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At least 217 records · Page 12

Submillimeter Confocal Imaging Active Module

The term submillimeter confocal imaging active module (SCIAM) denotes a proposed airborne coherent imaging radar system that would be suitable for use in reconnaissance, surveillance, and navigation. The development of the SCIAM would include utilization and extension of recent achievements in monolithic microwave integrated circuits capable of operating at frequencies up to and beyond a nominal radio frequency of 340 GHz. Because the SCIAM would be primarily down-looking (in contradistinction to primarily side-looking), it could be useful for imaging shorter objects located between taller ones (for example, objects on streets between buildings). The SCIAM would utilize a confocal geometry to obtain high cross-track resolution, and would be amenable to synthetic-aperture processing of its output to obtain high along-track resolution. The SCIAM (see figure) would include multiple (two in the initial version) antenna apertures, separated from each other by a cross-track baseline of suitable length (e.g., 1.6 m). These apertures would both transmit the illuminating radar pulses and receive the returns. A common reference oscillator would generate a signal at a controllable frequency of (340 GHz + (Delta)f)/N, where (Delta)f is an instantaneous swept frequency difference and N is an integer. The output of this oscillator would be fed to a frequency- multiplier-and-power-amplifier module to obtain a signal, at 340 GHz + (Delta)f, that would serve as both the carrier signal for generating the transmitted pulses and a local-oscillator (LO) signal for a receiver associated with each antenna aperture. Because duplexers in the form of circulators or transmit/receive (T/R) switches would be lossy and extremely difficult to implement, the antenna apertures would be designed according to a spatial-diplexing scheme, in which signals would be coupled in and out via separate, adjacent transmitting and receiving feed horns. This scheme would cause the transmitted and received beams to be aimed in slightly different directions, and, hence, to not overlap fully on the targets on the ground. However, a preliminary analysis has shown that the loss of overlap would be small enough that the resulting loss in signal-to-noise ratio (SNR) would be much less than the SNR loss associated with the use of a 340-GHz T/R switch.

Hong, John↗

A modular suite of hardware enabling spaceflight cell culture research

BioServe Space Technologies, a NASA Research Partnership Center (RPC), has developed and operated various middeck payloads launched on 23 shuttle missions since 1991 in support of commercial space biotechnology projects. Modular cell culture systems are contained within the Commercial Generic Bioprocessing Apparatus (CGBA) suite of flight-qualified hardware, compatible with Space Shuttle, SPACEHAB, Spacelab and International Space Station (ISS) EXPRESS Rack interfaces. As part of the CGBA family, the Isothermal Containment Module (ICM) incubator provides thermal control, data acquisition and experiment manipulation capabilities, including accelerometer launch detection for automated activation and thermal profiling for culture incubation and sample preservation. The ICM can accommodate up to 8 individually controlled temperature zones. Command and telemetry capabilities allow real-time downlink of data and video permitting remote payload operation and ground control synchronization. Individual cell culture experiments can be accommodated in a variety of devices ranging from 'microgravity test tubes' or standard 100 mm Petri dishes, to complex, fed-batch bioreactors with automated culture feeding, waste removal and multiple sample draws. Up to 3 levels of containment can be achieved for chemical fixative addition, and passive gas exchange can be provided through hydrophobic membranes. Many additional options exist for designing customized hardware depending on specific science requirements.

manned↗

Progress in Acoustic Transmission of Power through Walls

A document presents updated information on implementation of the wireless acoustic-electric feed-through (WAEF) concept, which was reported in Using Piezoelectric Devices To Transmit Power Through Walls (NPO-41157), NASA Tech Briefs, Vol. 32, No. 6 (June 2008), page 70. To recapitulate: In a basic WAEF setup, a transmitting piezoelectric transducer on one side of a wall is driven at resonance to excite ultrasonic vibrations in the wall. A receiving piezoelectric transducer on the opposite side of the wall converts the vibrations back to an ultrasonic AC electric signal, which is then detected and otherwise processed in a manner that depends on the modulation (if any) applied to the signal and whether the signal is used to transmit power, data, or both. The present document expands upon the previous information concerning underlying physical principles, advantages, and potential applications of WAEF. It discusses the design and construction of breadboard prototype piezoelectric transducers for WAEF. It goes on to present results of computational simulations of performance and results of laboratory tests of the prototypes. In one notable test, a 100-W light bulb was lit by WAEF to demonstrate the feasibility of powering a realistic load.

Sherrit,Stewart↗

Low cost solar array project. Cell and module formation research area. Process research of non-CZ silicon material

Liquid diffusion masks and liquid dopants to replace the more expensive CVD SiO2 mask and gaseous diffusion processes were investigated. Silicon pellets were prepared in the silicon shot tower; and solar cells were fabricated using web grown where the pellets were used as a replenishment material. Verification runs were made using the boron dopant and liquid diffusion mask materials. The average of cells produced in these runs was 13%. The relationship of sheet resistivity, temperature, gas flows, and gas composition for the diffusion of the P-8 liquid phosphorus solution was investigated. Solar cells processed from web grown from Si shot material were evaluated, and results qualified the use of the material produced in the shot tower for web furnace feed stock.

Source record↗

TDM/FM/FDMA - A modulation technique for multiple-beam satellites which precludes cochannel interference and allows non-uniform geographic distribution of user channels

The technique outlined in this paper is intended to eliminate the problems of cochannel interference and uniform geographic distribution of user channels which arise in conventional designs for a multiple spot beam communication satellite to serve mobile telephony users across the CONUS. By time multiplexing FM/FDMA signal ensembles so that only those beams operating on distinct frequency subbands are allowed to transmit concurrently, cochannel interference arising from simultaneous frequency subband reuse is precluded. Thus, time disjoint frequency reuse is accomplished over a repetitive sequence of fixed time slots. By assigning different size subbands to each time slot, a market of nonuniform users can be accommodated. The technique results in a greatly simplified antenna feed system design for the satellite, at a cost of imposing the need for time slot synchronization on the mobile FM receivers whose ability for rejecting adjacent channel interference is somewhat diminished.

Springett, J. C.↗

Loss tolerant speech decoder for telecommunications

A method and device for extrapolating past signal-history data for insertion into missing data segments in order to conceal digital speech frame errors. The extrapolation method uses past-signal history that is stored in a buffer. The method is implemented with a device that utilizes a finite-impulse response (FIR) multi-layer feed-forward artificial neural network that is trained by back-propagation for one-step extrapolation of speech compression algorithm (SCA) parameters. Once a speech connection has been established, the speech compression algorithm device begins sending encoded speech frames. As the speech frames are received, they are decoded and converted back into speech signal voltages. During the normal decoding process, pre-processing of the required SCA parameters will occur and the results stored in the past-history buffer. If a speech frame is detected to be lost or in error, then extrapolation modules are executed and replacement SCA parameters are generated and sent as the parameters required by the SCA. In this way, the information transfer to the SCA is transparent, and the SCA processing continues as usual. The listener will not normally notice that a speech frame has been lost because of the smooth transition between the last-received, lost, and next-received speech frames.

Prieto, Jr., Jaime L.↗

ATS-6 - Cesium bombardment engine north-south stationkeeping experiment

Two 0.004 N thrust cesium bombardment ion thrustors have been developed and used for north-south stationkeeping in the geostationary Applications Technology Satellite-6 (ATS-6). The thrustor subsystems are mounted on the north and south faces of the earth viewing module such that 0.0026 N of thrust is applied normal to the orbit plane and 0.0036 N is applied radially upward. The change in the orbit inclination of the satellite is maintained at zero by operating the two thrustors alternately so that their thrust components, normal to the orbital plane, are symmetrically applied about the nodal crossings. Initial operation of the thrustors was successful. There was no interference with the satellite communications systems and the predicted spacecraft operating potential was verified. Subsequent trials failed due to a defect in the operation of the propellant reservoirs in zero g. A feed line valve is under development to correct this difficulty.

Worlock, R. M.↗

An Assessment of Molten Metal Detachment Hazards During Electron Beam Welding in the Space Shuttle Bay at LEO for the International Space Welding Experiment

In 1997, the United States [NASA] and the Paton Electric Welding Institute are scheduled to cooperate in a flight demonstration on the U.S. Space Shuttle to demonstrate the feasibility of welding in space for a possible repair option for the International Space Station Alpha. This endeavor, known as the International Space Welding Experiment (ISWE), will involve astronauts performing various welding exercises such as brazing, cutting, welding, and coating using an electron beam space welding system that was developed by the E.O. Paton Electric Welding Institute (PWI), Kiev Ukraine. This electron beam welding system known as the "Universal Weld System" consists of hand tools capable of brazing, cutting, autogeneous welding, and coating using an 8 kV (8000 volts) electron beam. The electron beam hand tools have also been developed by the Paton Welding Institute with greater capabilities than the original hand tool, including filler wire feeding, to be used with the Universal Weld System on the U.S. Space Shuttle Bay as part of ISWE. The hand tool(s) known as the Ukrainian Universal Hand [Electron Beam Welding] Tool (UHT) will be utilized for the ISWE Space Shuttle flight welding exercises to perform welding on various metal alloy samples. A total of 61 metal alloy samples, which include 304 stainless steel, Ti-6AI-4V, 2219 aluminum, and 5456 aluminum alloys, have been provided by NASA for the ISWE electron beam welding exercises using the UHT. These samples were chosen to replicate both the U.S. and Russian module materials. The ISWE requires extravehicular activity (EVA) of two astronauts to perform the space shuttle electron beam welding operations of the 61 alloy samples. This study was undertaken to determine if a hazard could exist with ISWE during the electron beam welding exercises in the Space Shuttle Bay using the Ukrainian Universal Weld System with the UHT. The safety issue has been raised with regard to molten metal detachments as a result of several possible causes such as welder procedural error, externally applied impulsive forces(s), filler wire entrainment and snap-out, cutting expulsion, and puddle expulsion. Molten metal detachment from either the weld/cut substrate or weld wire could present harm to a astronaut in the space environment it the detachment was ti burn through the fabric of the astronaut Extravehicular Mobility Unit (EMC). In this paper an experimental test was performed in a 4 ft. x 4 ft. vacuum chamber at MSFC enabling protective garment to be exposed to the molten metal drop detachments to over 12 inches. The chamber was evacuated to vacuum levels of at least 1 x 10(exp -5) torr (50 micro-torr) during operation of the 1.0 kW Universal Hand Tool (UHT). The UHT was manually operated at the power mode appropriate for each material and thickness. The space suit protective welding garment, made of Teflon fabric (10 oz. per yard) with a plain weave, was placed on the floor of the vacuum chamber to catch the molten metal drop detachments. A pendulum release mechanism consisting of four hammers, each weighing approximately 3.65 lbs, was used to apply an impact forces to the weld sample/plate during both the electron beam welding and cutting exercises. Measurements were made of the horizontal fling distances of the detached molten metal drops. The volume of a molten metal drop can also be estimated from the size of the cut. Utilizing equations, calculations were made to determine chande in surafec area (Delat a(surface)) for 304 stainless steel for cutting based on measurements of metal drop sizes at the cut edges. For the cut sample of 304 stainless steel based on measurement of the drop size at the edge, Delta-a(surface) was determined to be 0.0054 2 in . Calculations have indicated only a small amount of energy is required to detach a liquid metal drop. For example, approximately only 0.000005 ft-lb of energy is necessary to detach a liquid metal steel drop based on the above theoretical analysis. However, some of the energy will be absorbed by the plate before it reaches the metal drop. Based on the theoretical calculations, it was determined that during a weld cutting exercise, the titanium alloy would be the most difficult to detach molten metal droplets followed by stainless steel and then by aluminum. The results of the experimental effort have shown that molten metal will detach if large enough of a hammer blow is applied to the weld sample plate during the full penetration welding and cutting exercises. However, no molten metal detachments occurred as a result of the filler wire snap-out tests from the weld puddle since it was too difficult to cause the metal to flick-out from the pool. Molten metal detachments, though not large in size, did result from the direct application of the electron beam on the end of the filler weld wire.

Fragomeni, James M.↗

Shock Associated Periodicities

The magnetosphere is often thought of as a cavity resonator, with eigenfrequencies dependent on the size of the magnetospheric cavity and the Alfven speed profile. A commonly invoked mechanism to "ring the bell" is a solar wind shock or dynamic pressure discontinuity. The sudden impulse feeds broadband compressional power into the magnetosphere, feeding energy into the cavity eigenmodes. Although the cavity mode model has strong theoretical and simulation support, there are few observations validating the scenario. We present several case studies indicating that damped oscillations observed in the magnetosphere following a shock are clearly directly driven by oscillations already present in the solar wind. We discuss these new observations in the context of the turbulent solar wind model, and discuss recent observations relating these periodicities to the solar surface. We further report on similar oscillations observed in magnetotail flow bursts, and relate them to the solar wind phenomena. We close with a discussion of the role of modulated magnetic reconnection, a potentially universal physical process.

Kepko, Larry↗

Modeling the Impacts of Hydrogen Extraction on Anaerobic Fermentation Systems Using a Modified ADM1 Model

Here, this paper presents a modified ADM1 (mADM1) model for use in assessing the influence of active dissolved H 2 extraction on biogas production from anaerobic fermentation reactors, specifically in the context of high-strength brewery wastewater as the feed. The modified model adds regulation factors to account for the varying product stoichiometry of glucose degradation reactions as a function of H 2 concentration in anaerobic digestion, and incorporates the use of both lactate and ethanol as intermediates. The changes to the model are expected to better predict the effects of H 2 removal on the production of H 2 in fermentation processes. Both ADM1 and mADM1 were calibrated against experimental data from a fluidized-bed reactor containing encapsulated acidogenic-acetogenic microbial communities treating real brewery wastewater. The calibrated models were validated against another fluidized-bed reactor identical to the calibration reactor, with the addition of a hollow-fiber membrane module that was used to reduce dissolved H 2 concentrations in the validation reactor. It was found that ADM1 over-estimated the H 2 production rates of the validation reactor (117 mL/day simulated vs. 16.48 mL/day experimental), whereas mADM1 was able to successfully predict fermentation, and specifically the H 2 production rate (17 mL/day). The presented model is a first step towards a model that can predict the effects of dissolved H 2 removal on fermentation processes.

Anaerobic Digestion↗

Noncoherent DTTLs for Symbol Synchronization

Noncoherent data-transition tracking loops (DTTLs) have been proposed for use as symbol synchronizers in digital communication receivers. [Communication- receiver subsystems that can perform their assigned functions in the absence of synchronization with the phases of their carrier signals ( carrier synchronization ) are denoted by the term noncoherent, while receiver subsystems that cannot function without carrier synchronization are said to be coherent. ] The proposal applies, more specifically, to receivers of binary phase-shift-keying (BPSK) signals generated by directly phase-modulating binary non-return-to-zero (NRZ) data streams onto carrier signals having known frequencies but unknown phases. The proposed noncoherent DTTLs would be modified versions of traditional DTTLs, which are coherent. The symbol-synchronization problem is essentially the problem of recovering symbol timing from a received signal. In the traditional, coherent approach to symbol synchronization, it is necessary to establish carrier synchronization in order to recover symbol timing. A traditional DTTL effects an iterative process in which it first generates an estimate of the carrier phase in the absence of symbol-synchronization information, then uses the carrier-phase estimate to obtain an estimate of the symbol-synchronization information, then feeds the symbol-synchronization estimate back to the carrier-phase-estimation subprocess. In a noncoherent symbol-synchronization process, there is no need for carrier synchronization and, hence, no need for iteration between carrier-synchronization and symbol- synchronization subprocesses. The proposed noncoherent symbolsynchronization process is justified theoretically by a mathematical derivation that starts from a maximum a posteriori (MAP) method of estimation of symbol timing utilized in traditional, coherent DTTLs. In that MAP method, one chooses the value of a variable of interest (in this case, the offset in the estimated symbol timing) that causes a likelihood function of symbol estimates over some number of symbol periods to assume a maximum value. In terms that are necessarily oversimplified to fit within the space available for this article, it can be said that the mathematical derivation involves a modified interpretation of the likelihood function that lends itself to noncoherent DTTLs. The proposal encompasses both linear and nonlinear noncoherent DTTLs. The performances of both have been computationally simulated; for comparison, the performances of linear and nonlinear coherent DTTLs have also been computationally simulated. The results of these simulations show that, among other things, the expected mean-square timing errors of coherent and noncoherent DTTLs are relatively insensitive to window width. The results also show that at high signal-to-noise ratios (SNRs), the performances of the noncoherent DTTLs approach those of their coherent counterparts at, while at low SNRs, the noncoherent DTTLs incur penalties of the order of 1.5 to 2 dB.

Simon, Marvin↗

Integrated Software for Analyzing Designs of Launch Vehicles

Launch Vehicle Analysis Tool (LVA) is a computer program for preliminary design structural analysis of launch vehicles. Before LVA was developed, in order to analyze the structure of a launch vehicle, it was necessary to estimate its weight, feed this estimate into a program to obtain pre-launch and flight loads, then feed these loads into structural and thermal analysis programs to obtain a second weight estimate. If the first and second weight estimates differed, it was necessary to reiterate these analyses until the solution converged. This process generally took six to twelve person-months of effort. LVA incorporates text to structural layout converter, configuration drawing, mass properties generation, pre-launch and flight loads analysis, loads output plotting, direct solution structural analysis, and thermal analysis subprograms. These subprograms are integrated in LVA so that solutions can be iterated automatically. LVA incorporates expert-system software that makes fundamental design decisions without intervention by the user. It also includes unique algorithms based on extensive research. The total integration of analysis modules drastically reduces the need for interaction with the user. A typical solution can be obtained in 30 to 60 minutes. Subsequent runs can be done in less than two minutes.

Philips, Alan D.↗

Impact of aeroelasticity on propulsion and longitudinal flight dynamics of an air-breathing hypersonic vehicle

Many air-breathing hypersonic aerospacecraft design concepts incorporate an elongated fuselage forebody acting as the aerodynamic compression surface for a hypersonic combustion module, or scram jet. This highly integrated design approach creates the potential for an unprecedented form of aero-propulsive-elastic interaction in which deflections of the vehicle fuselage give rise to propulsion transients, producing force and moment variations that may adversely impact the rigid body flight dynamics and/or further excite the fuselage bending modes. To investigate the potential for such interactions, a math model was developed which included the longitudinal flight dynamics, propulsion system, and first seven elastic modes of a hypersonic air-breathing vehicle. Perturbation time histories from a simulation incorporating this math model are presented that quantify the propulsive force and moment variations resulting from aeroelastic vehicle deflections. Root locus plots are presented to illustrate the effect of feeding the propulsive perturbations back into the aeroelastic model. A concluding section summarizes the implications of the observed effects for highly integrated hypersonic air-breathing vehicle concepts.

Raney, David L.↗

Initial Criticality Assessments to Guide FMEAs on Rocket Engine Hot Fire Testing

Presented is an explanation of the use of the Initial Criticality Assessment (ICA) technique, a triage process for prioritizing required Failure Modes and Effects Analysis (FMEAs), for the European Service Module's main propulsion system's hot-fire test bed at White Sands New Mexico. Rather than instinctively performing many FMEAs of subsystems, or one large system level FMEA where every subcomponent is analyzed, the ICA guided an informed analysis of only the hardware that had a large impact to hazards. The low criticality hardware was documented via the ICA and no FMEA was performed; the work could then focus on the high criticality hardware. Thus a savings of Program resources was achieved. The experiences gained in creating these ICAs for this international collaborative project confirmed that the need for continuous communication across the technical teams is one of the greatest areas of emphasis. The European Space Agency (ESA) is developing the European Service Module (ESM), with its primary contractor, Airbus Defence and Space in Germany, for delivery to the National Aeronautics and Space Administration (NASA). The module will be equipped with a total of 21 engines to support NASA’s Orion spacecraft: one U.S. Space Shuttle Orbital Maneuvering System-Engine (OMS-E), eight auxiliary thrusters and 12 smaller RCS (Reaction Control System) thrusters. The main ESM propulsion system, used for large translational maneuvers, consists of one OMS-E... To qualify the design of the ESM propulsion subsystem (PSS) an all-steel Propulsion Qualification Module (PQM) structure is used to test the propulsion systems on Orion, including “hot firing” of the OMS engine, thrusters, and RCS. The PQM has been developed as a hot-fire test bed to be tested at the NASA White Sands Test Facility (WSTF). One of the objectives of the testing is to assure that the OMS-E can be safely operated with the PQM. Testing will also demonstrate that the PQM can set the proper upstream pressures and temperatures for the OMS-E to operate nominally given the PQM has never been tested in hot-fire operation with OMS-E before. In order to safely conduct the test campaign, hardware such as the engine subassembly, fluid feed lines, valves, electrical power lines, instrumentation, stiff links, installation Ground Support Equipment (GSE), and diffuser [whose objectives are to collect the exhaust of the OMS-E to actively cool down the exhaust gases, reduce thermal exchanges, and create a vacuum at OMS-E level before igniting], had to be analyzed for any hazards and failure modes.

Fault Tolerance↗

NASA's Rodent Research Project on ISS: Validation of a New Platform for Conducting Biomedical and Basic Research into the Consequences of Long Duration Habitation in Space

Rodent research has played a key role in advancing biomedical discoveries both on Earth and in space. The National Research Counsel’s Decadal survey(1) emphasized the importance of expanding NASAs life sciences research to perform long duration, rodent experiments on the International Space Station (ISS). To accomplish this objective, flight hardware, operations, and science capabilities were developed at NASA ARC to support both commercial and government-sponsored rodent research.Rodent Research-1 (RR-1) was the first mission in which animals were delivered and maintained in the ISS for a long duration mission in modified Animal Enclosure Module hardware. Both RR validation and commercial science objectives were pursued on the RR-1 mission. Adult female mice (20 total Flight, FLT) were launched Sept 21, 2014 in RR hardware within a Dragon Capsule (SpaceX4), then after 4 days in transit, were transferred for habitation on the ISS for 17 days (commercial) or 33 days (validation), when animals were euthanized and select tissues recovered on orbit. Various controls groups consisted of: 1) Basal mice from the same cohorts as FLT mice, but tissues were recovered at time of launch, 2) Vivarium (VIV) were housed in standard cages 3) Ground Controls (GC) were housed in flight hardware within an environmental chamber at Kennedy Space Center. The health and behavior of all mice on the ISS were monitored by video feed on a daily basis. Mice were euthanized by injection of Euthasol, then either fast frozen intact or dissected to preserve livers (fast frozen) and spleens (RNAlater). Samples were stored at ≤ -80˚C until their return to Earth for later analyses.Hardware performed nominally throughout the mission and the planned in-flight science operations were completed successfully. FLT mice appeared generally more physically active on orbit than respective GC groups. After 33 days on the ISS, mean body weights of FLT mice did not differ from GC, with both groups showing a 6% rise compared to time of launch, while VIV mice showed an 8% rise over the same period. Importantly, there were no significant differences in body weights between groups at the end of 33 days on the ISS, providing an indication that the RR hardware supported the health of the mice both on Earth and in space. Based on the preliminary data obtained from the livers and spleens of mice after 17 days on the ISS, purified RNA was of high quality (RIN values of spleen: FLT=9.48 +0.40, GC=9.28 +0.44, n=5/group); therefore, RNA quality from samples retrieved on orbit was acceptable for even the most demanding transcriptomic analyses. In addition, liver enzyme activity levels (units/mg protein) of FLT mice (after 17d on ISS) and all control mice were similar in magnitude to samples that were optimally prepared by freezing in liquid nitrogen in the laboratory (enzymes analyzed included catalase, glutathione reductase and glyceraldehyde-3-phosphate dehydrogenase). Validation analyses still in progress include behavior and tissue biochemistries, as well as optimization of science return by post-flight recovery of tissues for biospecimen sharing and global expression analyses.Together, these preliminary findings demonstrate new capability for supporting long duration rodent research on the ISS to achieve both basic science and biomedical objectives.

Globus, R. K.↗

A transceiver module of the Mu radar

The transceiver (TR) module of a middle and upper atmospheric radar is described. The TR module used in the radar is mainly composed of two units: a mixer (MIX unit) and a power amplifier (PA unit). The former generates the RF wave for transmission and converts the received echo to the IF signal. A 41.5-MHz local signal fed to mixers passes through a digitally controlled 8-bit phase shifter which can change its value up to 1,000 times in a second, so that the MU radar has the ability to steer its antenna direction quickly and flexibly. The MIX unit also contains a buffer amplifier and a gate for the transmitting signal and preamplifier for the received one whose noise figure is less than 5 dB. The PA unit amplifies the RF signal supplied from the MIX unit up to 63.7 dBm (2350 W), and feeds it to the crossed Yagi antenna.

Kato, S.↗

Cis-regulatory evolution shapes facial diversity in birds and mammals

Birds and mammals exhibit extraordinary facial diversity, reflecting adaptations to distinct ecological niches and feeding strategies. While core face-building developmental programs are conserved and orchestrated by interactions between ectodermal organizers and the underlying mesenchyme, mechanisms driving facial shape variation remain poorly understood. Here, we integrate single-cell transcriptomic and chromatin accessibility profiling of mouse and chicken developing face to construct a comparative regulatory map. Although both ectodermal and mesenchymal populations display distinct regulatory features in each species, the mesenchyme exhibits markedly greater divergence, pointing to its central role in shaping facial morphology. We further reveal unexpected molecular complexity in the main face-shaping organizer, including a mouse-specific Shh/Wnt5a expression domain. At key morphogen loci (Bmp4, Fgf8, and Wnt5a), conserved and lineage-specific enhancers exhibit spatially restricted activity patterns that mirror divergent signaling domains. These findings demonstrate how cis-regulatory evolution modulates conserved developmental programs to generate morphological novelty, providing a valuable resource for studying vertebrate facial evolution.

Kyomen, Stella [Max Planck Institute for Evolution↗

NASA Tech Briefs, January 2008

Topics covered include: Induction Charge Detector with Multiple Sensing Stages; Generic Helicopter-Based Testbed for Surface Terrain Imaging Sensors; Robot Electronics Architecture; Optimized Geometry for Superconducting Sensing Coils; Sensing a Changing Chemical Mixture Using an Electronic Nose; Inertial Orientation Trackers with Drift Compensation; Microstrip Yagi Antenna with Dual Aperture-Coupled Feed; Patterned Ferroelectric Films for Tunable Microwave Devices; Micron-Accurate Laser Fresnel-Diffraction Ranging System; Efficient G(sup 4)FET-Based Logic Circuits; Web-Enabled Optoelectronic Particle-Fallout Monitor; SiO2/TiO2 Composite for Removing Hg from Combustion Exhaust; Lightweight Tanks for Storing Liquefied Natural Gas; Hybrid Wound Filaments for Greater Resistance to Impacts; Making High-Tensile-Strength Amalgam Components; Bonding by Hydroxide-Catalyzed Hydration and Dehydration; Balanced Flow Meters without Moving Parts; Deflection-Compensating Beam for Use inside a Cylinder; Four-Point-Latching Microactuator; Curved Piezoelectric Actuators for Stretching Optical Fibers; Tunable Optical Assembly with Vibration Dampening; Passive Porous Treatment for Reducing Flap Side-Edge Noise; Cylindrical Piezoelectric Fiber Composite Actuators; Patterning of Indium Tin Oxide Films; Gimballed Shoulders for Friction Stir Welding; Improved Thermal Modulator for Gas Chromatography; Nuclear-Spin Gyroscope Based on an Atomic Co-Magnetometer; Utilizing Ion-Mobility Data to Estimate Molecular Masses; Optical Displacement Sensor for Sub-Hertz Applications; Polarization/Spatial Combining of Laser-Diode Pump Beams; Spatial Combining of Laser-Diode Beams for Pumping an NPRO; Algorithm Optimally Orders Forward-Chaining Inference Rules; Project Integration Architecture; High Power Amplifier and Power Supply; Estimating Mixing Heights Using Microwave Temperature Profiler; and Multiple-Cone Sunshade for a Spaceborne Telescope.

Source record↗