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NASA NTRS2016

Evidence Report: Risk of Radiation Carcinogenesis

As noted by Durante and Cucinotta (2008), cancer risk caused by exposure to space radiation is now generally considered a main hindrance to interplanetary travel for the following reasons: large uncertainties are associated with the projected cancer risk estimates; no simple and effective countermeasures are available, and significant uncertainties prevent scientists from determining the effectiveness of countermeasures. Optimizing operational parameters such as the length of space missions, crew selection for age and sex, or applying mitigation measures such as radiation shielding or use of biological countermeasures can be used to reduce risk, but these procedures have inherent limitations and are clouded by uncertainties. Space radiation is comprised of high energy protons, neutrons and high charge (Z) and energy (E) nuclei (HZE). The ionization patterns and resulting biological insults of these particles in molecules, cells, and tissues are distinct from typical terrestrial radiation, which is largely X-rays and gamma-rays, and generally characterized as low linear energy transfer (LET) radiation. Galactic cosmic rays (GCR) are comprised mostly of highly energetic protons with a small component of high charge and energy (HZE) nuclei. Prominent HZE nuclei include He, C, O, Ne, Mg, Si, and Fe. GCR ions have median energies near 1 GeV/n, and energies as high as 10 GeV/n make important contributions to the total exposure. Ionizing radiation is a well known carcinogen on Earth (BEIR 2006). The risks of cancer from X-rays and gamma-rays have been established at doses above 50 mSv (5 rem), although there are important uncertainties and on-going scientific debate about cancer risk at lower doses and at low dose rates (<50 mSv/h). The relationship between the early biological effects of HZE nuclei and the probability of cancer in humans is poorly understood, and it is this missing knowledge that leads to significant uncertainties in projecting cancer risks during space exploration (Cucinotta and Durante 2006; Durante and Cucinotta 2008).

Huff, Janice↗

NASA NTRS2015

Practical Applications of Cosmic Ray Science: Spacecraft, Aircraft, Ground-Based Computation and Control Systems, Exploration, and Human Health and Safety

In this presentation a review of galactic cosmic ray (GCR) effects on microelectronic systems and human health and safety is given. The methods used to evaluate and mitigate unwanted cosmic ray effects in ground-based, atmospheric flight, and space flight environments are also reviewed. However not all GCR effects are undesirable. We will also briefly review how observation and analysis of GCR interactions with planetary atmospheres and surfaces and reveal important compositional and geophysical data on earth and elsewhere. About 1000 GCR particles enter every square meter of Earth’s upper atmosphere every second, roughly the same number striking every square meter of the International Space Station (ISS) and every other low- Earth orbit spacecraft. GCR particles are high energy ionized atomic nuclei (90% protons, 9% alpha particles, 1% heavier nuclei) traveling very close to the speed of light. The GCR particle flux is even higher in interplanetary space because the geomagnetic field provides some limited magnetic shielding. Collisions of GCR particles with atomic nuclei in planetary atmospheres and/or regolith as well as spacecraft materials produce nuclear reactions and energetic/highly penetrating secondary particle showers. Three twentieth century technology developments have driven an ongoing evolution of basic cosmic ray science into a set of practical engineering tools needed to design, test, and verify the safety and reliability of modern complex technological systems and assess effects on human health and safety effects. The key technology developments are: 1) high altitude commercial and military aircraft; 2) manned and unmanned spacecraft; and 3) increasingly complex and sensitive solid state micro-electronics systems. Space and geophysical exploration needs drove the development of the instruments and analytical tools needed to recover compositional and structural data from GCR induced nuclear reactions and secondary particle showers. Finally, the possible role of GCR secondary particle showers in addressing an important homeland security problem, finding nuclear contraband and weapons, will be briefly reviewed.

Koontz, Steve↗

NASA NTRS2020

The NASA MODIS-VIIRS Continuity Cloud Optical Properties Products

The NASA Aqua MODIS and Suomi National Polar-Orbiting Partnership (SNPP) Visible Infrared Imaging Radiometer Suite (VIIRS) climate data record continuity cloud properties products (CLDPROP) were publicly released in April 2019 with an update later that year (Version 1.1). These cloud products, having heritage with the NASA Moderate-resolution Imaging Spectroradiometer (MODIS) MOD06 cloud optical properties product and the NOAA GOES-R Algorithm Working Group (AWG) Cloud Height Algorithm (ACHA), represent an effort to bridge the multispectral imager records of NASA’s Earth Observing System (EOS) and NOAA’s current generation of operational weather satellites to achieve a continuous, multi-decadal climate data record for clouds that can extend well into the 2030s. CLDPROP offers a “continuity of approach,” applying common algorithms and ancillary datasets to both MODIS and VIIRS, including utilizing only a subset of spectral channels available on both sensors to help mitigate instrument differences. The initial release of the CLDPROP_MODIS and CLDPROP_VIIRS data records spans the SNPP observational record (2012-present). Here, we present an overview of the algorithms and an evaluation of the intersensor continuity of the core CLDPROP_MODIS and CLDPROP_VIIRS cloud optical property datasets, i.e., cloud thermodynamic phase, optical thickness, effective particle size, and derived water path. The evaluation includes analyses of pixel-level MODIS/VIIRS co-locations as well as spatial and temporal aggregated statistics, with a focus on identifying and understanding the root causes of individual dataset discontinuities. The results of this evaluation will inform future updates to the CLDPROP products and help scientific users determine the appropriate use of the product datasets for their specific needs.

satellite remote sensing↗

NASA NTRS2003

Numerical Simulation of One- and Two-Phase Flows in Propulsion Systems

Four subprojects were conducted using analytical methods, numerical simulation and experimental tests: (A) Shock wave mitigation by spike-shaped blunt bodies with application for the purpose of drag, lift and longitudinal momentum optimization. The main result in this subproject is: application of a single needle against a supersonic flow provides higher benefits for blunt body drag reduction and heat transfer to the body than the application of multiple needles. (B) Solid particles, liquid and air jet injection through the front of a blunt body against a supersonic flow. In this case, the research conducted and analysis of multiple previous investigations in this area have shown essential benefits and preferable application of solid particle injection. (C) Comparison of different methods of fuel injection into supersonic duct flows. Preliminary numerical simulations and theoretical analysis show promising results for Telescope-shaped inlet applications in SCRAMJET; and (D) Development of an acoustic source location method for different applications including propulsion systems.

Gilinsky, Mikhail↗

NASA NTRS2014

Mars Atmosphere Resource Verification INsitu (MARVIN) - In Situ Resource Demonstration for the Mars 2020 Mission

The making of oxygen from resources in the Martian atmosphere, known as In Situ Resource Utilization (ISRU), has the potential to provide substantial benefits for future robotic and human exploration. In particular, the ability to produce oxygen on Mars for use in propulsion, life support, and power systems can provide significant mission benefits such as a reducing launch mass, lander size, and mission and crew risk. To advance ISRU for possible incorporation into future human missions to Mars, NASA proposed including an ISRU instrument on the Mars 2020 rover mission, through an announcement of opportunity (AO). The purpose of the the Mars Atmosphere Resource Verification INsitu or (MARVIN) instrument is to provide the first demonstration on Mars of oxygen production from acquired and stored Martian atmospheric carbon dioxide, as well as take measurements of atmospheric pressure and temperature, and of suspended dust particle sizes and amounts entrained in collected atmosphere gases at different times of the Mars day and year. The hardware performance and environmental data obtained will be critical for future ISRU systems that will reduce the mass of propellants and other consumables launched from Earth for robotic and human exploration, for better understanding of Mars dust and mitigation techniques to improve crew safety, and to help further define Mars global circulation models and better understand the regional atmospheric dynamics on Mars. The technologies selected for MARVIN are also scalable for future robotic sample return and human missions to Mars using ISRU.

Sanders, Gerald B.↗

NASA NTRS2012

How are Space Weather and Space Climate Connected to Solar Phenomena?

Many aspects of modern society are susceptible to space weather effects. Pertinent space weather effects include high-energy electromagnetic and particle radiation, changes of atmospheric drag, reduction of GPS accuracy or complete loss of GPS signals, communication outages, and the generation of potentially harmful DC currents in our electric power grid. Beginning in the early 1990s, researchers and government have been increasingly aware of the need to understand the causes of space weather, and to find ways to mitigate deleterious effects associated with it. New research and development programs have been created to address space weather primarily at NASA but also at other agencies. This investment has been very fruitful by generating a new class of entirely new space weather specification and forecast capabilities. This presentation provides an overview of space weather causes and effects, as well as of research and development to forecast and mitigate space weather effects. It will include a discussion of modern space weather analysis and forecasting, and conclude by pointing out paths into the future.

Hesse, Michael↗

NASA NTRS2001

Radiation transport modeling and assessment to better predict radiation exposure, dose, and toxicological effects to human organs on long duration space flights

NASA is very interested in improving its ability to monitor and forecast the radiation levels that pose a health risk to space-walking astronauts as they construct the International Space Station and astronauts that will participate in long-term and deep-space missions. Human exploratory missions to the moon and Mars within the next quarter century, will expose crews to transient radiation from solar particle events which include high-energy galactic cosmic rays and high-energy protons. Because the radiation levels in space are high and solar activity is presently unpredictable, adequate shielding is needed to minimize the deleterious health effects of exposure to radiation. Today, numerous models have been developed and used to predict radiation exposure. Such a model is the Space Environment Information Systems (SPENVIS) modeling program, developed by the Belgian Institute for Space Aeronautics. SPENVIS, which has been assessed to be an excellent tool in characterizing the radiation environment for microelectronics and investigating orbital debris, is being evaluated for its usefulness with determining the dose and dose-equivalent for human exposure. Thus far. the calculations for dose-depth relations under varying shielding conditions have been in agreement with calculations done using HZETRN and PDOSE, which are well-known and widely used models for characterizing the environments for human exploratory missions. There is disagreement when assessing the impact of secondary radiation particles since SPENVIS does a crude estimation of the secondary radiation particles when calculating LET versus Flux. SPENVIS was used to model dose-depth relations for the blood-forming organs. Radiation sickness and cancer are life-threatening consequences resulting from radiation exposure. In space. exposure to radiation generally includes all of the critical organs. Biological and toxicological impacts have been included for discussion along with alternative risk mitigation methods--shielding and anti-carcinogens. c 2001. Elsevier Science Ltd. All rights reserved.

STS-91 Shuttle Project↗

NASA NTRS2019

Lunar and Martian Vertical Takeoff & Vertical Landing (VTVL) Pad Concepts

Landing space craft rocket plume exhaust interactions with the regolith surfaces on the Moon and Mars will result in cratering and regolith particle ejecta traveling at velocities up to 2,000 meters per second in the vacuum surroundings. This phenomenon creates hazards for the spacecraft that is landing or launching and may also cause damage to surrounding assets, personnel and infrastructure. One potential solution to this issue is to construct vertical takeoff and vertical landing (VTVL) pad infrastructure systems which will mitigate these rocket plume exhaust effects. Concepts will be presented for the construction and maintenance of such VTVL pads in lunar and martian environments.

Pad↗

NASA NTRS2004

Novel Optical Diagnostic Techniques for Studying Particle Contact and Deposition Upon a Large Cylinder in a Sheared Suspension

The objectives of this research project were: 1) To study the fluid dynamics of sheared particle-liquid suspensions and the impact of differential particle-fluid inertia; 2) To develop new techniques for observing suspension particle contact and deposition upon solid surfaces. Dr. Yoda was supported by the NASA Office of Biological and Physical Research on a four-year grant from March 2000 through November 2004 for a ground-based study on the fluid dynamics of sheared particle-liquid suspensions and the impact of differential particle-fluid inertia on such flows. Such inertial effects can only be observed in reduced-gravity environments since they are overwhelmed by buoyancy effects on Earth. Moreover, these inertial effects will have a significant impact upon suspension flows in microgravity. Suspension dynamics are of importance in a wide variety of advanced life systems applications, including water reclamation and dust mitigation in confined habitats.

Rashidnia, Nasser↗

NASA NTRS2005

Single Event Transients in Linear Integrated Circuits

On November 5, 2001, a processor reset occurred on board the Microwave Anisotropy Probe (MAP), a NASA mission to measure the anisotropy of the microwave radiation left over from the Big Bang. The reset caused the spacecraft to enter a safehold mode from which it took several days to recover. Were that to happen regularly, the entire mission would be compromised, so it was important to find the cause of the reset and, if possible, to mitigate it. NASA assembled a team of engineers that included experts in radiation effects to tackle the problem. The first clue was the observation that the processor reset occurred during a solar event characterized by large increases in the proton and heavy ion fluxes emitted by the sun. To the radiation effects engineers on the team, this strongly suggested that particle radiation might be the culprit, particularly when it was discovered that the reset circuit contained three voltage comparators (LM139). Previous testing revealed that large voltage transients, or glitches appeared at the output of the LM139 when it was exposed to a beam of heavy ions [NI96]. The function of the reset circuit was to monitor the supply voltage and to issue a reset command to the processor should the voltage fall below a reference of 2.5 V [PO02]. Eventually, the team of engineers concluded that ionizing particle radiation from the solar event produced a negative voltage transient on the output of one of the LM139s sufficiently large to reset the processor on MAP. Fortunately, as of the end of 2004, only two such resets have occurred. The reset on MAP was not the first malfunction on a spacecraft attributed to a transient. That occurred shortly after the launch of NASA s TOPEX/Poseidon satellite in 1992. It was suspected, and later confirmed, that an anomaly in the Earth Sensor was caused by a transient in an operational amplifier (OP-15) [KO93]. Over the next few years, problems on TDRS, CASSINI, [PR02] SOHO [HA99,HA01] and TERRA were also attributed to transients. In some cases, such events produced resets by falsely triggering circuits designed to protect against over- voltage or over-current. On at least three occasions, transients caused satellites to switch into "safe mode" in which most of the systems on board the satellites were powered down for an extended period. By the time the satellites were reconfigured and returned to full operational state, much scientific data had been lost. Fortunately, no permanent damage occurred in any of the systems and they were all successfully re-activated.

Buchner, Stephen↗

NASA NTRSDate not supplied

Developing High-Throughput Organ-on-a-Chip Models to Investigate the Effects of Ionizing Radiation on the Central Nervous System

One of the main health risks in human space exploration is central nervous system (CNS) damage by ionizing radiation due to exposure to the galactic cosmic rays (GCRs). In animal models, irradiation with simulated GCRs or their components has been shown to cause neuronal damage and neuroinflammation associated with cognitive and behavioral dysfunction. In general, the extent of CNS damage is partially regulated by the blood-brain barrier (BBB), which enables immune cells to enter the CNS. The main cellular regulators of BBB permeability are astrocytes, which also modulate neuronal death, immune responses and oxidative stress, and thus could serve as a robust CNS-specific target for countermeasure development. However, studies on BBB permeability and astrocyte functions in regulating CNS responses to ionizing radiation have been limited, especially in human tissue/organ analogs. Therefore, we established a high-throughput 3D organ-on-a-chip system to study human CNS and BBB impairments in response to ionizing radiation, based on commercially available OrganoPlates (Mimetas, Inc.) seeded with primary or induced pluripotent stem cell-derived human cells. We investigated both immediate and delayed CNS responses to major GCR components: 0.15-0.5 Gy 250MeV/n 4-He, and 0.3-0.8 Gy 600 MeV/n 56-Fe; as well as to 0.5-1 Gy X-rays. We observed ionizing radiation-mediated increases in BBB permeability that was exacerbated by astrocyte presence and accompanied by morphological changes in endothelial cells and tight junctions, altered cytokine profile including TNFa upregulation, and increased oxidative stress. We also quantified irradiation-mediated changes in astrocyte activation and neuronal functions, revealing major astrocyte damage mediated by 600MeV/n 56-Fe particles. Thus, we demonstrate that deep space radiation may contribute to CNS damage by disrupting both astrocyte and endothelial cell components of the blood-brain barrier. Our next steps include mapping and validating the transcriptomic changes induced by simulated GCRs and their components in human CNS models. Ultimately, we aim to uncover potential novel targets for countermeasure developments to mitigate CNS damage in long duration spaceflight.

Radiation↗

NASA NTRS1992

Modelling the near-Earth space environment using LDEF data

Near-Earth space is a dynamic environment, that is currently not well understood. In an effort to better characterize the near-Earth space environment, this study compares the results of actual impact crater measurement data and the Space Environment (SPENV) Program developed in-house at POD, to theoretical models established by Kessler (NASA TM-100471, 1987) and Cour-Palais (NASA SP-8013, 1969). With the continuing escalation of debris there will exist a definite hazard to unmanned satellites as well as manned operations. Since the smaller non-trackable debris has the highest impact rate, it is clearly necessary to establish the true debris environment for all particle sizes. Proper comprehension of the near-Earth space environment and its origin will permit improvement in spacecraft design and mission planning, thereby reducing potential disasters and extreme costs. Results of this study directly relate to the survivability of future spacecraft and satellites that are to travel through and/or reside in low Earth orbit (LEO). More specifically, these data are being used to: (1) characterize the effects of the LEO micrometeoroid an debris environment on satellite designs and components; (2) update the current theoretical micrometeoroid and debris models for LEO; (3) help assess the survivability of spacecraft and satellites that must travel through or reside in LEO, and the probability of their collision with already resident debris; and (4) help define and evaluate future debris mitigation and disposal methods. Combined model predictions match relatively well with the LDEF data for impact craters larger than approximately 0.05 cm, diameter; however, for smaller impact craters, the combined predictions diverge and do not reflect the sporadic clouds identified by the Interplanetary Dust Experiment (IDE) aboard LDEF. The divergences cannot currently be explained by the authors or model developers. The mean flux of small craters (approximately 0.05 cm diameter) is overpredicted by Kessler and underpredicted by Cour-Palais. This divergence may be a result of beta-meteoroid fluxes, elliptical orbits or a combination of the two. The results of this study illustrate the definite need for more intensive study of the near-Earth space environment, particularly the small particle regime, as it is the most degrading to spacecraft in LEO.

Atkinson, Dale R.↗

NASA NTRS2015

Jovian plasma modeling for mission design

The purpose of this report is to address uncertainties in the plasma models at Jupiter responsible for surface charging and to update the jovian plasma models using the most recent data available. The updated plasma environment models were then used to evaluate two proposed Europa mission designs for spacecraft charging effects using the Nascap-2k code. The original Divine/Garrett jovian plasma model (or "DG1", T. N. Divine and H. B. Garrett, "Charged particle distributions in Jupiter's magnetosphere," J. Geophys. Res., vol. 88, pp. 6889-6903,1983) has not been updated in 30 years, and there are known errors in the model. As an example, the cold ion plasma temperatures between approx.5 and 10 Jupiter radii (Rj) were found by the experimenters who originally published the data to have been underestimated by approx.2 shortly after publication of the original DG1 model. As knowledge of the plasma environment is critical to any evaluation of the surface charging at Jupiter, the original DG1 model needed to be updated to correct for this and other changes in our interpretation of the data so that charging levels could beproperly estimated using the Nascap-2k charging code. As an additional task, the Nascap-2k spacecraft charging tool has been adapted to incorporate the so-called Kappa plasma distribution function--an important component of the plasma model necessary to compute the particle fluxes between approx.5 keV and 100 keV (at the outset of this study,Nascap-2k did not directly incorporate this common representation of the plasma thus limiting the accuracy of our charging estimates). The updating of the DG1 model and its integration into the Nascap-2k design tool means that charging concerns can now be more efficiently evaluated and mitigated. (We note that, given the subsequent decision by the Europa project to utilize solar arrays for its baseline design, surface charging effects have becomeeven more of an issue for its mission design). The modifications and results of those modifications to the DG1 model to produce the new DG2 model presented here and the steps taken to integrate the DG2 predictions into Nascap-2k are described in this report.

Voyager 2↗

NASA NTRS2015

Jovian Plasma Modeling for Mission Design

Garrett, Henry B.↗

NASA NTRSDate not supplied

Genomic and Phenotypic Associations to Predict Human Sensitivity to SpaceRadiation

High-linear energy transfer (LET) ionizing radiation is a major health hazard for astronauts who will be exposed to galactic cosmic rays during upcoming lunar and Mars missions. Predicting and mitigating this risk requires understanding the factors underlying individual radiation sensitivity. We started to address this challenge by identifying the genomic and phenotypic associations with sensitivity to low and high-LET ionizing radiation ex vivo in over 750 healthy human donors. We exposed primary human blood mononuclear cells to simulated galactic cosmic ray components: 350MeV/n 28Si, 350MeV/n 40Ar and 600MeV/n 56Fe particles, at 1.1 and 3 particles/100 sq.m fluences, as well as 0.1 Gy and 1 Gy doses of gamma rays, and analyzed the outcomes at 4 and 24 hours post-irradiation. We quantified DNA damage and repair responses based on 53BP1+ radiation-induced foci formation, together with oxidative stress and changes in secreted factors including immune cytokines and exosomes. We also analyzed phenotypic associations with spontaneous DNA repair foci at baseline prior to irradiation. We identified an increase in spontaneous DNA repair associated with age and latent viral infection, and observed that human spontaneous DNA repair foci at baseline can serve as a negative predictor of DNA repair and immunoregulatory cytokine production after irradiation. Furthermore, we observed a wide variability of subject- and LET-dependent radiation responses, with radiation-induced DNA repair foci increasing by dose and LET, and high-LET particle radiation resulting in more residual DNA damage compared to low-LET particles and gamma rays. We have developed multiple metrics to quantify human radio sensitivity across the spectrum of conditions. Here we present their dependence on radiation quality and phenotypic variables, including an age-dependent decrease in DNA repair after irradiation, and genomic associations with radio sensitivity based on low-coverage whole genome sequencing. We anticipate that our work will pave the way for understanding the spectrum of human radio sensitivity and identifying targets for countermeasure development to reduce DNA and cellular damage and radiation carcinogenesis during deep space exploration.

GWAS radiation human↗

NASA NTRSDate not supplied

Space Shuttle Program Dual Docked Operations

Due to the ever-increasing visiting vehicle traffic to and from the International Space Station (ISS) during mated Orbiter/ISS missions, it became apparent to both the ISS Program (ISSP) and the Space Shuttle program (SSP) that there would arise occasions where a visiting vehicle docking and/or undocking could overlap when the Space Shuttle Orbiter was docked to the ISS, referred to as Dual Docked Operations (DDO). The primary concerns were that plumes from the visiting vehicles would cause contamination, corrosion, and erosion to Space Shuttle surfaces and present a toxicity hazard to ground personnel when processing the Space Shuttle after landing. This potential conflict provided the genesis for evaluating risk mitigations to gain maximum flexibility for managing potential visiting vehicle traffic to and from the ISS and to maximize launch and landing opportunities for all visiting vehicles. The overarching goal of this effort was to assess the viability and readiness of the SSP to protect for DDO on any given mission. To assess the viability of performing DDO, the ISSP delivered plume particle fluence (i.e., number of particles per unit area) and contamination deposition based on the visiting vehicle’s proximity operations to the SSP for evaluation. This paper summarizes the concept definition, studies, and analysis results generated by the SSP, ISSP, and Mission Operations Directorate (MOD) for implementing DDO involving the Orbiter and Russian vehicles (RVs). Discussion and results presented herein represent a generic assessment of the SSP and ISSP integrated safety and technical evaluations of DDO involving the Orbiter and RVs. Mission-specific analysis and operational impacts were conducted flight-by-flight as they arose.

Launch vehicles↗

NASA NTRSDate not supplied

Scaling Laws of Ejecta Streaks in Lunar Landings

From the crewed Apollo missions of the 1960s to the recent Chang’e uncrewed lunar missions, the interaction between the supersonic exhaust and the lunar surface generates a striking ray system of ejecta particles that travel radially outward at high speeds. While this intriguing pattern has been observed in experiments and simulations, the underlying mechanism remains unclear. These radial ejecta streaks were also observed during an experimental campaign using a Mach 5.3 jet impinging on a granular bed within a large-scale vacuum chamber. Our findings reveal that the radial ejecta streaks are caused by the Gortler instability, which, due to the curvature of the extremely underexpanded jet, induces counter-rotating streamwise vortices within the jet shear layer. These vortices impact the ground and entrain particles in their upwash regions. Experimental measurements from both ground tests and the literature show that the number of streaks strongly depends on the jet diameter at impact and the shear layer thickness, further revealing a power-law scaling with the jet pressure ratio. These insights highlight the pivotal role of fluid dynamics in extraterrestrial landings and provide a foundation for mitigating risks in future planetary missions.

Lunar Landing↗

NASA NTRSDate not supplied

NASA Space Radiation Laboratory Galactic Cosmic Ray Simulator

With exciting new Agency plans for a sustainable return to the moon, astronauts will once again leave earth’s protective magnetosphere only to endure higher levels of radiation from galactic cosmic rays (GCR) and the possibility of a large solar particle event (SPE). Gateway, lunar landers, and surface habitats will be designed to protect crew against SPEs with vehicle optimization, storm shelter concepts, and/or active dosimetry; however, the ever-penetrating GCR will continue to pose the most significant health risks especially as lunar missions increase in duration and as NASA sets its aspirations on Mars. The primary risks of concern include carcinogenesis, central nervous system effects resulting in potential in-mission cognitive or behavioral impairment and/or late neurological disorders, degenerative tissue effects including cataracts, circulatory and heart disease, as well as, potential immune system decrements impacting multiple aspects of crew health. Characterization and mitigation of these risks requires a significant reduction in the large biological uncertainties of chronic (low-dose rate) heavy ion exposures and the validation of countermeasures in a relevant space environment. NASA has developed the “GCR Simulator” at Brookhaven National Laboratory to generate a spectrum of ion beams that approximates the primary and secondary GCR field experienced at human organ locations within a deep-space vehicle. The majority of the dose is delivered from protons (~65-75%) and helium ions (~10-20%) with heavier ions (Z>3) contributing the remainder. The “GCR Simulator” exposes state-of-the art cellular and animal model systems to 33 sequential beams including 4 proton energies plus degrader, 4 helium energies plus degrader, and the five heavy ions of C, O, Si, Ti, and Fe. A polyethylene degrader is used with the 100 MeV/n H and He beams to provide a nearly continuous distribution of low energy particles. A 500 mGy exposure, delivering doses from each of the 33 beams, requires 75-90 minutes. To more closely simulate the low dose rates found in space, sequential field exposures can be divided into daily fractions over 2-6 weeks, with individual beam fractions as low as 0.1-0.2 mGy. In the large beam configuration (60 x 60 cm2), 54 special housing cages can accommodate 2-3 mice each for a 70-75 min duration or ~15 individually housed rats. Emerging research results from our 2018 runs utilizing mixed heavy ion fields and protracted space exposures are forthcoming and will deepen our understanding of the numerous health risks faced by astronauts. This talk discusses NASA’s innovative technology solution for a ground-based GCR simulator at the NASA Space Radiation Laboratory to enable future exploration missions.

galactic cosmic ray simulator↗