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All sources NASA NTRS DOE OSTI

NASA NTRS2017

The NASA Ames Life Sciences Data Archive: Biobanking for the Final Frontier

The NASA Ames Institutional Scientific Collection involves the Ames Life Sciences Data Archive (ALSDA) and a biospecimen repository, which are responsible for archiving information and non-human biospecimens collected from spaceflight and matching ground control experiments. The ALSDA also manages a biospecimen sharing program, performs curation and long-term storage operations, and facilitates distribution of biospecimens for research purposes via a public website (https:lsda.jsc.nasa.gov). As part of our best practices, a tissue viability testing plan has been developed for the repository, which will assess the quality of samples subjected to long-term storage. We expect that the test results will confirm usability of the samples, enable broader science community interest, and verify operational efficiency of the archives. This work will also support NASA open science initiatives and guides development of NASA directives and policy for curation of biological collections.

Biobank↗

NASA NTRS1987

USSR Space Life Sciences Digest. Index to issues 5-9

An index to issues 5 through 9 of the USSR Space Life Sciences Digest is provided in two sections. The first section lists bibliographic citations of abstracts contained in the Digest issues covered, grouped by topic area categories. Cross references to other relevant abstracts in different categories are also provided. The second section provides a key word index for the same set of abstracts.

Hooke, Lydia Razran↗

NASA NTRS1987

Life sciences biomedical research planning for Space Station

The Biomedical Research Project (BmRP), a major component of the NASA Life Sciences Space Station Program, incorporates a laboratory for the study of the effects of microgravity on the human body, and the development of techniques capable of modifying or counteracting these effects. Attention is presently given to a representative scenario of BmRP investigations and associated engineering analyses, together with an account of the evolutionary process by which the scenarios and the Space Station design requirements they entail are identified. Attention is given to a tether-implemented 'variable gravity centrifuge'.

Primeaux, Gary R.↗

NASA NTRS2010

Life Sciences Research and Development Opportunities During Suborbital Space Flight

Suborbital space platforms provide a unique opportunity for Space Life Sciences in the next few years. The opportunities include: physiological characterization of the first few minutes of space flight; evaluation of a wide-variety of medical conditions during periods of hyper and hypo-gravity through physiological monitoring; and evaluation of new biomedical and environmental health technologies under hyper and hypo-gravity conditions

Davis, Jeffrey R.↗

NASA NTRS1999

New challenges for Life Sciences flight project management

Scientists have conducted studies involving human spaceflight crews for over three decades. These studies have progressed from simple observations before and after each flight to sophisticated experiments during flights of several weeks up to several months. The findings from these experiments are available in the scientific literature. Management of these flight experiments has grown into a system fashioned from the Apollo Program style, focusing on budgeting, scheduling and allocation of human and material resources. While these areas remain important to the future, the International Space Station (ISS) requires that the Life Sciences spaceflight experiments expand the existing project management methodology. The use of telescience with state-the-art information technology and the multi-national crews and investigators challenges the former management processes. Actually conducting experiments on board the ISS will be an enormous undertaking and International Agreements and Working Groups will be essential in giving guidance to the flight project management Teams forged in this matrix environment must be competent to make decisions and qualified to work with the array of engineers, scientists, and the spaceflight crews. In order to undertake this complex task, data systems not previously used for these purposes must be adapted so that the investigators and the project management personnel can all share in important information as soon as it is available. The utilization of telescience and distributed experiment operations will allow the investigator to remain involved in their experiment as well as to understand the numerous issues faced by other elements of the program The complexity in formation and management of project teams will be a new kind of challenge for international science programs. Meeting that challenge is essential to assure success of the International Space Station as a laboratory in space.

NASA Discipline General Space Life Sciences↗

NASA NTRS1992

The future of U.S./International life sciences cooperation for Space Shuttle and beyond - A guide for the young professional

Current international capabilities in the space life sciences/technology areas are reviewed focusing on the cooperative potential of the international community as applied to advanced Shuttle/Spacelab flights. The review of the international experience base and mutual cooperative benefits of the United States and international partners presented in the paper provides a guide to the young professional in planning for a space life sciences career.

Garshnek, V.↗

NASA NTRS1985

Visual monitoring of autonomous life sciences experimentation

The goal of this research project is the development of a computer vision system to monitor and control life sciences experimentation on board space stations. The vision system is organized as a multiprocessor system with distributed processes selectively analyzing hierarchical imagery in order to monitor and control the appropriate instrumentation.

Blank, G. E.↗

NASA NTRS1988

USSR Space Life Sciences Digest. Index to issues 10-14

An index is provided for issues 10 through 14 of the USSR Space Life Sciences Digest. There are two sections. The first section lists bibliographic citations of abstracts contained in the Digest issues covered grouped by topic area categories. The second section provides a key word index for the same set of abstracts.

Hooke, Lydia Razran↗

NASA NTRS1994

Advanced Biotelemetry Systems for Space Life Sciences

The Sensors 2000! Program at NASA-Ames Research Center is developing an Advanced Biotelemetry System (ABTS) for Space Life Sciences applications. This modular suite of instrumentation is planned to be used in operational spaceflight missions, ground-based research and development experiments, and collaborative, technology transfer and commercialization activities. The measured signals will be transmitted via radio-frequency (RF), electromagnetic or optical carriers and direct-connected leads to a remote ABTS receiver and data acquisition system for data display, storage, and transmission to Earth. Intermediate monitoring and display systems may be hand held or portable, and will allow for personalized acquisition and control of medical and physiological data.

Hines, John W.↗

NASA NTRS2018

The Importance of Conducting Life Sciences Experiments on the Deep Space Gateway Platform

Over the last several decades important information has been gathered by conducting life science experiments on the Space Shuttle and on the International Space Station. It is now time to leverage that scientific knowledge, as well as aspects of the hardware that have been developed to support the biological model systems, to NASA's next frontier - the Deep Space Gateway. In order to facilitate long duration deep space exploration for humans, it is critical for NASA to understand the effects of long duration, low dose, deep space radiation on biological systems. While carefully controlled ground experiments on Earth-based radiation facilities have provided valuable preliminary information, we still have a significant knowledge gap on the biological responses of organisms to chronic low doses of the highly ionizing particles encountered beyond low Earth orbit. Furthermore, the combined effects of altered gravity and radiation have the potential to cause greater biological changes than either of these parameters alone. Therefore a thorough investigation of the biological effects of a cis-lunar environment will facilitate long term human exploration of deep space.

microgravity↗

NASA NTRS2000

Life into Space: Space Life Sciences Experiments, Ames Research Center, Kennedy Space Center, 1991-1998, Including Profiles of 1996-1998 Experiments

We have now conducted space life sciences research for more than four decades. The continuing interest in studying the way living systems function in space derives from two main benefits of that research. First, in order for humans to engage in long-term space travel, we must understand and develop measures to counteract the most detrimental effects of space flight on biological systems. Problems in returning to the conditions of Earth must be kept to a manageable level. Second, increasing our understanding of how organisms function in the absence of gravity gives us new understanding of fundamental biological processes. This information can be used to improve human health and the quality of life on Earth.

Souza, Kenneth↗

DOE OSTI2022

Scanning structural mapping at the Life Science X-ray Scattering Beamline

This work describes the instrumentation and software for microbeam scattering and structural mapping at the Life Science X-ray Scattering (LiX) beamline at NSLS-II. Using a two-stage focusing scheme, an adjustable beam size between a few micrometres and a fraction of a millimetre is produced at the sample position. Scattering data at small and wide angles are collected simultaneously on multiple Pilatus detectors. A recent addition of an in-vacuum Pilatus 900k detector, with the detector modules arranged in a C-shaped configuration, has improved the azimuthal angle coverage in the wide-angle data. As an option, fluorescence data can be collected simultaneously. Fly scans have been implemented to minimize the time interval between scattering patterns and to avoid unnecessary radiation damage to the sample. For weakly scattering samples, an in-vacuum sample environment has been developed here to minimize background scattering. Data processing for these measurements is highly sample-specific. To establish a generalized data process workflow, first the data are reduced to reciprocal coordinates at the time of data collection. The users can then quantify features of their choosing from these intermediate data and construct structural maps. As examples, results from in-vacuum mapping of onion epidermal cell walls and 2D tomographic sectioning of an intact poplar stem are presented.

36 MATERIALS SCIENCE↗

NASA NTRS1986

USSR Space Life Sciences Digest. Index to issues 1-4

This document is an index to issues 1 to 4 of the USSR Space Life Sciences Digest and is arranged in three sections. In section 1, abstracts from the first four issues are grouped according to subject; please note the four letter codes in the upper right hand corner of the pages. Section 2 lists the categories according to which digest entries are grouped and cites additional entries relevant to that category by four letter code and entry number in section 1. Refer to section 1 for titles and other pertinent information. Key words are indexed in section 3.

Teeter, R.↗

NASA NTRS1989

USSR Space Life Sciences Digest. Index to issues 15-20

This bibliography provides an index to issues 15 through 20 of the USSR Space Life Sciences Digest. There are two sections. The first section lists bibliographic citations of abstracts in these issues, grouped by topic area categories. The second section provides a key word index for the same abstracts. The topic categories include exobiology, space medicine and psychology, human performance and man-machine systems, various life/body systems, human behavior and adaptation, biospherics, and others.

Hooke, Lydia Razran↗

NASA NTRS1990

USSR Space Life Sciences Digest. Index to issues 21-25

This bibliography provides an index to issues 21 through 25 of the USSR Space Life Sciences Digest. There are two sections. The first section lists bibliographic citations of abstracts in these issues, grouped by topic area categories. The second section provides a key word index for the same abstracts. The topic categories include exobiology, space medicine and psychology, human performance and man-machine systems, various life/body systems, human behavior and adaptation, biospherics, and others.

Hooke, Lydia Razran↗

NASA NTRS1991

USSR Space Life Sciences Digest. Index to issues 26-29

This bibliography provides an index to issues 26 through 29 of the USSR Space Life Sciences Digest. There are two sections. The first section lists bibliographic citations of abstracts in these issues, grouped by topic area categories. The second section provides a key word index for the same abstracts. The topic categories include exobiology, space medicine and psychology, human performance and man-machine systems, various life/body systems, human behavior and adaptation, biospherics, and others.

Stone, Lydia Razran↗

NASA NTRS1982

Life science research in space - The Spacelab era

The events leading up to Spacelab mission 4, which is to be dedicated exclusively to life sciences experimentation in 1984-85, are described. Out of 400 experiment proposals initially received and assessed, 87 candidates were chosen for definition studies to identify the resources which would be required. These proposals addressed such problems encountered in previous space flights as space motion sickness, cardiovascular deconditioning and muscle wasting, calcium loss, and red cell mass reduction. Additional experiments were selected from bioengineering, plant physiology, and cell biology. Human subjects will consist of a Mission Specialist Astronaut and up to four Payload Specialists. Equipment to be used in experimentation includes biotelemetry systems, microscopes, cameras, centrifuges and refrigerators, all of which have been designed for use in weightless conditions. The 87 candidate experiments will be further reduced to about 20.

Farrell, R. M.↗

NASA NTRS1985

System analysis study of space platform and station accommodations for life sciences research facilities. Volume 2: Study results. Appendix E: Work breakdown structure and dictionary

A work breakdown structure for the Space Station Life Sciences Research Facility (LSRF) is presented up to level 5. The purpose is to provide the framework for task planning and control and to serve as a basis for budgeting, task assignment, cost collection and report, and contractual performance measurement and tracking of the Full Scale Development Phase tasks.

Wiley, Lowell F.↗