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Protein kinetics during and after long-duration spaceflight on MIR

Human spaceflight is associated with a loss of body protein. Bed rest studies suggest that the reduction in the whole body protein synthesis (PS) rate should be approximately 15%. The objectives of this experiment were to test two hypotheses on astronauts and cosmonauts during long-duration (>3 mo) flights on MIR: that 1) the whole body PS rate will be reduced and 2) dietary intake and the PS rate should be increased postflight because protein accretion is occurring. The 15N glycine method was used for measuring whole body PS rate before, during, and after long-duration spaceflight on the Russian space station MIR. Dietary intake was measured together with the protein kinetics. Results show that subjects lost weight during flight (4.64 +/- 1.0 kg, P < 0.05). Energy intake was decreased inflight (2,854 +/- 268 vs. 2,145 +/- 190 kcal/day, n = 6, P < 0.05), as was the PS rate (226 +/- 24 vs. 97 +/- 11 g protein/day, n = 6, P < 0.01). The reduction in PS correlated with the reduction in energy intake (r2 = 0.86, P < 0.01, n = 6). Postflight energy intake and PS returned to, but were not increased over, the preflight levels. We conclude that the reduction in PS found was greater than predicted from ground-based bed rest experiments because of the shortfall in dietary intake. The expected postflight anabolic state with increases in dietary intake and PS did not occur during the first 2 wk after landing.

STS-40 Shuttle Project↗

The Role and Training of NASA Astronauts in the Post-Shuttle Era

In May 2010 the National Research Council (NRC) was asked by NASA to address several questions related to the Astronaut Corps. The NRC's Committee on Human Spaceflight Crew Operations was tasked to: 1. How should the role and size of the activities managed by the Johnson Space Center Flight Crew Operations Directorate change following space shuttle retirement and completion of the assembly of the International Space Station (ISS)? 2. What are the requirements for crew-related ground-based facilities after the Space Shuttle program ends? 3. Is the fleet of aircraft used for training the Astronaut Corps a cost-effective means of preparing astronauts to meet the requirements of NASA's human spaceflight program? Are there more cost-effective means of meeting these training requirements? Although the future of NASA's human spaceflight program has garnered considerable discussion in recent years, and there is considerable uncertainty about what that program will involve in the coming years, the committee was not tasked to address whether or not human spaceflight should continue, or what form it should take. The committee's task restricted it to studying those activities managed by the Flight Crew Operations Directorate, or those closely related to its activities, such as crew-related ground-based facilities and the training aircraft.

Source record↗

Preparing for the High Frontier: The Role and Training of NASA Astronauts in the Post- Space Shuttle Era

In May 2010, the National Research Council (NRC) was asked by NASA to address several questions related to the Astronaut Corps. The NRC s Committee on Human Spaceflight Crew Operations was tasked to answer several questions: 1. How should the role and size of the activities managed by the Johnson Space Center Flight Crew Operations Directorate change after space shuttle retirement and completion of the assembly of the International Space Station (ISS)? 2. What are the requirements for crew-related ground-based facilities after the Space Shuttle program ends? 3. Is the fleet of aircraft used for training the Astronaut Corps a cost-effective means of preparing astronauts to meet the requirements of NASA s human spaceflight program? Are there more cost-effective means of meeting these training requirements? Although the future of NASA s human spaceflight program has garnered considerable discussion in recent years and there is considerable uncertainty about what the program will involve in the coming years, the committee was not tasked to address whether human spaceflight should continue or what form it should take. The committee s task restricted it to studying activities managed by the Flight Crew Operations Directorate or those closely related to its activities, such as crew-related ground-based facilities and the training aircraft.

Source record↗

Science and the Constellation Systems Program Office

An underlying tension has existed throughout the history of NASA between the human spaceflight programs and the external scientific constituencies of the robotic exploration programs. The large human space projects have been perceived as squandering resources that might otherwise be utilized for scientific discoveries. In particular, the history of the relationship of science to the International Space Station Program has not been a happy one. The leadership of the Constellation Program Office, created in NASA in October, 2005, asked me to serve on the Program Manager s staff as a liaison to the science community. Through the creation of my position, the Program Manager wanted to communicate and elucidate decisions inside the program to the scientific community and, conversely, ensure that the community had a voice at the highest levels within the program. Almost all of my technical contributions at NASA, dating back to the Apollo Program, has been within the auspices of what is now known as the Science Mission Directorate. However, working at the Johnson Space Center, where human spaceflight is the principal activity, has given me a good deal of incidental contact and some more direct exposure through management positions to the structures and culture of human spaceflight programs. I entered the Constellation family somewhat naive but not uninformed. In addition to my background in NASA science, I have also written extensively over the past 25 years on the topic of human exploration of the Moon and Mars. (See, for example, Mendell, 1985). I have found that my scientific colleagues generally have little understanding of the structure and processes of a NASA program office; and many of them do not recognize the name, Constellation. In many respects, the international ILEWG community is better informed. Nevertheless, some NASA decision processes on the role of science, particularly with respect to the formulation of a lunar surface architecture, are not well known, even in ILEWG. At the recent annual Lunar and Planetary Science Conference, I reviewed the evolution of the program as a function of Agency leadership and the constraints put on NASA by the President in his 2004 announcement. I plan to continue my long-time ILEWG tradition of reporting a personal view of the state of development of human exploration of the solar system, this time coming from within the program office tasked to implement the vision for the United States. The current NASA implementation of the Vision for Space Exploration is consistent with certain classical scenarios that have been discussed extensively in the literature. I will discuss the role of science within the Vision, both from official policy and from a de facto interaction. While science goals are not officially driving the implementation of the Vision, the tools of scientific exploration are integral to defining the extraterrestrial design environments. In this respect the sharing of results from international missions to the Moon can make significant contributions to the success of the future human activities.

Mendell, Wendell↗

Deep Space Habitat Concept of Operations for Transit Mission Phases

The National Aeronautics and Space Administration (NASA) has begun evaluating various mission and system components of possible implementations of what the U.S. Human Spaceflight Plans Committee (also known as the Augustine Committee) has named the flexible path (Anon., 2009). As human spaceflight missions expand further into deep space, the duration of these missions increases to the point where a dedicated crew habitat element appears necessary. There are several destinations included in this flexible path a near Earth asteroid (NEA) mission, a Phobos/Deimos (Ph/D) mission, and a Mars surface exploration mission that all include at least a portion of the total mission in which the crew spends significant periods of time (measured in months) in the deep space environment and are thus candidates for a dedicated habitat element. As one facet of a number of studies being conducted by the Human Spaceflight Architecture Team (HAT) a workshop was conducted to consider how best to define and quantify habitable volume for these future deep space missions. One conclusion reached during this workshop was the need for a description of the scope and scale of these missions and the intended uses of a habitat element. A group was set up to prepare a concept of operations document to address this need. This document describes a concept of operations for a habitat element used for these deep space missions. Although it may eventually be determined that there is significant overlap with this concept of operations and that of a habitat destined for use on planetary surfaces, such as the Moon and Mars, no such presumption is made in this document.

Hoffman, Stephen J.↗

Short-duration spaceflight impairs human carotid baroreceptor-cardiac reflex responses

The effect of a spaceflight on the vagally mediated baroreceptor-cardiac reflex responses of humans were investigated by measuring the responses (provoked by neck pressure changes) in supine position and the heart rate and blood pressure in the supine and standing positions in 16 astronauts before and after 4- to 5-day long Space Shuttle missions. The results showed that exposures to spaceflight resulted in reduced baseline levels of the vagal-cardiac outflow and the vagally mediated responses to changes of the arterial baroreceptor input and that these changes contribute to postflight reductions of astronauts' ability to maintain standing arterial pressures.

Fritsch, Janice M.↗

Spaceflight and protein metabolism, with special reference to humans

Human space missions have shown that human spaceflight is associated with a loss of body protein. Specific changes include a loss of lean body mass, decreased muscle mass in the calves, decreased muscle strength, and changes in plasma proteins and amino acids. The major muscle loss is believed to be associated with the antigravity (postural) muscle. The most significant loss of protein appears to occur during the first month of flight. The etiology is believed to be multifactorial with contributions from disuse atrophy, undernutrition, and a stress type of response. This article reviews the results of American and Russian space missions to investigate this problem in humans, monkeys, and rats. The relationship of the flight results with ground-based models including bedrest for humans and hindlimb unweighting for rats is also discussed. The results suggest that humans adapt to spaceflight much better than either monkeys or rats.

Review↗

Envisioning an Analog Work Domain Across Deep-Ocean Exploration and Human-Robot Spaceflight Exploration

What if one existing work domain could be leveraged to inform an instantiation of a second type of work domain? This is the question that informed a three year NASA-funded study, SUBSEA (Systematic Underwater Biogeochemical Science and Exploration Analog), on the use of ocean science and exploration via telepresence as an analog for future human-robot spaceflight. SUBSEA included two field programs performed in 2018 and 2019. Each was comprised of a multidisciplinary team of natural scientists studying deep-sea venting sites in tandem with a team of social scientists conducting work ethnography to understand the existing ocean exploration domain. This paper presents results from the 2018 field program which includes analyses that were required to generate specific “flight-like” conditions for the 2019 field program.

Miller, Matthew J.↗

Crowd Sourcing Medical Data Collection Using Medical Students

OBJECTIVE We undertook an upgrade of the Evidence Library database of NASA HRP’s Integrated Medical Model, assessing 120 medical conditions which integrate with a novel probabilistic risk assessment (IMPACT) tool of medical risk and resource utilization for long duration exploration human spaceflight. This data collection process included a selection of these conditions crowd sourced over one year via three 4-week medical student electives at the University of Colorado School of Medicine (IDPT 8059 Space Medicine: Human Spaceflight Factors & Medical Risk Assessment). Students undertook a rapid systematic review of each medical condition, under close preceptors with backgrounds in clinical medicine, library science, epidemiology, biostatistics, and evidence-based medicine. As part of the elective, students also received instruction in core space medicine concepts, evidence based medicine and problem based learning sessions as a flight surgeon supporting a simulated Mars mission. METHODS The list of 120 medical conditions includes both common, terrestrial illness/injury (epistaxis, diverticulitis) as well as spaceflight-specific ones (space adaptation conditions, EVA-related injuries). A rapid systematic review process was developed that would allow students to find the data for determining disease incidence/prevalence, return to definitive care (often a surrogate such as hospitalization rates), loss of crew life, and treatment duration. Each data point required a tailored, specialized search process using different databases and corresponding specialized search filters. Databases were selected on their ability to provide high quality literature in an efficient manner and prioritized by their ability to provide graded evidence via a set rubrics specific to human spaceflight. Students were responsible for performing all literature searches and identifying the highest quality available evidence for each data point. Completed student data sheets underwent initial review by faculty preceptors followed by a secondary editing review by the ExMC Clinical Science Team. RESULTS Over the course of three electives, approximately 105 medical conditions were researched by students using spreadsheets with pre-crafted search strategies. Overall, this process was successful in allowing students to perform the preponderance of work to update incidence, treatment duration, return to definitive care, and loss of crew life data points. Students were successful in running searches, identifying the necessary data points within the literature, and determining the types of terrestrial data that most aligns with the astronaut population for successful completion of their tasks. Limitations included variable student experience with search methodologies [PubMed], differing values of evidence grading [best practice evidence based medicine vs. relevant to spaceflight], and students’ unfamiliarity with spaceflight specific conditions. CONCLUSION Finding the relevant literature for medical conditions in spaceflight within terrestrial databases in a systematic method is time consuming and not intuitive. However, the stepwise process that balanced sensitivity with specificity allowed for students to be highly successful in a short amount of time. Additionally, as the process was refined over the course of three electives, preceptors were better able to anticipate where students were likely to encounter barriers, which allowed the course to be adjusted to account for certain data points needing more time for completion. This replicable process may be an efficient way to accomplish rapid systematic reviews for a large volume of data in a short amount of time.

J Lemery↗

Effects of orbital spaceflight on human osteoblastic cell physiology and gene expression

During long-term spaceflight, astronauts lose bone, in part due to a reduction in bone formation. It is not clear, however, whether the force imparted by gravity has direct effects on bone cells. To examine the response of bone forming cells to weightlessness, human fetal osteoblastic (hFOB) cells were cultured during the 17 day STS-80 space shuttle mission. Fractions of conditioned media were collected during flight and shortly after landing for analyses of glucose utilization and accumulation of type I collagen and prostaglandin E(2) (PGE(2)). Total cellular RNA was isolated from flight and ground control cultures after landing. Measurement of glucose levels in conditioned media indicated that glucose utilization occurred at a similar rate in flight and ground control cultures. Furthermore, the levels of type I collagen and PGE(2) accumulation in the flight and control conditioned media were indistinguishable. The steady-state levels of osteonectin, alkaline phosphatase, and osteocalcin messenger RNA (mRNA) were not significantly changed following spaceflight. Gene-specific reductions in mRNA levels for cytokines and skeletal growth factors were detected in the flight cultures using RNase protection assays. Steady-state mRNA levels for interleukin (IL)-1alpha and IL-6 were decreased 8 h following the flight and returned to control levels at 24 h postflight. Also, transforming growth factor (TGF)-beta(2) and TGF-beta(1) message levels were modestly reduced at 8 h and 24 h postflight, although the change was not statistically significant at 8 h. These data suggest that spaceflight did not significantly affect hFOB cell proliferation, expression of type I collagen, or PGE(2) production, further suggesting that the removal of osteoblastic cells from the context of the bone tissue results in a reduced ability to respond to weightlessness. However, spaceflight followed by return to earth significantly impacted the expression of cytokines and skeletal growth factors, which have been implicated as mediators of the bone remodeling cycle. It is not yet clear whether these latter changes were due to weightlessness or to the transient increase in loading resulting from reentry.

Non-NASA Center↗

Small Aerostationary Telecommunications Orbiter Concept for Mars in the 2020s

Current Mars science orbiters carry UHF proximity payloads to provide limited access and data services to landers and rovers on Mars surface. In the era of human spaceflight to Mars, very high rate and reliable relay services will be needed to serve a large number of supporting vehicles, habitats, and orbiters, as well as astronaut EVAs. These will likely be provided by a robust network of orbiting assets in very high orbits, such as areostationary orbits. In the decade leading to that era, telecommunications orbits can be operated at areostationary orbit that can support a significant population of robotic precursor missions and build the network capabilities needed for the human spaceflight era. Telecommunications orbiters of modest size and cost, delivered by Solar Electric Propulsion to areostationary orbit, can provide continuous access at very high data rates to users on the surface and in Mars orbit.In the era of human spaceflight to Mars very high rate andreliable relay services will be needed to serve a largenumber of supporting vehicles, habitats, and orbiters, aswell as astronaut EVAs. These could be provided by arobust network of orbiting assets in very high orbits. In thedecade leading to that era, telecommunications orbiterscould be operated at areostationary orbit that could support asignificant population of robotic precursor missions andbuild the network capabilities needed for the humanspaceflight era. These orbiters could demonstrate thecapabilities and services needed for the future but withoutthe high bandwidth and high reliability requirements neededfor human spaceflight.Telecommunications orbiters of modest size and cost,delivered by Solar Electric Propulsion to areostationaryorbit, could provide continuous access at very high datarates to users on the surface and in Mars orbit. Twoexamples highlighting the wide variety of orbiter deliveryand configuration options were shown that could providehigh-performance service to users.

Lock, Robert E.↗

Human Performance in Space

Human factors is a critical discipline for human spaceflight. Nearly every human factors research area is relevant to space exploration -- from the ergonomics of hand tools used by astronauts, to the displays and controls of a spacecraft cockpit or mission control workstation, to levels of automation designed into rovers on Mars, to organizational issues of communication between crew and ground. This chapter focuses more on the ways in which the space environment (especially altered gravity and the isolated and confined nature of long-duration spaceflight) affects crew performance, and thus has specific novel implications for human factors research and practice. We focus on four aspects of human performance: neurovestibular integration, motor control and musculo-skeletal effects, cognitive effects, and behavioral health. We also provide a sampler of recent human factors studies from NASA.

Jones, Patricia M.↗

Ultimately Reliable Pyrotechnic Systems

This paper presents the methods by which NASA has designed, built, tested, and certified pyrotechnic devices for high reliability operation in extreme environments and illustrates the potential applications in the oil and gas industry. NASA's extremely successful application of pyrotechnics is built upon documented procedures and test methods that have been maintained and developed since the Apollo Program. Standards are managed and rigorously enforced for performance margins, redundancy, lot sampling, and personnel safety. The pyrotechnics utilized in spacecraft include such devices as small initiators and detonators with the power of a shotgun shell, detonating cord systems for explosive energy transfer across many feet, precision linear shaped charges for breaking structural membranes, and booster charges to actuate valves and pistons. NASA's pyrotechnics program is one of the more successful in the history of Human Spaceflight. No pyrotechnic device developed in accordance with NASA's Human Spaceflight standards has ever failed in flight use. NASA's pyrotechnic initiators work reliably in temperatures as low as -420 F. Each of the 135 Space Shuttle flights fired 102 of these initiators, some setting off multiple pyrotechnic devices, with never a failure. The recent landing on Mars of the Opportunity rover fired 174 of NASA's pyrotechnic initiators to complete the famous '7 minutes of terror.' Even after traveling through extreme radiation and thermal environments on the way to Mars, every one of them worked. These initiators have fired on the surface of Titan. NASA's design controls, procedures, and processes produce the most reliable pyrotechnics in the world. Application of pyrotechnics designed and procured in this manner could enable the energy industry's emergency equipment, such as shutoff valves and deep-sea blowout preventers, to be left in place for years in extreme environments and still be relied upon to function when needed, thus greatly enhancing safety and operational availability.

Scott, John H.↗

Management of Service Projects in Support of Space Flight Research

Goal:To provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration . [HRP-47051] Specific Objectives: 1) Develop capabilities, necessary countermeasures, and technologies in support of human space exploration, focusing on mitigating the highest risks to human health and performance. 2) Define and improve human spaceflight medical, environmental, and human factors standards. 3) Develop technologies that serve to reduce medical and environmental risks, to reduce human systems resource requirements (mass, volume, power, data, etc.) and to ensure effective human-system integration across exploration systems. 4) Ensure maintenance of Agency core competencies necessary to enable risk reduction in the following areas: A. Space medicine B. Physiological and behavioral effects of long duration spaceflight on the human body C. Space environmental effects, including radiation, on human health and performance D. Space "human factors" [HRP-47051]. Service projects can form integral parts of research-based project-focused programs to provide specialized functions. Traditional/classic project management methodologies and agile approaches are not mutually exclusive paradigms. Agile strategies can be combined with traditional methods and applied in the management of service projects functioning in changing environments. Creative collaborations afford a mechanism for mitigation of constrained resource limitations.

Love, J.↗

Johnson Space Center Thermal Technology Roadmap 2024

This presentation gives an overview of thermal technology development efforts at the Johnson Space Center (JSC), NASA’s center for human spaceflight. The presentation begins with an overview of NASA’s current human spaceflight programs, followed by the various JSC organizations that support thermal technologies. Lastly, thermal capability gaps are described along with current development efforts that are part of the roadmap to close those gaps.

Thomas O Leimkuehler↗

Johnson Space Center Thermal Technology Roadmap 2024

This presentation gives an overview of thermal technology development efforts at the Johnson Space Center (JSC), NASA’s center for human spaceflight. The presentation begins with an overview of NASA’s current human spaceflight programs, followed by the various JSC organizations that support thermal technologies. Lastly, thermal capability gaps are described along with current development efforts that are part of the roadmap to close those gaps.

spacecraft thermal control↗

Space Studies Board Annual Report, 2009

The year 2009 was one of transition for the nation, for NASA, and for the Space Studies Board (SSB). The nation pulled back from 2008's economic precipice, but did not return to the path of economic growth that it had been on. The United States inaugurated a new president who set out to build his administration. By mid-year President Obama had announced the appointment of Charlie Bolden as NASA administrator, and Lori Garver as deputy administrator. The president and Charlie Bolden jointly appointed an independent commission, the now well-known Augustine Commission, to provide guidance on the future of NASA's human spaceflight program. Many had known for quite a while that NASA's human spaceflight program faced a profound change at the time of the retirement of the space shuttle. This year was also a year of transition for the SSB. In 2009, Marcia Smith stepped down as staff director for both SSB and ASEB, and Dick Rowberg had a very good turn at the plate as a pinch-hitter. We are deeply indebted to both of them. We are pleased that, after a successful run as study director for Astro2010, Michael Moloney is now director of SSB and ASEB. The profound work begun in 2009 on the decadal surveys will only see the light of day later as they are released and the scientific work begins. The SSB will have much to report for 2010.

National Aeronautics and Space Administration(NASA↗