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At least 217 records · Page 12
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Circulating SARS-CoV-2 + megakaryocytes are associated with severe viral infection in COVID-19

Several independent lines of evidence suggest that megakaryocytes are dysfunctional in severe COVID-19. Herein, we characterized peripheral circulating megakaryocytes in a large cohort of inpatients with COVID-19 and correlated the subpopulation frequencies with clinical outcomes. Using peripheral blood, we show that megakaryocytes are increased in the systemic circulation in COVID-19, and we identify and validate S100A8/A9 as a defining marker of megakaryocyte dysfunction. We further reveal a subpopulation of S100A8/A9 + megakaryocytes that contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein and RNA. Using flow cytometry of peripheral blood and in vitro studies on SARS-CoV-2–infected primary human megakaryocytes, we demonstrate that megakaryocytes can transfer viral antigens to emerging platelets. Mechanistically, we show that SARS-CoV-2–containing megakaryocytes are nuclear factor κB (NF-κB)-activated, via p65 and p52; express the NF-κB–mediated cytokines interleukin-6 (IL-6) and IL-1β; and display high surface expression of Toll-like receptor 2 (TLR2) and TLR4, canonical drivers of NF-κB. In a cohort of 218 inpatients with COVID-19, we correlate frequencies of megakaryocyte subpopulations with clinical outcomes and show that SARS-CoV-2–containing megakaryocytes are a strong risk factor for mortality and multiorgan injury, including respiratory failure, mechanical ventilation, acute kidney injury, thrombotic events, and intensive care unit admission. Furthermore, we show that SARS-CoV-2 + megakaryocytes are present in lung and brain autopsy tissues from deceased donors who had COVID-19. To our knowledge, this study offers the first evidence implicating SARS-CoV-2 + peripheral megakaryocytes in severe disease and suggests that circulating megakaryocytes warrant investigation in inflammatory disorders beyond COVID-19.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2020

Computational Fluid Dynamics Analysis of a 12 MW Circulating Fluidized Bed Rise

A three-dimensional (3D) two fluid model (TFM) model of the 12 MW circulating fluidized bed (CFB) riser at Chalmers University was developed using the open-source Multiphase Flow with Interphase eXchanges (MFiX) Software Suite. The hydrodynamic behavior of the riser was validated by comparing axial pressure profiles from experimental measurements with the results from the simulations. Under some of the operating conditions where there was no external circulation of solids, the pressure profiles from the simulation matched well with the experimental measurements. For the cases where there was external circulation of solids, the pressure profiles with the monodisperse solid phase modeling underpredicted the solids concentration in the freeboard region. With the inclusion of polydispersity in the model, the predicted pressure profiles agreed well with the experimental measurements. A two-dimensional (2D) model of the riser was used to perform simulations of coal combustion. The predicted flue gas outlet compositions of oxygen and carbon dioxide compared reasonably to experiments. The experiments also reported some concentration of carbon monoxide which was overpredicted in the simulations. Additional experimental data such as axial oxygen concentration profile and pressure profiles were also compared with the experiment. It was observed that the oxygen concentration in the bottom bed from the simulations was higher than in the experiments, which suggested that most of the oxidation reactions occurred in the bottom bed. The concentration of volatiles and char in the simulations was lower in the bottom bed than in the experiments, which suggest that there is not sufficient penetration of the solid phase species into the bed.

20 FOSSIL-FUELED POWER PLANTS↗
DOE OSTI2024

The Role of Deep Convection and Large-scale Circulation in Driving Model Spread in Low Cloud Feedback and Equilibrium Climate Sensitivity

This project aims to advance the understanding of the processes that drive the large uncertainties in climate change projections, use observations to constrain model physics and reduce the inter-model spread in equilibrium climate sensitivity (ECS). There are three major goals: 1) Characterize the representation of the physical pathways that link deep convection, large-scale circulation and low cloud feedback in CMIP6 model simulations and determine the relative contribution of each pathway to the CMIP6 model spread in low cloud feedback and ECS; 2) Use process-oriented diagnostics and multiple observations to evaluate CMIP6 model performance in capturing the observed cloud-circulation relation and deep convection characteristics including convective transition statistics and the bulk properties of mesoscale convective systems (MCSs). Error decomposition in CMIP6 models will be performed. 3) Conduct E3SM short-range hindcasts following the DOE Cloud-Associated Parameterizations Testbed (CAPT) protocol to pinpoint specific model parameters/processes that are crucial to the representation of deep convection, circulation, clouds and the pathways that connect them. We will modify convective parameters in E3SM and analyze the perturbed physics experiments (PPEs) to isolate model parameters that are critical to the uncertainty of ECS.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2022

Identification of a new circulating recombinant form of human immunodeficiency virus type 1, CRF124_cpx involving subtypes A, G, H, and CRF27_cpx in Angola

Angola, located in Central Africa, has around 320,000 (270,000–380,000) people living with human immunodeficiency virus (HIV)/AIDS, equivalent to 1% of the country’s population at the end of 2021. A previous study conducted in 2012, using Angolan samples collected between 2008 and 2010 revealed a high prevalence of HIV-1 recombinants, around 42% of sequences, with 21% showing the same UH profile in partial pol region which were grouped into a monophyletic cluster with high bootstrap support. Thus, the objective of the present work was to obtain complete genomes of those sequences and characterize them, aiming at a description of a new circulating recombinant form (CRF). Whole blood from nine HIV-1 UH pol -infected individuals had their genomic DNA extracted, and nested PCR was used to amplify seven overlapping fragments targeting the full-length HIV-1 genome. The final classification was based on maximum likelihood trees, and recombination analyses were performed using a bootscan from the Simplot program. BLAST and Los Alamos Database inspections were used to search other similar H-like pol sequences. Complete genome amplification was possible for three samples, partial genomes were obtained for the other three, and only pol was available for the remaining three sequences. Bootscan analysis of the two whole-genome and three partial genome sequences retrieved from people living with HIV/AIDS (PLHIVA) without epidemiological linkage showed the same complex recombination profile involving HIV-1 subtypes A/G/H/CRF27_cpx, with a total of six recombinant breakpoints, aiming to classify a new HIV-1 CRF124_cpx. We found no other full-length HIV-1 genomes with the same mosaic profile; however, we identified 33 partial pol sequences, mainly sampled from Angola between 2001 to 2019, with the same H-like profile. Bayesian analysis of H and H-like pol sequences indicates that CRF124_cpx probably originated in Angola at mid-1970s, indicating that this CRF has been circulating in the country for a long time. In summary, our study describes a new CRF circulating principally in Angola and highlights the importance of continuing molecular surveillance studies, especially in countries with high molecular diversity of HIV.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2023

Analysis of Fire-Induced Circulations during the FireFlux2 Experiment

Despite recent advances in both coupled fire modeling and measurement techniques to sample the fire environment, the fire–atmosphere coupling mechanisms that lead to fast propagating wildfires remain poorly understood. This knowledge gap adversely affects fire management when wildland fires propagate unexpectedly rapidly and shift direction due to the fire impacts on local wind conditions. In this work, we utilized observational data from the FireFlux2 prescribed burn and numerical simulations performed with a coupled fire–atmosphere model WRF-SFIRE to assess the small-scale impacts of fire on local micrometeorology under moderate wind conditions (10–12 m/s). The FireFlux2 prescribed burn provided a comprehensive observational dataset with in situ meteorological observations as well as IR measurements of fire progression. To directly quantify the effects of fire–atmosphere interactions, two WRF-SFIRE simulations were executed. One simulation was run in a two-way coupled mode in which the heat and moisture fluxes emitted from the fire were injected into the atmosphere, and the other simulation was performed in a one-way coupled mode for which the atmosphere was not affected by the fire. The difference between these two simulations was used to analyze and quantify the fire impacts on the atmospheric circulation at different sections of the fire front. The fire-released heat fluxes resulted in vertical velocities as high as 10.8 m/s at the highest measurement level (20 m above ground level) gradually diminishing with height and dropping to 7.9 m/s at 5.77 m. The fire-induced horizontal winds indicated the strongest fire-induced flow at the lowest measurement levels (as high as 3.3 m/s) gradually decreasing to less than 1 m/s at 20 m above ground level. The analysis of the simulated flow indicates significant differences between the fire-induced circulation at the fire head and on the flanks. The fire-induced circulation was much stronger near the fire head than at the flanks, where the fire did not produce particularly strong cross-fire flow and did not significantly change the lateral fire progression. However, at the head of the fire the fire-induced winds blowing across the front were the strongest and significantly accelerated fire progression. The two-way coupled simulation including the fire-induced winds produced 36.2% faster fire propagation than the one-way coupled run, and more realistically represented the fire progression.

Benik, Jeremy T.↗
DOE OSTI2022

Local-thermal-gradient and large-scale-circulation impacts on turbine-height wind speed forecasting over the Columbia River Basin

Abstract. We investigate the sensitivity of turbine-height wind speed forecast to initial condition (IC) uncertainties over the Columbia River Gorge (CRG) and Columbia River Basin (CRB) for two typical weather phenomena, i.e., local-thermal-gradient-induced marine air intrusion and a cold frontal passage. Four types of turbine-height wind forecast anomalies and their associated IC uncertainties related to local thermal gradients and large-scale circulations are identified using the self-organizing map (SOM) technique. The four SOM types are categorized into two patterns, each accounting for half of the ensemble members. The first pattern corresponds to IC uncertainties that alter the wind forecast through a modulating weather system, which produces the strongest wind anomalies in the CRG and CRB. In the second pattern, the moderate uncertainties in local thermal gradient and large-scale circulation jointly contribute to wind forecast anomaly. We analyze the cross section of wind and temperature anomalies through the gorge to explore the evolution of vertical features of each SOM type. The turbine-height wind anomalies induced by large-scale IC uncertainties are more concentrated near the front. In contrast, turbine-height wind anomalies induced by the local IC thermal uncertainties are found above the surface thermal anomalies. Moreover, the wind forecast accuracy in the CRG and CRB is limited by IC uncertainties in a few specific regions, e.g., the 2 m temperature within the basin and large-scale circulation over the northeast Pacific around 140∘ W.

17 WIND ENERGY↗
NASA NTRS1972

Circulation of Prince William Sound

The author has identified the following significant results. Visual examination of the available ERTS-1 and NASA NP-3 aircraft imagery has suggested that sediment-laden plumes from rivers may be useful in tracking surface circulation over the regions where these plumes retain their visible identities. Plumes of ice derived from tidewater glaciers are highly visible on the ERTS-1 imagery, but are generally of too small an areal extent to be useful in tracing surface circulation. Shore-fast ice is also highly visible on the ERTS-1 data. Practical scientific results include a corroboration of the westward flow just offshore in the Gulf of Alaska with inflow through Hinchinbrook Entrance into Prince William Sound. The tracer in this case was the Copper River Plume, which originates at the mouth of the Copper River east of Prince William Sound. A single partial image of Port Valdez, in northeastern Prince William Sound, suggests by the visible suspended sediment distribution that surface circulation there was cyclonic, as deduced previously from oceanographic baseline data. Surf along the shoreline of the Gulf of Alaska is highly visible on ERTS-1 imagery.

Muench, R. D.↗
NASA NTRS1974

The influence of surface waves on water circulation in a mid-Atlantic continental shelf region

The importance of wave-induced currents in different weather conditions and water depths (18.3 m and 36.6 m) is assessed in a mid-Atlantic continental-shelf region. A review of general circulation conditions is conducted. Factors which perturb the general circulation are examined using analytic techniques and limited experimental data. Actual wind and wave statistics for the region are examined. Relative magnitudes of the various currents are compared on a frequency of annual occurrence basis. Results indicated that wave-induced currents are often the same order of magnitude as other currents in the region and become more important at higher wind and wave conditions. Wind-wave and ocean-swell characteristics are among those parameters which must be monitored for the analytical computation of continental-shelf circulation.

Whitlock, C. H.↗
NASA NTRS1977

Dynamics, winds, circulation and turbulence in the atmosphere of Venus

With the possible exception of the lowest one or two scale heights, the dominant mode of circulation of Venus' atmosphere is a rapid, zonal, retrograde motion. Global albedo variations in the ultraviolet may reflect planetary scale waves propagating relative to the zonal winds. Other special phenomena such as cellular convection in the subsolar region and internal gravity waves generated in the interaction of the zonal circulation with the subsolar disturbance may also be revealed in ultraviolet imagery of the atmosphere. We discuss the contributions of experiments on the Orbiter and Entry Probes of Pioneer Venus toward unravelling the mystery of the planet's global circulation and the role played by waves, instabilities and convection therein

Schubert, G.↗
NASA NTRS1978

The zonally averaged circulation of the middle atmosphere

The steady-state, zonally averaged circulation of the middle atmosphere (15-125 km) is studied with a quasigeostrophic, numerical model that explicitly includes a self-consistent calculation of solar radiative heating due to O2 and O3 absorption, Newtonian cooling, Rayleigh friction, tropopause boundary conditions based on climatological averages, and the effects of vertically propagating planetary waves. It is found that the direct, radiatively driven pole-to-pole circulation at solstice is sufficient to account for the cold summer mesopause and warm isothermal winter mesosphere with associated zonal jets of realistic magnitude. The climatological heat and momentum fluxes associated with planetary wavenumber 2 have a negligible effect on the mean circulation. With planetary wavenumber 1, no steady-state solution could be obtained due to the formation of easterlies and hence critical layers in the winter mesosphere. The radiative heating associated with secondary peaks in the O3 density at the mesopause could render the polar mesopause region convectively unstable.

Schoeberl, M. R.↗
NASA NTRS1979

Numerical simulation of ozone production, transport and distribution with a global atmospheric general circulation model

The production, transport, and distribution of ozone are simulated for a January with a global atmospheric general circulation model. In this model, the ozone influences the radiational heating and the photochemical ozone production and destruction, the radiational heating influences the atmospheric circulation, and the circulation redistributes the ozone. The model has simulated the synoptic and time-averaged observed large-scale fields of temperature, mass, and velocity in the troposphere and stratosphere, although with deficiencies which are seen in the time-averaged O3 distribution. Transport of ozone in the summer and winter hemispheres, in different seasons, and in various latitudes is discussed, and it is concluded that the divergence of the ozone transport maintains it below its photochemical equilibrium concentration in the tropics and subtropics, and the convergence of the ozone transport maintains it above its photochemical equilibrium concentration in the middle and high latitudes of both hemispheres. Thus, both the atmospheric motions and the O3 photochemistry determine the O3 sources and sinks.

Schlesinger, M. E.↗
NASA NTRS1980

Computer-aided design of stripline ferrite junction circulators

A general design procedure is presented for stripline Y-junction circulators employing solid dielectric between ground planes. The resonator design and impedance matching are derived in a form suitable for computer evaluation. The procedure is applicable to cases where either the circulator bandwidth or the ground plane spacing is specified. An experimental S-band switching circulator design illustrates the technique.

Uzdy, Z.↗
NASA NTRS1981

On the dynamics of droughts in northeast Brazil - Observations, theory and numerical experiments with a general circulation model

The establishment of a thermally direct local circulation which has its ascending branch at about 10 deg N and its descending branch over northeast Brazil and the adjoining oceanic region is proposed as a possible mechanism for the occurrence of severe droughts over this Brazilian region. The driving for this anomalous circulation is provided by enhanced moist convection due to the effect of warmer sea surface anomalies over the northern tropical Atlantic and cooling associated with colder sea surface temperature anomalies in the southern tropical Atlantic. A simple primitive equation model is used to calculate the frictionally-controlled and thermally-driven circulation due to a prescribed heating function in a resting atmosphere, and a series of numerical experiments are carried out to test the sensitivity of the Goddard Laboratory's model to prescribed sea surface temperature anomalies over the tropical Atlantic.

Moura, A. D.↗
NASA NTRS1982

Zonal mean circulation at the cloud level on Venus - Spring and fall 1979 OCPP observations

Independent observations are presented of the zonal mean circulation deduced from the Pioneer Venus Orbiter images which substantiate the somewhat different circulation in the Venus atmosphere at the time of Pioneer observations. The most reassuring result from the present investigation is that measurements made by different individuals on the same set of images yield virtually the same zonal mean statistics for the cloud top circulation of Venus. The mean zonal component is about -95 m/sec at the equator, corresponding to a rotational period of about 4.8 days. The period of rotation increases to about 4.2 days for latitude regions 35-45 deg south and 25-40 deg north. The mean meridional motion is toward the northern pole north of 5 deg south latitude and toward the southern pole south of this latitude.

Limaye, S. S.↗
NASA NTRS1983

General circulation and the dynamical state of the Venus atmosphere

The principal mode of atmospheric circulation on Venus is a zonal retrograde superrotation of the entire atmosphere, from the lowest scale height to altitudes of more than 100 km, with an angular momentum that is about 0.15 percent of the solid planet angular momentum. These values suggest the possibility of significant angular momentum exchanges between the two reservoirs, yielding day length changes that may be of the order of hours and could therefore be detected by earth-based radar. Eddies, the mean meridional circulation, and planetary-scale waves may all be involved in the upward transport of retrograde angular momentum to maintain atmospheric counterrotation. Eddies have been observed in the lower atmoshere and may also transport heat and momentum latitudinally and vertically. Waves are present throughout the atmosphere, over a wide range of spatial scales. The mean zonal and meridional circulations may not be symmetric about the equator.

Schubert, G.↗
NASA NTRS1983

Ozone transport by diabatic and planetary wave circulations on a beta plane

A beta plane model is used to study the transport of ozone and a tracer distributed like ozone. In the first experiment, ozone is transported with a time dependent diabatic circulation in a beta channel. Increase in the ozone column density occurs principally through downward advection from the high altitude source region into the lower stratosphere. Compared with observations, the maximum in the total ozone field occurs too late and is too large. Transient planetary waves produce large temporary increases in total ozone near the pole during sudden warming events, but permanent increases are much smaller. Warmings which penetrate below the chemical transition region (major warmings) are most effective in changing the zonal mean ozone distribution. Combining the sudden warming and diabatic circulations simulates many of the observed features of the seasonal changes in total ozone at high latitudes. The diabatic circulation provides the major enhancement of the ozone column density while the transient planetary waves move ozone to high latitudes. This result suggests sudden warmings can play an important role in our understanding of the fluctuations in total ozone, and the final warming may be the key event which determines the date and magnitude of the spring maximum.

Rood, R. B.↗
NASA NTRS1983

Oceanic mesoscale variability and general circulation from satellite altimetry: A status report

Progress on the applications of satellite altimetry from SEASAT and Geos-3 to the study of oceanic mesoscale variability and general circulation is reviewed. The major conclusion for the applications to mesoscale variability is that an optimally designed altimetric mission with a lifetime of several years will improve our knowledge of the global mesoscale variability to an extent unattainable by any other practical means. The proposed Topex mission will allow one to view the global oceanic variability in such a wide range of periods and wavelengths: from 20 days to 3 to 5 years; from 50 to 10,000 km. However, the goal of determining the general circulation cannot be achieved by a single altimetric mission, because a highly accurate geoid needs to be determined independently. The scenario of the combination of Topex with Gravsat, a gravity mission that will give accurate geoid information, will allow the global general circulation to be determined at scales as small as 100 km. Areas of research needing to be performed with existing altimeter data are also discussed.

Fu, L. L.↗
NASA NTRS1983

Recent progress in the application of satellite altimetry to observing the mesoscale variability and general circulation of the oceans

The application of GEOS-3 and Seasat altimeter data to the study of mesoscale variability and general circulation in the oceans is discussed in a survey of recent investigations. Seasat provided much more accurate measurements, but lasted only 3.5 months (compared to 3.5 years for GEOS-3). General-circulation studies are shown to be strongly dependent on an accurate geoid, which has not yet been developed; hence even large-wave-length (7000-km) mapping is of limited value. Geoid-independent methods allow the global mapping of mesoscale sea-surface height and geostrophic current and the analysis of their distribution in wavenumber space, at least to the limits allowed by the accuracy of the instruments. These studies demonstrate the feasibility of future satellite-altimeter measurements of variability over a wide range of periods and wavelengths, which if combined with improved mapping of the earth's gravity field) would permit the determination of the general circulation on scales as small as 200 km.

Fu, L.-L.↗