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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 217 records · Page 12
All sourcesNASA NTRSDOE OSTI
NASA NTRS2000

Orthostatic stress is necessary to maintain the dynamic range of cardiovascular control in space

In the upright position, gravity fills the low-pressure systems of human circulation with blood and interstitial fluid in the sections below the diaphragm. Without gravity one pressure component in the vessels disappears and the relationship between hydrostatic pressure and oncotic pressure, which regulates fluid passage across the capillary endothelium in the terminal vascular bed, shifts constantly. The visible consequences of this are a puffy face and "bird" legs. The plasma volume shrinks in space and the range of cardiovascular control is reduced. When they stand up for the first time after landing, 30-50% of astronauts suffer from orthostatic intolerance. It remains unclear whether microgravity impairs cardiovascular reflexes, or whether it is the altered volume status that causes the cardiovascular instability following space flight. Lower body negative pressure was used in several space missions to stimulate the cardiovascular reflexes before, during and after a space flight. The results show that cardiovascular reflexes are maintained in microgravity. However, the astronauts' volume status changed in space, towards a volume-retracted state, as measurements of fluid-regulating hormones have shown. It can be hypothesized that the control of circulation and body fluid homeostasis in humans is adapted to their upright posture in the Earth's gravitational field. Autonomic control regulates fluid distribution to maintain the blood pressure in that posture, which most of us have to cope with for two-thirds of the day. A determined amount of interstitial volume is necessary to maintain the dynamic range of cardiovascular control in the upright posture; otherwise orthostatic intolerance may occur more often.

manned↗
NASA NTRS1985

Effects of thermal stress and exercise on blood volume in humans

The available experimental data base on the effects of exercise, posture and the environment (heat) on the blood volume, composition and concentration in humans is surveyed in depth to synthesize supportable conclusions. A large disparity is noted in the effective controls which were initiated in previous experimental conditions, resulting in contradictory findings regarding, e.g., hemoconcentrations and hemodilution in response to exercise. Comparisons between the results of exercise and of supine, seated and upright subjects has underscored the importance of gravity in hemoconcentration, particularly in the legs, and the generation of aldotestosterone. Hemoconcentration has been confirmed to increase with exercise in a seated or supine position. Exercise in a heated environment transfers cardiac output from core areas and reduces filtration efficiencies. Also, plasma volume increases, an action which cannot yet be associated with crystalloidal or colloidal influences on the osmotic behavior of cell walls.

Harrison, M. H.↗
NASA NTRS1973

Blood electrolytes and exercise in relation to temperature regulation in man.

It is shown that the body temperature rise during physical exercise is a regulated process and is not due to a failure of heat-dissipating mechanisms. Core and skin temperatures do not provide sufficient information to account for the control of sweating during exercise. Evidence is presented that suggests an association between equilibrium levels of rectal temperature and the osmotic concentration of the blood with essentially no influence from variations in plasma volume.-

Greenleaf, J. E.↗
NASA NTRS1974

Unified method for serial study of body fluid compartments

Methods for the simultaneous determination of equilibrium space of I-125/RISA(radio-iodinated serum albumin) (plasma volume), Cr-51 red cell mass, Br-82 space (extracellular fluid volume), and tritiated water space (total body water) are described. Determinations were made on two occasions separated by a 1 week interval in 43 healthy young men who were on a strict metabolic diet. Hourly samples were taken for 6 hours after injection of the radionuclides. Correlation of these values to the inscribed exponential disappearance curve was high. In 15 subjects, earlier and more-frequent sampling led to no improvement in the accuracy of estimation of the I-125/RISA space. Use of this method gave results in 12 subjects for Br-82 space and in 11 subjects for tritiated water space which were not significantly different from those obtained by correction for urine loss.

Spears, C. P.↗
NASA NTRS1973

Blood electrolytes and exercise in relation to temperature regulation in man

Current knowledge and theories about the relation of blood electrolytes and exercise to thermoregulation in man are reviewed. It is shown that the elevation of body temperature during physical exercise is a regulated process and is not due to a failure of the heat dissipating mechanisms. Core and skin temperatures do not provide sufficient information to account for the control of sweating during exercise. Evidence is presented that suggests an association between equilibrium levels of rectal temperature and the osmotic concentration of the blood with essentially no influence of variations in plasma volume.

Greenleaf, J. E.↗
NASA NTRS1975

Proceedings of the 1973 Lyndon B. Johnson Space Center Endocrine Program Conference

Papers given at the conference are presented. Subjects covered include the following: biochemical changes during 28 days of space flight, modulating the pituitary-adrenal response to stress, the significance of biorhythms in space flight, the importance of the rein-angiotensin system in normal cardiovascular homeostasis, a progress report of stress-induced changes in corticosteroid metabolism, recent studies of physiological factors involved in the regulation of serotonin content and turnover in the brain, the role of brain biogenic amines in the control of pituitary-adrenocortical activity, application of the water immersion model to man by studies of acid-base homeostasis during simulated weightlessness, the present status of physiological studies and analysis of calcium homeostasis in the Apollo and Skylab programs, and endocrine considerations in the red-cell-mass and plasma-volume changes of Skylab 2 and 3 crews.

Source record↗
NASA NTRS1975

Dense plasma focus production in a hypocycloidal pinch

A type of high-power pinch apparatus consisting of disk electrodes was developed, and diagnostic measurements to study its mechanism of dense plasma production were made. The collapse fronts of the current sheets are well organized, and dense plasma focuses are produced on the axis with radial stability in excess of 5 microns. A plasma density greater than 10 to the 18th power/cubic cm was determined with Stark broadening and CO2 laser absorption. A plasma temperature of approximately 1 keV was measured with differential transmission of soft X-rays through thin foils. Essentially complete absorption of a high-energy CO2 laser beam was observed. The advantages of this apparatus over the coaxial plasma focus are in (1) the plasma volume, (2) the stability, (3) the containment time, (4) the easy access to additional heating by laser or electron beams, and (5) the possibility of scaling up to a multiple array for high-power operation.

Lee, J. H.↗
NASA NTRS1975

Hot ion plasma production in HIP-1 using water-cooled hollow cathodes

A steady-state ExB plasma was formed by applying a strong radially inward dc electric field near the mirror throats. Most of the results were for hydrogen, but deuterium and helium plasmas were also studied. Three water-cooled hollow cathodes were operated in the hot-ion plasma mode with the following results: (1) thermally emitting cathodes were not required to achieve the hot-ion mode; (2) steady-state operation (several minutes) was attained; (3) input powers greater than 40 kW were achieved; (4) cathode outside diameters were increased from 1.2 cm (uncooled) to 4.4 cm (water-cooled); (5) steady-state hydrogen plasma with ion temperatures from 185 to 770 eV and electron temperatures from 5 to 21 eV were produced. Scaling relations were empirically obtained for discharge current, ion temperature, electron temperature, and relative ion density as a function of hydrogen gas feed rate, magnetic field, and cathode voltage. Neutrons were produced from deuterium plasma, but it was not established whether thay came from the plasma volume or from the electrode surfaces.

Reinmann, J. J.↗
NASA NTRS1976

Effect of hypovolemia, infusion, and oral rehydration on gradual onset +Gz acceleration tolerance

The purpose of this study was to determine the effect of blood withdrawal, blood infusion, and oral fluid intake on +Gz tolerance at an acceleration rate of 0.5 G/min. Six healthy men aged 21-27 yr were centrifuged after the withdrawal of 400 ml of blood (hypovolemia) from each man; they were centrifuged again following blood infusion (Phase I). Three weeks later the men were accelerated after similar hypovolemia and again after consuming 800 ml of an isotonic NaCl drink (Phase II). Phase I hypovolemia resulted in a reduction in tolerance in all subjects from a mean control level of 6.42 + or - 0.35 min to 5.45 + or - 0.17 min (-15.1%, p less than 0.05). Both infusion and drinking returned tolerances to control levels. During acceleration there were significant (p less than 0.05) increases in plasma vasopressin levels to 35 pg/ml; these were not influenced appreciably by infusion or drinking. In all acceleration runs there was an obligatory shift (loss) of plasma volume and electrolytes, especially potassium, regardless of the experimental treatments. Oral rehydration is shown to be as effective as blood replacement in restoring +Gz acceleration tolerance decrements due to hypovolemia.

Greenleaf, J. E.↗
NASA NTRS1976

Cardiorespiratory deconditioning with static and dynamic leg exercise during bed rest

Results are presented for an experimental study designed to compare the effects of heavy static and dynamic exercise training during 14 days of bed rest on the cardiorespiratory responses to submaximal and maximal exercise performed by seven healthy men aged 19-22 yr. The parameters measured were submaximal and maximal oxygen uptake, minute ventilation, heart rate, and plasma volume. The results indicate that exercise alone during bed rest reduces but does not eliminate the reduction in maximal oxygen uptake. An additional positive hydrostatic effect is therefore necessary to restore maximal oxygen uptake to ambulatory control levels. The greater protective effect of static exercise on maximal oxygen uptake is probably due to a greater hydrostatic component from the isometric muscular contraction. Neither the static nor the dynamic exercise training regimes are found to minimize the changes in all the variables studied, thereby suggesting a combination of static and dynamic exercises.

Stremel, R. W.↗
NASA NTRS1977

Fluid shifts during thermal stress with and without fluid replacement

Six unacclimatized men rested for 4 hr in a hot, dry environment without fluid replacement (DH). Another group of six men were exposed to the same thermal stress, replacing evaporative fluid loss with warm 0.1% NaCl solution (FRP). Total grams of circulating hemoglobin, determined by CO immediately prior to and again during the last minutes of heat exposure, increased an insignificant 1.6 and 1.3% during DH and FRP, respectively. With DH, body weight loss of 2.6% was accompanied by a 7.8% reduction in calculated plasma volume (PV). Even when body weight was maintained (FRP), PV decreased 2.9% during the heat exposure. Total circulating serum protein did not change as a result of the heat stress with either DH or FRP. In a test-retest series of experiments on four men, DH was not detrimental to sweat rate. It is shown that hemodilution is not a general response to acute heat exposure. The disproportionately large reduction in PV during thermal dehydration is confirmed.

Myhre, L. G.↗
NASA NTRS1977

Production of dense plasmas in a hypocycloidal pinch apparatus

A high-power pinch apparatus consisting of disk electrodes was developed, and diagnostic measurements to study its mechanism of dense plasma production have been made. The collapse fronts of the current sheets are well organized, and dense plasma foci are produced on the axis with radial stability in excess of 5 microsec. A plasma density greater than 10 to the 18th power per cu cm is determined with Stark broadening and CO2 laser absorption. Essentially complete absorption of a high-energy CO2 laser beam has been observed. A plasma temperature of approximately 1 keV is measured with differential transmission of soft X-rays through thin foils. The advantages of this apparatus over the coaxial plasma focus are improvements in (1) plasma volume, (2) stability, (3) containment time, (4) access to additional heating by laser or electron beams, and (5) the possibility of scaling up to a multiple array for high-power operation.

Lee, J. H.↗
NASA NTRS1977

Effect of bedrest on circadian rhythms of plasma renin, aldosterone, and cortisol

Previous studies of normal men after 5 d of bedrest showed that circulatory instability on head-up tilt or standing is preceded by increased plasma renin activity (PRA) at bedrest. In the present study, the circadian rhythms of PRA, aldosterone, and cortisol have been observed in five normal men on a constant diet. In ambulatory controls, PRA and aldosterone increased normally after standing. On the third morning of bedrest, PRA was higher than before, and at noon, PRA was higher than in standing controls. The nocturnal peaks of PRA resulting from episodic renin secretion during sleep were higher after bedrest. Plasma aldosterone was also increased by bedrest. The findings are compatible with the theory that intermittent beta-adrenergic nerve activity during sleep is increased after bedrest, but other factors, such as loss of body sodium and a lower plasma volume, may also be involved.

Chavarri, M.↗
NASA NTRS1977

Insulin and glucose responses during bed rest with isotonic and isometric exercise

The effects of daily intensive isotonic (68% maximum oxygen uptake) and isometric (21% maximum extension force) leg exercise on plasma insulin and glucose responses to an oral glucose tolerance test (OGTT) during 14-day bed-rest (BR) periods were investigated in seven young healthy men. The OGTT was given during ambulatory control and on day 10 of the no-exercise, isotonic, and isometric exercise BR periods during the 15-wk study. The subjects were placed on a controlled diet starting 10 days before each BR period. During BR, basal plasma glucose concentration remained unchanged with no exercise, but increased (P less 0.05) to 87-89 mg/100 ml with both exercise regimens on day 2, and then fell slightly below control levels on day 13. The fall in glucose content during BR was independent of the exercise regimen and was an adjustment for the loss of plasma volume. The intensity of the responses of insulin and glucose to the OGTT was inversely proportional to the total daily energy expenditure during BR. It was estimated that at least 1020 kcal/day must be provided by supplemental exercise to restore the hyperinsulinemia to control levels.

Dolkas, C. B.↗
NASA NTRS1978

Effect of dehydration on erythropoiesis in mice - Relevance to the 'anemia' of space flight

Mice deprived of water for 24 h showed an increase in hematocrit and loss of body weight comparable to that seen in men during space flight. The increase in hematocrit was entirely due to a decrease in plasma volume and was associated with suppression of erythropoiesis, but with no significant change in the serum titer of a presumptive humoral regulator of erythropoiesis, Erythroid Stimulating Activity (ESA). Mice deprived of water for 24 h may be a useful model for the study of the early hematological effects of space flight. The suppression of erythropoiesis due to a relative erythrocytosis appears to be independent of ESA.

Dunn, C. D. R.↗
NASA NTRS1979

Ion confinement and transport in a toroidal plasma with externally imposed radial electric fields

Strong electric fields were imposed along the minor radius of the toroidal plasma by biasing it with electrodes maintained at kilovolt potentials. Coherent, low-frequency disturbances characteristic of various magnetohydrodynamic instabilities were absent in the high-density, well-confined regime. High, direct-current radial electric fields with magnitudes up to 135 volts per centimeter penetrated inward to at least one-half the plasma radius. When the electric field pointed radially toward, the ion transport was inward against a strong local density gradient; and the plasma density and confinement time were significantly enhanced. The radial transport along the electric field appeared to be consistent with fluctuation-induced transport. With negative electrode polarity the particle confinement was consistent with a balance of two processes: a radial infusion of ions, in those sectors of the plasma not containing electrodes, that resulted from the radially inward fields; and ion losses to the electrodes, each of the which acted as a sink and drew ions out of the plasma. A simple model of particle confinement was proposed in which the particle confinement time is proportional to the plasma volume. The scaling predicted by this model was consistent with experimental measurements.

Roth, J. R.↗
NASA NTRS1978

Studies on the erythron and the ferrokinetic responses in beagles adapted to hypergravity

Red cell survival, ferrokinetics, and hematologic parameters were investigated in beagle dogs exposed to chronic hypergravity (2.6 Gx). Ineffective erythropoiesis, red cell mass, plasma volume, and Cr-51-elution were significantly increased; maximum Fe-59 incorporation was decreased; and there was no change in the mean erythrocyte life span following autologous injection of Cr-51-labeled red cells and Fe-59-labeled transferrin. Red cell count, F(cells), total body hemoglobin (Hb), susceptability to osmotic lysis, and differential reticulocyte count were increased. White blood cell count, venous blood %Hb, mean cell volume, mean cell Hb, mean cell Hb concentration, and serum iron were decreased. No changes were observed for body mass, mg Fe per g Hb, iron binding capacity, percent saturation of iron carrying capacity, or the electrophoretic mobility of purified Hb. This study indicated that chronic exposure to hypergravity induced changes in red cell size, volume, total mass, and membrane permeability.

Beckman, D. A.↗