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At least 217 records · Page 12

Altitude Performance of Modified J71 Afterburner with Revised Engine Operating Conditions

An investigation was conducted in an altitude test chamber at the NACA Lewis laboratory to determine the effect of a revision of the rated engine operating conditions and modifications to the afterburner fue1 system, flameholder, and shell cooling on the augmented performance of the J71-A-2 (x-29) turbo jet engine operating at altitude . The afterburner modifications were made by the manufacturer to improve the endurance at sea-level, high-pressure conditions and to reduce the afterburner shell temperatures. The engine operating conditions of rated rotational speed and turbine-outlet gas temperature were increased. Data were obtained at conditions simulating flight at a Mach number of 0.9 and at altitudes from 40,000 to 60,000 feet. The afterburner modifications caused a reduction in afterburner combustion efficiency. The increase in rated engine speed and turbine-outlet temperature coupled with the afterburner modifications resulted in the over-all thrust of the engine and afterburner being unchanged at a given afterburner equivalence ratio, while the specific fuel consumption was increased slightly. A moderate shift in the range of equivalence ratios over which the afterburner would operate was encountered, but the maximum operable altitude remained unaltered. The afterburner-shell temperatures were also slightly reduced because of the modifications to the afterburner.

Useller, James W.↗

Some Altitude Operational Characteristics of a Prototype Iroquois Turbojet Engine. COORD. NO. AF-P-6

The evaluation of the altitude operational characteristics was part of the over-all investigation of the early developmental Iroquois engine. Engine steady-state windmilling characteristics were evaluated over a range of flight Mach numbers from 0.48 to 1.72 at altitudes of 35,000 and 50,000 feet. Engine altitude ignition limits were obtained over a range of flight Mach numbers from 0.5 to 1.5 with the standard engine ignition system and also with an oxygen boost system. A short investigation of high-speed altitude reignition following combustor blowout was conducted.

Peters, Daniel J.↗

Pulsed Airborne Lidar Measurements of Atmospheric CO2 Column Absorption and Line Shapes from 3-13 km Altitudes

We have developed a lidar technique for measuring the tropospheric C02 concentrations as a candidate for NASA's planned ASCENDS mission. Our technique uses two pulsed laser transmitters allowing simultaneous measurement of a C02 absorption line in the 1570 nm band, 02 extinction in the Oxygen A-band and surface height and backscatter. The lidar measures the energy and time of flight of the laser echoes reflected from the atmosphere and surface. The lasers are stepped in wavelength across the C02 line and an 02 line region during the measurement. The receiver uses a telescope and photon counting detectors, and measures the background light and energies of the laser echoes from the surface along with scattering from any aerosols in the path. The gas extinction and column densities for the C02 and 02 gases are estimated from the ratio of the on- and off- line signals via the DIAL technique. Time gating is used to isolate the laser echo signals from the surface, and to reject laser photons scattered in the atmosphere. We have developed an airborne lidar to demonstrate the C02 measurement from the NASA Glenn Lear 25 aircraft. The airborne lidar steps the pulsed laser's wavelength across a selected C02 line with 20 steps per scan. The line scan rate is 450 Hz and laser pulse widths are I usec. The time resolved laser backscatter is collected by a 20 cm telescope, detected by a photomultiplier and is recorded by a photon counting system. We made initial airborne measurements on flights during October and December 2008. Laser backscatter and absorption measurements were made over a variety of land and water surfaces and through thin and broken clouds. Atmospheric C02 column measurements using the 1571.4, 1572.02 and 1572.33 nm C02 lines. Two flights were made above the DOE SGP ARM site at altitudes from 3-8 km. These nights were coordinated with DOE investigators who Hew an in-situ C02 sensor on a Cessna aircraft under the path. The increasing C02 line absorptions with altitudes were evident and comparison with in-situ measurements showed agreements to 6 ppm. This spring we improved the aircraft's nadir window. During July and August 2009 we made 9 additional 2 hour long flights and measured the atmospheric C02 absorption and line shapes using the 1572.33 nm C02 line. Measurements were made at stepped altitudes from 3-13 km over a variety of surface types in Nebraska, Illinois, the SGP ARM site, and near and over the Chesapeake Bay in North Carolina and Virginia. Strong laser signals and clear line shapes were observed at all altitudes, and some measurements were made through thin clouds. The flights over the ARM site were underflown with in-situ measurements made from the DOE Cessna. The Oklahoma and east coast t1ights were coordinated with a LaRC/ITT C02 lidar on the LaRC UC-12 aircraft, a LaRC in~situ C02 sensor, and the Oklahoma flights also included a JPL C02 lidar on a Twin Otter aircraft. Ed Browell and Gary Spiers led the LaRC and JPL teams. More details of the t1ights, measurements and analysis will be described in the presentation.

Abshire, J. B.↗

Pulsed Airborne Lidar Measurements of Atmospheric CO2 Column Absorption and Line Shapes from 3-13 km Altitudes

We have developed a pulsed lidar technique for measuring the tropospheric CO2 concentrations as a candidate for NASA's planned ASCENDS space mission. Our technique uses two pulsed laser transmitters allowing simultaneous measurement of a CO2 absorption line in the 1570 nm band, O2 extinction in the Oxygen A-band and surface height and backscatter. The lidar measures the energy and time of flight of the laser echoes reflected from the atmosphere and surface. The lasers are rapidly and precisely stepped in wavelength across the CO2 line and an O2 line region during the measurement. The direct detection receiver uses a telescope and photon counting detectors, and measures the background light and energies of the laser echoes from the surface along with scattering from any aerosols in the path. The gas extinction and column densities for the CO2 and O2 gases are estimated from the ratio of the on- and off- line signals via the DIAL technique. Time gating is used to isolate the laser echo signals from the surface, and to reject laser photons scattered in the atmosphere. The time of flight of the laser pulses are also used to estimate the height of the scattering surface and to identify cases of mixed cloud and ground scattering. We have developed an airborne lidar to demonstrate the CO2 measurement from the NASA Glenn Lear-25 aircraft. The airborne lidar steps the pulsed laser's wavelength across the selected CO2 line with 20 steps per scan. The line scan rate is 450 Hz, the laser pulse widths are 1 usec, and laser pulse energy is 24 uJ. The time resolved laser backscatter is collected by a 20 cm telescope, detected by a photomultiplier and is recorded by a photon counting system. We made initial airborne measurements on flights during fall 2008. Laser backscatter and absorption measurements were made over a variety of land and water surfaces and through thin clouds. The atmospheric CO2 column measurements using the 1572.33 nm CO2 lines. Two flights were made above the US Department of Energy's (DOE) SGP ARM site at altitudes from 3-8 km. These flights were coordinated with DOE investigators who flew an in-situ CO2 sensor on a Cessna aircraft under the path. The increasing CO2 line absorptions with altitudes were evident and comparison with in-situ measurements showed agreements to 6 ppm. In spring 2009 we improved the aircraft's nadir window and during July and August we made 9 additional 2 hour long flights and measured the atmospheric CO2 absorption and line shapes using the 1572.33 nm CO2 line. Measurements were made at stepped altitudes from 3-13 km over a variety of surface types in Nebraska, Illinois, the SGP ARM site, and near and over the Chesapeake Bay in North Carolina and eastern Virginia. Strong laser signals and clear CO2 line shapes were observed at all altitudes, and some measurements were made through thin clouds. The flights over the ARM site were underflown with in-situ measurements made from the DOE Cessna. Analysis shows that the average signal levels follow predicted values, the altimetry measurements had an uncertainty of about 4 m, and that the average optical line depths follow the number density calculated from in-situ sensor readings. The Oklahoma and east coast flights were coordinated with a LaRC/ITT CO2 lidar on the LaRC UC-12 aircraft, a LaRC in-situ CO2 sensor, and the Oklahoma flights also included a JPL CO2 lidar on a Twin Otter aircraft. More details of the flights, measurements, analysis and scaling to space will be described in the presentation.

Abshire, James↗

Characteristics of Deep Tropical and Subtropical Convection from Nadir-Viewing High-Altitude Airborne Doppler Radar

This paper presents observations of deep convection characteristics in the tropics and subtropics that have been classified into four categories: tropical cyclone, oceanic, land, and sea breeze. Vertical velocities in the convection were derived from Doppler radar measurements collected during several NASA field experiments from the nadir-viewing high-altitude ER-2 Doppler radar (EDOP). Emphasis is placed on the vertical structure of the convection from the surface to cloud top (sometimes reaching 18-km altitude). This unique look at convection is not possible from other approaches such as ground-based or lower-altitude airborne scanning radars. The vertical motions from the radar measurements are derived using new relationships between radar reflectivity and hydrometeor fall speed. Various convective properties, such as the peak updraft and downdraft velocities and their corresponding altitude, heights of reflectivity levels, and widths of reflectivity cores, are estimated. The most significant findings are the following: 1) strong updrafts that mostly exceed 15 m/s, with a few exceeding 30 m/s, are found in all the deep convection cases, whether over land or ocean; 2) peak updrafts were almost always above the 10-km level and, in the case of tropical cyclones, were closer to the 12-km level; and 3) land-based and sea-breeze convection had higher reflectivities and wider convective cores than oceanic and tropical cyclone convection. In addition, the high-resolution EDOP data were used to examine the connection between reflectivity and vertical velocity, for which only weak linear relationships were found. The results are discussed in terms of dynamical and microphysical implications for numerical models and future remote sensors.

Heymsfield, Gerald M.↗

Modeling Relativistic Electron Precipitation Bremsstrahlung X-Ray Intensities at 10-100 km Manned Vehicle Altitudes

Relativisitic electron precipitation (REP) events occur when beams or bunches of relativistic electrons of magnetospheric origin enter the Earth's atmosphere, typically at auroral latitudes. REP events are associated with a variety of space weather effects, including production of transitional and bremsstrahlung radiation, catalytic depletion of stratospheric ozone, and scintillation of transionospheric radio waves. This study examines the intensities of x‐rays produced at airliner, manned balloon, and space reuseable launch vehicles (sRLVs). The monoenergetic beam is modeled in cylindrical symetry using the paraxial ray equation. Bremsstrahlung photon production is calculated using the traditional Sauter‐Elwert cross‐section, providing x‐ray emission spectra differential in energy and angle. Attenuation is computed for a plane‐stratified standard atmosphere, and the loss processes include photoionization, Rayleigh and Compton scattering, electron‐positron pair production, and photonuclear interaction. Peak altitudes of electron energy deposition and bremsstrahlung x‐ray production were calculated for beams of energies from 1 MeV through 100 MeV. The altitude peak of bremsstrahlung deposition was consistently and significantly lower that that of the electron deposition due to the longer mean free paths of x‐rays compared to electrons within the atmosphere. For example, for a nadir‐directed monoenergetic 5 MeV beam, the peak deposition altitude was calculated to be 42 km, but the resulting bremsstrahlung deposition peaked at 25 km. This has implications for crew and passenger safety, especially with the growth of the space tourism industry. A survey of results covering the 1‐100 MeV spectrum for the three altitude ranges of interest will be presented.

Krause, L. Habsh↗

Altitude Compensating Nozzle

The dual-bell nozzle (fig. 1) is an altitude-compensating nozzle that has an inner contour consisting of two overlapped bells. At low altitudes, the dual-bell nozzle operates in mode 1, only utilizing the smaller, first bell of the nozzle. In mode 1, the nozzle flow separates from the wall at the inflection point between the two bell contours. As the vehicle reaches higher altitudes, the dual-bell nozzle flow transitions to mode 2, to flow full into the second, larger bell. This dual-mode operation allows near optimal expansion at two altitudes, enabling a higher mission average specific impulse (Isp) relative to that of a conventional, single-bell nozzle. Dual-bell nozzles have been studied analytically and subscale nozzle tests have been completed.1 This higher mission averaged Isp can provide up to a 5% increase2 in payload to orbit for existing launch vehicles. The next important step for the dual-bell nozzle is to confirm its potential in a relevant flight environment. Toward this end, NASA Marshall Space Flight Center (MSFC) and Armstrong Flight Research Center (AFRC) have been working to develop a subscale, hot-fire, dual-bell nozzle test article for flight testing on AFRC's F15-D flight test bed (figs. 2 and 3). Flight test data demonstrating a dual-bell ability to control the mode transition and result in a sufficient increase in a rocket's mission averaged Isp should help convince the launch service providers that the dual-bell nozzle would provide a return on the required investment to bring a dual-bell into flight operation. The Game Changing Department provided 0.2 FTE to ER42 for this effort in 2014.

Ruf, Joseph H.↗

Comparison of Mesospheric Winds From a High-Altitude Meteorological Analysis System and Meteor Radar Observations During the Boreal Winters of 2009-2010 and 2012-2013

We present a study of horizontal winds in the mesosphere and lower thermosphere (MLT) during the boreal winters of 2009-2010 and 2012-2013 produced with a new high-altitude numerical weather prediction (NWP) system. This system is based on a modified version of the Navy Global Environmental Model (NAVGEM) with an extended vertical domain up to approximately 116 km altitude coupled with a hybrid four-dimensional variational (4DVAR) data assimilation system that assimilates both standard operational meteorological observations in the troposphere and satellite-based observations of temperature, ozone and water vapor in the stratosphere and mesosphere. NAVGEM-based MLT analyzed winds are validated using independent meteor radar wind observations from nine different sites ranging from 69 deg N-67 deg S latitude. Time-averaged NAVGEM zonal and meridional wind profiles between 75 and 95 km altitude show good qualitative and quantitative agreement with corresponding meteor radar wind profiles. Wavelet analysis finds that the 3-hourly NAVGEM and 1-hourly radar winds both exhibit semi-diurnal, diurnal, and quasi-diurnal variations whose vertical profiles of amplitude and phase are also in good agreement. Wavelet analysis also reveals common time-frequency behavior in both NAVGEM and radar winds throughout the Northern extra tropics around the times of major stratospheric sudden warmings (SSWs) in January 2010 and January 2013, with a reduction in semi-diurnal amplitudes beginning around the time of a mesospheric wind reversal at 60 deg N that precedes the SSW, followed by an amplification of semi-diurnal amplitudes that peaks 10-14 days following the onset of the mesospheric wind reversal. The initial results presented in this study demonstrate that the wind analyses produced by the high altitude NAVGEM system accurately capture key features in the observed MLT winds during these two boreal winter periods.

McCormack, J.↗

Characterization of Atmospheric Turbulence as a Function of Altitude

A novel radical shape change approach (Aerodynamically Actuated Radical Shape Change concept) was developed at NASA Langley Research Center. The radical shape change enables cruise at a lowered altitude of 15-25,000 feet and yields substantial performance and environmental benefits. This lowered altitude has however raised concerns in the community due to past experience with decreased ride quality in this altitude range. This paper describes the analysis performed by the team to address this concern. First, the team assessed and quantified turbulence occurrence as a function of altitude. Secondly, the team analyzed the effects of turbulence gust loads on the proposed concept when compared to conventional aircraft.

Prasad, Suparnamaaya↗

Climatological Study of the Short-Term Variation of the 0 C, -10 C, and -20 C Altitude Levels over the Florida Spaceport

For evaluation of the potential of cloud electrification, it is necessary to know the altitude of the 0, -10 and -20 degree Celsius levels. Cape Canaveral Air Force Station has recorded balloon launch data back to 1989. In support of rocket launches, often multiple balloons are launched within minutes of each other in the 4-6 hours leading up to launch. In the past, temperature data from sondes was typically available every hour or so through the launch countdown, allowing for frequent updates of these critical temperature thresholds. Recently, launch customers are relying on Jimsphere and wind profiler data that do not have a thermodynamic component in the latter 4-6 hours of a countdown. This study compares the altitude differences of the 0, -10 and -20 degree Celsius levels from consecutive balloon pairs not to exceed 6 hours apart. The analysis uses 9685 soundings from 1989 to 2013. Approximately 5 of the time the altitude of the temperature level in question (0, -10, -20 degrees C), varies by more than 500 feet (operationally significant threshold) within 6 hours. This study analyzes the altitude variability as a function of several meteorological parameters, such as change in sonde type, dew point depression, and solar zenith angle. Additionally, the study concludes with impacts to launch operations.

Huddleston, Lisa L.↗

Fe(3): An Evaluation Tool for Low-Altitude Air Traffic Operations

The concepts of unmanned aircraft system traffic management (UTM) and urban air mobility (UAM) are introducing high-density operations in low altitude airspace in closer proximity to populated areas than conventional high-altitude air traffic. The Flexible engine for Fast-time Evaluation of Flight Environments (Fe (sup 3)) provides the capability of statistically analyzing the high-density, high-fidelity, and low-altitude traffic system under numerous scenarios, such that stake holders can study impacts of factors in the low-altitude high-density traffic system and define requirements, policies, and protocols needed to support a safe yet efficient traffic system, and even assess operational risks and optimize flight schedules without conducting infeasible and cost-prohibitive flight tests that involve a large volume of aerial vehicles. This work provides an introduction to this simulation tool including its architecture and various models involved. Its performance and sample application in UAM and UTM are also presented.

Collision Avoidance↗

Fe3: An Evaluation Tool for Low-Altitude Air Traffic Operations

The concepts of unmanned aircraft system traffic management (UTM) and urban air mobility (UAM) are introducing high-density operations in low altitude airspace in closer proximity to populated areas than conventional high-altitude air traffic. The Flexible engine for Fast-time Evaluation of Flight Environments (Fe (sup 3)) provides the capability of statistically analyzing the high-density, high-fidelity, and low-altitude traffic system under numerous scenarios, such that stake holders can study impacts of factors in the low-altitude high-density traffic system and define requirements, policies, and protocols needed to support a safe yet efficient traffic system, and even assess operational risks and optimize flight schedules without conducting infeasible and cost-prohibitive flight tests that involve a large volume of aerial vehicles. This work provides an introduction to this simulation tool including its architecture and various models involved. Its performance and sample application in UAM and UTM are also presented.

Trajectory Modeling↗

MAVEN Case Studies of Plasma Dynamics in Low‐Altitude Crustal Magnetic Field at Mars 1: Dayside Ion Spikes Associated With Radial Crustal Magnetic Fields

We report for the first time, simultaneous ion, electron, magnetic field vector and electric field wave measurements made possible by Mars Atmosphere and Volatile EvolutioN, during ion energy flux spikes in low‐altitude radial crustal magnetic fields on the Mars dayside. Observations show energetic electrons and ions (E > 25 eV) precipitating on magnetic field lines assumed as closed. Ions (E < 1.4 keV) display broad velocity distributions toward Mars, showing ions flowing from higher altitude possibly after magnetic reconnection or loss cone filling from pitch angle scattering effects. Precipitating ions (E < 1.4 keV) show nonadiabatic features depending on ion mass and energy and returning ions (E < 1.4 keV) show evidence of conserving the first adiabatic invariant in a mirror field. We observe magnetic field perturbations up to 60 nT, electric field wave amplitudes up to 38 mV/m, and brief periods of peaked electron spectra. At ∼175 km and at times Mars Atmosphere and Volatile EvolutioN is below the mirroring altitude of electrons, we observe mirroring and transverse heating of H+ ions alongside increased electric field wave amplitude fluctuations. It suggests field aligned potential drops result from different mirror altitudes of ions and electrons. Ions E > 1.4 keV (O+) occur as injected accelerated ion beams and ions heated after energization or deceleration. Energy dispersed kilo‐electron‐volt ions suggest a selection effect in radial magnetic fields for lower‐energy Marsward ions, compared to reflection of higher‐energy anti‐Sunward ions. Precipitating kilo‐electron‐volt ions show energy deposition rates of 3.6 ×10(exp -6) W/sq m and sputtering escape rates from precipitating O+ ions of 1.5 ×10(exp 5)/(sq cm.s) and 2.1 ×10(exp 6)/(sq cm.s) are calculated.

Plasma Dynamics↗

Estimating the Altitudes of Martian Water-Ice Clouds Above the Mars Science Laboratory Rover Landing Site

This study retrieved estimated altitudes of Martian water-ice clouds through a comparison of observations taken by the Mars Science Laboratory (MSL, Curiosity) rover and the Mars Regional Atmospheric Modelling System (MRAMS). The vertical pointing of a Zenith Movie (ZM) allows many wind velocities and directions to be measured when clouds are observed, however without a lidar onboard the altitude of these clouds cannot be directly determined. By simulating conditions at Gale Crater with MRAMS, wind properties found in ZMs can be correlated with model outputs to estimate cloud altitudes at Gale Crater from the surface for the first time. These results are evaluated to assess any diurnal and seasonal cloud altitude patterns above Gale crater.

Campbell, Charissa L.↗

High-Altitude ADS-B Flight Tests on a NASA ER-2 Research Airplane

Researchers at the National Aeronautics and Space Administration (NASA) Armstrong Flight Research Center (Edwards, California); the Federal Aviation Administration (FAA); and Regulus Group, LLC (Atlantic City, New Jersey) collaborated for the flight-test demonstration of an Automatic Dependent Surveillance-Broadcast (ADS-B) system equipped on a high-altitude Earth Resources-2 (ER-2) research airplane. The unique ER-2 airplane is a NASA-owned and operated airborne science version of the United States Air Force / Lockheed Martin Aeronautics (Bethesda, Maryland) U-2S airplane. The FAA has mandated that by the year 2020, aircraft operating within certain sections of the United States National Airspace system be equipped with ADS-B Out technology; the research presented in this paper is the first to show how the NASA ADS-B architecture satisfies the mandate for a unique high-altitude aircraft. An exceptional military aircraft design, security protocols, and the performance envelope of the ER-2 airplane made the avionics integration remarkably challenging. The design required the ADS-B avionics to survive the harsh flight environment of the ER-2 airplane. The most prominent challenge was the functional integration of modern civilian avionics into federated military legacy avionics. Flight-test objectives were to certify an ADS-B Out (1090ES) passive surveillance integrated with a Traffic Alert and Collision Avoidance System (TCAS) I active surveillance system on an ER-2 platform for high-altitude cruise operations. In April 2022, NASA conducted three flights at Edwards Air Force Base (Edwards, California) - each greater than one-hour flight reaching altitudes above 60,000 ft.

ADS-B↗

The effect of exercise and rest duration on the generation of venous gas bubbles at altitude

BACKGROUND: Decompression, as occurs with aviators and astronauts undergoing high altitude operations or with deep-sea divers returning to surface, can cause gas bubbles to form within the organism. Pressure changes to evoke bubble formation in vivo during depressurization are several orders of magnitude less than those required for gas phase formation in vitro in quiescent liquids. Preformed micronuclei acting as "seeds" have been proposed, dating back to the 1940's. These tissue gas micronuclei have been attributed to a minute gas phase located in hydrophobic cavities, surfactant-stabilized microbubbles, or arising from musculoskeletal activity. The lifetimes of these micronuclei have been presumed to be from a few minutes to several weeks. HYPOTHESIS: The greatest incidence of venous gas emboli (VGE) will be detected by precordial Doppler ultrasound with depressurization immediately following lower extremity exercise, with progressively reduced levels of VGE observed as the interval from exercise to depressurization lengthens. METHODS: In a blinded cross-over design, 20 individuals (15 men, 5 women) at sea level exercised by performing knee-bend squats (150 knee flexes over 10 min, 235-kcal x h(-1)) either at the beginning, middle, or end of a 2-h chair-rest period without an oxygen prebreathe. Seated subjects were then depressurized to 6.2 psia (6,706 m or 22,000 ft altitude equivalent) for 120 min with no exercise performed at altitude. RESULTS: Of the 20 subjects with VGE in the pulmonary artery, 10 demonstrated a greater incidence of bubbles with exercise performed just prior to depressurization, compared with decreasing bubble grades and incidence as the interval of rest increased prior to depressurization. No decompression illness was reported. CONCLUSIONS: There is a significant increase in decompression-induced bubble formation at 6.2 psia when lower extremity exercise is performed just prior to depressurization as compared with longer rest intervals. Analysis indicated that micronuclei half-life is on the order of an hour under these hypobaric conditions.

Controlled Clinical Trial↗

Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass

BACKGROUND: Studies of space-flight anemia have uncovered a physiologic process, neocytolysis, by which young red blood cells are selectively hemolyzed, allowing rapid adaptation when red cell mass is excessive for a new environment. OBJECTIVES: 1) To confirm that neocytolysis occurs in another situation of acute plethora-when high-altitude dwellers with polycythemia descend to sea level; and 2) to clarify the role of erythropoietin suppression. DESIGN: Prospective observational and interventional study. SETTING: Cerro de Pasco (4380 m) and Lima (sea level), Peru. PARTICIPANTS: Nine volunteers with polycythemia. INTERVENTIONS: Volunteers were transported to sea level; three received low-dose erythropoietin. MEASUREMENTS: Changes in red cell mass, hematocrit, hemoglobin concentration, reticulocyte count, ferritin level, serum erythropoietin, and enrichment of administered(13)C in heme. RESULTS: In six participants, red cell mass decreased by 7% to 10% within a few days of descent; this decrease was mirrored by a rapid increase in serum ferritin level. Reticulocyte production did not decrease, a finding that establishes a hemolytic mechanism.(13)C changes in circulating heme were consistent with hemolysis of young cells. Erythropoietin was suppressed, and administration of exogenous erythropoietin prevented the changes in red cell mass, serum ferritin level, and(13)C-heme. CONCLUSIONS: Neocytolysis and the role of erythropoietin are confirmed in persons with polycythemia who descend from high altitude. This may have implications that extend beyond space and altitude medicine to renal disease and other situations of erythropoietin suppression, hemolysis, and polycythemia.

Non-NASA Center↗

Testing of hypotheses about altitude decompression sickness by statistical analyses

This communication extends a statistical analysis of forced-descent decompression sickness at altitude in exercising subjects (J Appl Physiol 1994; 76:2726-2734) with a data subset having an additional explanatory variable, rate of ascent. The original explanatory variables for risk-function analysis were environmental pressure of the altitude, duration of exposure, and duration of pure-O2 breathing before exposure; the best fit was consistent with the idea that instantaneous risk increases linearly as altitude exposure continues. Use of the new explanatory variable improved the fit of the smaller data subset, as indicated by log likelihood. Also, with ascent rate accounted for, replacement of the term for linear accrual of instantaneous risk by a term for rise and then decay made a highly significant improvement upon the original model (log likelihood increased by 37 log units). The authors conclude that a more representative data set and removal of the variability attributable to ascent rate allowed the rise-and-decay mechanism, which is expected from theory and observations, to become manifest.

NASA Center JSC↗