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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 217 records · Page 12
All sourcesNASA NTRSDOE OSTI
NASA NTRS2016

Protective Effect of Pyruvate Against Radiation-Induced Damage in Collagenized Tissues

Exposure to high doses of ionizing radiation produces both acute and late effects on the collagenized tissues and have profound effects on wound healing. Because of the crucial practical importance for new radioprotective agents, our study has been focused on evaluation of the efficacy of non-toxic naturally occurring compounds to protect tissue integrity against high-dose gamma radiation. Here, we demonstrate that molecular integrity of collagen may serve as a sensitive biological marker for quantitative evaluation of molecular damage to collagenized tissue and efficacy of radioprotective agents. Increasing doses of gamma radiation (0-50kGy) result in progressive destruction of the native collagen fibrils, which provide a structural framework, strength, and proper milieu for the regenerating tissue. The strategy used in this study involved the thermodynamic specification of all structural changes in collagenized matrix of skin, aortic heart valve, and bone tissue induced by different doses and conditions of g-irradiation. This study describes a simple biophysical approach utilizing the Differential Scanning Calorimetry (DSC) to characterize the structural resistance of the aortic valve matrix exposed to different doses of g-irradiation. It allows us to identify the specific response of each constituent as well as to determine the influence of the different treatments on the characteristic parameters of protein structure. We found that pyruvate, a substance that naturally occurs in the body, provide significant protection (up to 80%) from biochemical and biomechanical damage to the collagenized tissue through the effective targeting of reactive oxygen species. The recently discovered role of pyruvate in the cell antioxidant defense to O2 oxidation, and its essential constituency in the daily human diet, indicate that the administration of pyruvate-based radioprotective formulations may provide safe and effective protection from deleterious effects of ionizing radiation.

Differential Scanning Calorimetry↗
NASA NTRS2010

Fermi Gamma-Ray Space Telescope: Science Highlights for the First 8 Months

The Fermi Gamma-ray Space Telescope was launched on June 11, 2008 and since August 2008 has successfully been conducting routine science observations of high energy phenomena in the gamma-ray sky. A number of exciting discoveries have been made during its first year of operation, including blazar flares, high-energy gamma-ray bursts, and numerous new,gamma-ray sources of different types, among them pulsars and Active Galactic Nuclei (AGN). fermi-LAT also performed accurate mea.<;urement of the diffuse gamma-radiation which clarifies the Ge V excess reported by EGRET almost 10 years ago, high precision measurement of the high energy electron spectrum, and other observations. An overview of the observatory status and recent results as of April 30, 2009, are presented. Key words: gamma-ray astronomy, cosmic rays, gamma-ray burst, pulsar, blazar. diffuse gamma-radiation

Moiseev, Alexander↗
NASA NTRS1972

Effect of slow rotational diffusion on angular correlations.

The theory for perturbed angular correlations of gamma radiation has been extended to include the possibility of adiabatic variation in the interaction Hamiltonian, K, for the intermediate state. The calculation begins from a polycrystalline model. It is shown that adiabatic variation in K introduces a time dependence into the angles which express the orientation of the molecular frame. The relevance of the adiabatic limit to the use of perturbed angular correlations of gamma radiation for study of the motion of radioactive species in viscous media is discussed.

Marshall, A. G.↗
NASA NTRS2009

Cytogenetic Response to Ionizing Radiation Exposure in Human Fibroblasts with Suppressed Expression of Non-DSB Repair Genes

Changes of gene expression profile are one of the most important biological responses in living cells after ionizing radiation (IR) exposure. Although some studies have shown that genes up-regulated by IR may play important roles in DNA damage repair, the relationship between the regulation of gene expression by IR, particularly genes not known for their roles in double-strand break (DSB) repair, and its impact on cytogenetic responses has not been well studied. The purpose of this study is to identify new roles of IR inducible genes in radiation-induced chromosome aberrations and micronuclei formation. In the study, the expression of 25 genes selected on the basis of their transcriptional changes in response to IR was individually knocked down by small interfering RNA in human fibroblast cells. Frequencies of micronuclei (MN) formation and chromosome aberrations were measured to determine the efficiency of cytogenetic repair, and the fraction of bi-nucleated cells in the MN analysis was used as a marker for cell cycle progression. In response to gamma radiation, the formation of MN was significantly increased by suppressed expression of five genes: Ku70 (DSB repair pathway), XPA (nucleotide excision repair pathway), RPA1 (mismatch repair pathway), RAD17 and RBBP8 (cell cycle control). Knocked-down expression of four genes (MRE11A, RAD51 in the DSB pathway, SESN1, and SUMO1) significantly inhibited cell cycle progression, possibly because of severe impairment of DNA damage repair. Moreover, decreased XPA, p21, or MLH1 expression resulted in both significantly enhanced cell cycle progression and increased yields of chromosome aberrations, indicating that these gene products modulate both cell cycle control and DNA damage repair. Nine of these eleven genes, whose knock-down expression affected cytogenetic repair, were up-regulated in cells exposed to gamma radiation, suggesting that genes transcriptionally modulated by IR were critical to regulate IR-induced biological consequences. Furthermore, eight non-DBS repair genes showed involvement in regulating DSB repair, indicating that successful DSB repair requires both DSB repair mechanisms and non-DSB repair systems.

Zhang, Ye↗
NASA NTRS1979

Detection of 6.13 MeV gamma-rays within and at the top of the atmosphere

A measurement of the 6.13 MeV gamma-radiation from excited O-16 in the atmosphere has been made with a high-resolution Ge(Li) spectrometer flown from Palestine, Texas, 1974 June 10, on a high-altitude balloon. This measurement, made both within and near the top of the atmosphere, is found to have the same general profile as predicted by a semiempirical model, but gives a flux about a factor of 2 higher than predicted. Certain variations in the intensity at float altitude have led to the hypothesis of an extraterrestrial source of 6.13 MeV gamma-radiation from the galactic anticenter. The 3 sigma upper limits for a number of other astrophysically significant line fluxes are also given. The data presented here are consistent with either a source or a no-source hypothesis.

Willett, J. B.↗
NASA NTRS2022

Rapid Radiolytic Degradation of Amino Acids in the Martian Shallow Subsurface: Implications for the Search for Extinct Life

Amino acids are fundamental to life as we know them as the monomers of proteins and enzymes. They are also readily synthesized under a variety of plausible prebiotic conditions and are common in carbon-rich meteorites. Thus, they represent a reasonable class of organics to target in the search for prebiotic chemistry or chemical evidence of life on Mars. However, regardless of their origin, amino acids and other organic molecules present in near-surface regolith and rocks on Mars can be degraded by exposure to cosmic rays that can penetrate to a depth of a few meters. We exposed several pure amino acids in dry and hydrated silicate mixtures and in mixtures of silicates with perchlorate salts to gamma radiation at various temperatures and radiation doses representative of the martian near-subsurface. We found that irradiation of amino acids mixed with dry silica powder increased the rate of amino acid radiolysis, with the radiolysis constants of amino acids in silicate mixtures at least a factor of 10 larger compared with the radiolysis constants of amino acids alone. The addition of perchlorate salts to the silicate samples or hydration of silicate samples further accelerated the rate of amino acid destruction during irradiation and increased the radiolysis constants by a factor of *1.5. Our results suggest that even low-molecular-weight amino acids could degrade in just *20 million years in the top 10 cm of the martian surface regolith and rock, and even faster if the material contains elevated abundances of hydrated silicate minerals or perchlorates. We did not detect evidence of amino acid racemization after gamma radiation exposure of the samples, which indicates that the chirality of some surviving amino acids may still be preserved. Our experimental results suggest serious challenges for the search of ancient amino acids and other potential organic biosignatures in the top 2 m of the martian surface.

Alexander A. Pavlov↗
NASA NTRS1994

The influence of dose, dose-rate and particle fragmentation on cataract induction by energetic iron ions

Because activities in space necessarily involve chronic exposure to a heterogeneous charged particle radiation field it is important to assess the influence of dose-rate and the possible modulating role of heavy particle fragmentation on biological systems. Using the well-studied cataract model, mice were exposed to plateau 600 MeV/amu Fe-56 ions either as acute or fractionated exposures at total doses of 5-504 cGy. Additional groups of mice received 20, 360 and 504 cGy behind 50 mm of polyethylene, which simulates body shielding. The reference radiation consisted of Co-60 gamma radiation. The animals were examined by slit lamp biomicroscopy over their three year life spans. In accordance with our previous observations with heavy particles, the cataractogenic potential of the 600 MeV/amu Fe-56 ions was greater than for low-Linear Energy Transfer (LET) radiation and increased with decreasing dose relative to gamma rays. Fractionation of a given dose of Fe-56 ions did not reduce the cataractogenicity of the radiation compared to the acute regimen. Fragmentation of the beam in the polyethylene did not alter the cataractotoxicity of the ions, either when administered singly or in fractions.

Medvedovsky, C.↗
NASA NTRS1973

Mechanisms for production of the diffuse gamma-ray continuum radiation

Basic mechanisms involved in the production of cosmic gamma radiation are outlined. They include Compton interactions with low energy protons, bremsstrahlung interactions, cosmic ray induced neutral pion production, and matter-antimatter annihilation. Detailed data are given on diffuse continuum radiation. Comparative data results are given in tables and graphs.

Stecker, F. W.↗