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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Proteome-Scale Tissue Mapping Using Mass Spectrometry Based on Label-Free and Multiplexed Workflows
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Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults
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Gross tumor volume confidence maps prediction for soft tissue sarcomas from multi-modality medical images using a diffusion model
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A Methodology Study on Chemical and Molecular Structure Imaging in Modified Forage Leaf Tissue with Cutting-Edge Synchrotron-Powered Technology (SR-IMS) as a Potential Research Tool.
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Novel Use of Ultra-Resolution Synchrotron Vibrational Micropectroscopy (SR-FT/vIMS) to Assess Carinata and Canola oilseed tissues within Cellular and Subcellular Dimensions
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Scanning x-ray microdiffraction: In situ molecular imaging of tissue and materials
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Predicting Prostate Cancer Directly from Tissue Images using Deep Learning on Mass Spectrometry Imaging and Whole Slide Imaging Data
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Differential Protein Citrullination in Human ER– and ER+ Tumor and Adjacent Healthy Breast Tissue
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Capturing Biologically Complex Tissue-Specific Membranes at Different Levels of Compositional Complexity
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Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer’s Disease and Associated Amyloid-Disease Brain Tissue
Antibodies that target the β-amyloid peptide (Aβ) and its associated assemblies are important tools in Alzheimer’s disease research and have emerged as promising Alzheimer’s disease therapies. This paper reports the creation and characterization of a triangular Aβ trimer mimic composed of Aβ 17–36 β-hairpins and the generation and study of polyclonal antibodies raised against the Aβ trimer mimic. The Aβ trimer mimic is covalently stabilized by three disulfide bonds at the corners of the triangular trimer to create a homogeneous oligomer. Structural, biophysical, and cell-based studies demonstrate that the Aβ trimer mimic shares characteristics with oligomers of full-length Aβ. X-ray crystallography elucidates the structure of the trimer and reveals that four copies of the trimer assemble to form a dodecamer. SDS-PAGE, size exclusion chromatography, and dynamic light scattering reveal that the trimer also forms higher-order assemblies in solution. Cell-based toxicity assays show that the trimer elicits LDH release, decreases ATP levels, and activates caspase-3/7 mediated apoptosis. Immunostaining studies on brain slices from people who lived with Alzheimer’s disease and people who lived with Down syndrome reveal that the polyclonal antibodies raised against the Aβ trimer mimic recognize pathological features including different types of Aβ plaques and cerebral amyloid angiopathy.
Development of Optimized Tissue-Factor-Targeted Peptide Amphiphile Nanofibers to Slow Noncompressible Torso Hemorrhage
Abstract not provided