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At least 217 records · Page 12

GEONEX: Progressive Conditional Generative Adversarial Training Using Transfer learning

Obtaining accurate segmentation on large scale images is an open problem in deep learning. The main problem is the amount of labeled data that exists for large scale images. Traditionally, the common solution to this problem is to crop the large images into smaller images to increase the amount of available data and train a Conditional Generative Adversarial Network (CGAN). CGANs are currently the state of the art in image to image translation and provide better accuracy than the traditional method of training a encoder based conv-net architecture to minimize the loss at each pixel. This method can produce noisy and discontinuous images with inaccurate results. We seek to solve this problem by utilizing the concepts of transfer learning and progressive training to create a CGAN that can segment large scale images with a limited amount of labeled data. In transfer learning we recognize that many learned features are applicable to many classes from multiple domains. This introduces the concept of feature reusability, which is the basis for finetuning. Progressive training got its start in training models on the same images at different resolutions. In this work we instead train a GAN on increasing image scales by transferring the weights from the smaller scales to the larger scales. The learned features at the smaller scales are continually reused and applied to larger scales to create a CGAN that can perform accurate segmentation on large scale images. We apply this method to detect building footprints on very high-resolution overhead imagery (e.g Digital Globe and high resolution airborne platforms).

GEONEX↗

Detect-and-Avoid Alerting Performance for High-Speed UAS and Non-Cooperative Aircraft

This paper presents a set of experiments designed to assess the viability of using a smaller Detect and Avoid (DAA) volume for large Unmanned Aircraft Systems (UAS) when they are trying to remain well clear of non-cooperative visual flight rules (VFR) aircraft, in compliance with Federal regulations. The current DAA volume was defined for both cooperative and non-cooperative VFR traffic by the work of RTCA (Radio Technical Commission for Aeronautics) Special Committee 228 in 2017, in what is referred to in this paper as the Phase 1 standards. Subsequent work by the committee has been focused on enabling operations by smaller UAS that cannot carry the heavy radars required for the Phase 1 DAA Minimum Operational Performance Standards (MOPS). The work discussed in this paper will explore whether a Phase 1 UAS using a Phase 1 radar can use the reduced non-cooperative DAA alerting volume being studied for smaller, slower Phase 2 UAS without significantly degrading system safety. The study uses UAS models and background traffic from previous Phase 1 and Phase 2 research to run an unmitigated simulation that will examine alerting performance using different DAA well clear definitions. The primary metrics are also tied to the alerting performance of the DAA system, and include average alerting times, probabilities of missed and late alerts, and the probability of a near mid-air collision given a loss of "well clear," as defined by the DAA system. Results are expected to help RTCA make the determination whether or not the DAA well clear definition for Phase 1 UAS can be reduced for non-cooperative VFR aircraft.

UAS↗

The NASA Orbital Debris Engineering Model 3.1: Development, Verification, and Validation

The NASA Orbital Debris Program Office has developed the Orbital Debris Engineering Model (ORDEM) primarily as a tool for spacecraft designers and other users to understand the long-term risk of collisions with orbital debris. The newest version, ORDEM 3.1, incorporates the latest and highest fidelity datasets available to build and validate representative orbital debris populations encompassing low Earth orbit (LEO) to geosynchronous orbit (GEO) altitudes for the years 2016-2050. ORDEM 3.1 models fluxes for object sizes > 10 μm within or transiting LEO and > 10 cm in GEO. The deterministic portion of the populations in ORDEM 3.1 is based on the U.S. Space Surveillance Network (SSN) catalog, which provides coverage down to approximately 10 cm in LEO and 1 m in GEO. Observational datasets from radar, in situ, and optical sources provide a foundation from which the model populations are statistically extrapolated to smaller sizes and orbit regions that are not well-covered by the SSN catalog, yet may pose the greatest threat to operational spacecraft. Objects in LEO ranging from approximately 5 mm to 10 cm are modeled using observational data from ground-based radar, namely the Haystack Ultrawideband Satellite Imaging Radar (HUSIR – formerly known as Haystack). The LEO population smaller than approximately 3 mm in size is characterized based on a reanalysis of in situ data from impacts to the windows and radiators of the U.S. Space Transportation System orbiter vehicle, i.e., the Space Shuttle. Data from impacts on the Hubble Space Telescope are also used to validate the sub-millimeter model populations in LEO. Debris in GEO with sizes ranging from 10 cm to 1 m is modeled using optical measurement data from the Michigan Orbital DEbris Survey Telescope (MODEST). Specific, major debris-producing events, including the Fengyun-1C, Iridium 33, and Cosmos 2251 debris clouds, and unique populations, such as sodium-potassium droplets, have been re-examined and are modeled and added to the ORDEM environment separately. The debris environment greater than 1 mm is forecast using NASA’s LEO-to- GEO ENvironment Debris model (LEGEND). Future explosions of intact objects and collisions involving objects greater than 10 cm are assessed statistically, and the NASA Standard Satellite Breakup Model is used to generate fragments from these events. Fragments smaller than 10 cm are further differentiated based on material density categories, i.e., high-, medium-, and low-density, to better characterize the potential debris risk posed to spacecraft. The future projection of the sub-millimeter environment is computed using a special small-particle degradation model where small particles are created from intact spacecraft and rocket bodies. This work discusses the development, features, and capabilities of the ORDEM 3.1 model; the ne new data analyses used to build the model populations; and sample verification and validation results.

Matney, M.↗

The Updated GEO Population for ORDEM 3.1

The limited availability of data for satellite fragmentations and debris in the geosynchronous orbit (GEO) region creates challenges to building accurate models for the orbital debris environment at such altitudes. Updated methods to properly incorporate and extrapolate measurement data have become a cornerstone of the GEO component in the newest version of the NASA Orbital Debris Engineering Model (ORDEM), ORDEM 3.1. For the GEO region, the Space Surveillance Network (SSN) catalog provides coverage down to a limit of approximately 1 m. A more statistically complete representation of the GEO population for smaller objects, which can pose a high risk to operational spacecraft, is thus dependent on dedicated observations by instruments optimized to observe debris smaller than the SSN cataloging threshold. For ORDEM 3.1, optical data from the Michigan Orbital DEbris Survey Telescope (MODEST) provided the input for building the GEO population down to approximately 30 cm (converting absolute magnitude to size). For smaller sizes, the size distribution of debris in the MODEST dataset was extrapolated down to 10 cm, and orbital parameters were estimated based on the orbits of the larger objects. When compared to previous versions of the model, significant improvements were made to the process of building the GEO population in ORDEM 3.1, both in the assessment of fragmentation debris in the data and assignment of orbital elements within the model. A so-called “debris ring filter,” based on a range of angles between an orbit’s angular momentum vector and that of the stable Laplace plane, was applied to the data to reduce biases from non- GEO objects, such as objects in a GEO-transfer orbit. In addition, a new approach was implemented to assign noncircular mean motions and eccentricities to the fragmentation debris observed by MODEST because the short observation window (5 min) in GEO limits orbit resolution to a circular orbit assumption for assigning orbital parameters. For ORDEM 3.1, non-circular orbital elements were assigned using relationships that were identified between mean motion and the angle between the orbit plane and the stable Laplace plane, as well as between mean motion and eccentricity, based on breakup clouds modeled by the NASA Standard Breakup Model. This approach has yielded a high-fidelity GEO model that has been validated with data from more recent MODEST observation campaigns.

Manis, A.↗

Similarities in the Lidar-Observed Optical Properties in the 2020 Australian Bushfire PyroCb and the 2017 Pacific Northwest PyroCb Stratospheric Plumes

Recent fire seasons have featured volcanic-sized injections of smoke aerosols into the stratosphere where they persist for many months. Unfortunately, the aging and transport of these aerosols are not well understood. Using space-based lidar, the vertical and spatial propagation of these aerosol layers can be tracked and inferences can be made as to the size and shape of the constituent aerosol particles. In this study, space-based CALIOP and CATS lidar were used to track the evolution of the stratospheric aerosol plumes resulting from the 2019 - 2020 Australian bushfire and 2017 Pacific Northwest pyrocumulonimbus events and were compared to two volcanic events: Calbuco (2015) and Puyehue (2011) and two smaller pyrocumulonimbus events: California’s Rim Fire (2013) and Australia’s Black Saturday (2009). The aerosol plumes from the large pyrocumulonimbus events rose many kilometers in the stratosphere in the weeks after injection to upwards of 30km in altitude. The layer-integrated depolarization ratios and color ratios of the 2020 Australian bushfire and 2017 Pacific Northwest pyrocumulonimbus plumes both vary by altitude with the lidar-measured depolarization and color ratios indicating the higher altitude aerosol layers contain smaller and more irregularly shaped aerosol particles. This relationship between altitude and optical properties was not observed in the smaller pyrocumulonimbus or the volcanic event stratospheric plumes.

Kenneth Christian↗

Segmented Ion Engine Operation and Performance

The continuing trend toward smaller and smaller planetary spacecraft to enable the use of smaller, less expensive launch vehicles has motivated an examination of new approaches to reduce the size and mass of xenon ion propulsion systems for these new spacecraft. A system is proposed which is based on the use of a single 4x15-cm segmented ion thruster operated from a single internally redundant power processing unit. An engine input power throttling range of 380 to 4640 W is projected. The design and operation over a power range of 600 to 2400 W of a laboratory model segmented ion engine equipped with carbon-carbon grids is presented. There appear to be no problems associated with interactions with multiple ion sources operating from a single set of high voltage power supplies, neutralization of multiple ion sources from a single centrally located neutralizer, or operation of flat, thin carbon-carbon grids.

ion↗

HabEx Lite: a Starshade-only Habitable Exoplanet Imager Alternative

The HabEx mission concept is intended to directly image planetary systems around nearby stars, and to perform a wide range of general astrophysics and solar system observations. Its main goal is the discovery and characterization of Earthlike exoplanets through high-contrast imaging and spectroscopy. The baseline HabEx concept would use both a coronagraph and a starshade for exoplanet science. We describe an alternative, “HabEx Lite” concept, which would use a starshade (only) for exoplanet science. The benefit is lower cost: by deleting the complex coronagraph instrument; by lowering observatory mass; by relaxing tolerances and stability requirements; by permitting use of a compact on-axis telescope design; by use of a smaller launch vehicle. The scientific penalty of this lower cost option is a smaller number of detected exoplanets of all types, including exoEarth candidates, and a smaller fraction of exoplanets with measured orbits. Our approach uses a non-deployed segmented primary mirror, whose manufacture is within current capabilities.

Stark, Chris↗

Satellite Remote Sensing Observations of Trans-Atlantic Dust Transport and Deposition: A Multi-Sensor Analysis

We analyze the decade-long (2007-2016) record of aerosol measurements from four distinctive sensors, namely CALIOP, MODIS, MISR, and IASI, to quantify the trans-Atlantic dust transport and deposition. These satellite sensors use different techniques to characterize particle size and shape properties; and we have developed sensor-specific methods (broadly categorized into size-based and shape-based method) to derive dust optical depth (DOD). The size-based DOD from MODIS and IASI generally agrees better with AERONET-derived DOD than the shape-based DOD from CALIOP and MISR does. Overall, the shape-based DOD is smaller than the size-based DOD by about 25%, which is consistent with distinctive ways of accounting for coarse-spherical particles of dust-pollution internal mixture. While such dust-pollution mixtures are counted as dust in the size-based DOD, they are excluded in the shape-based DOD. DOD is not a good proxy for dust deposition. Instead, the dust deposition depends strongly on the gradient of DOD on a monthly basis and can be derived by calculating the meridional and zonal dust mass flux based on the three-dimensional distributions of dust. Among the remote sensing measurements, difference in dust deposition is smaller than that of DOD, suggesting that different satellites characterize the DOD gradient more consistently than DOD itself. Satellite measurements of dust deposition and DOD also provide an accurate estimate of the dust loss frequency (LF) that measures how efficient the dust is removed from the atmosphere. We found that these remote sensing measurements yield similar LF values of 0.078 –0.102 d-1, which however is factors of 2-5 smaller than model simulations. This analysis provides valuable insights into potential deficiencies in models’ emission and transport/removal processes and hence helps guide model improvement.

remote sensing↗

Press-fit Connectors in Spaceflight Applications - Drivers and Challenges

Starting from the 1970s when press-fit technology was nascent and confined within the telecommunications industry, this technology has matured as its adoption has increased within high reliability applications such as medical devices and avionics. Press-fit connectors are strongly preferred in today’s designs because the smaller press-fit pins require smaller diameter holes which require smaller pads and allows more routing real-estate without taking exceptions to specs. The lack of solder for a press-fit connection makes the conductive path more predictable for high-speed digital design and impedance discontinuities can be minimized as the signal moves from the printed circuit board to the connector. Touch-up during manufacturing is also reduced and streamlines the assembly process. This presentation at the 2022 NEPP ETW will introduce the audience to press-fit connectors and its contact physics followed by a deeper dive into specific press-fit applications for space flight environments, including information on qualification, testing, and screening.

pressfit↗

Future High-Resolution and High-Cadence Observations for Unraveling Eruptive Solar Features

Many of the key advances in solar science over recent decades have been strongly influenced by imaging with increasing resolution and cadence of the Sun’s atmosphere from space. There is still much room for further advances in this area in the coming decades. Here we demonstrate this potential using recent advances in observation and understanding of the features known as solar coronal jets. Modern jet studies started in the 1990s, but have progressed substantially over the past ten years. Much of this progress is due to improved resolution and cadence in imaging, along with concurrent improved magnetic field and spectroscopic observations. Moreover, it is now clear that jets are smaller-size-scale, shorter-time-scale versions of less-frequent larger solar eruptions. Jets are also likely representative of yet more numerous eruptions occurring on smaller size scales. We propose development of instrumentation focused on multi-wavelength observations of jet-sized-scale eruptive solar activity, as a window to understanding both larger-scale and smaller-scale eruptive solar events.

Alphonse C. Sterling↗

DNA Break Clustering as a Predictor of Cell Death across Various Radiation Qualities: Influence of Cell Size, Cell Asymmetry, and Beam Orientation

Cosmic radiation, composed of high charge and energy (HZE) particles, causes cellular DNA damage that can result in cell death or mutation that can evolve into cancer. In this work, a cell death model is applied to several cell lines exposed to HZE ions spanning a broad range of linear energy transfer (LET) values. We hypothesize that chromatin movement leads to the clustering of multiple double strand breaks (DSB) within one radiation-induced foci (RIF). The survival probability of a cell population is determined by averaging the survival probabilities of individual cells, which is function of the number of pairwise DSB interactions within RIF. The simulation code RITCARD was used to compute DSB. Two clustering approaches were applied to determine the number of RIF per cell. RITCARD outputs were combined with experimental data from four normal human cell lines to derive the model parameters and expand its predictions in response to ions with LET ranging from ∼0.2keV/μmto∼3000keV/μm. Spherical and ellipsoidal nuclear shapes and two ion beam orientations were modeled to assess the impact of geometrical properties on cell death. The calculated average number of RIF per cell reproduces the saturation trend for high doses and high-LET values that is usually experimentally observed. The cell survival model generates the recognizable bell shape of LET dependence for the relative biological effectiveness (RBE). At low LET, smaller nuclei have lower survival due to increased DNA density and DSB clustering. At high LET, nuclei with a smaller irradiation area either because of a smaller size or a change in beam orientation have a higher survival rate due to a change in the distribution of DSB/RIF per cell. If confirmed experimentally, the geometric characteristics of cells would become a significant factor in predicting radiation-induced biological effects.

cell survival↗

High Performance Access to Archival Data Stored in HDF4 and HDF5 on Cloud Object Stores Without Reformatting the Files

Cloud computing offers numerous advantages for users of extensive Earth science data collections. These benefits encompass direct online access to data files and granules from any location, scalable access supporting parallel computing workflows, and flexible computing tools enabling innovative experimentation with processing techniques. However, older archival file formats designed for distinct computing systems hinder efficient access to decade-long time-series data when compared to data stored in modern cloud-optimized formats like Web Object Stores (WOS), exemplified by Amazon Web Services’ Simple Storage Service (S3). We describe DMR++ (Dataset Metadata Response plus plus), a technology facilitating efficient access to HDF5 (Hierarchical Data Format, version 5) and HDF4 files stored on WOS systems without requiring data reformatting. DMR++ achieves performance comparable to technologies like Zarr while preserving the original file structure, a substantial benefit considering the vast quantity of archival files held by organizations such as NASA. Moreover, DMR++ typically outperforms cloud-optimized versions of HDF5. Essentially an XML (Extensible Markup Language) document usually stored alongside the described data, DMR++ can also be generated on-the-fly but is generally created during data staging to the WOS. Archival files that use HDF4/5 often store large arrays of numerical data. The data in these files is often compressed, typically reducing their size by a factor of four or more. To achieve efficient access to portions of those arrays, they are 'chunked' into smaller sub-arrays, each individually compressed. The chunk size is a compromise, where spinning disks can efficiently access data in smaller chunks while S3 favors larger chunks. A simple optimization of aggregating smaller chunks that are stored adjacently, transferring them in a single access and then individually decompressing them will improve performance. NASA data pose an additional challenge: special Application Programmer Interface (API) libraries are often needed to compute some variables. These libraries are incompatible with WOS environments. Our solution involves storing computed values in the DMR++ document or a companion file, making them accessible like other variables and eliminating the need for specialized APIs. We outline specific optimizations for both satellite grid and swath data stored in HDF4-EOS2 (Earth Observing System).

James Gallagher↗

AC and DC Fault Management for Megawatt Electrified Aircraft Electrical Powertrains Task 3: Lifetime and Reliability of Electrical Insulators

This research project was a collaborative investigation between researchers at the RTX Technology Research Center (RTRC) and the University of Texas at Austin and made a significant contribution to enabling electric aircraft. The transport of electric power between the points of generation and use requires power cables. These cables must be smaller, lighter and provide a more predictable life than power cables used in stationary applications. Consequently, this investigation provided heretofore unavailable information supporting the safety and reliability of smaller lighter power cables for electrified aircraft. In addition, the research identified key additional engineering data needed to support quantitative reliability assessments. Important advances included: • Demonstrated that at least one manufacturer can make a novel, smaller, lighter power cable that is free from serious defects. • Developed and published an appropriate analytical construct to describe the life of this novel cable. This is a necessary step for use in aviation where the understanding of remaining life is critical. • Demonstrated thermal-mechanical aging that suggested 1000+ flights before the thermal-mechanical processes produced defects large enough that the defect growth was accelerated electrically. • Showed that electrical aging took place at two rates. The first possibly lasting weeks to months and the second possibly days to weeks. If robust, this provides a good diagnostic for cable replacement. • Demonstrated that the traditional electrical testing of cable materials using manufactured voids can be misleading due to the size of the voids. Emerging laser drilling technology permitted demonstration that the physics of failure in realistically small voids is different from that in the unrealistically large voids used in earlier research, which is very important for high-quality, high-performance, small aircraft cables. Although this project represents a significant contribution to the specifics of cable aging in the aircraft environment, important additional research remains to be completed, including: • Non-uniform thermal cycling by applying the heat from the center conductor to maximize thermal stress next to the core area where the electric gradient is the strongest. This builds on the uniform thermal cycling that has been completed. • The augmentation of the thermal-mechanical failure rate by electrical processes. Better understanding of these time constants strongly affects the ability to predict life. • Termination design: Terminations provide not only electrical reflection potential, but a location for a series arc fault and an area where ozone can diffuse into the center conductor and negatively affect cable insulation. • The abrasion and ozone resistance of the cable jacket. • Pressure cycling as an accelerant of thermal, mechanical, and/or electrical aging. • Possible methods for online PD detection and offline PD localization

model↗

Femto-second Laser’s Enabling New Length Scale Fabrications for Rapid Post Irradiation Examination of Materials: Concluding LDRD Project Poster

Mechanical testing campaigns are required to qualify materials for advanced reactor conditions, yet economical and safety limitations restrict the number of standardized mechanical tests that can be performed. Reducing the size of the sample is one approach to addressing these challenges and to accelerating testing. Previous research has shown that smaller mechanical test samples produce higher yield and ultimate stress values compared to values measured from standard sample sizes: the “smaller is stronger” effect. Specimens used in accelerated material testing campaigns must reflect bulk material performance to enable engineering scale material property measurement. The objective of this research project was to determine if engineering scale mechanical behavior—the yield stress—could be measured with micro-tensile test samples smaller than traditional standard testing geometries. The relationship between yield stress and sample size was explored with two different nuclear-relevant structural materials: Zircaloy-4 and tungsten. Mechanical testing of both metals demonstrated decreasing yield stress values with increasing sample gauge size across three different sizes. Yield stress values from the largest gauge size, fabricated with a femto-second laser ablation system, approach bulk material yield stress values reported in published literature. Preliminary analysis of the tungsten samples indicates the yield stress value depends on the grain characteristics within the gauge section, in addition to the gauge size. Accompanying modeling efforts, including response surface generation and crystal plasticity approaches, further demonstrated that the size of the sample gauge section alone cannot explain the change in yield stress values.

36 MATERIALS SCIENCE↗

040226_AnnularFuel_FuelPerformance_LRSv2

This slide deck summarizes a comparative fuel performance assessment of four annular fuel concepts for pressurized water reactor applications against a reference 17×17 fuel design. Overall, annular fuel geometry improves several key thermal-mechanical performance metrics, with the large-annulus configuration providing the most favorable balance of benefits. Relative to the reference design, annular fuel reduces peak fuel temperature by lowering thermal resistance through a thinner fuel pellet and smaller heat-conduction path. At the same time, the reduced fuel volume raises local burnup and correspondingly increases fission gas release. Despite this, rod internal pressure at end of life decreases because the annular geometry provides greater internal void volume. Annular designs also tend to delay fuel-cladding gap closure, although this advantage diminishes in thin-gap configurations where the smaller initial gap accelerates closure. Similarly, hoop stress and hoop strain are generally reduced for annular fuel, but both increase as the initial gap becomes smaller, indicating a potential cladding integrity concern for thin-gap designs. Corrosion performance shows no meaningful variation among the concepts considered. Taken together, the results indicate that annular fuel can offer significant performance advantages in a PWR environment, with large-annulus designs emerging as the strongest candidate while thin-gap geometries introduce more challenging mechanical margins.

11 - NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Dispersion Loss Counteracts Embedding Condensation and Improves Generalization in Small Language Models

Large language models (LLMs) achieve remarkable performance through ever-increasing parameter counts, but scaling incurs steep computational costs. To better understand LLM scaling, we study representational differences between LLMs and their smaller counterparts, with the goal of replicating the representational qualities of larger models in smaller models. We observe a geometric phenomenon which we term embedding condensation, where token embeddings collapse into a narrow cone-like subspace in some language models. Through systematic analyses across multiple Transformer families, we show that small models such as GPT2 and Qwen3-0.6B exhibit severe condensation, whereas larger models such as GPT2-x1 and Qwen3-32B are more resistant to this phenomenon. Additional observations show that embedding condensation is not reliably mitigated by knowledge distillation from larger models. To fight against it, we formulate a dispersion loss that explicitly encourages embedding dispersion during training. Experiments demonstrate that it mitigates condensation, recovers dispersion patterns seen in larger models, and yields performance gains across 10 benchmarks. We believe this work offers a principled path toward improving smaller Transformers without additional parameters.

Xiao, Xi [ORNL] (ORCID:0009000009316982)↗

The Evolution of Randomized Clinical Trial Designs to Assess Therapeutics in Alzheimer Disease

Importance The success of recent randomized clinical trials (RCTs) for Alzheimer disease (AD), particularly those focusing on anti-amyloid therapies, has been discussed at length. However, the evolution of RCT design features for AD that preceded this success remain underexplored. Objective To describe temporal changes in the features of RCT design for interventions in AD. Evidence Review PubMed, Scopus, and Web of Science databases were searched in January 2025 for phase 2 and 3 AD RCTs published between January 1992 and December 2024. RCTs that investigated an intervention for AD, with a placebo or standard-of-care control group, were included. Four assessors independently reviewed full-text articles to capture study characteristics. Main Outcomes and Measures The number of participants and the duration of RCTs as well as the target population, outcomes, and funding were extracted from published reports. These features were analyzed with respect to time using linear regression and χ 2 analyses. Results The study included 203 RCTs with 79 589 participants testing interventions in AD. From 1992 to 2024, the mean sample size increased by 464% for phase 2 RCTs (from 42 to 237), and 50% for phase 3 RCTs (from 632 to 951), while the mean trial duration increased by 188% (from 16 to 46 weeks) for phase 2, and 256% (from 20 to 71 weeks) for phase 3 RCTs. This longer duration of RCTs may be partially attributed by a greater share of disease-modifying rather than symptomatic treatments. Similarly, more recent trials required AD biomarker evidence for enrollment (from 1 of 36 [2.7%] before 2006 to 40 of 76 [52.6%] since 2019). A substantial difference in the type of therapeutics researched was observed, with anti-amyloid and anti-tau RCTs being more likely to be funded by the pharmaceutical industry compared with neurotransmitter or other RCTs (anti-amyloid or anti-tau, 68 of 71 [95.8%]; neurotransmitter, 52 of 69 [77.6%]; other, 33 of 52 [63.5%]). RCT transparency improved, with more frequent data accessibility statements, registered reports, and better reporting on race and ethnicity. Conclusions and Relevance This methodology research of AD RCTs highlights substantial changes in key features of AD clinical trials from 1992 to 2024. AD RCTs have become larger and longer, such that they are powered to detect smaller clinical differences. The increased sample sizes and duration should enable the detection of smaller and more slowly occurring outcomes, which may lead to successful RCTs of therapies with slower and more subtle efficacy.

General & Internal Medicine↗

What's on the menu? Examining native apex‐ and invasive meso‐predator diets to understand impacts on ecosystems

Abstract Understanding how carnivores impact ecological communities is essential for guiding effective management actions and conserving biodiversity. Quantifying predators' diets, including prey selectivity, allows for the assessment of the relative effects native and invasive predators may have on prey populations. In Australia, populations of a native, terrestrial apex predator, the dingo Canis dingo/C. familiaris , and introduced and invasive subordinate mesopredators, the European red fox Vulpes vulpes and feral cat Felis catus , co‐occur, but there is limited understanding of their relative impacts on native and invasive prey in different ecosystems. To assess the possible effects of dingoes, foxes and cats on prey, we examined their diet and prey selectivity across a ~10,000 km 2 semi‐arid mallee ecosystem. Using macroscopic scat analysis, we identified strong dietary niche separation. Larger‐bodied dingoes primarily consumed large marsupial herbivores, whereas foxes and cats primarily consumed smaller prey, including introduced and native rodents and birds. Foxes had the broadest diet, and the greatest dietary overlap with cats ( = 0.81), compared with dingoes ( = 0.50) or between dingoes and cats ( = 0.36). Livestock were identified in 2% of dingo and 7% of fox scats. Cats and foxes consumed more than 15 times the volume of small native mammals compared with dingoes, including threatened species such as fat‐tailed dunnarts Sminthopsis crassicaudata . Cats and foxes also selectively consumed small mammals relative to their estimated availability and consumed fewer large mammals. In contrast, dingoes consumed fewer birds and more echidnas relative to their availability. Our results suggest limited intraguild competition within this semi‐arid ecosystem, as dingoes are primarily exerting top‐down pressure on large herbivores, whereas invasive mesopredators are disproportionately impacting smaller prey, including threatened native mammals. Practical implication . Our findings suggest that ongoing conservation management of dingoes, red foxes and feral cats must consider the variation in diets, impacts on prey and ecological roles of these different predator species, and avoid indiscriminate lethal control methods. Quantifying actual, rather than assumed, impacts of predators on threatened native species, large herbivores and livestock is essential to achieve effective and integrated ecosystem management.

Mason, Rachel T. [School of Life and Environmental↗