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At least 235 records · Page 13

Age effects on rat hindlimb muscle atrophy during suspension unloading

The effects of hindlimb unloading on muscle mass and biochemical responses were examined and compared in adult (450-g) and juvenile (200-g) rats after 1, 7, or 14 days of whole-body suspension. Quantitatively and qualitatively the soleus, gastrocnemius, plantaris, and extensor digitorum longus (EDL) muscles of the hindlimb exhibited a differential sensitivity to suspension and weightlessness unloading in both adults and juveniles. The red slow-twitch soleus exhibited the most pronounced atrophy under both conditions, with juvenile responses being greater than adult. In contrast, the fast-twitch EDL hypertrophied during suspension and atrophied during weightlessness, with no significant difference between adults and juveniles. Determination of biochemical parameters (total protein, RNA, and DNA) indicates a less rapid rate of response in adult muscles.

Steffen, Joseph M.↗

Skeletal muscle response to spaceflight, whole body suspension, and recovery in rats

The effects of a 7-day spaceflight (SF), 7- and 14-day-long whole body suspension (WBS), and 7-day-long recovery on the muscle weight and the morphology of the soleus and the extensor digitorum longus (EDL) of rats were investigated. It was found that the effect of 7-day-long SF and WBS were highly comparable for both the soleus and the EDL, although the soleus muscle from SF rats showed greater cross-sectional area reduction than that from WBS rats. With a longer duration of WBS, there was a continued reduction in cross-sectional fast-twitch fiber area. Muscle plasticity, in terms of fiber and capillary responses, showed differences in responses of the two types of muscles, indicating that antigravity posture muscles are highly susceptible to unloading.

Musacchia, X. J.↗

Interactive effects of growth hormone and exercise on muscle mass in suspended rats

Measures to attenuate muscle atrophy in rats in response to simulated microgravity (hindlimb suspension (HS)) have been only partially successful. In the present study, hypophysectomized rats were in HS for 7 days, and the effects of recombinant human growth hormone (GH), exercise (Ex), or GH+Ex on the weights, protein concentrations, and fiber cross-sectional areas (CSAs) of hindlimb muscles were determined. The weights of four extensor muscles, i.e., the soleus (Sol), medial (MG) and lateral (LG) gastrocnemius, and plantaris (Plt), and one adductor, i.e., the adductor longus (AL), were decreased by 10-22% after HS. Fiber CSAs were decreased by 34% in the Sol and by 1 17% in the MG after HS. In contrast, two flexors, i.e., the tibialis anterior (TA) and extensor digitorum longus (EDL), did not atrophy. In HS rats, GH treatment alone maintained the weights of the fast extensors (MG, LG, Plt) and flexors (TA, EDL) at or above those of control rats. This effect was not observed in the slow extensor (Sol) or AL. Exercise had no significant effect on the weight of any muscle in HS rats. A combination of GH and Ex treatments yielded a significant increase in the weights of the fast extensors and in the CSA of both fast and slow fibers of the MG and significantly increased Sol weight and CSA of the slow fibers of the Sol. The AL was not responsive to either GH or Ex treatments. Protein concentrations of the Sol and MG were higher only in the Sol of Ex and GH+Ex rats. These results suggest that while GH treatment or intermittent high intensity exercise alone have a minimal effect in maintaining the mass of unloaded muscle, there is a strong interactive effect of these two treatments.

Grindeland, Richard E.↗

Mars Pathfinder Status at Launch

The Mars Pathfinder Flight System is in final test, assembly and launch preparations at the Kennedy Space Center in Florida. Launch is scheduled for 2 Dec. 1996. The Flight System development, in particular the Entry, Descent, and Landing (EDL) system, was a major team effort involving JPL, other NASA centers and industry. This paper provides a summary Mars Pathfinder description and status at launch. In addition, a section by NASA's Langley Research Center, a key EDL contributor, is provided on their support to Mars Pathfinder. This section is included as an example of the work performed by Pathfinder team members outside JPL.

Spear, A. J.↗

Next-Generation Entry/Descent/Landing System for Mars Landers

Many important scientific objectives for Mars exploration require the ability to land safely at select sites. The 'first-generation' entry, descent, and landing (EDL) systems used in previous missions imposed limitations on target site selection due to the delivery accuracy achievable and those systems' inability to recognize and avoid hazardous terrain. This abstract outlines key capabilities of a proposed second-generation EDL system, currently under development by a consortium of NASA centers, Industry, and academic institutions.

Thurman, Sam W.↗

Entry System Design Considerations for Mars Landers

The objective for the next generation or Mars landers is to enable a safe landing at specific locations of scientific interest. The 1st generation entry, descent and landing systems, ex. Viking and Pathfinder, provided successful landing on Mars but by design were limited to large scale, 100s of km, landing sites with minimal local hazards. The 2 nd generation landers, or smart landers, will provide scientists with access to previously unachievable landing sites by providing precision landing to less than 10 km of a target landing site, with the ability to perform local hazard avoidance, and provide hazard tolerance. This 2nd generation EDL system can be utilized for a range of robotic missions with vehicles sized for science payloads from the small 25-70 kg, Viking, Pathfinder, Mars Polar Lander and Mars Exploration Rover-class, to the large robotic Mars Sample Return, 300 kg plus, science payloads. The 2nd generation system can also be extended to a 3nd generation EDL system with pinpoint landing, 10's of meters of landing accuracy, for more capable robotic or human missions. This paper will describe the design considerations for 2nd generation landers. These landers are currently being developed by a consortium of NASA centers, government agencies, industry and academic institutions. The extension of this system and additional considerations required for a 3nd generation human mission to Mars will be described.

Lockwood, Mary Kae↗

Microgravity Investigation of Crew Reactions in 0-G (MICR0-G): Ground-Based Development Effort

This report describes the technology development of an advanced load sensor ground-based prototype and details the preliminary tests in microgravity during parabolic flights. The research effort is entitled, the Microgravity Investigation and Crew Reactions in 0-G (MICR0-G), a ground-based research effort funded by the National Aeronautics and Space Administration (NASA). The MICR0-G project was a follow-on to the Enhanced Dynamic Load Sensors (EDLS) spaceflight experiment flown on the Russian Space Station Mir. The technology development of the advanced load sensor prototype has been carried out by the Massachusetts Institute of Technology (MIT), with collaboration from Politecnico di Milano University and the Italian Space Agency (ASI). The key hardware of the advanced sensor prototype is a set of two types of load sensors - a hand-hold and foot restraints - similar in appearance to the mobility aids found in the Space Shuttle orbiter to assist the crew in moving inside the spacecraft, but able to measure the applied forces and moments about the x-, y-, and z- axes. The aim of Chapter 1 is to give a brief overview of the report contents. The first section summarizes the previous research efforts on astronaut-induced loads in microgravity. The second section provides information on the MICR0-G research project and the technology development work conducted at MIT. Section 1.3 details the motivation for designing a new generation of load sensors and describes the main enhancements and contributions of the MICR0-G advanced load sensors system compared to the EDLS system. Finally, the last section presents the outline of the report.

Newman, Dava J.↗

Analysis of Atmospheric Mesoscale Models for Entry, Descent and Landing

Each Mars Exploration Rover (MER) is sensitive to the martian winds encountered near the surface during the Entry, Descent and Landing (EDL) process. These winds are strongly influenced by local (mesoscale) conditions. In the absence of suitable wind observations, wind fields predicted by martian mesoscale atmospheric models have been analyzed to guide landing site selection. Two different models were used, the MRAMS model and the Mars MM5 model. In order to encompass both models and render their results useful to the EDL engineering team, a series of statistical techniques were applied to the model results. These analyses cover the high priority landing sites during the expected landing times (1200 to 1500 local time). The number of sites studied is limited by the computational and analysis cost of the mesoscale models.

D M Kass↗

Engineering-Level Model Atmospheres For Titan and Mars

An engineering-level atmospheric model for Titan has been developed for use in NASA s systems analysis studies of aerocapture and entry, descent and landing (EDL) applications in potential missions to Titan. Analogous to highly successful Global Reference Atmospheric Models for Earth (GRAM) and Mars (Mars-GRAM), the new model is called Titan-GRAM. Like GRAM and Mars-GRAM, an important feature of Titan-GRAM is its ability to simulate quasi-random perturbations for Monte-Carlo analyses in developing guidance, navigation and control algorithms, and for thermal systems design. Titan-GRAM features and sample results will be presented. Features of Mars-GRAM especially related to EDL applications will also be presented and illustrated.

Justus, C. G.↗

Mars Exploration Rovers Entry, Descent, and Landing Trajectory Analysis

The Mars Exploration Rover mission successfully landed two rovers "Spirit" and "Opportunity" on Mars on January 4th and 25th of 2004, respectively. The trajectory analysis performed to define the entry, descent, and landing (EDL) scenario is described. The entry requirements and constraints are presented, as well as uncertainties used in a Monte Carlo dispersion analysis to statistically assess the robustness of the entry design to off-nominal conditions. In the analysis, six-degree-of-freedom and three-degree-of-freedom trajectory results are compared to assess the entry characteristics of the capsule. Comparison of the preentry results to preliminary post-landing reconstruction data shows that all EDL parameters were within the requirements. In addition, the final landing position for both "Spirit" and "Opportunity" were within 15 km of the predicted landing location.

Desai, Prasun N.↗

Spaceflight effects on adult rat muscle protein, nucleic acids, and amino acids

Exposure to conditions of weightlessness has been associated with decrements in muscle mass and strength. The present studies were undertaken to determine muscle responses at the cellular level. Male Sprague-Dawley rats (360-410 g) were exposed to 7 days of weightlessness during the Spacelab-3 shuttle flight (May 1985). Animals were killed 12 h postflight, and soleus (S), gastrocnemius (G), and extensor digitorum longus (EDL) muscles were excised. Muscle protein, RNA, and DNA were extracted and quantified. Differential muscle atrophy was accompanied by a significant (P less than 0.05) reduction in total protein only in S muscles. There were no significant changes in protein concentration (mg/g) in the muscles examined. In S muscles from flight animals, sarcoplasmic protein accounted for a significantly greater proportion of total protein that in ground controls (37.5 vs. 32.5%). Tissue concentrations (nmol/g) of asparagine-aspartate, glutamine-glutamate, glycine, histidine, and lysine were significantly reduced (from 17 to 63%) in S muscles from flight animals, but only glutamine-glutamate levels were decreased in the G and EDL. Muscle DNA content (microgram) was unchanged in the tissues examined, but S muscle DNA concentration (micrograms/mg) increased 27%. RNA content (micrograms) was significantly (P less than 0.025) reduced in S (-28%) and G(-22%) muscles following spaceflight. These results identify specific alterations in rat skeletal muscle during short term (7-day) exposure to weightlessness and compare favorably with observations previously obtained from ground-based suspension simulations.

short duration↗

Aerodynamic Decelerators for Planetary Exploration: Past, Present, and Future

In this paper, aerodynamic decelerators are defined as textile devices intended to be deployed at Mach numbers below five. Such aerodynamic decelerators include parachutes and inflatable aerodynamic decelerators (often known as ballutes). Aerodynamic decelerators play a key role in the Entry, Descent, and Landing (EDL) of planetary exploration vehicles. Among the functions performed by aerodynamic decelerators for such vehicles are deceleration (often from supersonic to subsonic speeds), minimization of descent rate, providing specific descent rates (so that scientific measurements can be obtained), providing stability (drogue function - either to prevent aeroshell tumbling or to meet instrumentation requirements), effecting further aerodynamic decelerator system deployment (pilot function), providing differences in ballistic coefficients of components to enable separation events, and providing height and timeline to allow for completion of the EDL sequence. Challenging aspects in the development of aerodynamic decelerators for planetary exploration missions include: deployment in the unusual combination of high Mach numbers and low dynamic pressures, deployment in the wake behind a blunt-body entry vehicle, stringent mass and volume constraints, and the requirement for high drag and stability. Furthermore, these aerodynamic decelerators must be qualified for flight without access to the exotic operating environment where they are expected to operate. This paper is an introduction to the development and application of aerodynamic decelerators for robotic planetary exploration missions (including Earth sample return missions) from the earliest work in the 1960s to new ideas and technologies with possible application to future missions. An extensive list of references is provided for additional study.

Juan R Cruz↗

Entry, Descent, and Landing Operations Analysis for the Stardust Re-Entry Capsule

On the morning of January 15, 2006, the Stardust capsule successfully landed at the Utah Test and Training range in northwest Utah returning cometary samples from the comet Wild-2. An overview of the entry, descent, and landing (EDL) trajectory analysis that was performed for targeting during the Stardust Mission Navigation Operations Phase upon final approach to Earth is described. In addition, how the predicted landing location and the resulting overall 99 percentile landing footprint ellipse obtained from a Monte Carlo analysis changed over the final days and hours prior to entry is also presented. The navigation and EDL operations effort accurately delivered the entry capsule to the desired landing site. The final landing location was 8.1 km from the target, which was well within the allowable landing area.

Desao, Prasun N.↗

Lithium-sulfur dioxide batteries on Mars rovers

NASA's 2003 Mars Exploration Rover (MER) missions, Spirit and Opportunity, have been performing exciting surface exploration studies for the past six months. These two robotic missions were aimed at examining the presence of water and, thus, any evidence of life, and at understanding the geological conditions of Mars, These rovers have been successfully assisted by primary lithium-sulfur dioxide batteries during the critical entry, descent, and landing (EDL) maneuvers. These batteries were located on the petals of the lander, which, unlike in the Mars Pathfinder mission, was designed only to carry the rover. The selection of the lithium-sulfur dioxide battery system for this application was based on its high specific energy and high rate discharge capability, combined with low heat evolution, as dictated by this application. Lithium-sulfur dioxide batteries exhibit voltage delay, which tends to increase at low discharge temperatures, especially after extended storage at warm temperatures, In the absence of a depassivation circuit, as provided on earlier missions, e.g., Galileo, we were required to depassivate the lander primary batteries in a unique manner. The batteries were brought onto a shunt-regulated bus set at pre-selected discharge voltages, thus affecting depassivation during constant discharge voltages. Several ground tests were preformed, on cells, cell strings and battery assembly with five parallel strings, to identify optimum shunt voltages and durations of depassivation. We also examined the repassivation of lithium anodes, subsequent to depassivation. In this paper, we will describe these studies, in detail, as well as the depassivation of the lander flight batteries on both Spirit and Opportunity rover prior to the EDL sequence and their performance during landing on Mars.

Lithium-SO2 batteries↗

A methodology of MSL breakup analysis for Earth accidental reentry and its application to breakup analysis for Mars off-nominal entry

Vehicle breakup analysis has been performed for missions that may carry nuclear fuel for heating or power purposes to assess nuclear safety in case of launch failure leading to atmospheric reentry. Also, failure scenarios exist which could lead to breakup during Entry / Descent / Landing (EDL) at Mars due to off-nominal entries, with implications for planetary protection requirements. Since the Mars Science Laboratory (MSL) spacecraft may include a Multi-Mission Radioisotope Thermoelectric Generator (MMRTG), an analysis of breakup in case of launch failure is required. Also, breakup during Mars EDL due to off-nominal entries could release the RTG heat source that has implications for planetary protection requirements. This paper presents a methodology of MSL breakup analysis for launch failure with application to Mars off-nominal entry.

nuclear safety↗

Overview of the Phoenix Entry, Descent and Landing System

A viewgraph presentation on the entry, descent and landing system of Phoenix is shown. The topics include: 1) Phoenix Mission Goals; 2) Payload; 3) Aeroshell/Entry Comparison; 4) Entry Trajectory Comparison; 5) Phoenix EDL Timeline; 6) Hypersonic Phase; 7) Parachute Phase; 8) Terminal Descent Phase; and 9) EDL Communications.

Grover, Rob↗

MSL Entry, Descent and Landing Performance and Environments

A viewgraph presentation on the MARS Science Laboratory (MSL) Entry, Descent and Landing (EDL) performance and environments is shown. The topics include: 1) High Altitude and Precision Landing; 2) Guided, Lifting, Ballistic Trade; 3) Supersonic Chute Deploy Altitude; 4) Guided, Lifting, Ballistic Landing Footprint Video; 5) Transition Indicator at Peak Heating Point on Trajectory; 6) Aeroheating at Peak Heating Point on Trajectory Nominal, No Uncertainty Included; 7) Comparison to Previous Missions; 8) Pork Chop Plots - EDL Performance for Mission Design; 9) Max Heat Rate Est (CBE+Uncert) W/cm2; 10) Nominal Super Chute Deploy Alt Above MOLA (km); 11) Monte Carlo; 12) MSL Option M2 Entry, Descent and Landing; 13) Entry Performance; 14) Entry Aeroheating and Entry g's; 15) Terminal Descent; and 16) How An Ideal Chute Deployment Altitude Varies with Time of Year and Latitude (JSC Chart).

Lockwood, Mary Kae↗

An Update of the Ground Testing of the Li-ion Batteries in Support of JPL's 2003 Mars Exploration Rover Mission

In early 2004, JPL successfully landed two Rovers, named Spirit and Opportunity, on the surface of Mars after traveling > 300 million miles over a 6-7 month period. In order to operate for extended duration (>9 months), both Rovers are equipped with rechargeable Lithium-ion batteries, which have enabled operation for over 854 and 834 Sols of operation, respectively, to date. Given that the batteries were required to support the mission for 90 Sols of operation by design, it is significant that the batteries have demonstrated over a nine fold increase in life over mission objectives. In addition to supporting the surface operations in conjunction with a triple-junction deployable solar arrays, the batteries were designed to aid in the launch and the EDL pyros, and allow for anomalies during cruise. In summary, the requirements of the Lithium-ion battery include the ability to provide power at least 90 sols on the surface of Mars, operate over a wide temperature range (-20 C to +30 C), withstand long storage periods (e.g., cruise period), operate in an inverted orientation, and support high current pulses (e.g., firing pyro events). In order to determine the viability of meeting these requirements, ground testing was performed on a Rover Battery Assembly Unit (RBAU), consisting of two 8-cell 10 Ah lithium-ion batteries connected in parallel. The RBAU upon which the performance testing was performed is nearly identical to the batteries incorporated into the two Rovers currently on Mars. The testing includes, (a) performing initial characterization tests (discharge capacity at different temperatures), (b) simulating the launch conditions, (c) simulating the cruise phase conditions (including trajectory correction maneuvers), (d) simulating the entry, decent, and landing (EDL) pulse load profile (required to support the pyros) (e) simulating the Mars surface operation mission simulation conditions, as well as, (f) assessing capacity loss and impedance characteristics as a function of temperature and life. This paper provides further detail to previously reported results1 of the RBAU testing program, especially with regard to the life characteristics. To date, the lithium-ion batteries (fabricated by Lithion/Yardney, Inc.) have been demonstrated to far exceed the requirements defined by the mission, both on Mars and on the ground, and are projected to support an extended mission (> 4 years).

Mars Exploration Rovers (MER) Mission↗