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At least 253 records · Page 14

Clinical applications of angiocardiography

Several tables are presented giving left ventricular (LV) data for normal patients and patients with heart disease of varied etiologies, pointing out the salient features. Graphs showing LV pressure-volume relationships (compliance) are presented and discussed. The method developed by Rackley et al. (1964) for determining left ventricular mass in man is described, and limitations to the method are discussed. Some clinical methods for determining LV oxygen consumption are briefly described, and the relation of various abnormalities of ventricular performance to coronary artery disease and ischemic heart disease is characterized.

Dodge, H. T.↗

Biochemical responses of the Skylab crewman

The biochemical investigations of the Skylab crewmen were designed to study the physiological changes that were observed on flight crews returning from previous space flight missions as well as to study those changes expected to result from prolonged weightless exposure. These studies can be divided into two broad categories. One category included routine blood studies similar to those used in clinical medical practice. The second included research-type endocrine analyses used to investigate more thoroughly the metabolic/endocrine responses to the space flight environment. The premission control values indicated that all Skylab crewmen were healthy and were free from biochemical abnormalities. The routine results during and after flight showed slight but significant changes in electrolytes, glucose, total protein, osmolality, uric acid, cholesterol, and creatinine. Plasma hormal changes included adrenocorticotrophic hormone, cortisol, angiotensin I, aldosterone, insulin, and thyroxine. The 24-hour urine analyses results revealed increased excretion of cortisol, catecholamines, antidiuretic hormone, and aldosterone as well as excretion of significant electrolyte and uric acid during the Skylab flights.

Leach, C. S.↗

Experiment M115: Special hematologic effects: Dynamic changes in red cell shape in response to the space-flight environment

The significance of the transformations in red cell shape observed during the Skylab study must be considered relative to the limitation of man's participation in extended space flight missions. The results of this one study are not conclusive with respect to this question. Based on these examinations of red cells in normal, healthy men and based on other Skylab experiment data relative to the functional capacity of the red cells in vitro and the performance capacity of man as an integrated system, the changes observed would not appear to be the limiting factor in determining man's stay in space. However, the results of this experiment and the documented red cell mass loss during space flight raise serious questions at this time relative to the selection criteria utilized for passengers and crews of future space flights. Until the specific cause and impact of the red cell shape change on cell survival in vivo can be resolved, individuals with diagnosed hematologic abnormalities should not be considered as prime candidates for missions, especially those of longer duration.

Kimzey, S. L.↗

Vectorcardiographic results from Skylab medical experiment M092: Lower body negative pressure

Vectorcardiograms were recorded via a modified Frank lead system from all crewmen of the three Skylab missions in conjuction with the Lower Body Negative Pressure - M092 Experiment. Data were analyzed by a specially developed computer program (VECTAN). Design of the test sequences allowed direct comparisons of supine resting, Earth based (reference) vectorcardiograms with those taken during lower body negative pressure stress and those obtained at rest in orbit, as well as combinations of these conditions. Results revealed several statistically significant space flight related changes; namely, increased testing and lower body negative pressure stressed heart rates, modestly increased PR interval and corrected QTC interval, and greatly increased P and QPS loop maximal amplitudes. In addition, orientation changes in the QRS maximum vector and the J-vector at rest in space seem quite consistent among crewmen and different from those caused by the application of lower body negative pressure. No clinical abnormalities were observed. Etiology of these findings is conjectured to be, at least in part, related to fluid mass shifts occurring in weightlessness and attendant alterations in cardiovascular dynamics and myocardial autonomic control mechanisms.

Hoffler, G. W.↗

A multisensor analysis of Nimbus-5 data recorded on 22 January 1973

The Nimbus 5 meteorological satellite has a full complement of radiation sensors. Data from these sensors were analyzed and intercompared for orbits 569 and 570. The electrically-scanning microwave radiometer (19.35-GHz region) delineated rain areas over the ocean off the U.S. east coast, in good agreement with radar imagery, and permitted the estimation of rainfall rates in this region. Residual ground water, from abnormal rainfall in the lower Mississippi Valley, was indicated under clear sky conditions by soil brightness temperature values in the Nimbus 5 electrically scanning microwave radiometer and U.S. Air Force Data Acquisition and Processing Program infrared data. The temperature-humidity infrared radiometer (6.7 micron and 11 micron) showed the height and spatial configuration of frontal clouds along the east coast and outlined the confluence of a polar jet stream with a broad subtropical jet stream along the U.S. Gulf Coast. Temperature profiles from three vertical temperature sounders are found to be in good agreement with related radiosonde ascents along orbit 569 from the subtropics to the Arctic Circle.

Allison, L. J.↗

Velocity variations of an Equatorial plume throughout a Jovian year

Features in the equatorial zone of Jupiter show that the equatorial plume reported by Pioneer 10 has existed for an 11-year interval. During this interval the plume has shown an acceleration which can be interpreted as a constant component of 3 x 10 to minus 8th power m/sq cm and a sinusoidal component which anticorrelates with the planetocentric declination of the sun, D sub s, and has an amplitude of -0.96 meters per second per degree change of D sub s. The sinusoidal component has been interpreted in terms of solar heating. Throughout this interval of time the equatorial zone has appeared abnormally dark and has contained many dark projections along the northern edge. When the plume approaches to within 25 to 30 deg of these features they are deflected in the direction of motion of the plume and then dissipate or become obscured as the plume passes. After passage of the plume normal features are again observed.

Reese, E.↗

Acute pulmonary pathology and sudden death in rats following the intravenous administration of the plasticizer, DI (2-ethylhexyl) phthalate, solubilized with Tween surfactants

Intravenous administration of 200-300 mg/kg of di(2-ethylhexyl)phthalate (DEHP) solubilized in aqueous solutions of several Tween surfactants caused respiratory distress in rats. There was a dose-dependent lethality with death generally occurring within 90 minutes after injection. The lungs from DEHP:Tween treated animals were enlarged, generally darkened, and in some cases showed hemorrhagic congestion. Neither the overt symptoms nor the morphologic alterations resulting from DEHP:Tween administration could be reproduced by intravenous administration of aqueous Tween solutions alone. The absence of pulmonary abnormalities following the intravenous administration of DEHP as an aqueous emulsion given either alone or even as soon as 2 minutes after pretreatment with Tween 80, suggests that the specific in vivo interaction between DEHP and Tween surfactants depends on the prior formation of water-soluble micelles of DEHP.

Schulz, C. O.↗

A study of the oxide dispersion and recrystallization in NiCrAl prepared from preoxidized powder

The sintered aluminum powder (SAP) technique of dispersion strengthening (formation of an oxide dispersion by preoxidation of metal powders) was applied to atomized powder of a nickel alloy containing, by weight, 17% Cr, 5% Al, and 0.2% Y. The SAP-NiCrAl alloy (without the ytterbium removed by oxdation) was worked by extrusion and rod rolling at 1205 C and by swaging at 760 C. Annealing treatments were applied after working to determine the recrystallization response. The NiCrAlY alloy, similarly prepared from atomized powder, but without a preoxidation treatment, was examined for comparison. The SAP-NiCrAl alloy exhibited oxide particle size and spacing much larger than that usually observed in oxide dispersion strengthened alloys; nonetheless, it was possible to achieve abnormal (secondary) recrystallization in the SAP-NiCrAl alloy as has been reported for other oxide dispersion strengthened alloys. In contrast, the unoxidized NiCrAlY alloy exhibited only primary recrystallization.

Glasgow, T. K.↗

Engineering flight evaluation report

The primary objective was to determine if the two-segment profile equipment, and operational procedures as defined by the B-727 Simulation Evaluation are operationally sound under all flight conditions expected to be encountered in line service. The evaluation was divided into the following areas: (1) to verify that the two-segment system operates as it was designed; (2) to conduct sufficient tests to secure a supplemental type certificate for line operation of the system; (3) to evaluate the normal operation of the equipment and procedures; (4) to evaluate the need for an autothrottle system for two-segment approaches; (5) to investigate abnormal operation of the equipment and procedures, including abused approaches and malfunctions of airborne and ground components; (6) to determine the accuracy and ease of flying the two-segment approach; (7) to determine the improvement in ground noise levels; and (8) to develop a guest pilot flight test syllabus.

Morrison, J. A.↗

Lidar measurements of two intense stratospheric dust layers

Lidar measurements were made of two stratospheric dust layers on November 26, 1974, using the NASA 48-inch laser radar system. The dust was probably of volcanic origin. The measurements, made at a wavelength of 0.6943 micron, indicated a 6-km thick layer centered at an altitude of 16 km, and a 1.5-km thick layer centered at 20.25 km. The abnormal scattering ratios, scattering functions, and particle concentrations were evaluated. Measurements made on November 28 showed that both layers had considerably diminished.

Mccormick, M. P.↗

Effect of potassium depletion in normal males - An Apollo 15 simulation

In the course of Apollo 15, physiologic abnormalities, manifested by ectopic activity on the ECG and unusual alterations in exercise tolerance, occurred in the crew of the Lunar Excursion Module. These were associated with decreases in total body potassium, measured by K-42, of 10% and 15%. The possibility of inadequate potassium (K+) intake existed. A simulation study was performed prior to Apollo 16, corresponding in duration to Apollo 15. Subjects endured the same sleep aberrations and caloric expenditure as the Apollo 15 astronauts. Subjects consumed a diet containing only 15 mEq/d of K+ during the entire 12 days of absolute bedrest. Study implications and reasons for discrepancies between K+ loss measured by balance techniques and K-42 are reviewed.

Hyatt, K. H.↗

Evaluation of viscera and other tissues

Histopathological findings in the lungs, livers, bone marrows, small intestines, gonads, kidneys, and other tissues of the four pocket mice (Perognathus longimembris) that survived the Apollo XVII flight were evaluated in the light of their immediate environment and as targets of HZE cosmic ray particles. Results of this study failed to disclose changes that could be ascribed to the HZE particle radiation. Decreased numbers of erythropoietic cells in the bone marrow of the flight mice were probably related to the increased oxygen pressure. The small intestine showed no changes. Ovaries and testes appeared normal. Two of the three surviving male flight mice displayed early stages of spermatogenesis, just as ground-based controls did at the same season. Abnormalities were also not found in the thyroid, parathyroids, adrenals, or kidneys. The status of the juxtaglomerular apparatus could not be evaluated. The lungs exhibited nonspecific slight reactions. A variety of incidental lesions were noted in the livers of both the flight mice and their controls. The heart muscle showed nothing that could be regarded as pathological. Sections of skeletal muscle examined were free from significant change.

Ellis, J. T.↗

Emission-line strengths and the chemical compositions of quasi-stellar objects

Estimates of emission-line strengths in 160 QSOs are listed. They are used, together with those for 60 objects published earlier, to compile a table of rest-frame equivalent widths for a composite QSO containing 28 lines seen in objects with z from 0.06 to 3.53. Models are computed for matter partially filling a spherical volume, ionized by ultraviolet flux from a central object and optically thick with absorption from heavy elements taken into account. Constant temperature and density are taken for the He II region, where most of the important lines are emitted. Allowance is made for lower and higher temperatures in the H I and He III regions. Emergent emission-line equivalent widths are computed and compared with the observations. An abnormally low helium abundance is not needed to achieve a fit, since the only anomalously weak line is He II 4686 A whose upper level may be depopulated by stimulated emission of He II 1215 A caused by very strong L-alpha 1216 A flux.

Chan, Y.-W. T.↗

Optical and X-ray observations of the PSR 1913 + 16 field

We have obtained medium-resolution spectra in the yellow of seven stars in the error box of the binary radio pulsar PSR 1913 + 16, using the image-tube scanner at the Lick 3-m telescope. None of the objects is spectroscopically abnormal and thus a strong candidate for membership in the system. The data are used to establish the extinction in the field, which is modest for this low galactic latitude. For three of the stars, limits of the order V exceeding 23 mag on optical pulsations with the frequency of the radio pulsar are derived. X-ray observations of the field have been obtained in the 2.5-7.5 keV band, using the UCL experiment aboard OAO Copernicus. No source is detected, with a 2 sigma upper limit on the time-averaged flux of 1.0 times 10 to the -10th power ergs per sq cm per sec.

Davidsen, A.↗

Clinical biochemistry

The objectives of the biochemical studies conducted for the Apollo program were (1) to provide routine laboratory data for assessment of preflight crew physical status and for postflight comparisons; (2) to detect clinical or pathological abnormalities which might have required remedial action preflight; (3) to discover as early as possible any infectious disease process during the postflight quarantine periods following certain missions; and (4) to obtain fundamental medical knowledge relative to man's adjustment to and return from the space flight environment. The accumulated data presented suggest that these requirements were met by the program described. All changes ascribed to the space flight environment were subtle, whereas clinically significant changes were consistent with infrequent illnesses unrelated to the space flight exposure.

W.C. Alexander↗

Mineral target areas in Nevada from geological analysis of LANDSAT-1 imagery

Geological analysis of LANDSAT-1 Scene MSS 1053-17540 suggests that certain known mineral districts in east-central Nevada frequently occur near faults or at faults or lineament intersections and areas of complex deformation and flexures. Seventeen (17) areas of analogous characteristics were identified as favorable targets for mineral exploration. During reconnaissance field trips eleven areas were visited. In three areas evidence was found of mining and/or prospecting not known before the field trips. In four areas favorable structural and alteration features were observed which call for more detailed field studies. In one of the four areas limonitic iron oxide samples were found in the regolith of a brecciated dolomite ridge. This area contains quartz veins, granitic and volcanic rocks and lies near the intersection of two linear fault structures identified in the LANDSAT-1 imagery. Semiquantitative spectroscopic analysis of selected portions of the samples showed abnormal contents of arsenic, molybdenum, copper, lead, zinc, and silver. These limonitic samples found were not in situ and further field studies are required to assess their source and significance.

Abdel-Gawad, M.↗

NASA/MSFC multilayer diffusion models and computer programs, version 5

The transport and diffusion models and algorithms developed for use by NASA in predicting concentrations and dosages downwind from normal and abnormal launches of rocket vehicles are described along with the associated computer programs for use in performing the calculations. Topics discussed include: the mathematical specifications and procedures used in the Preprocessor Program to calculate rocket exhaust cloud rise, cloud dimensions, and other input parameters to the transport and diffusion models; the revised mathematical specifications for the Multilayer Diffusion Models; users' instructions for implementing the Preprocessor and Multilayer Diffusion Models Programs; and worked example problems illustrating the use of the models and computer programs.

Dumbauld, R. K.↗

Loadcell supports for a dynamic force plate

An apparatus was developed to accurately measure components of force along three mutually perpendicular axes, torque, and the center of pressure imposed by the foot of a subject walking over its surface. The data obtained were used to supplement high-speed motion picture and electromyographic (EMG) data for in-depth studies of normal or abnormal human gait. Significant features of the design (in particular, the mechanisms used to support the loadcell transducers) are described. Results of the development program and typical data obtained with the device are presented and discussed.

Keller, C. W.↗