Bayesian Attack Detection and Recommendation of Actions for Operational Response (BAD REACTOR) Final Scientific / Technical Report
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22 GENERAL STUDIES OF NUCLEAR REACTORS↗
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IMPACT Community Action final report
Final report on American Addition project
Urban, Beth [IMPACT Community Action]↗
Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice
ABSTRACT The development of Wnt-based osteoanabolic agents has progressed rapidly in recent years, given the potent effects of Wnt modulation on bone homeostasis. Simultaneous pharmacologic inhibition of the Wnt antagonists sclerostin and Dkk1 can be optimized to create potentiated effects in the cancellous bone compartment. We looked for other candidates that might be co-inhibited along with sclerostin to potentiate the effects in the cortical compartment. Sostdc1 (Wise), like sclerostin and Dkk1, also binds and inhibits Lrp5/6 coreceptors to impair canonical Wnt signaling, but Sostdc1 has greater effects in the cortical bone. To test this concept, we deleted Sostdc1 and Sost from mice and measured the skeletal effects in cortical and cancellous compartments individually. Sost deletion alone produced high bone mass in all compartments, whereas Sostdc1 deletion alone had no measurable effects on either envelope. Mice with codeletion of Sostdc1 and Sost had high bone mass and increased cortical properties (bone mass, formation rates, mechanical properties), but only among males. Combined administration of sclerostin antibody and Sostdc1 antibody in wild-type female mice produced potentiation of cortical bone gain despite no effect of Sostdc1 antibody alone. In conclusion, Sostdc1 inhibition/deletion can work in concert with sclerostin deficiency to improve cortical bone properties. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
59 BASIC BIOLOGICAL SCIENCES↗
The Triple Catalytic Action of Tertiary Nitrogen Catalysts in Recyclable Epoxy-Anhydride Thermosets
The thermosetting polymer matrix in fiber reinforced composites is an important component for energy related applications, such as the lightweighting of vehicles or their use in wind and waterpower turbine blades, due to their ability to provide superior adhesion, stiffness, and applicability to a wide range of manufacturing processes. Despite these benefits, today's thermosets are widely considered to be unrecyclable; thus, there is a large interest in redesigning these materials to be inherently recyclable so that energy intensive production of fibers and monomers can be circumvented, bolstering composite manufacture supply chains. Polyester covalent adaptable networks (PECANs) are one such promising alternative to the incumbent, nonrecyclable epoxy-amine thermosets. PECANs can be formed from the ring-opening co-polymerization (ROCOP) of epoxy-anhydride monomer mixtures and subsequent curing at mild temperatures to exhibit similar performance to conventional epoxies while also possessing unique dynamic chemistries along the ester-hydroxyl backbone that are capable of transesterification and thus reprocessability. While significant advancements have been made in formulating these materials for improved mechanical properties or optimizing solvolysis and reprocessing strategies, less attention has been placed on the impact of the residing amine catalyst used to generate the polyester network. In this work, we evaluated the triple-catalytic efficacy of 12 tertiary amines that act as a curing (bulk ROCOP), a transesterification (internal bond exchange), and a deconstruction (methanolysis) catalyst for PECAN thermosets. Specifically, we first distinguish between chain-growth and step-growth polymerization mechanisms for epoxy-amine and epoxy-anhydride mechanisms. We also utilized density functional theory (DFT) to estimate the basicity (pKb) of each catalyst. Of the tested catalysts, the ROCOP of the studied PECAN network can be completed between 95 and 247 min (at 80 degrees C), with variable gelation phenomena. Additionally, the stress relaxation (transesterification metric) efficiency of the tested PECAN networks with alternative embedded catalysts ranged from 95% to 15% reduction in stress after 5 h at 200 degrees C, and the depolymerization efficacy ranged from 2.5% to 9.8% deconstruction after 36 h at 130 degrees C. Overall, the nitrogen-based moieties were demonstrated to influence polymerization kinetics, catalyze the dynamic transesterification exchange mechanism, and aid in the solvolysis of the thermosets at end-of-life.
36 MATERIALS SCIENCE↗
Predicting Search Task Difficulty through a Discrete‐Time Action Log Representation on Spectrum Kernel
ABSTRACT Predicting perceived difficulty on a web search task is an open problem in the interactive information retrieval field. A common approach to tackle it, is through features obtained from full search sessions, which are then used to train classification models. In this poster we attempt to predict perceived task difficulty at different stages of the search process. To do so, we use the spectrum kernel for support vector machine (SVM) classification. Our preliminary results suggest that by using behavioral data from the first query segment, it is possible to provide timely classifications of whether a search task is perceived as hard or easy.
Gacitúa, Daniel↗
Scenario Planning Management Actions to Restore Cold Water Stream Habitat: Comparing Mechanistic and Statistical Modeling Approaches
ABSTRACT Under the United States Clean Water Act, states are required to periodically assess state waters to determine compliance with water quality criteria (including temperature) and then to develop total maximum daily loads (TMDLs) for impaired waters as necessary to bring them into compliance. We compared the performance of mechanistic stream temperature models (HeatSource, QUAL2K, and QUAL2Kw) applied to the mainstem of three TMDL watersheds (Middle Fork John Day, OR; Wind River, WA; South Fork Nooksack, WA) with that of spatial stream network (SSN) models applied to the full watersheds and used these to evaluate the potential effectiveness of restoration strategies. SSN models performed well with slightly lesser accuracy (RMSE = 0.47–0.87) for mainstem predictions than mechanistic models (RMSE = 0.4) but provided additional benefits to inform management, including information on spatial and temporal heterogeneity of restoration effectiveness throughout the watershed. Of the four scenarios considered (restoration of riparian zones to potential natural vegetation, channel narrowing, increasing flow by restricting irrigation withdrawals, and combined applications), riparian zone restoration was consistently the most effective in reducing temperatures at the outlet, mainstem, and throughout the watersheds. Predicted restoration effectiveness for thermal regimes varied significantly both within and among watersheds. A focus on water quality criteria exceedance only at the watershed outlet or along the mainstem reach can obscure knowledge of restoration potential for fish habitat in tributaries and headwaters, potential for creation of thermal refuge areas along the mainstem critical for maintaining migration corridors, and thermal regime heterogeneity across space and time.
Fuller, M. R.↗
Electrowetting‐Mediated Transport to Produce Electrochemical Transistor Action in Nanopore Electrode Arrays
Abstract Understanding water behavior in confined volumes is important in applications ranging from water purification to healthcare devices. Especially relevant are wetting and dewetting phenomena which can be switched by external stimuli, such as light and electric fields. Here, these behaviors are exploited for electrochemical processing by voltage‐directed ion transport in nanochannels contained within nanopore arrays in which each nanopore presents three electrodes. The top and middle electrodes (TE and ME) are in direct contact with the nanopore volume, but the bottom electrode (BE) is buried beneath a 70 nm silicon nitride (SiN x ) insulating layer. Electrochemical transistor operation is realized when small, defect‐mediated channels are opened in the SiN x . These defect channels exhibit voltage‐driven wetting that mediates the mass transport of redox species to/from the BE. When BE is held at a potential maintaining the defect channels in the wetted state, setting the potential of ME at either positive or negative overpotential results in strong electrochemical rectification with rectification factors up to 440. By directing the voltage‐induced electrowetting of defect channels, these three‐electrode nanopore structures can achieve precise gating and ion/molecule separation, and, as such, may be useful for applications such as water purification and drug delivery.
Kwon, Seung‐Ryong↗
LSZ in action: extracting form factors from correlators nonperturbatively in 2d ϕ4 theory
Abstract In this paper, we compute multiparticle form factors of local operators in 2dϕ 4 theory using a recently proposed method [1] for efficiently implementing the LSZ prescription with Hamiltonian Truncation methods, and we adopt Lightcone Conformal Truncation (LCT) in particular for our calculations. We perform various checks of our results at weak and strong coupling, and elucidate the parametric behavior of truncation errors. This opens up the possibility to compute S-matrix in various strongly coupled models using the LSZ method in LCT.
Physics↗
Color-kinematics dual representations of one-loop matrix elements in the open-superstring effective action
Abstract Theα ′ -expansion of string theory provides a rich set of higher-dimension operators, indexed byζvalues, which can be used to study color-kinematics duality and the double copy. These two powerful properties, actually first noticed in tree-level string amplitudes, simplify the construction of both gauge and gravity amplitudes. However, their applicability and limitations are not fully understood. We attempt to construct a set of color-kinematics dual numerators at one loop and four points for insertions of operator combinations corresponding to the lowest fourζ 2 -free operator insertions from the open superstring:ζ 3 ,ζ 5 ,$$ {\zeta}_3^2 $$ ζ 3 2 , andζ 7 . We succeed in finding a representation for the first three in terms of box, triangle, and bubble numerators. In the case ofζ 7 we find an obstruction to a fully color-dual representation related to the bubble-on-external-leg type diagrams. We discuss two paths around this obstruction, both of which signal an incompatability between color-kinematics duality and manifesting certain desired properties. Using the constructed color-dual numerators, we find two different Bern-Carrasco-Johansson double copies that produce candidate closed-string-insertion numerators. Both approaches to the double copy match the kinematics of the cuts, with relative normalization set by either summing over both double copies including degeneracy or by including an explicit prefactor on the double-copy numerator definitions.
Physics↗
A persistent adjoint method with dynamic time-scaling and an application to mass action kinetics
In this article, we consider an optimization problem where the objective function is evaluated at the fixed-point of a contraction mapping parameterized by a control variable, and optimization takes place over this control variable. Since the derivative of the fixed-point with respect to the parameter can usually not be evaluated exactly, an adjoint dynamical system can be used to estimate gradients. Using this estimation procedure, the optimization algorithm alternates between derivative estimation and an approximate gradient descent step. We analyze a variant of this approach involving dynamic time-scaling, where after each parameter update the adjoint system is iterated until a convergence threshold is passed. Here, we prove that, under certain conditions, the algorithm can find approximate stationary points of the objective function. We demonstrate the approach in the settings of an inverse problem in chemical kinetics, and learning in attractor networks.
97 MATHEMATICS AND COMPUTING↗
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells
Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines that are produced by antigen-presenting cells to regulate the activation and differentiation of lymphocytes, and they share IL-12Rβ1 as a receptor signaling subunit. In this paper, we present a crystal structure of the quaternary IL-23 (IL-23p19/p40)/IL-23R/IL-12Rβ1 complex, together with cryoelectron microscopy (cryo-EM) maps of the complete IL-12 (IL-12p35/p40)/IL-12Rβ2/IL-12Rβ1 and IL-23 receptor (IL-23R) complexes, which reveal “non-canonical” topologies where IL-12Rβ1 directly engages the common p40 subunit. We targeted the shared IL-12Rβ1/p40 interface to design a panel of IL-12 partial agonists that preserved interferon gamma (IFNγ) induction by CD8+ T cells but impaired cytokine production from natural killer (NK) cells in vitro. These cell-biased properties were recapitulated in vivo, where IL-12 partial agonists elicited anti-tumor immunity to MC-38 murine adenocarcinoma absent the NK-cell-mediated toxicity seen with wild-type IL-12. Thus, the structural mechanism of receptor sharing used by IL-12 family cytokines provides a protein interface blueprint for tuning this cytokine axis for therapeutics.
59 BASIC BIOLOGICAL SCIENCES↗
Scientists’ call to action: Microbes, planetary health, and the Sustainable Development Goals
Microorganisms, including bacteria, archaea, viruses, fungi, and protists, are essential to life on Earth and the functioning of the biosphere. Here, we discuss the key roles of microorganisms in achieving the United Nations Sustainable Development Goals (SDGs), highlighting recent and emerging advances in microbial research and technology that can facilitate our transition toward a sustainable future. Given the central role of microorganisms in the biochemical processing of elements, synthesizing new materials, supporting human health, and facilitating life in managed and natural landscapes, microbial research and technologies are directly or indirectly relevant for achieving each of the SDGs. More importantly, the ubiquitous and global role of microbes means that they present new opportunities for synergistically accelerating progress toward multiple sustainability goals. By effectively managing microbial health, we can achieve solutions that address multiple sustainability targets ranging from climate and human health to food and energy production. Emerging international policy frameworks should reflect the vital importance of microorganisms in achieving a sustainable future.
59 BASIC BIOLOGICAL SCIENCES↗
Structural basis for human ZBTB7A action at the fetal globin promoter
Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF, bind directly to the fetal globin promoter elements positioned at -115 and -200, respectively. Here, we describe X-ray structures of the ZBTB7A DNA-binding domain, consisting of four adjacent ZFs, in complex with the -200 sequence element, which contains two copies of four consecutive C:G base pairs. ZF1 and ZF2 recognize the 5' C:G quadruple, and ZF4 contacts the 3' C:G quadruple. Natural non-coding DNA mutations associated with hereditary persistence of fetal hemoglobin (HPFH) impair ZBTB7A DNA binding, with the most severe disruptions resulting from mutations in the base pairs recognized by ZF1 and ZF2. Our results firmly establish ZBTB7A/LRF as a key molecular regulator of fetal globin expression and inform genome-editing strategies that inhibit repressor binding and boost fetal globin expression to treat hemoglobinopathies.
59 BASIC BIOLOGICAL SCIENCES↗
A small-angle neutron scattering study of the physical mechanism that drives the action of a viral fusion peptide
Viruses have evolved a variety of ways for delivering their genetic cargo to a target cell. One mechanism relies on a short sequence from a protein of the virus that is referred to as a fusion peptide. In some cases, the isolated fusion peptide is also capable of causing membranes to fuse. Infection by HIV-1 involves the 23 amino acid N-terminal sequence of its gp41 envelope protein, which is capable of causing membranes to fuse by itself, but the mechanism by which it does so is not fully understood. In this study, a variant of the gp41 fusion peptide that does not strongly promote fusion was studied in the presence of vesicles composed of a mixture of unsaturated lipids and cholesterol by small-angle neutron scattering and circular dichroism spectroscopy to improve the understanding of the mechanism that drives vesicle fusion. The peptide concentration and cholesterol content govern both the peptide conformation and its impact on the bilayer structure. The results indicate that the mechanism that drives vesicle fusion by the peptide is a strong distortion of the bilayer structure by the peptide when it adopts the β-sheet conformation.
60 APPLIED LIFE SCIENCES↗
Flame Chemistry Workshop: a perspective on challenges and strategic actions in combustion experiments and chemical kinetics modeling
Continued progress in the development of predictive models for combustion chemistry—including ignition and flame behavior, species evolution, and combustion system performance—relies on overcoming enduring and emerging challenges in experimental measurements, theoretical formulations, and chemical kinetics mechanism construction. As combustion science continues to coincide with advances in sustainable fuels development, plasma technologies, and automated modeling capabilities, the need for coordinated, community-driven strategies is essential. The Flame Chemistry Workshop (FCWS), held biennially before the International Symposium on Combustion, serves as a dedicated platform to identify, consolidate, and address these challenges in a structured and collaborative manner. This perspective arises from discussions at the 7th FCWS in Milan, Italy (2024), and presents a collective view of the critical barriers currently limiting progress. Across the five technical domains discussed during the 7th FCWS – sustainable fuels combustion, advanced diagnostics for combustion measurements, experiments and modeling in plasma combustion, artificial intelligence and automated methods for theory and mechanisms generation, and chemical kinetic models—a series of persistent and emerging scientific challenges were identified, highlighting the need for deeper integration between three areas: theory, experiments, and modeling. In conclusion, the present article concisely describes present challenges that were identified in each of the technical domains in an effort to streamline and coordinate solutions to accelerate progress in combustion science.
Chemical kinetics↗
Evaluation of riparian enhancement actions in the Columbia River Basin
Riparian enhancement is a common restoration technique in the Columbia River Basin (CRB) and the Pacific Northwest. However, relatively few studies have evaluated its success and even fewer studies include long-term monitoring. Forty-one riparian planting projects located in the CRB, each with a paired treatment and control reach, were evaluated in the summer of 2018 and 2019 using an extensive post-treatment (EPT) design. At each reach, we quantified woody plant abundance, richness, diversity, and vegetation and canopy cover as riparian response variables, and measured terrace height and documented individuals with bud browse, deceased, and with predator protection as potential explanatory variables. Species richness, woody plant abundance (all height classes combined and within shrub height class), and the proportion of woody plants with bud browse or deceased were all higher in treatment than control reaches. However, no significant improvements were observed for any other riparian response or explanatory variables. Implementation techniques, including invasive species removal efforts, follow-up planting, watering, and the type of restoration project (floodplain restoration and planting, in-stream restoration and planting, or solely planting) were also considered as potential explanatory variables and were found to have significant impacts on restoration response for abundance and cover variables. Further, our results suggest that planting implementation methods, site level physical factors, and time since planting all influence the success of riparian planting projects and if not addressed in restoration design and implementation can contribute to a lack of detectable response.
54 ENVIRONMENTAL SCIENCES↗
The pollutant perfluorohexane sulfonate (PFHxS) reduces serum thyroxine but does not alter thyroid action in the postnatal rat brain
Not Available
Environmental Sciences & Ecology↗