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At least 253 records · Page 14

The NASA Twins Study: The Effect of One Year in Space on Long-Chain Fatty Acid Desaturases and Elongases

Background: To date, there is no clear understanding of the effect of long-duration spaceflight on the major enzymes that govern the metabolism of omega-6 and omega-3 fatty acids. To address this gap in knowledge, we used data from the NASA Twins Study, which includes a multi-scale omic investigation of the changes that occurred during a year-long (340 days) human spaceflight. Embedded within the NASA Twins data are specific analytes associated with fatty acid metabolism. Objectives: To examine the long-chain fatty acid desaturases and elongases in a single human during one year in space. Method: One male twin was on board the International Space Station (ISS) for one year, while his monozygotic twin served as a genetically matched ground control. Longitudinal assessments included the genome, epigenome, transcriptome, proteome, metabolome, microbiome, and immunome during the mission, as well as six months before and after. The gene-specific fatty acid desaturase and elongase transcriptome data (FADS1, FADS2, ELOVL2 and ELOVL5) were extracted from untargeted RNA-seq measurements derived from white blood cell fractions. Results: Most data from the elongases and desaturases exhibited relatively similar expression profiles (R2>0.6) over time for the CD8, CD19, and LD cell fractions, indicating overall conservation of function within and between the subjects. Both cell-type and temporal specificity was observed in some cases, and some differences were also apparent between the poly-adenylated fraction (polyA) of processed RNAs vs. the ribo-depleted (ribo-) fraction. The flight subject showed a stronger enrichment of the Fatty Acid Metabolic processes pathway across almost all cell types (columns, CD4, CD8, CPT, LD), most especially in the ribodepleted fraction of RNA, but also with the polyA+ fraction of RNA. GSEA enrichment measures across three related Fatty Acid Metabolism pathways showed a differential between the ground and flight subject. Conclusions: There appears to be no persistent alteration of desaturase and elongase gene expression associated with one year in space. However, these data provide evidence that cellular lipid metabolism can be responsive and dynamic to spaceflight, even though it appears cell-type- and context-specific, most notably in terms of the fraction of RNA measured and the collection protocols. These results also provide new evidence of mid-flight spikes in expression of selected genes, which may indicate transient responses to specific insults during spaceflight.

Elongase↗

Impact of Lateral Alignment on the Energy Savings of a Truck Platoon: Preprint

A truck platooning system was tested using two heavy-duty tractor-trailer trucks on a closed test track to investigate the sensitivity of intentional lateral offsets over a range of intervehicle spacings. The fuel consumption for both trucks in the platoon was measured using the SAE J1321 gravimetric procedure while travelling at 65 mph and loaded to a gross weight of 65,000 lb. In addition, the SAE J1939 instantaneous fuel rate was calibrated against the gravimetric measurements and used as proxy for additional analyses. The testing campaign demonstrated the effects of intervehicle gaps, following-vehicle longitudinal control, and manual lateral control. The new results are compared to previous truck-platooning studies to reinforce the value of the new information and demonstrate similarity to past trends. Fuel savings for the following vehicle was observed to exceed 10% at closer following distances. The results showed that energy savings generally increased in a non-linear fashion as the gap was reduced. The impact of different following-truck lateral offsets had a measurable impact, with up to 4% reduction in total fuel-savings (relative to an isolated vehicle condition) observed for offsets up to 1.3 m. The fuel-consumption savings on the straight segments of the track exceeded those on the curved segments by upwards of 6% and highlight some potential differences expected between close-track testing and on-highway use.

adaptive cruise control↗

Coupled Bunch Instabilities Growth in the Fermilab Booster during Acceleration Cycle

Currently, Fermilab Booster accelerates ~4.5E12 protons per pulse (ppp) in 81 bunches from 400 MeV to 8 GeV at 15 Hz to provide beam to multiple HEP experiments and is being upgraded to handle higher beam intensity >6.7E12 ppp at a repetition rate of 20 Hz. In the current mode of operation, we control longitudinal coupled bunch instabilities (LCBI) using combination of passive and active dampers. The issues with LCBI are expected to worsen at higher beam intensities. Here, we would like to investigate at what time in the beam cycle a particular mode is going to originate and how much it contributes at a different time of the acceleration cycle using the collected wall current monitor data from injection to extraction. Also, measure growth rates as a function of beam intensity for some dominant modes. Finally, this paper presents results from the observed LCBI analysis for the highest available beam intensities, unexpected findings, and future plans to mitigate the LCBI at higher beam intensities

43 PARTICLE ACCELERATORS↗

Flight-Determined Subsonic Longitudinal Stability and Control Derivatives of the F-18 High Angle of Attack Research Vehicle (HARV) with Thrust Vectoring

The subsonic longitudinal stability and control derivatives of the F-18 High Angle of Attack Research Vehicle (HARV) are extracted from dynamic flight data using a maximum likelihood parameter identification technique. The technique uses the linearized aircraft equations of motion in their continuous/discrete form and accounts for state and measurement noise as well as thrust-vectoring effects. State noise is used to model the uncommanded forcing function caused by unsteady aerodynamics over the aircraft, particularly at high angles of attack. Thrust vectoring was implemented using electrohydraulically-actuated nozzle postexit vanes and a specialized research flight control system. During maneuvers, a control system feature provided independent aerodynamic control surface inputs and independent thrust-vectoring vane inputs, thereby eliminating correlations between the aircraft states and controls. Substantial variations in control excitation and dynamic response were exhibited for maneuvers conducted at different angles of attack. Opposing vane interactions caused most thrust-vectoring inputs to experience some exhaust plume interference and thus reduced effectiveness. The estimated stability and control derivatives are plotted, and a discussion relates them to predicted values and maneuver quality.

Iliff, Kenneth W.↗

The High-Speed Longitudinal Stability and Control of the Bell P-39N-1 Airplane as Calculated from Propeller-Off Tests of a 0.35-Scale Model

This report presents the result of tests of a 0.35-scale model of the Bell P-39N-l airplane. Included are the longitudinal-stability and - control characteristics of the airplane as indicated by tests of the model equipped with each of two different sets of elevators. The results indicate good longitudinal stability and control throughout the speed range encounterable in flight. The variation of estimated stick force with speed was less when the model was equipped with elevators constructed to the theoretical design dimensions than when equipped with elevators as built to scale from measurements of the corresponding-parts of the actual airplane. The predicted stick forces required to produce the normal accelerations attainable in flight are within the limits specified by the Army Air Forces.

Robinson, Robert C.↗

The High-Speed Longitudinal Stability and Control of the Bell P-39N-1 Airplane as Calculated from Propeller-Off Tests of a 0.35-Scale Model

This report presents the results of tests of a .35-scale model of the Bell P-39N-1 airplane. Included are the longitudinal-stability and -control characteristics of the airplane as indicated by tests of the model equipped with each of two different sets of elevators. The results indicate good longitudinal stability and control throughout the speed range encounterable in flight. The variation of estimated stick force with speed was less when the model was equipped with elevators constructed to the theoretical design dimensions than when equipped with elevators as built to scale from measurements of the corresponding parts of the actual airplane. The predicted stick forces required to produce the normal accelerations attainable in flight are within the limits specified by the Army Air Forces.

Robinson, Robert C.↗

Entry dynamics of space shuttle orbiter with longitudinal stability and control uncertainties at supersonic and hypersonic speeds

A six-degree-of-freedom simulation analysis was conducted to examine the effects of longitudinal static aerodynamic stability and control uncertainties on the performance of the space shuttle orbiter automatic (no manual inputs) entry guidance and control systems. To establish the acceptable boundaries, the static aerodynamic characteristics were varied either by applying a multiplier to the aerodynamic parameter or by adding an increment. With either of two previously identified control system modifications included, the acceptable longitudinal aerodynamic boundaries were determined.

Stone, H. W.↗

Measurements of the Longitudinal Stability and Control and Stalling Characteristics of a North American P-51H Airplane (AAF No. 4-64164)

Flight tests have been made to determine the longitudinal stability and control and stalling characteristics of a North American P-51H airplane. The results indicate that the airplane has satisfactory longitudinal stability in all the flight conditions tested at normal loadings up to 25,000 feet altitude. At Mach numbers above 0.7, the elevator push force required for longitudinal trim decreased somewhat because of compressibility effects. The elevator stick force per g in accelerated turns at the forward center-of-gravity position of 24 percent mean aerodynamic chord above 250 miles per hour was in excess of the required limits at both 5,000 and 25,OOO feet altitude. The longitudinal-trim-force changes due to flaps and power were small, but the rudder-trim-force change with power change was high. The stalling characteristics in all the conditions tested were satisfactory.

Kraft, Christopher C., Jr.↗

Evaluation of the longitudinal stability and control characteristics of a mixed-flow remote-lift STOVL aircraft in transition and hover

An evaluation of the longitudinal stability and control characteristics of a mixed-flow remote-lift (MFRL) STOVL aircraft in the powered-lift portion of the flight envelope is presented. A stabilization and command augmentation system was implemented on the MFRL aircraft to meet the requirements for satisfactory flying qualities. The pitch portion of this control system uses a state-rate feedback implicit model following controller to achieve the desired flying qualities and to suppress the effects of external variations and disturbances in the aircrafts characteristics over the low speed envelope.

Engelland, Shawn A.↗

Full-scale Wind-tunnel Tests of the Longitudinal Stability and Control Characteristics of the XV-1 Convertiplane in the Autorotating Flight Range

Force and moments were measured for the XV-1 convertaplane at 75 to 150 knots. Rotor on and off and propeller powered and off configurations were investigated. The characteristics of the V-tab horizontal tail and its downwash field were studied. Lift interference between fixed wing and rotor and possible means of drag reduction were considered.

STABILITY, LONGITUDINAL - STATIC↗

Longitudinal stability and control in wind shear with energy height rate feedback

The longitudinal linearized equations of motion in wind shear were derived for the NASA Terminal Configured Vehicle, a modified Boeing 737 airplane. In addition to the apparent acceleration terms resulting from wind shear, the equations included altitude dependent stability derivatives. A linear analysis of these equations indicates a first order divergence type of instability due to wind shear in which head wind decreased with altitude. Furthermore, this instability cannot be stabilized by attitude control alone. However, attitude control used in combination with an addition feedback loop which consisted of the energy height rate feedback to the throttle proved to be effective in suppressing instability due to wind shear. A brief piloted, real time, nonlinear simulation indicated the desirability of using a display based on the rate of change of energy height rate and of commanded thrust.

Gera, J.↗

Static Longitudinal Stability and Control Characteristics of an Unswept Wing and Unswept Horizontal-Tail Configuration at Mach Numbers from 0.70 to 2.22

Results of an investigation of the static longitudinal stability and control characteristics of an aspect-ratio-3.1, unswept wing configuration equipped with an aspect-ratio-4, unswept horizontal tail are presented without analysis for the Mach number range from 0.70 to 2.22. The hinge line of the all-movable horizontal tail was in the extended wing chord plane, 1.66 wing mean aerodynamic chords behind the reference center of moments. The ratio of the area of the exposed horizontal-tail panels to the total area of the wing was 13.3 percent and the ratio of the total areas was 19.9 percent. Data are presented at angles of attack ranging"from -6 deg to +18 deg for the horizontal tail set at angles ranging from +5 deg to -20 deg and for the tail removed.

Peterson, Victor L.↗

Low-Subsonic-Speed Static Longitudinal Stability and Control Characteristics of a Winged Reentry-Vehicle Configuration Having Wingtip Panels that Fold up for High-Drag Reentry

An investigation of the low-subsonic-speed static longitudinal stability and control characteristics of a model of a manned reentry-vehicle configuration capable of high-drag reentry and glide landing has been a made in the Langley free-flight tunnel. The model had a modified 63 deg delta plan-form wing with a fuselage on the upper surface. This configuration had wingtip panels designed to fold up 90 deg for the high-drag reentry phase of the flight and to extend horizontally for the glide landing. Data for the basic configurations and modifications to determine the effects of plan form, wingtip panel incidence, dihedral, and vertical position of the wingtip panels are presented without analysis.

Ware, George M.↗

Static Longitudinal Stability and Control Characteristics At A Mach Number of 1.99 of a Lenticular-Shaped Reentry Vehicle

An investigation has been made in the Langley 4- by 4-foot supersonic pressure tunnel at a Mach number of 1.99 to determine the longitudinal stability and control characteristics of a reentry model consisting of a lenticular-shaped body with two fin configurations (horizontal fins with end plates). Effects of deflecting the larger size fins as pitch-control surfaces were also investigated. The results indicate that the body alone was unstable from an angle of attack of 0 deg to about 55 deg where it became stable and remained so to 90 deg. The addition of fins provided positive longitudinal stability throughout the angle-of-attack range and increased the lift-drag ratio of the configuration. Reducing the horizontal-fin area at the inboard trailing edge of the fin had only a small effect on the aerodynamic characteristics of the vehicle for the condition of no fin deflection. Deflecting the fins, appeared to be an effective means of pitch control and had only a small effect on lift-drag ratio.

Jackson, Charles M., Jr.↗

Estimation of longitudinal stability and control derivatives for an icing research aircraft from flight data

The results of applying a modified stepwise regression algorithm and a maximum likelihood algorithm to flight data from a twin-engine commuter-class icing research aircraft are presented. The results are in the form of body-axis stability and control derivatives related to the short-period, longitudinal motion of the aircraft. Data were analyzed for the baseline (uniced) and for the airplane with an artificial glaze ice shape attached to the leading edge of the horizontal tail. The results are discussed as to the accuracy of the derivative estimates and the difference between the derivative values found for the baseline and the iced airplane. Additional comparisons were made between the maximum likelihood results and the modified stepwise regression results with causes for any discrepancies postulated.

Batterson, James G.↗

Longitudinal stability and control with special reference to slipstream effects

Report presents the results of a study of data obtained in the NACA full-scale wind tunnel concerning the effects of interference and of propeller operation on longitudinal stability and control. The data include pitching moments for various power conditions for airplanes with tails removed and with tails set at various stabilizer and elevator angles. A number of surveys of the dynamic pressure and the flow direction in the region of the horizontal tail surface are also included. Results are given for eight airplanes, including a model of a four-engine airplane tested both as a tractor and as a pushed and a model of two-engine pusher. The effects are shown of propeller operation on the downwash angles and the dynamic pressures at the tail and on the pitching-moment contribution of the propeller and the wing.

Katzoff, S↗

Longitudinal Stability and Control Characteristics of a Semispan Model of the XF7U-1 Tailless Airplane at Transonic Speeds by the NACA Wing-Flow Method, TED No. NACA DE307

An investigation was made by the NACA wing-flow method to determine the longitudinal stability and control characteristics at transonic speeds of a semispan model of the XF7U-1 tailless airplane. The 25-percent chord line of the wing of the model was swept back 35 deg. The airfoil sections of the wing perpendicular to the 25-percent chord line were 12 percent thick. Measurements were made of the normal force and pitching moment through an angle-of-attack range from about -3 deg to 14 deg for several ailavator deflections at Mach numbers from 0.65 to about 1.08. The results of the tests indicated no adverse effects of compressibility up to a Mach number of at least 0.85 at low normal-force coefficients and small ailavator deflections. Up to a Mach number of 0.85, the neutral point at low normal-force coefficients was at about 25 percent of the mean aerodynamic chord and moved rearward irregularly to 41 or 42 percent with a further increase in Mach number to about 1.05. For deflections up to -8.0 percent, the ailavator was effective in changing the pitching moment except at Mach numbers from 0.93 to about 1.0 where ineffectiveness or reversal was indicated for deflections and normal-force coefficients. With -13.2 deg deflection at normal-force coefficients above about 0.3, reversal of ailavator effectiveness occurred at Mach numbers as low as 0.81. A nose-down trim change, which began at a Mach number of about 0.85, together with the loss in effectiveness of the ailavator, indicated that with increase in the Mach number from about 0.95 to 1.05 an abrupt ailavator movement of 5 deg or 6 deg first up and then down would be required to maintain level flight.

Sawyer, Richard H.↗