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At least 235 records · Page 13

Developing, mechanizing and testing of a digital active flutter suppression system for a modified B-52 wind-tunnel model

A digital flutter suppression system was developed and mechanized for a significantly modified version of the 1/30-scale B-52E aeroelastic wind tunnel model. A model configuration was identified that produced symmetric and antisymmetric flutter modes that occur at 2873N/sq m (60 psf) dynamic pressure with violent onset. The flutter suppression system, using one trailing edge control surface and the accelerometers on each wing, extended the flutter dynamic pressure of the model beyond the design limit of 4788N/sq m (100 psf). The hardware and software required to implement the flutter suppression system were designed and mechanized using digital computers in a fail-operate configuration. The model equipped with the system was tested in the Transonic Dynamics Tunnel at NASA Langley Research Center and results showed the flutter dynamic pressure of the model was extended beyond 4884N/sq m (102 psf).

Matthew, J. R.↗

Bi-Axial Solar Array Drive Mechanism: Design, Build and Environmental Testing

The development of the Bi-Axial Solar Array Drive Mechanism (BSADM) presented in this paper is a demonstration of SSTL's unique space manufacturing approach that enables performing rapid development cycles for cost-effective products that meet ever-challenging mission requirements: The BSADM is designed to orient a solar array wing towards the sun, using its first rotation axis to track the sun, and its second rotation axis to compensate for the satellite orbit and attitude changes needed for a successful payload operation. The tight development schedule, with manufacture of 7 Flight Models within 1.5 year after kick-off, is offset by the risk-reduction of using qualified key component-families from other proven SSTL mechanisms. This allowed focusing the BSADM design activities on the mechanism features that are unique to the BSADM, and having an Engineering Qualification Model (EQM) built 8 months after kick-off. The EQM is currently undergoing a full environmental qualification test campaign. This paper presents the BSADM design approach that enabled meeting such a challenging schedule, its design particularities, and the ongoing verification activities.

Scheidegger, Noemy↗

Mechanisms of insulin action on sympathetic nerve activity

Insulin resistance and hyperinsulinemia may contribute to the development of arterial hypertension. Although insulin may elevate arterial pressure, in part, through activation of the sympathetic nervous system, the sites and mechanisms of insulin-induced sympathetic excitation remain uncertain. While sympathoexcitation during insulin may be mediated by the baroreflex, or by modulation of norepinephrine release from sympathetic nerve endings, it has been shown repeatedly that insulin increases sympathetic outflow by actions on the central nervous system. Previous studies employing norepinephrine turnover have suggested that insulin causes sympathoexcitation by acting in the hypothalamus. Recent experiments from our laboratory involving direct measurements of regional sympathetic nerve activity have provided further evidence that insulin acts in the central nervous system. For example, administration of insulin into the third cerebralventricle increased lumbar but not renal or adrenal sympathetic nerve activity in normotensive rats. Interestingly, this pattern of regional sympathetic nerve responses to central neural administration of insulin is similar to that seen with systemic administration of insulin. Further, lesions of the anteroventral third ventricle hypothalamic (AV3V) region abolished increases in sympathetic activity to systemic administration of insulin with euglycemic clamp, suggesting that AV3V-related structures are critical for insulin-induced elevations in sympathetic outflow.

Muntzel, Martin S.↗

Computational mechanics needs study

In order to assess the needs in computational mechanics over the next decade, we formulated a questionnaire and contacted computational mechanics researchers and users in industry, government, and academia. As expected, we found a wide variety of computational mechanics usage and research. This report outlines the activity discussed with those contacts, as well as that in our own organizations. It should be noted that most of the contacts were made before the recent decline of the defense industry. Therefore, areas which are strongly defense-oriented may decrease in relative importance. In order to facilitate updating of this study, names of a few key researchers in each area are included as starting points for future literature surveys. These lists of names are not intended to represent those persons doing the best research in that area, nor are they intended to be comprehensive. They are, as previously stated, offered as starting points for future literature searches. Overall, there is currently a broad activity in computational mechanics in this country, with the breadth and depth increasing as more sophisticated software and faster computers become more available. The needs and desires of the workers in this field are as diverse as their background and organizational products. There seems to be some degree of software development in any organization (although the level of activity is highly variable from one organization to another) which has any research component in its mission. It seems, however, that there is considerable use of commercial software in almost all organizations. In most industrial research organizations, it appears that very little actual software development is contracted out, but that most is done in-house, using a mixture of funding sources. Government agencies vary widely in the ratio of in-house to out-house ratio. There is a considerable amount of experimental verification in most, but not all, organizations. Generally, the amount of experimental verification is more than we expected. Of all the survey contacts, one or two believe that the resources they are allocated are sufficient, but most do not. Some believe they have only half the resources they need. Some see their resource deficits as short-term, while others see it as a trend which will continue or perhaps worsen. The pessimism is stronger in the defense and aerospace industry. When considering only the nonlinear development efforts, there appears to be an even mix of geometric and material nonlinearity. There is not much particular emphasis in linear analysis unless it is in extension of current analysis capabilities to larger problems. The primary exception is concern about modeling of composites, where proven methodologies have trailed element and computer hardware development. Most of the people we spoke to use finite element techniques, but there is some finite difference and boundary element work ongoing. There is also some interest in multiple methods. Coupling of finite elements and boundary elements appears to be of high interest, since the two analysis types are complementary.

Griffin, O. Hayden, Jr.↗

Experiments on the abiotic amplification of optical activity

Experiments concerning the physical mechanisms for the abiotic generation and chemical mechanisms for the amplification of optical activity in biological compounds are reviewed. Attention is given to experiments involving the determination of the differential adsorption of racemic amino acids on d- and l-quartz, the asymmetric photolysis of racemic amino acids by circularly polarized light, and the asymmetric radiolysis of solid amino acids by longitudinally polarized electrons, and the enantiomeric enrichments thus obtained are noted. Further experiments on the amplification of the chirality in the polymerization of D, L-amino acid mixtures and the hydrolysis of D-, L-, and D, L-polypeptides are discussed. It is suggested that a repetitive cycle of partial polymerization-hydrolyses may account for the abiotic genesis of optically enriched polypeptides on the primitive earth.

Bonner, W. A.↗

Simulating A Massive, Mobile Structure

Simulator replicates, kinematically and dynamically, mating of large, massive mobile structure with similarly large and massive fixed structure. Developed for testing berthing-and-latching mechanism. Fixed section holds active berthing-and-latching mechanism and its motor control system with optical encoder to maintain synchronization among four latches in mechanism. Tripodal load-cell network gathers data on load history of berthing operation, and infrared tracking system including light-emitting diodes produces data for position history.

Fantasia, Peter M.↗

Sensor Web in Antarctica: Developing an Intelligent, Autonomous Platform for Locating Biological Flourishes in Cryogenic Environments

The most rigorous tests of the ability to detect extant life will occur where biotic activity is limited by severe environmental conditions. Cryogenic environments are among the most severe-the energy and nutrients needed for biological activity are in short supply while the climate itself is actively destructive to biological mechanisms. In such settings biological activity is often limited to brief flourishes, occurring only when and where conditions are at their most favorable. The closer that typical regional conditions approach conditions that are actively hostile , the more widely distributed biological blooms will be in both time and space. On a spatial dimension of a few meters or a time dimension of a few days, biological activity becomes much more difficult to detect. One way to overcome this difficulty is to establish a Sensor Web that can monitor microclimates over appropriate scales of time and distance, allowing a continuous virtual presence for instant recognition of favorable conditions. A more sophisticated Sensor Web, incorporating metabolic sensors, can effectively meet the challenge to be in "the right place in the right time". This is particularly of value in planetary surface missions, where limited mobility and mission timelines require extremely efficient sample and data acquisition. Sensor Webs can be an effective way to fill the gap between broad scale orbital data collection and fine-scale surface lander science. We are in the process of developing an intelligent, distributed and autonomous Sensor Web that will allow us to monitor microclimate under severe cryogenic conditions, approaching those extant on the surface of Mars. Ultimately this Sensor Web will include the ability to detect and/or establish limits on extant microbiological activity through incorporation of novel metabolic gas sensors. Here we report the results of our first deployment of a Sensor Web prototype in a previously unexplored high altitude East Antarctic Plateau "micro-oasis" at the MacAlpine Hills, Law Glacier, Antarctica.

Delin, K. A.↗

Microgravity and Immunity: Changes in Lymphocyte Gene Expression

Earlier studies had shown that modeled and true microgravity (MG) cause multiple direct effects on human lymphocytes. MG inhibits lymphocyte locomotion, suppresses polyclonal and antigen-specific activation, affects signal transduction mechanisms, as well as activation-induced apoptosis. In this study we assessed changes in gene expression associated with lymphocyte exposure to microgravity in an attempt to identify microgravity-sensitive genes (MGSG) in general and specifically those genes that might be responsible for the functional and structural changes observed earlier. Two sets of experiments targeting different goals were conducted. In the first set, T-lymphocytes from normal donors were activated with antiCD3 and IL2 and then cultured in 1g (static) and modeled MG (MMG) conditions (Rotating Wall Vessel bioreactor) for 24 hours. This setting allowed searching for MGSG by comparison of gene expression patterns in zero and 1 g gravity. In the second set - activated T-cells after culturing for 24 hours in 1g and MMG were exposed three hours before harvesting to a secondary activation stimulus (PHA) thus triggering the apoptotic pathway. Total RNA was extracted using the RNeasy isolation kit (Qiagen, Valencia, CA). Affymetrix Gene Chips (U133A), allowing testing for 18,400 human genes, were used for microarray analysis. In the first set of experiments MMG exposure resulted in altered expression of 89 genes, 10 of them were up-regulated and 79 down-regulated. In the second set, changes in expression were revealed in 85 genes, 20 were up-regulated and 65 were down-regulated. The analysis revealed that significant numbers of MGS genes are associated with signal transduction and apoptotic pathways. Interestingly, the majority of genes that responded by up- or down-regulation in the alternative sets of experiments were not the same, possibly reflecting different functional states of the examined T-lymphocyte populations. The responder genes (MGSG) might play an essential role in adaptation to MG and/or be responsible for pathologic changes encountered in Space and thus represent potential targets for molecular-based countermeasures

Risin, D.↗

Analysis of in Vitro Evolution Reveals the Underlying Distribution of Catalytic Activity Among Random Sequences

The emergence of catalytic RNA is believed to have been a key event during the origin of life. Understanding how catalytic activity is distributed across random sequences is fundamental to estimating the probability that catalytic sequences would emerge. Here, we analyze the in vitro evolution of triphosphorylating ribozymes and translate their fitnesses into absolute estimates of catalytic activity for hundreds of ribozyme families. The analysis efficiently identified highly active ribozymes and estimated catalytic activity with good accuracy. The evolutionary dynamics follow Fisher’s Fundamental Theorem of Natural Selection and a corollary, permitting retrospective inference of the distribution of fitness and activity in the random sequence pool for the first time. The frequency distribution of rate constants appears to be log-normal, with a surprisingly steep dropoff at higher activity, consistent with a mechanism for the emergence of activity as the product of many independent contributions.

Abe Pressman↗

Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein

Oxidized low-density lipoprotein (oxLDL) is known to activate a number of signal transduction pathways in endothelial cells. Among these are the c-Jun NH(2)-terminal kinase (JNK), also known as stress-activated protein kinase, and extracellular signal-regulated kinase (ERK). These mitogen-activated protein kinases (MAP kinase) determine cell survival in response to environmental stress. Interestingly, JNK signaling involves redox-sensitive mechanisms and is activated by reactive oxygen and nitrogen species derived from both NADPH oxidases, nitric oxide synthases (NOS), peroxides, and oxidized low-density lipoprotein (oxLDL). The role of endothelial NOS (eNOS) in the activation of JNK in response to oxLDL has not been examined. Herein, we show that on exposure of endothelial cells to oxLDL, both ERK and JNK are activated through independent signal transduction pathways. A key role of eNOS activation through a phosphatidylinositol-3-kinase-dependent mechanism leading to phosphorylation of eNOS is demonstrated for oxLDL-dependent activation of JNK. Moreover, we show that activation of ERK by oxLDL is critical in protection against the cytotoxicity of oxLDL.

Non-NASA Center↗

Initiation of non-tropical thunderstorms by solar activity

Correlative evidence accumulating since 1926 suggests that there must be some physical coupling mechanism between solar activity and thunderstorm occurrence in middle to high latitudes. Such a link may be provided by alteration of atmospheric electric parameters through the combined influence of high-energy solar protons and decreased cosmic ray intensities, both of which are associated with active solar events. The protons produce excess ionization near and above 20km, while the Forbush decreases a lowered conductivity and enhanced fair-weather atmospheric electric field below that altitude. Consequent effects ultimately lead to a charge distribution similar to that found in thunderclouds, and then other cloud physics processes take over to generate the intense electric fields required for lightning discharge.

Herman, J. R.↗

Control of jet noise

To investigate the possibility of active control of jet noise, knowledge of the noise generation mechanisms in natural jets is essential. Once these mechanisms are determined, active control can be used to manipulate the noise production processes. We investigated the evolution of the flow fields and the acoustic fields of rectangular and circular jets. A predominant flapping mode was found in the supersonic rectangular jets. We hope to increase the spreading of supersonic jets by active control of the flapping mode found in rectangular supersonic jets.

Schreck, Stefan↗

Praying Mantis Bending Core Breakoff and Retention Mechanism

Sampling cores requires the controlled breakoff of the core at a known location with respect to the drill end. An additional problem is designing a mechanism that can be implemented at a small scale, yet is robust and versatile enough to be used for a variety of core samples. The new design consists of a set of tubes (a drill tube, an outer tube, and an inner tube) and means of sliding the inner and outer tubes axially relative to each other. Additionally, a sample tube can be housed inside the inner tube for storing the sample. The inner tube fits inside the outer tube, which fits inside the drill tube. The inner and outer tubes can move axially relative to each other. The inner tube presents two lamellae with two opposing grabbing teeth and one pushing tooth. The pushing tooth is offset axially from the grabbing teeth. The teeth can move radially and their motion is controlled by the outer tube. The outer tube presents two lamellae with radial extrusions to control the inner tube lamellae motion. In breaking the core, the mechanism creates two support points (the grabbing teeth and the bit tip) and one push point. The core is broken in bending. The grabbing teeth can also act as a core retention mechanism. The praying mantis that is disclosed herein is an active core breaking/retention mechanism that requires only one additional actuator other than the drilling actuator. It can break cores that are attached to the borehole bottom as

Badescu, Mircea↗

Effects of hirudin-induced activation of nonenzymatic fibrinolysis during immobilization stress

The specific inhibitor of thrombin, hirudin, was used for studying the mechanism of the activating effect of ACTH and adrenalin on nonenzymatic fibrinolytic activity (NEFA), the latter characterizing the function of the anticoagulation system (ACS). Simultaneous administration of ACTH and hirudin to animals subjected to immobilization stress did not reduce the effect of ACTH on NEFA, while simultaneous administration of adrenalin and hirudin revealed a diminished effect of the former. This suggests different mechanisms of ACTH and adrenalin effects upon NEFA: the stimulating effect of norepinephrine is realized through throminogenesis followed by activation of the ACS function and by increased NEFA and therefore inhibitable by hirudin which forms an inactive complex with thrombin. In fact the stimulating effect of ACTH upon NEFA is brought about specifically by another route than thrombinogenesis and thus occurs in the presence of hirudin. Hirudin itself has no effect upon NEFA.

Shapiro, F. B.↗

An explanation for Iapetus' asymmetric reflectance

Cook and Franklin (1970) consider Iapetus originally to have been coated with about a meter of ice. They suggest that Iapetus' orbital velocity about Saturn has caused an asymmetric erosion of this ice layer which has now nearly laid bare its 'leading' hemisphere, but not as yet the entire 'trailing' hemisphere. Rather than an erosion process which operates more actively on the leading side, this paper considers an ice deposition mechanism operating more actively on the trailing side. The two main assumptions used are (1) that there are more icy than rocky meteoroids in Saturn's environment, and (2) that some portion of each icy meteoroid will stick to a surface at collision velocities less than 2.4 km per sec, but will completely vaporize itself at greater velocities. A meteoroid can have the minimum collision velocity of about 1.7 km per sec with Iapetus only if their velocity vectors are nearly parallel, and under these conditions such collisions would tend to be with the trailing hemisphere. Collisions with the leading hemisphere will tend to be at a much higher velocity.

Peterson, C.↗

Prestressing Shock Resistant Mechanical Components and Mechanisms Made from Hard, Superelastic Materials

A method and an apparatus confer full superelastic properties to the active surface of a mechanical component constructed of a superelastic material prior to service. A compressive load is applied to the active surface of the mechanical component followed by removing the compressive load from the active surface whereby substantially all load strain is recoverable after applying and removing of subsequent compressive loads.

DellaCorte, Christopher↗