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Intravenous Fluid Generation Mini (IVGEN Mini) Summary and Related Research

This paper assists the ongoing effort to support NASA Glenn’s mission and its Human Research Program (HRP) core competency by investigating a technology demonstration to mitigate human health and performance risks during space exploration. Crew health and performance are critical to successful human exploration beyond low Earth orbit. Four hundred forty-two medical conditions have been identified and may present and require treatment during long-duration space exploration missions. One hundred fifteen out of four hundred forty-two identified medical conditions would require medical fluid treatment, generating a need for an on-demand or continuous supply of medical fluid. Intravenous Fluid Generation Mini (IVGEN Mini) is a technology demonstration designed to demonstrate a water purification and pharmaceutical mixing system that can make intravenous (IV) fluid in microgravity and builds on the success of the original Intravenous Fluid Generation for Exploration Missions (IVGEN) experiment, which flew on the ISS in March 2010. IVGEN Mini seeks to increase the Technology Readiness Level (TRL) and the overall function of the original IVGEN experiment to reduce the dependence of a needed medical consumable and streamline the size of the device and process to generate IV fluid IVGEN Mini is funded by the Advanced Exploration Systems (AES) directorate via the Exploration Medical Integrated Product Team (XMIPT) as a part of their mission to advance exploration medical technologies to benefit the overall health and safety of crews for beyond low Earth orbit space missions. This paper discusses a collection of related research topics such as microgravity fluid mixing and studying past efforts of IV fluid usage in extreme environments to aid IVGEN Mini project scientists in developing the IVGEN Mini technology.

iv generation↗

An editorial to the Special Issue on “Severe climate Risks”

The history of this Special Issue (https://www.sciencedirect.com/special-issue/10JD7LNJNQ0) indirectly dates back to the early 1990s, when the signature of the United Nations Framework Convention on Climate Change kicked-off an international political process based on one overarching and foundational principle: to avoid “dangerous anthropogenic interference with the climate system” at the global level. More than three decades later, such a principle remains central, though complementary aims made their way through the climate negotiation process, such as the importance of ensuring equity and justice, to give just one example here. Scientific knowledge also considerably progressed and we know more about the range of risks that climate change imposes and will continue to impose to the biosphere and humankind, worldwide and at all territorial levels. It is also clear that societal responses to these risks —“climate adaptation” as we know it— are increasingly happening, but definitely not at the pace of climate risk trends (Berrang-Ford et al., 2021, Erisken et al., 2021, Olazabal and Ruiz De Gopegui, 2021, Magnan et al., 2023a, Reckien et al., 2023, UNEP, 2023). As a result, concerns have emerged over the recent years in both the scientific and policy arenas around the idea that societies may not be able to address all climate risks, and that limits to adaptation and induced residual risks need to be considered more seriously. Such concerns further highlight the continuing importance of the imperative to minimise dangerous anthropogenic interference with the climate system, at any scale. But what does “dangerous interference” mean? How can we decide that we are entering the “dangerous” space, compared to a broader range of climate risks that would qualify as problematic but not necessarily “dangerous”? Who should make such a decision? Which conditions drive risk severity over time, including in the future? And what would be the environmental, economic, social and cultural implications of prioritising some climate risks over others? The Intergovernmental Panel on Climate Change (IPCC) was a pioneer in addressing such questions through the development of the “Key Risks” framing that describes those climate risks having the potential to become dangerous or “severe” over the course of this century (Schellnhuber et al., 2006, Schneider et al., 2007, Oppenheimer et al., 2014, O’Neill et al., 2022). The Fifth and Sixth assessment cycles (AR5 and AR6) went a step further by identifying about 120 Key Risks across regions and sectors, and clustering them into 8 “Representative Key Risks” covering a range of geographical systems (low-lying coasts, and to terrestrial and ocean ecosystems), sectors (critical infrastructure, living standards, human health, food security, and water security) and human dimensions (peace and mobility) (Oppenheimer et al., 2014, O’Neill et al., 2022). This Special Issue was born of the efforts of a range of authors, during the development of the IPCC AR6 main Assessment Report between 2019 and 2022, to characterise Key Risks and Representative Key Risks, and advance knowledge on what shapes “severe climate risks” conceptually as well as in the real-world. The series of papers forming this Special Issue is not intended to cover the topic exhaustively, but rather to give readers an overview through the following narrative: defining “severe climate risks” is highly challenging (Magnan et al., 2023b), but knowledge is expanding on the driving climate hazards (Tebaldi et al., 2023) and their implications on geographical systems, sectors and human dimensions, using here food security (Mirzabaev et al., 2023), human mobility (Gilmore et al., 2024) and peace (Buhaug et al., 2023) as illustrative examples. The overall intention is to support especially decision-makers, whatever the scale or sector considered, in asking severity-driven questions to identify sector- and context-specific “priority” risks from climate change.

54 ENVIRONMENTAL SCIENCES↗

Risk of Oxidative Damage to Bone from Increased Iron Stores During Space Flight

Iron stores are increased secondary to neocytolysis of red blood cells and a high dietary intake of iron during space flight. This raises concerns about the risk of excess iron causing oxidative damage in many tissues, including bone. Biomarkers of iron status, oxidative damage, and bone resorption during space flight were analyzed for 23 (16 M/7 F) International Space Station crewmembers as part of the Nutrition SMO project. Up to 5 in-flight blood samples and 24-h urine pools were collected over the course of the 4-6 month missions. Serum iron increased slightly during space flight and was decreased at landing (P < 0.0004). An increase in serum ferritin early in flight (217% in women and 68% in men, P < 0.0004), returning to preflight concentrations at landing, and a decrease in transferrin and transferrin receptors during flight indicated that a transient increase in iron stores occurred. No inflammatory response was observed during flight. The oxidative damage markers 8-hydroxy-2'-deoxyguanosine and prostaglandin F(sub 2(alpha)) were positively correlated (both P < 0.001) with serum ferritin. A greater area under the curve for ferritin during flight was correlated with greater changes in bone mineral density of several bone regions after flight (1). In a separate study (2), a ground-based investigation was conducted that examined the combined effects of radiation exposure and iron overload on sensitivity to radiation injury in several physiological systems in 12-wk male Sprague-Dawley rats. The rats were acclimated to an adequate iron diet (45 mg iron (ferric citrate)/kg diet) for 3 wk and then assigned to one of four groups: adequate iron (Fe) diet/no radiation, adequate Fe diet/ radiation, moderately high Fe diet (650 mg Fe (ferric citrate)/kg diet)/no radiation, and moderately high Fe diet/radiation. Animals remained on the assigned diet for 4 wk. Starting on day 14 of experimental diet treatment, animals were exposed to a fractionated dose (0.375 Gy) of Cs-137 every other day (3 Gy total dose). On day 29 (24 h after last radiation exposure), animals were euthanized. Oxidative stress markers in the liver, bone, eyes, and serum were assessed. There was evidence that the iron diet contributed to DNA damage as well as radiation exposure in the liver, eyes, and bone. Together, the results suggest that increased iron stores do constitute a risk factor for oxidative damage and bone resorption, during space flight and on Earth. Funded by the Human Health and Countermeasures Element of the NASA Human Research Program.

Zwart, S. R.↗

Managing Research in a Risk World

The Office of Chief Medical Officer (OCHMO) owns all human health and performance risks managed by the Human System Risk Board (HSRB). While the HSRB manages the risks, the Human Research Program (HRP) manages the research portion of the overall risk mitigation strategy for these risks. The HSRB manages risks according to a process that identifies and analyzes risks, plans risk mitigation and tracks and reviews the implementation of these strategies according to its decisions pertaining to the OCHMO risk posture. HRP manages risk research work using an architecture that describes evidence-based risks, gaps in our knowledge about characterizing or mitigating the risk, and the tasks needed to produce deliverables to fill the gaps and reduce the risk. A planning schedule reflecting expected research milestones is developed, and as deliverables and new evidence are generated, research progress is tracked via the Path to Risk Reduction (PRR) that reflects a risk's research plan for a design reference mission. HRP's risk research process closely interfaces with the HSRB risk management process. As research progresses, new deliverables and evidence are used by the HSRB in conjunction with other operational and non-research evidence to inform decisions pertaining to the likelihood and consequence of the risk and risk posture. Those decisions in turn guide forward work for research as it contributes to overall risk mitigation strategies. As HRP tracks its research work, it aligns its priorities by assessing the effectiveness of its contributions and maintaining specific core competencies that would be invaluable for future work for exploration missions.

Anton, W.↗

Enhancing Interdisciplinary Human System Risk Research Through Modeling and Network Approaches

NASA's Human Research Program (HRP) supports research to reduce human health and performance risks inherent in future human space exploration missions. Understanding risk outcomes and contributing factors in an integrated manner allows HRP research to support development of efficient and effective mitigations from cross‐disciplinary perspectives, and to enable resilient human and engineered systems for spaceflight. The purpose of this work is to support scientific collaborations and research portfolio management by utilizing modeling for analysis and visualization of current and potential future interdisciplinary efforts.

Mindock, Jennifer↗

2015 Sensorimotor Risk Standing Review Panel Evidence and Status Review For: the Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

The 2015 Sensorimotor Risk Standing Review Panel (from here on referred to as the SRP) participated in a WebEx/teleconference with members of the Human Health Countermeasures (HHC) Element, representatives from the Human Research Program (HRP), NASA Headquarters, and NASA Research and Education Support Services (NRESS) on December 17, 2015 (list of participants is in Section VI of this report). The SRP reviewed the new Evidence Report for the Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight (from here on referred to as the 2015 Sensorimotor Evidence Report), and also received a status review of the Risk. The opening section of the 2015 Sensorimotor Evidence Report provides written descriptions of various incidents that have occurred during space missions. In most of these incidents, the main underlying contributing factors are not easy to identify unambiguously. For example, in section 1.9, a number of falls occurred while astronauts were walking on the moon. It is not clear to the SRP, however, why they fell. It is only possible to extrapolate from likely specific psychophysical or physiological abnormalities, but how these abnormalities were determined, and how they were directly responsible for the falls is unclear to the SRP. Section 2.1.2 on proprioception is very interesting, but the functional significance of the abnormalities detected is not clear. The SRP sees this as a problem throughout the report: a mapping between the component abnormalities identified and the holistic behaviors that are most relevant, for example, controlling the vehicle, and locomotion during egress, is generally lacking. The SRP thinks the cognitive section is too strongly focused on vestibular functioning. The SRP questions the notion that the main cognitive effects are mainly attributable to reversible vestibular changes induced by spaceflight. The SRP thinks that there can also be independent cognitive effects. The Functional Task Test (FTT) protocols and the Field Test are particularly valuable. The conclusion is that the unloading of major postural muscles experienced during spaceflight plays a central role in the alteration of functional task performance and balance control. This conclusion stands in contrast with the statements in other parts of the document that emphasize the role of vestibular changes on these functions. It would help to more fully integrate these two views on the predominant effects of spaceflight. Although the SRP thinks the countermeasures section is interesting, the proposed countermeasures are not well integrated with the abnormalities described in previous sections. The SRP thinks it would help enormously to have explicit links among each abnormality, its 2015 Sensorimotor Risk SRP Evidence Review Final Report 2 overall importance/impact on function, and the appropriate countermeasure that can be implemented to maintain adequate functioning.

Steinberg, Susan↗

Perspectives on Asthenia in Astronauts and Cosmonauts: Review of the International Research Literature

The Behavioral Health and Performance Element (BHP) is one of the 6 elements in the NASA Human Research Program (HRP) and is responsible for managing 4 of the identified and named risks to human health and performance from human space exploration: a) Risk of Behavioral Conditions (BMed), b) Risk of Psychiatric Disorders (BMed), c) Risk of Performance Decrements due to inadequate Cooperation, Coordination, Communication and Psychological Adaptation within a Team (Team), and d) Risk of Performance Errors due to Sleep Loss, Circadian De-synchronization, Fatigue and Work Overload (Sleep). Each risk is reviewed by a NASA HRP Standing Review Panel (SRP), and recently the Behavioral Medicine Risk of Psychiatric Disorders was reviewed. The aim of this report is to address one of the recommendations made by that panel, specifically the recommendation that the "literature on asthenia should be evaluated (possibly as a psychological or psychosomatic / psycho-physiological analogue of chronic fatigue syndrome)" (SRP p. 4), in addition to General Recommendation 4, which states that "all reviews must include non-English language materials as well as materials appearing in conferences reports, books, and other non-refereed journal outlets" (SRP p. 2).

Sandoval, Luis↗

Lunar Dust Mitigation: A Guide and Reference: First Edition (2021)

On the surface of the Moon, lunar dust specifically presents unique challenges to operations long-term due to regolith particles’ ubiquitous presence in the lunar environment, potential to electrostatically charge and possible chemical reactivity. Whether to avoid exposure, try to remove or simply to tolerate lunar dust infiltrating a system becomes a complex question involving length of required service life, dust effects and critical risks, mass and complexity trades for the entire system. This publication provides a snapshot of advice from topical experts for specific areas of concern to systems targeted for deployment on the lunar surface. Following introductory overview commentary, dust mitigation approaches appropriate to the lunar surface are first addressed for typically static structures such as optical surfaces, radiators, and other thermal control surfaces, followed by regolith exposure concerns for communications equipment and non-optical sensors. The broad topic of mechanisms and mechanical assemblies is broken down to address relevant component level concerns, such as for bearings and for seals. “Soft goods” components of space suits (fabric) specific concerns are discussed, followed finally by brief coverage of human health issues and concerns, though the emphasis of this publication remains with components directly exposed to the harsh lunar surface environment. A description of some lunar surface hazard details, in particular characteristics of lunar surface dust, follows in Appendix A, and more detailed explanations of quantification issues for particulates are in Appendix B. The simple inertial removal of particles from a surface is discussed in Appendix C, followed by a summary of terrestrial best practices for dust mitigation recommended within select industries in Appendix D. The aggregated bibliography of references, while extensive and very useful, should not be construed to be exhaustive and can serve as a constructive start.

dust↗

Managing HRP’S External Deliverables: The Process and the Customers

The Human Research Program’s (HRP) external deliverables (EDs) are the final outcomes of the research that the HRP Elements develop and execute. Four categories of HRP EDs exist: standards, requirements, countermeasures, and tools/technology. The NASA Human Health and Performance directorate’s primary stakeholders, i.e., the customers for the EDs, include the Office of the Chief Health and Medical Officer (OCHMO) (Standards Team, Chief Health and Performance Officers and Chief Medical Officers, Human System Risk Board), and the agency’s System Capability Leadership Teams. The EDs may address the need of a specific customer, a specific design reference mission, or a vehicle lifecycle milestone. HRP’s Maturation and Integration Office External Programs facilitates the process of delivering the EDs to the targeted customers according to the customer’s expectations. This presentation describes this coordinated process and provides an overview of the nature of different types of EDs and how they impact the customers’ products. Successful transfer of the EDs to the customers will help mitigate the health and performance risks that crewmembers will face during NASA’s future exploration missions.

HRP research external deliverables↗

Managing HRP's External Deliverables: The Process and the Customers

The Human Research Program’s (HRP) external deliverables (EDs) are the final outcomes of the research that the HRP Elements develop and execute. The NASA Human Health and Performance directorate’s primary stakeholders, i.e., the customers for the EDs, include the Office of the Chief Health and Medical Officer (OCHMO) (Standards Team, Chief Health and Performance Officers and Chief Medical Officers, Human System Risk Board), and the agency’s System Capability Leadership Teams. The EDs may address the need of a specific customer, a specific design reference mission, or a vehicle lifecycle milestone. HRP’s Maturation and Integration Office External Programs facilitates the process of delivering the EDs to the targeted customers according to the customer’s expectations. This presentation describes this coordinated process and provides an overview of the nature of different types of EDs and how they impact the customers’ products. Successful transfer of the EDs to the customers will help mitigate the health and performance risks that crewmembers will face during NASA’s future exploration missions.

research↗

The Role of Game Based Learning in the Health Literacy of African American Adolescent Males

Twenty-first century literacy is more than being able to encode for spelling ability, decode for reading comprehension, and calculate for numeric reasoning. It demands the skills to negotiate the world of technology. Health literacy is lower than general literacy, and general literacy is lower among African American males than the overall population. The authors discuss the prospects of incorporating Game Based Learning approaches into strategies for teaching health literacy. Results of a survey administered to youth to determine their level of involvement in video game playing indicate that key elements must be in place to ensure that a game will be played. These include action, strategy, and entertainment. Future investigation will examine the knowledge level of African American adolescent males of the nexus of certain concepts of climate change and health literacy. Climate change has significant implications for human health. This understanding will produce a scientifically based foundation for curricular and instructional decisions that include GBL. Results of this study will be used to design a video game concept and will contribute to the body of knowledge concerning environmental justice and empower individuals to make informed decisions about their own health and those they influence.

Connell, Judith↗

Improving Regional Air Quality Forecasting Through Chemical Data Assimilation and Dynamic Emissions Adjustment

Poor air quality (AQ) is one of the most important human-health and environmental problems facing the United States (US). In addition to the detrimental impacts on human- and environmental-health, poor AQ has an economic cost of ~5% of the US gross domestic product (~$790 billion). AQ managers use AQ analyses and modeling to better understand, anticipate, and avoid poor AQ events. Our research focuses on improving AQ analysis/forecast skill, predictability, and emission estimates through improved and more efficient: (i) modeling and data assimilation strategies; (ii) dynamic emissions adjustment strategies; and (iii) use of satellite remote-sensing Earth observations (e.g., MOPITT, IASI, MODIS, OMI, TROPOMI, TEMPO, etc.). This seminar will review: (i) regional chemical weather forecasting/data assimilation with dynamic emissions adjustment with WRF-Chem/DART; (ii) strategies for efficiently assimilating satellite retrieval profiles with ‘compact phase space retrievals’ (CPSRs); (iii) results from joint assimilation of multiple satellite retrievals at medium (12 km × 12 km) and high (4 km × 4 km) spatial resolutions; and (iv) results from observing system simulation experiments (OSSEs) to investigate whether we can recover COVID-period anthropogenic emissions by assimilating synthetic TEMPO NO2 tropospheric column retrievals with dynamic emissions adjustment. Biographical Sketch: Dr. Mizzi is a Senior Research Fellow working and Dr. Johnson at the NASA Ames Research Center. He holds BA and MS degrees in Environmental Science from the University of Virginia, MS and PhD degrees in Applied Mathematics from the University of Colorado at Boulder (CUB), and a JD degree (with an emphasis in Environmental Law) from the University of Colorado School of Law. He worked at the National Center for Atmospheric Research for nearly 25 years on global atmospheric modeling, dynamic and physical initialization, regional hybrid data assimilation, and most recently on regional chemical data assimilation. He also worked as an environmental attorney and consultant for nearly 15 years. He is an expert in numerical modeling and is recognized internationally as a leading expert in regional, chemical data assimilation with dynamic emissions adjustment. Dr. Mizzi became affiliated with NASA Ames in March 2020 to work on improving AQ analysis/forecast skill, predictability, and ‘top-down’ emissions adjustment though the assimilation of Earth observations. An emphasis of his current work is developing methods for assimilating synthetic TEMPO retrievals to quantify the expected benefits of TEMPO relative to existing AQ observations.

Arthur P. Mizzi↗

Machine Learning for the Validation of Expert-Elicited Causal Risk Diagrams

Exposure to spaceflight poses risk to human health in complex ways. To help manage this risk, the Human Systems Risk Board (HSRB) at the National Aeronautics and Space Administration (NASA) maintains a set of causal diagrams that attempt to explain how spaceflight hazards generate health risks and lead to adverse outcomes both in-mission, immediately post-mission, and over the long term. These causal risk diagrams are formulated as directed acyclic graphs (DAGs) and can function as knowledge graphs of connected risks and outcomes. These DAGs have proven useful for communication, and, through network analysis, have allowed for the identification of structurally important factors in the risk network. However, the utility these DAGs provide is directly proportional to their verisimilitude, making assessment of this trait using empirical data – whether from actual human spaceflight or various spaceflight analogue exposures and model organisms – a high priority. In this research we explore the use of machine learning algorithms to learn DAG structure from empirical data as a means of evaluating human-elicited DAG structures. To do so, we test several different graph structure-learning algorithms on data concerning changes in the bones of rats and mice after exposure to either spaceflight or a spaceflight analogue. We explore potential methods for indexing the similarity between each algorithm’s output DAG with all the others and with that of the expert-elicited DAG. We discuss next steps in this ongoing line of research and open science initiatives underway to complete them.

directed acyclic graphs↗

Deciphering the Role of Desert Dust in the Climate Puzzle: The Mediterranean Israeli Dust Experiment (MEIDEX)

Numerous studies have shown that aerosol particles may be one of the primary agents that can offset the climate warming induced by the increase in the amount of atmospheric greenhouse gases. Desert aerosols are probably the most abundant and massive type of aerosol particles that are present in the atmosphere worldwide. These aerosols are carried over large distances and have various global impacts. They interact with clouds, impact the efficiency of their rain production and change their optical properties. They constitute one of the primary sources of minerals for oceanic life and influence the health of coral reefs. They have direct effects on human health, especially by inducing breathing difficulties in children. It was lately discovered that desert particles carry pathogens from the Sahara desert over the Atlantic Ocean, a fact that may explain the migration of certain types of diseases. Aerosols not only absorb solar radiation but also scatter it, so that their climatic effect is influenced not only by their physical properties and height distribution but also by the reflectivity of the underlying surface. This latter property changes greatly over land and is low over ocean surfaces. Aerosol plumes are emitted from discrete, sporadic sources in the desert areas of the world and are transported worldwide by the atmosphere's wind systems. For example, Saharan dust reaches Mexico City, Florida, Ireland, Switzerland and the Mediterranean region, while Asian dust reaches Alaska, Hawaii and the continental United States. This means that in order to assess its global effects, one must observe dust from space. The Space Shuttle is a unique platform, because it flies over the major deserts of our planet, enabling measurements and remote sensing of the aerosols as they travel from source to sink regions. Such efforts must always be accompanied by in-situ data for validation and calibration, with direct sampling of the airborne particles. MEIDEX is a joint project of the Israel Space Agency (ISA) and NASA, under a cooperation agreement between the two agencies.

Levin, Zev↗

Biennial Research and Technology Development Report: Johnson Space Center

The Biennial Research and Technology Development Report is a compilation of advances in research and technology accomplished by Johnson Space Center (JSC) engineers and scientists. The articles contained within this report further JSC's and NASA's historical tradition of working with colleges and universities, industry, federal laboratories, and other research and technology development organizations for the betterment of humankind. This report is organized into10 broad categories: Human Health, Life Support and Habitation Systems, and Space Medicine; Human Exploration Systems, Technologies for Extravehicular Activity and Harsh Environments; Environmental Technologies; Materials, Structures, Development and Testing; Space Power, Energy Storage, and Propulsion; Robotics, Tele-Robotics, Autonomous Systems, and Software; Exploration, Planetary Science, and Sensor Systems; Flammability and Explosive Technologies; Space and Ground Operations; and Education and Outreach.

Lulla, Kamlesh↗

The Artemis Gateway as a Cislunar Science Platform

The Artemis Gateway is a lunar orbiting platform that will enable a sustainable human presence on and around the Moon beginning in this decade. Along with serving as a habitat for astronauts in support of lunar landing missions, Gateway provides a unique opportunity for science and research within cislunar space, from human health to space weather, with an eye toward deep space human space flight. Payloads are planned to be manifested on a rotating basis both internally and externally on the Gateway as well as on visiting Logistics Modules. Similar to the International Space Station, the Gateway benefits from significant international cooperation, and partnering agencies are collaborating to facilitate multilateral research across disciplines. We will present an overview of the Gateway mission and its unique capabilities and rich exploration space.

Gateway↗

Artemis III and IV Crew Health and Performance System Model Development

To maintain Crew Health and Performance (CHP) during an Artemis mission, the NASA Human Research Program (HRP) and Exploration Medical Capabilities (ExMC) element recognize the challenge that many different vehicles, habitats, and operational groups must come together to develop and implement cross program capabilities. To address this challenge, the ExMC team created the prototype 2023 Artemis CHP System Model to analyze how human system requirements are implemented throughout an Artemis mission and help understand the effects of changing an individual vehicle or habitat requirement on a full mission. Since presenting this work at the 2024 HRP Investigators’ Workshop, ExMC has continued this effort, now called the Artemis III and IV CHP System Model, to better support its operational end users within the NASA Human Health and Performance Directorate (HHPD) workforce. In this presentation, we will recapitulate how visualizing requirements and their relationships using a Model-Based Systems Engineering approach (MBSE) serves to improve understanding of an Artemis mission’s CHP capabilities along with discussion on updates made to the model to increase accessibility for users within HHPD so that it may be used in the development of cross program CHP capabilities at NASA.

Crew Health and Performance↗

Comparison of Health and Performance Risk for Accelerated Mars Mission Scenarios

This document details the results for a quantitative estimate of the difference in human health and performance risk that crews would face for two hypothetical variations on Mars mission scenarios: an Accelerated Mars Mission (AMM) and a Standard Mars Mission(SMM).NASA goals for Mars mission concepts, duration, and tasks have varied over the years. While neither of the cases considered here are likely to accurately represent the initial mission to Mars, the exercise of evaluating significant differences in mission duration from an astronaut health perspective can provide bounding insight to the level of risk that is likely to be encountered in an eventual Mars mission. Medical Probabilistic Risk Assessment using the Integrated Medical Model (IMM)(1–3)and the NASA Space Radiation Cancer Risk Model (NSCR)(4,5) are used here to help mission planners gain the best insight currently available into the expected magnitude of impacts to astronaut health when undertaking a Mars mission. These impacts occur both in-mission as well as in the long-term health of the astronauts post-mission. These evaluations are currently the best available modeling estimates to characterize and bound the health risks in a proposed mission domain where humans have no experience.

Erik Antonsen↗