization of the Modal Characteristics of Structures Operating in Dense Liquid Oxygen Turbopumps

A number of valuable conclusions can be drawn from this study. First, knockdown factors for a specific fluid are not constant but instead are dependent on the mode shape, although the largest this variability gets is about 10% for LOX, the densest fluid. The factors decrease the most for lower frequency shapes and less for higher ones. It follows, therefore, that mode number mismatch between air and fluid operation becomes not only possible, but common, as a knockdown factor for a particular mode shape may be higher than for another mode shape. Since this is a function of added mass, the mismatch is more prevalent for higher density fluids, but it initiates even for very low density ones. Another important conclusion reached is that it appears that the basic mode shapes of a structure do not change if it is fully symmetric, which includes its geometry and boundary conditions. There is some indication of small changes in the relative magnitudes within the mode shape. This conclusion is evident in the results from the cantilever rectangular plate and the inducer, which are not symmetric, and the fixed-fixed plate and the annular disk, which are. For non-symmetric structures, though, the mode shapes almost universally change for dense fluids, as shown by the very low MAC calculations. For the inducer in particular, the changes follow a trend of reduced parabolic and sine wavelengths with increasing density. It is critical to recognize the change in mode shape for several reasons. First, model updating with modal test becomes problematic if the shapes change. Second, design to avoid resonance is highly critical on the mode shape for modes other than the primary ones, as resonance is only a factor when the excitation shape matches the mode shape. Finally, application of the modal superposition method of forced response analysis is dependent on the use of accurate mode shapes. A more-refined assessment of the "knockdown" factor values and ranges than any previously reported in the literature for a realistic engineering structure is also presented in this paper. This data is of tremendous benefit for preliminary analysis and design, where a quick estimate is necessary. These results are important not just for rocket engine turbomachinery, but for water pumps and turbines, propellers, and any other structure operating in a heavy fluid with dynamic excitation. The clear avenue for future work for this endeavor is to expand the analytical techniques discussed in the literature to develop analytical expressions and justification for the mode shape changes and associated frequency knockdowns. These expressions must be able to accurately predict the functional relationship to the shapes, which will enable accurate tracing of the mode number from vacuum analysis (or testing in air) to analysis and operation in the intended fluid environment.

Chiu, Joseph↗
NASA NTRS2023

Comment on “Advanced Testing of Low, Medium, and High ECS CMIP6 GCM Simulations Versus ERA5-T2m” by N. Scafetta (2022)

Scafetta (2022, https://doi.org/10.1029/2022gl097716) purports to test Coupled Model Intercomparison Project Phase 6 (CMIP6) climate models through a comparison of temperature changes over three decades. Unfortunately, the paper contains numerous conceptual and statistical errors that undermine all of the conclusions. First, no uncertainty is given for the observational temperature difference, making it impossible to assess compatibility with any model result. Second, the CMIP6 data are the ensemble means for each model, but the metric being tested is sensitive to the internal variability and so the full ensemble for each model must be used. When this is corrected, the conclusion that “all models with ECS > 3.0°C overestimate the observed global surface warming” is not sustained. Third, the statistical test in Section 2 would reject all models even in a perfect model setup given sufficient ensemble members, thus the second conclusion “that spatial t-statistics rejects the data-model agreement” is also not sustainable.

CMIP6↗
DOE OSTI2020

Low Count and Background Radionuclides Analysis - 20488

The US Department of Energy (DOE) is often faced with the need to evaluate radionuclides at low concentrations. When site sample data are likely to be close to threshold activity concentrations of interest, then the means by which the radiochemical analysis is performed and reported is critical. This situation can occur when differentiating from zero (presence/absence) for radionuclides that do not occur naturally, close comparison with environmental background for naturally occurring radionuclides, close comparison with a risk- or dose-based threshold concentrations of interest, or even comparisons across studies. There are several analytical issues that are of concern, but the two that appear to cause incorrect decisions to be made most often involve establishing detection limits and subtracting ambient background conditions in the laboratory. These issues are not critical when radionuclide activity concentrations are large relative to thresholds of concern, but they seem to be poorly understood when it matters. When the comparisons are important and are likely to be close to a threshold of interest, then the general contract with the analytical laboratories needs to be changed so that the right or appropriate data are obtained. The concern is that important decisions are made incorrectly more often as greater scrutiny is placed on DoE's radionuclide cleanup or monitoring decisions by the public and other stakeholders. Examples are presented of problems that have been observed for different projects, both within and outside the realm of DOE and NRC remediation and radioactive waste disposal problems, and solutions are offered that should lead to better data from which important decisions need to be made. The first example is from Los Alamos National Laboratory (LANL) and involves radionuclide concentrations in soil and rock beneath LANL's Material Disposal Area (MDA) G. An initial review of the data led to a conclusion that americium and plutonium are a long way present beneath MDA G. A more thorough review of the data that accounted properly for ambient background and the detection limits that had been established led to the opposite conclusion. Another example is from the Nevada National Security Site where tritium results from one of the wells were unexpectedly high. Proper understanding and analysis of ambient background led to the conclusion that the increased concentrations were not so obvious, and that a different contract with the analytical laboratory was needed to provide more appropriate data to support a better determination. Other examples are used from regulatory review of projects in Nevada, where background levels and secular equilibrium for naturally occurring radionuclides are not established correctly because of analytical issues. The same basic issues have also been found to create difficulties analyzing historical data from the West Valley Demonstration Project. There is evidence in the data that the apparent lack of secular equilibrium where it is expected to exist is related to ambient background subtraction or other analytical issues. A final example is presented for analysis of Tc-99 in samples of depleted uranium. In this case, two different studies that were performed only three months apart provide quite different results. The US Environmental Protection Agency (EPA) established the data quality objectives (DQO) process in the mid-1980's to establish decision performance criteria for data collection. EPA guidance (EPA G-4, for example) clearly distinguishes between DQOs and measurement performance objectives (MQOs) that should be addressed for laboratory analysis of samples. The language of DQOs and MQOs has become confused over time it seems, and the subsequent effects seem to include a lack of attention to decision performance and a routine approach to measurement quality. In order to better address radionuclide sample analysis when the concentrations are close to thresholds of concern, which might be zero for some radionuclides, background for others, and risk-based thresholds for yet others, it is important that routine laboratory analysis methods are adjusted, and that the project team and the laboratory work closely together to ensure that the data meets the MQO requirements of laboratory analysis and reporting of results, and that the MQOs effectively support project-specific DQOs. This basic approach will be applied in Los Alamos in the coming year to the collection of moisture data from underneath MDA T that will be analyzed for americium and neptunium isotopes. Proper understanding of the radiochemistry methods and reporting, and of appropriate statistical methods is critical to the success of such projects, ensuring that the right decisions are made. (authors)

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2023

Palladium-Percolated Networks Enabled by Low Loadings of Branched Nanorods for Enhanced H 2 Separations

Nanoparticles (NPs) at high loadings are often used in mixed matrix membranes (MMMs) to improve gas separation properties, but they can lead to defects and poor processability that impede membrane fabrication. Herein, it is demonstrated that branched nanorods (NRs) with controlled aspect ratios can significantly reduce the required loading to achieve superior gas separation properties while maintaining excellent processability, as demonstrated by the dispersion of palladium (Pd) NRs in polybenzimidazole for H 2 /CO 2 separation. Increasing the aspect ratio from 1 for NPs to 40 for NRs decreases the percolation threshold volume fraction by a factor of 30, from 0.35 to 0.011. An MMM with percolated networks formed by Pd NRs at a volume fraction of 0.039 exhibits H 2 permeability of 110 Barrer and H 2 /CO 2 selectivity of 31 when challenged with simulated syngas at 200 °C, surpassing Robeson's upper bound. In conclusion, this work highlights the advantage of NRs over NPs and nanowires and shows that right-sizing nanofillers in MMMs is critical to construct highly sieving pathways at minimal loadings. In conclusion, this work paves the way for this general feature to be applied across materials systems for a variety of chemical separations.

36 MATERIALS SCIENCE↗
DOE OSTI2024

Mortality of older construction and craft workers employed at Department of Energy (DOE) nuclear sites: Follow‐up through 2021

Background To determine if construction and trades workers formerly employed at US Department of Energy (DOE) nuclear weapons sites are at significant risk for occupational diseases, we studied the mortality experience of participants in the Building Trades National Medical Screening Program (BTMed). Methods The cohort included 26,922 participants enrolled between 1998 and 2021 and 8367 deaths. Standardized mortality ratios were calculated based on US death rates. Cox models compared construction workers (n = 22,747; 7487 deaths) to two nonconstruction subpopulations: administrative, scientific and security workers (n = 1894; 330 deaths), and all other nonconstruction workers (n = 2218; 550 deaths). Results Mortality was elevated for all causes, all cancers, cancers of the trachea, bronchus, lung, kidneys, and lymphatic and hematopoietic system, mesothelioma, chronic obstructive pulmonary disease (COPD), asbestosis, transportation injuries, and other injuries, particularly accidental poisonings. There were 167 deaths from coronavirus disease 2019 (COVID-19), which was lower than expected using US death rates. Overall cause-specific mortality was significantly higher among construction workers than for internal comparison groups. Conclusions Construction workers employed at DOE sites have a significantly increased risk for occupational illnesses. Apart from COVID-19 deaths, this update: (1) found that mortality among construction workers is significantly elevated compared to the US population and significantly higher than in the internal comparison populations, and (2) confirmed excess risk for these workers for first employment after 1990. Cancer mortality risks are similar to the cancers identified for DOE compensation from radiation exposures. In conclusion, the high lung cancer risk supports the value of early lung cancer detection. Continued medical surveillance is important.

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTAN↗
DOE OSTI2021

Surface Functionalization of Black Phosphorus with Nitrenes: Identification of P=N Bonds Using Isotopic Labeling

Abstract: Surface functionalization of two-dimensional crystals is a key path to tuning their intrinsic physical and chemical properties. However, synthetic protocols and experimental strategies to directly probe chemical bonding in modified surfaces are scarce. Introduced here is a mild, surface-specific protocol for the surface functionalization of few-layer black phosphorus nanosheets using a family of photolytically generated nitrenes (RN) from the corresponding azides. By embedding spectroscopic tags in the organic backbone, a multitude of characterization techniques are employed to investigate in detail the chemical structure of the modified nanosheets, including vibrational (infrared, Raman), Xray (emission, photoelectron), CPMAS NMR, and UV-vis spectroscopy. To directly probe the functional groups introduced on the surface, R fragments were selected such that in conjunction with vibrational spectroscopy, 15N-labeling experiments, and DFT methods, diagnostic P=N vibrational modes indicative of iminophosphorane units on the nanosheet surface could be conclusively identified.

Walz, Kendall↗
DOE OSTI2021

Subacute safety assessment of recombinant Lactococcus lactis on the gut microbiota of male Sprague–Dawley rats

Abstract BACKGROUND Lactococcus lactis strain pGSMT/MG1363 is a genetically modified microorganism (GMM) that constitutively expresses human metallothionein‐I fusion protein to combine with intracellular lead. Unlike traditional probiotics, pGSMT/MG1363 lacks a history of safe use in food. Administration of microorganism could influence the gut microbial community and consequently confer health benefits or cause disadvantages to the host. To date, little has been done to assess the influence of recombinant strain pGSMT/MG1363 on the stability of gut microbiota. RESULTS Liver, testis and kidney sections of male Sprague–Dawley rats orally administered pGSMT/MG1363 for 6 weeks showed normal structure and no pathological damage. There were no adverse effects on the analyzed serum biochemical parameters between the pGSMT/MG1363 group and the MG1363 group. Principal coordinate analysis showed that, compared with the MG1363 group, the 6‐week‐old fecal gut microbiota of rats fed with pGSMT/MG1363 was not significantly different (Adonis, P = 0.802). pGSMT/MG1363 treatment for 6 weeks did not significantly change the relative abundance of gut microbiota at the phylum and genus levels in comparison with MG1363 treatment. CONCLUSION Compared to the non‐GM strain MG1363 group, administration of the recombinant strain pGSMT/MG1363 for 6 weeks showed no adverse effects on the analyzed physiological parameters and gut microbial compositions of male Sprague–Dawley rats. The results suggested that, in terms of gut microbiota stability, pGSMT/MG1363 could be considered as safe as MG1363, at least for short‐term intake. Further toxicological evaluations still need to be considered before drawing a definite conclusion concerning the safe use of pGSMT/MG1363. © 2021 Society of Chemical Industry.

Chen, Guowei↗
DOE OSTI2022

Flaxseed oil ameliorates aging in d ‐galactose induced rats via altering gut microbiota and mitigating oxidative damage

Abstract BACKGROUND Aging causes decreased antioxidant capacity and chronic inflammation and may even elevate cancer risks. Previous studies reported that flaxseed oil (FO) can alleviate age‐related diseases, including improving alcoholic liver disease, atherosclerosis and diabetes. However, whether the intestinal microbiota accountable for this alleviation is still unknown. This study aims to study the antioxidant effects of FO in an aging rat model and the underlying mechanism between the intestinal microbiota and aging. RESULTS Our results presented that serum and liver antioxidant capacities in FO group were up‐regulated, and liver inflammation in FO group was reduced. The 16S rDNA sequencing showed that FO regulated the microbial community, including up‐regulation of four families of Lactobacillus and six families of Clostridium. In addition, FO had also adjusted the relative abundance of several genera such as Ruminococcaceae_UCG‐005 and Prevotella_9 , which may be the key bacteria associated with the aging process. Colonic transcriptome analysis showed that there were 1679 differentially expressed genes (DEGs) in the Model group and the FO group (134 up‐regulated and 1545 down‐regulated). Gene set enrichment analysis (GSEA) revealed FO down‐regulates the expression of the upstream genes Ptprc , Lck , Zap70 , Lat and Lcp2 in the T cell receptor signaling pathway. CONCLUSION In conclusion, FO improved antioxidant capacity and reduced intestinal microbial disturbances caused by aging damage, indicating that dietary FO has the potential to fight aging damage. This study provides a more comprehensive view of dietary intervention to improve aging. © 2022 Society of Chemical Industry.

Sun, Xiaoyan↗
DOE OSTI2025

Contrasting Chemical Kinetic Parameters for Near In‐Service‐Temperature Aging and High‐Temperature Thermal Decomposition of Triaminotrinitrobenzene Formulations

Triaminotrinitrobenzene-based high explosives such as LX-17 offer high energy density and exceptional safety, yet their long-term aging behavior at low temperatures remains poorly understood. In this study, several legacy and new production lots of LX-17 were subjected to accelerated aging experiments below 100°C, during which the formation rate of the initial degradation product, monofurazan (F1), was monitored. Kinetic analysis was performed using a sample-age-aware computational approach, yielding activation energy estimates of 82–91 kJ mol −1 for the low-temperature initiation step—markedly lower than the ∼200 kJ mol −1 associated with high-temperature thermal decomposition. Extrapolation from established cookoff models supports the conclusion that the dominant degradation mechanism at low temperatures differs from that at high temperatures. In conclusion, our results provide a unified kinetic framework that bridges the gap between in-service conditions and high-temperature damage.

Chemistry - Chemical explosives↗