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At least 217 records · Page 12

Solution growth of crystals in zero gravity

A series of experiments will be performed in which triglycine sulfate (TGS) crystals will be grown by a low-temperature solution growth technique in the microgravity environment of the orbital Spacelab. Triglycine sulfate (TGS) crystals will be grown in the Fluid Experiment System (FES) facility on Spacelab 3 by slowly extracting heat at a controlled rate through a seed crystal of TGS suspended on an insulated sting in a saturated solution of TGS. The FES rack assembly designed for SL-3 is shown in Figure I-1, and a detailed view of the test cell layout is presented in Figure I-2. Variations in the liquid density, solution concentration and temperature around the growing crystal will be studied using a variety of techniques, such as schlieren, shadowgraph, and interferometric measurements. Growth in Earth gravity will also be studied by the same optical techniques, and in both cases the resulting crystalline features will be compared and correlated with the growth conditions.

Lai, R. B.↗

Morphology and chemistry of projectile residue in small experimental impact craters

Small-scale impact craters (5-7 mm in diameter) were produced with a light gas gun in high purity Au and Cu targets using soda lime glass (SL) and man-made basalt glass (BG) as projectiles. Maximum impact velocity was 6.4 km/s resulting in peak pressures of approximately 120-150 GPa. Copious amounts of projectile melts are preserved as thin glass liners draping the entire crater cavity; some of this liner may be lost by spallation, however. SEM investigations reveal complex surface textures including multistage flow phenomena and distinct temporal deposition sequences of small droplets. Inasmuch as some of the melts were generated at peak pressures greater than 120 GPa, these glasses represent the most severely shocked silicates recovered from laboratory experiments to date. Major element analyses reveal partial loss of alkalis; Na2O loss of 10-15 percent is observed, while K2O loss may be as high as 30-50 percent. Although the observed volatile loss in these projectile melts is significant, it still remains uncertain whether target melts produced on planetary surfaces are severely fractionated by selective volatilization processes.

Horz, F.↗

Response of amino acids in hindlimb muscles to recovery from hypogravity and unloading by tail-cast suspension

Concentrations of glutamine, glutamate, aspartate (+ asparagine) and alanine were compared in hindlimb muscles of SL-3 and ground control rats. Alanine was lower in the soleus of flown rats but not of suspended animals, with no response in other muscles except a slight increase in the unloaded plantaris. With recovery, alanine in the soleus was elevated. Since no differences in alanine metabolism were found by isolated muscle, changes in muscle alanine are probably due to altered body use of this amino acid leading to varied plasma levels.

Tischler, M. E.↗

Response of rat hindlimb muscles to 12 hours recovery from tail-cast suspension

Previous work has shown a number of biochemical changes which accompany atrophy or reduced muscle growth in hindlimb of tail-casted, suspended rats. These results clearly show that altered muscle growth was due to changes in protein turnover. Accordingly, the rise in soleus tyrosine following unloading reflects the more negative protein balance. Other major changes we found included slower synthesis of glutamine as indicated by lower ratios of glutamine/glutamate and reduced levels of aspartate which coincide with slower aspartate and ammonia metabolism in vitro. In conjunction with the study of SL-3 rats, which were subjected to 12 h of post-flight gravity, a study of the effects of 12 h eight bearing on metabolism of 6-day unloaded hindlimb muscles was carried out.

Tischler, M. E.↗

Spacelab 1 and the Life Sciences Flight Experiments Program

The Life Sciences Flight Experiments Program (LSFEP) was established by NASA in 1978 to plan and direct efforts necessary to conduct a continuing program of in-flight life science investigations throughout the Space Shuttle era. The Spacelab 1 (SL-1) mission, conducted from November 28 to December 8, 1983, was to verify Spacelab performance through a variety of scientific experiments including life science. A description is given of the seven NASA life sciences experiments, which consisted of four human experiments, a fungus experiment, a plant experiment, and radiation experiments. Ten life sciences experiments from the European Space Agency were also flown. The experiments include studies of the circadian rhythms in Neurospora crassa, the nutation of Helianthus annus, the vestibular function during weightlessness, the influence of space flight on erythrokinetics in man, and the adaptation of vestibulo-spinal reflex mechanisms during space flight.

Bush, W. H.↗

Flight evaluation of Spacelab 1 payload thermal/ECS interfaces

The Spacelab (SL-1) thermal/Environmental Control Systems (ECS) are discussed. Preflight analyses and flight data are compared in order to validate payload to Spacelab interfaces as well as corroborate modeling/analysis techniques. In doing so, a brief description of the Spacelab 1 payload configuration and the interactive Spacelab thermal/ECS systems are given. In particular, these interfaces address equipment cooling air, thermal and fluid conditions, humidity levels, both freon and water loop temperatures and load states, as well as passive radiant environment interfaces.

Ray, C. D.↗

Infrared measurements of spacecraft glow planned for Spacelab 2

A liquid helium cooled infrared telescope (IRT) was to be flown in July 1985 on Spacelab 2. The instrument is designed to measure both diffuse and discrete infrared astronomical sources, including the zodiacal light, galactic, and extragalactic components, as well as to evaluate the induced Orbiter environment. The focal plane contains ten photoconductive detectors covering six broad bands from 2 to 120 microns. Each detector has a 0.5 by 1.0 deg field of view optimized for detection of extended sources of IR radiation. Except for the 2 micron detector, the system noise is limited by the sky background noise. The measurements planned for the IRT use the 1 meter base of the Plasma Diagnostic Package (PDP), an already existing SL 2 experiment, as the glow generating surface. The measurements are repeated changing the position of the PDP, the attitude of the Orbiter, and the ram direction in an effort to remove both the thermal component of the PDP emission and the cosmic background radiation.

Fazio, G. G.↗

Shuttle flight experiment 30-day summary report

A total of 12 AFT training sessions were administered to SL 3 Payload Specialists over a 7 month period. Nine of these sessions were 2 hours in duration and three were 3 hours in duration. A total of three rotating chair tests were conducted in this time frame with four subjects. The performance of these crewmen across tests is shown. Test 1, a baseline motion sickness test, was conducted approximately 10 months prior to the mission, before any AFT was administered. Test 2 was administered after 2 hours of AFT, test 3 after 4 hours and test 4 after 6 hours (total) of training in symptom control. Improvement in performance is reflected by a subject's ability to tolerate a greater number of rotations across tests. Additional training for crewman was not possible within the constraints of the mission. Results of the mission indicate that, as predicted preflight, subject #32 was relatively symptom free inflight while subject #33 was not. Other preflight and postflight tests and analyses are reported.

Source record↗

Spacelab experiments on space motion sickness

Recent research results from ground and flight experiments on motion sickness and space sickness conducted by the Man Vehicle Laboratory are reviewed. New tools developed include a mathematical model for motion sickness, a method for quantitative measurement of skin pallor and blush in ambulatory subjects, and a magnitude estimation technique for ratio scaling of nausea or discomfort. These have been used to experimentally study the time course of skin pallor and subjective symptoms in laboratory motion sickness. In prolonged sickness, subjects become hypersensitive to nauseogenic stimuli. Results of a Spacelab-1 flight experiment are described in which 4 observers documented the stimulus factors for and the symptoms/signs of space sickness. The clinical character of space sickness differs somewhat from acute laboratory motion sickness. However SL-1 findings support the view that space sickness is fundamentally a motion sickness. Symptoms were subjectively alleviated by head movement restriction, maintenance of a familiar orientation with respect to the visual environment, and wedging between or strapping onto surfaces which provided broad contact cues confirming the absence of body motion.

Oman, C. M.↗

Response of rat hindlimb muscles to 12 hours recovery from tail-cast suspension

Previous work has shown a number of biochemical changes which accompany atrophy or reduced muscle growth in hindlimb of tail-casted, suspended rats. These results clearly show that altered muscle growth was due to changes in protein turnover. Accordingly, the rise in soleus tyrosine following unloading reflects the more negative protein balance. Other major changes we found included slower synthesis of glutamine as indicated by lower ratios of glutamine/glutamate and reduced levels of aspartate which coincide with slower aspartate and ammonia metabolism in vitro. In conjunction with the study of SL-3 rats, which were subjected to 12 h of post-flight gravity, a study of the effects of 12 h eight bearing on metabolism of 6-day unloaded hindlimb muscles was carried out.

Tischler, M. E.↗

Development and testing of a mouse simulated space flight model

The development and testing of a mouse model for simulating some aspects of weightlessness that occurs during space flight, and the carrying out of immunological experiments on animals undergoing space flight is examined. The mouse model developed was an antiorthostatic, hypokinetic, hypodynamic suspension model similar to one used with rats. The study was divided into two parts. The first involved determination of which immunological parameters should be observed on animals flown during space flight or studied in the suspension model. The second involved suspending mice and determining which of those immunological parameters were altered by the suspension. Rats that were actually flown in Space Shuttle SL-3 were used to test the hypotheses.

Sonnenfeld, Gerald↗

Growth hormone secretion during space flight and evaluation of the physiological responses of animals held in the research animal holding facility

The spaceflight of the Research Animal Holding Facility (RAHF) on the Space Laboratory 3 (SL 3) provided the opportunity to evaluate the suitability of the RAHF for housing and maintaining experimental animals during spaceflight, and to determine changes in the secretion of growth hormone during spaceflight. Using ground-based studies the following were investigated: the optimum conditions for creating gravitational force on space flight animals; neural pathways that may play a role in the space flight syndrome; and the time course of muscle atrophy due to hypodynamia and hypokenesia in hindlimb-suspended animals and the role of growth hormone in these processes.

Fast, Thomas N.↗

Transition from laminar to turbulent flow in separated shear layers

The location of boundary layer separation may be predicted by either semiempirical criteria or by various computer codes written for such calculations; attention is presently given to the streamwide length from separation to transition, denoted by Re(sL). It is demonstrated that the unit Reynolds number, a feature of the transition phenomenon implicit in the data of Schmidt et al. (1985) and overlooked in previous investigations, must be considered in future work.

Potter, J. Leith↗

Inhibited interferon-gamma but normal interleukin-3 production from rats flown on the Space Shuttle

Rats were flown on Space Shuttle SL-3 for one week. When spleen cells were removed from these rats and challenged with concanavalin-A, interferon-gamma production was severely inhibited, while interleukin-3 production was unaffected compared to ground-based control rats. These data indicate that there is a defect in interferon-gamma production in rats that have been exposed to spaceflight. This defect could contribute to, and be one reason for, immunosuppression observed after spaceflight.

Gould, Cheryl L.↗

PI-in-a-box: Intelligent onboard assistance for spaceborne experiments in vestibular physiology

In construction is a knowledge-based system that will aid astronauts in the performance of vestibular experiments in two ways: it will provide real-time monitoring and control of signals and it will optimize the quality of the data obtained, by helping the mission specialists and payload specialists make decisions that are normally the province of a principal investigator, hence the name PI-in-a-box. An important and desirable side-effect of this tool will be to make the astronauts more productive and better integrated members of the scientific team. The vestibular experiments are planned by Prof. Larry Young of MIT, whose team has already performed similar experiments in Spacelab missions SL-1 and D-1, and has experiments planned for SLS-1 and SLS-2. The knowledge-based system development work, performed in collaboration with MIT, Stanford University, and the NASA-Ames Research Center, addresses six major related functions: (1) signal quality monitoring; (2) fault diagnosis; (3) signal analysis; (4) interesting-case detection; (5) experiment replanning; and (6) integration of all of these functions within a real-time data acquisition environment. Initial prototyping work has been done in functions (1) through (4).

Colombano, Silvano↗

Plasma diagnostics package. Volume 2: Spacelab 2 section. Part B: Thesis projects

This volume (2), which consists of two parts (A and B), of the Plasma Diagnostics Package (PDP) Final Science Report contains a summary of all of the data reduction and scientific analyses which were performed using PDP data obtained on STS-51F as a part of the Spacelab 2 (SL-2) payload. This work was performed during the period of launch, July 29, 1985, through June 30, 1988. During this period the primary data reduction effort consisted of processing summary plots of the data received by 12 of the 14 instruments located on the PDP and submitting these data to the National Space Science Data Center (NSSDC). Three Master's and three Ph.D. theses were written using PDP instrumentation data. These theses are listed in Volume 2, Part B.

Pickett, Jolene S.↗

Influence of spaceflight on rat skeletal muscle

The effect of a 7-day spaceflight (aboard NASA's SL-3) on the size and the metabolism of single fibers from several rat muscles was investigated along with the specificity of these responses as related to the muscle type and the size of fibers. It was found that the loss of mass after flight was varied from 36 percent in the soleus to 15 percent in the extensor digitorum longus. Results of histochemical analyses showed that the succinate dehydrogenase (SDH) activity in muscles of flight-exposed rats was maintained at the control levels, whereas the alpha-glycerol phosphate dehydrogenase (GPD) activity was either maintained or increased. The analyses of the metabolic profiles of ATPase, SDH, and GPD indicated that, in some muscles, there was an increase in the poportion of fast oxidative-glycolytic fibers.

Martin, Thomas P.↗