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At least 217 records · Page 12

Effects of hypodynamic simulations on the skeletal system of monkeys

A research and development program was undertaken to evaluate the skeletal losses of subhuman primates in hypodynamic environments. The goals of the program are: (1) to uncover the mechanisms by which weightlessness affects the skeletal system; (2) to determine the consequences and reversibility of bone mineral losses; and (3) to acquire a body of data needed to formulate an appropriate countermeasure program for the prevention of skeletal deconditioning. Space flight experiment simulation facilities are under development and will be tested for their capability in supporting certain of the requirements for these investigations.

Young, D. R.↗

BIOSPEX: Biological space experiments, a compendium of life sciences experiments carried on US spacecraft

United States space life science experiments, encompassing 27 years of experience beginning with sounding rocket flights carrying primates (1948) to the last U.S. spaceflight, the joint US/USSR Apollo Test Project (1975), are presented. The information for each experiment includes Principal Investigators, the program and mission on which it was flown, the specimens used, the objectives, protocol, equipment, results, conclusions, and bibliographic reference citations for publications derived from each experiment.

Anderson, M.↗

Animal life support transporters for Shuttle/Spacelab

Two transporter devices have been developed by the NASA Ames Research Center, primarily for the purpose of stowing small vertebrates and primates in the mid-deck avionics bay of the Shuttle during launch and re-entry. These animals will be used in Life Science Spacelab experiments. Stowage in the mid-deck area will reduce animal exposure to the high noise levels existing in Spacelab during launch; further, the possible exposure of the animals to high temperatures in Spacelab during re-entry and post-landing will be eliminated. The transporters will provide experimenters more timely access to their animals during experiment-critical, pre-launch, and post-landing periods. Rechargeable batteries in the transporters will provide life support system functions for the animals during periods of transfer and during mission phases in which power is temporarily unavailable. The transporters have been successfully designed, fabricated, and tested. Integrated testing of the transporters was performed in the Space Mission Development III (SMD III) Simulation at the NASA Johnson Space Center.

Berry, W. E.↗

Spacelab mission development tests

The paper describes Spacelab Mission Development Test III (SMD III) whose principal scientific objective was to demonstrate the feasibility of conducting biological research in the Life Sciences Spacelab. The test also provided an opportunity to try out several items of Common Operational Research Equipment (CORE) hardware being developed for operational use in Shuttle/Spacelab, such as rodent and primate handling, transportation units, and a 'zero-g' surgical bench. Operational concepts planned for Spacelab were subjected to evaluation, including animal handling procedures, animal logistics, crew selection and training, and a 'remote' ground station concept. It is noted that all the objectives originally proposed for SMD III were accomplished

Dalton, B. P.↗

Single frequency RF powered ECG telemetry system

It has been demonstrated that a radio frequency magnetic field can be used to power implanted electronic circuitry for short range telemetry to replace batteries. A substantial reduction in implanted volume can be achieved by using only one RF tank circuit for receiving the RF power and transmitting the telemetered information. A single channel telemetry system of this type, using time sharing techniques, was developed and employed to transmit the ECG signal from Rhesus monkeys in primate chairs. The signal from the implant is received during the period when the RF powering radiation is interrupted. The ECG signal is carried by 20-microsec pulse position modulated pulses, referred to the trailing edge of the RF powering pulse. Satisfactory results have been obtained with this single frequency system. The concept and the design presented may be useful for short-range long-term implant telemetry systems.

Ko, W. H.↗

Mechanism of selective lesion of the cardiovascular system in psycho-emotional stress

A species predisposition to hypertensive and ischemic heart disease occurs in mammals only at the level of primates, and is associated with social regulation of biological reactions. The specific physiological mechanism giving rise to psychonerogenic pathology may be an inhibition of the motor component of the agressive-defensive response. Repeated combination of pursuit with subsequent immobilization resulted in four out of five experimental baboons developing serious arterial hypertension and ischemic lesion of the heart which lasted many years.

Repin, Y. M.↗

Self-adaptive incremental Newton-Raphson algorithms

Multilevel self-adaptive Newton-Raphson type strategies are developed to improve the solution efficiency of nonlinear finite element simulations of statically loaded structures. The overall strategy involves three basic levels. The first level involves preliminary solution tunneling via primative operators. Secondly, the solution is constantly monitored via quality/convergence/nonlinearity tests. Lastly, the third level involves self-adaptive algorithmic update procedures aimed at improving the convergence characteristics of the Newton-Raphson strategy. Numerical experiments are included to illustrate the results of the procedure.

Padovan, J.↗

Motion sickness in the squirrel monkey

In this study of susceptibility to motion sickness the specific aims were to examine the effects of combined vertical rotation and horizontal acceleration, phenotype, sex, visual cues, morning and afternoon testing, and repeated test exposures on incidence, frequency, and latency of emetic responses. The highest emetic incidence of 89% with an emetic frequency of 2.0 during 60 min and a latency of 19 min from onset of testing occurred at 25 rpm and 0.5 Hz linear acceleration. Since the emetic responses were quite similar to man in eliciting motion stimuli it was concluded that the squirrel monkey represents a very suitable primate model for studies of motion and space sickness.

Ordy, J. M.↗

U.S. biological experiments in space

The history of biologic experimentation in space is traced. Early balloon and rocket borne animals showed no abnormalities on the macroscale, and biosatellite launches with bacteria and amoebae revealed no microscopic dysfunctions. Adult Drosophila flies on board Cosmos spacecraft died with a shortened lifespan, while their offspring lived full lifespans. Green pepper plants grown in weightlessness showed a different orientation, but no physiological disturbances. Normal bone growth in rats has been found to almost cease after 11 days in space, and the mean life span of red blood cells decreases by four days. A series of experiments designed by U.S. scientists will be performed on primates provided and flown by the U.S.S.R. Finally, experiments on board Spacelab will involve determination of the persistence of circadian rhythms in bacteria and humans.

Klein, H. P.↗

Lunar sample analysis

Results are presented from an extensive series of new high resolution scanning electron microscope studies of the very primative group of meteorites known as unequilibrated chondrites. These include quantitative analyses of micrometer sized phases and interpretation in terms of relevant phase equilibria. Several new meteorite minerals including high chromium metal, have been discovered.

Housley, R. M.↗

Thermoregulation in Erythrocebus patas - A thermal balance study

The ability of nonacclimated patas monkeys (Erythrocebus patas) to maintain a constant core temperature at six ambient temperatures from 15 to 40 C is investigated experimentally in 3 male and 3 female animals weighing 3.9-6.0 kg. The monkeys were permitted to reach equilibrium at the test Ta for at least 2 h before O2-uptake, CO2 output, weighted skin temperature (Tsk), rectal temperature (Tre), respiratory evaporative water loss (Eresp) and total evaporative water loss (Etot) were measured for 30 min. The results are presented in tables and graphs. Tsk is found to vary (from about 30.7 to about 37.2 C) with Ta, while Tre increases only from 37.6 to 38.4 C; Etot increases from about 9 to about 76 W/sq m, mainly due to eccrine sweating. Total body conductance, Tsk, and Tre are shown to be lower (the conductance significantly) at 40 C than those of rhesus monkeys. It is suggested that the enhanced heat tolerance of E. patas makes this species an appropriate subject for further studies of primate temperature regulation.

Kolka, M. A.↗

Acute physiological responses of squirrel monkeys exposed to hyperdynamic environments

Physiological and behavioral responses to a hyperdynamic environment were examined in four adult male squirrel monkeys. After baseline monitoring at 1 G, monkeys were exposed to one of three conditions: (1) +2 Gz for 60 minutes, (2) +2.9 Gz max for 8 minutes (simulating Space Shuttle launch), or (3) +1.7 Gz max for 19 minutes (simulating Space Shuttle reentry). During all experimental conditions, heart rate rose, and colonic temperature began to decline within the first ten minutes of centrifugation and decreased by as much as 2 C in some instances. Behaviorally, during centrifugation, the monkeys seemed to exhibit drowsiness and fall asleep, an observation not made during the control period. It is concluded that primates are susceptible to acute hyperdynamic field exposure.

Fuller, C. A.↗

Algorithm for Calibrating Robot Arms

Robots made to less demanding specifications and yet be more accurate. Method, described in published paper, used on any serial-link robot with any combination of revolute and primatic joints. Increases accuracy of positioning manipulator at any point in workspace relative to fixed coordinate system. Accurate absolute positioning capability particularly useful for those tasks where robot is issued target location by external sensory devices, such as vision system. With new method, ultraprecise manufacturing and high-resolution measurements of robot components unnecessary. Method therefore reduces cost of robots in addition to increasing robot accuracy.

Hayati, S. A.↗

US monkey and rat experiments flown on the Soviet Satellite Cosmos 1514

On December 14, 1983, the U.S.S.R. launched Cosmos 1514, an unmanned spacecraft carrying biological and radiation physics experiments from nine countries, including five from the United States. This was the fourth flight with U.S. experiments aboard one of the Soviet unmanned spacecraft. The Cosmos 1514 flight was limited to five days duration because it was the first nonhuman primate flight. Cosmos 1514 marked a significant departure from earlier flights both in terms of Soviet goals and the degree of cooperation between the U.S.S.R. and the United States. This flight included more than 60 experiments on fish, crawfish eggs, plants and seeds, 10 Wistar pregnant rats, and 2 young adult rhesus monkeys as human surrogates. United States specialist participated in postflight data transfer and specimen transfer, and conducted rat neonatal behavioral studies. An overview of the mission is presented focusing on preflight, on-orbit, and postflight activites pertinent to the five U.S. experiments aboard Cosmos.

Mains, R. C.↗

Resynchronization of circadian sleep-wake and temperature cycles in the squirrel monkey following phase shifts of the environmental light-dark cycle

Circadian rhythms in physiological and behavioral functions gradually resynchronize after phase shifts in environmental time cues. In order to characterize the rate of circadian resynchronization in a diurnal primate model, the temperature, locomotor activity, and polygraphically determined sleep-wake states were monitored in squirrel monkeys before and after 8-h phase shifts of an environmental light-dark cycle of 12 h light and 12 h dark (LD 12:12). For the temperature rhythm, resynchronization took 4 d after phase delay shift and 5 d after phase advance shift; for the rest-activity cycle, resynchronization times were 3 d and 6 d, respectively. The activity acrophase shifted more rapidly than the temperature acrophase early in the post-delay shift interval, but this internal desynchronization between rhythms disappeared during the course of resynchronization. Further study of the early resynchronization process requires emphasis on identifying evoked effects and measuring circadian pacemaker function.

Wexler, D. B.↗

An orthogonal oriented quadrature hexagonal image pyramid

An image pyramid has been developed with basis functions that are orthogonal, self-similar, and localized in space, spatial frequency, orientation, and phase. The pyramid operates on a hexagonal sample lattice. The set of seven basis functions consist of three even high-pass kernels, three odd high-pass kernels, and one low-pass kernel. The three even kernels are identified when rotated by 60 or 120 deg, and likewise for the odd. The seven basis functions occupy a point and a hexagon of six nearest neighbors on a hexagonal sample lattice. At the lowest level of the pyramid, the input lattice is the image sample lattice. At each higher level, the input lattice is provided by the low-pass coefficients computed at the previous level. At each level, the output is subsampled in such a way as to yield a new hexagonal lattice with a spacing sq rt 7 larger than the previous level, so that the number of coefficients is reduced by a factor of 7 at each level. The relationship between this image code and the processing architecture of the primate visual cortex is discussed.

Watson, Andrew B.↗

Animal research on the Space Station

The need for in-depth, long- and short-term animal experimentation in space to qualify man for long-duration space missions, and to study the effects of the absence and presence of Earth's gravity and of heavy particle radiation on the development and functioning of vertebrates is described. The major facilities required for these investigations and to be installed on the Space Station are: modular habitats for holding rodents and small primates in full bioisolation; a habitat holding facility; 1.8 and 4.0 m dia centrifuges; a multipurpose workbench; and a cage cleaner/disposal system. The design concepts, functions, and characteristics of these facilities are described.

Bonting, S. L.↗

Efficiency of a model human image code

Hypothetical schemes for neural representation of visual information can be expressed as explicit image codes. Here, a code modeled on the simple cells of the primate striate cortex is explored. The Cortex transform maps a digital image into a set of subimages (layers) that are bandpass in spatial frequency and orientation. The layers are sampled so as to minimize the number of samples and still avoid aliasing. Samples are quantized in a manner that exploits the bandpass contrast-masking properties of human vision. The entropy of the samples is computed to provide a lower bound on the code size. Finally, the image is reconstructed from the code. Psychophysical methods are derived for comparing the original and reconstructed images to evaluate the sufficiency of the code. When each resolution is coded at the threshold for detection artifacts, the image-code size is about 1 bit/pixel.

Watson, Andrew B.↗