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At least 253 records · Page 14

Clinical Outcome Metrics for Optimization of Robust Training

Introduction: The emphasis of this research is on the Human Research Program (HRP) Exploration Medical Capability's (ExMC) "Risk of Unacceptable Health and Mission Outcomes Due to Limitations of In-Flight Medical Capabilities." Specifically, this project aims to contribute to the closure of gap ExMC 2.02: We do not know how the inclusion of a physician crew medical officer quantitatively impacts clinical outcomes during exploration missions. The experiments are specifically designed to address clinical outcome differences between physician and non-physician cohorts in both near-term and longer-term (mission impacting) outcomes. Methods: Medical simulations will systematically compare success of individual diagnostic and therapeutic procedure simulations performed by physician and non-physician crew medical officer (CMO) analogs using clearly defined short-term (individual procedure) outcome metrics. In the subsequent step of the project, the procedure simulation outcomes will be used as input to a modified version of the NASA Integrated Medical Model (IMM) to analyze the effect of the outcome (degree of success) of individual procedures (including successful, imperfectly performed, and failed procedures) on overall long-term clinical outcomes and the consequent mission impacts. The procedures to be simulated are endotracheal intubation, fundoscopic examination, kidney/urinary ultrasound, ultrasound-guided intravenous catheter insertion, and a differential diagnosis exercise. Multiple assessment techniques will be used, centered on medical procedure simulation studies occurring at 3, 6, and 12 months after initial training (as depicted in the following flow diagram of the experiment design). Discussion: Analysis of procedure outcomes in the physician and non-physician groups and their subsets (tested at different elapsed times post training) will allow the team to 1) define differences between physician and non-physician CMOs in terms of both procedure performance (pre-IMM analysis) and overall mitigation of the mission medical impact (IMM analysis); 2) refine the procedure outcome and clinical outcome metrics themselves; 3) refine or develop innovative medical training products and solutions to maximize CMO performance; and 4) validate the methods and products of this experiment for operational use in the planning, execution, and quality assurance of the CMO training process The team has finalized training protocols and developed a software training/testing tool in collaboration with Butler Graphics (Detroit, MI). In addition to the "hands on" medical procedure modules, the software includes a differential diagnosis exercise (limited clinical decision support tool) to evaluate the diagnostic skills of participants. Human subject testing will occur over the next year.

Ebert, D.↗

A Martian Quarantine Risk Model

Structured model using loss functions to assess risk of using given decontamination procedure on all Martian unmanned landing craft

Cornell, R. G.↗

An experimental study of the temporal statistics of radio signals scattered by rain

A fixed-beam bistatic CW experiment designed to measure the temporal statistics of the volume reflectivity produced by hydrometeors at several selected altitudes, scattering angles, and at two frequencies (3.6 and 7.8 GHz) is described. Surface rain gauge data, local meteorological data, surveillance S-band radar, and great-circle path propagation measurements were also made to describe the general weather and propagation conditions and to distinguish precipitation scatter signals from those caused by ducting and other nonhydrometeor scatter mechanisms. The data analysis procedures were designed to provide an assessment of a one-year sample of data with a time resolution of one minute. The cumulative distributions of the bistatic signals for all of the rainy minutes during this period are presented for the several path geometries.

Hubbard, R. W.↗

Investigation of resonance integrals occurring in cosmic ray diffusion theory

Critical assessment of two versions of a procedure for calculating the pitch angle diffusion coefficient for cosmic rays in a static random magnetic field using the 'resonance integral' method of Hasselmann and Wiberenz (1968) and Jokipii (1972). One of these versions is shown to represent the physics of the situation more accurately than the other.

Jones, F. C.↗

Full-scale crash test of a CH-47C helicopter

A full-scale crash test of a large troop/cargo carrying CH-47C helicopter was conducted at the Langley impact dynamics research facility. The crash test of this large helicopter was performed as part of a joint U.S. Army-NASA helicopter test program to provide dynamic structural and seat response data. The test, the procedures employed, the instrumentation, a general assessment of the resulting damage, and typical levels of accelerations experienced during the crash are reported. Various energy-absorbing seating systems for crew and troops were installed and instrumented to provide data for use in the development of design criteria for future aircraft. The crash conditions were selected to simulate known crash conditions and are representative of the 95th percentile accident environment for an autorotating helicopter. Visual examination of the crashed test specimen indicated irreparable damage to many of the structural components. The highest accelerations were recorded by the accelerometers located on the cabin floor in the aft section of the helicopter, directly above the primary impact location and on the floor of the cockpit above the secondary impact location(s).

Castle, C. B.↗

Shuttle Ku-band and S-band communications implementations study

The interfaces between the Ku-band system and the TDRSS, between the S-band system and the TDRSS, GSTDN and SGLS networks, and between the S-band payload communication equipment and the other Orbiter avionic equipment were investigated. The principal activities reported are: (1) performance analysis of the payload narrowband bent-pipe through the Ku-band communication system; (2) performance evaluation of the TDRSS user constraints placed on the S-band and Ku-band communication systems; (3) assessment of the shuttle-unique S-band TDRSS ground station false lock susceptibility; (4) development of procedure to make S-band antenna measurements during orbital flight; (5) development of procedure to make RFI measurements during orbital flight to assess the performance degradation to the TDRSS S-band communication link; and (6) analysis of the payload interface integration problem areas.

Huth, G. K.↗

Area estimation using multiyear designs and partial crop identification

Statistical procedures were developed for large area assessments using both satellite and conventional data. Crop acreages, other ground cover indices, and measures of change were the principal characteristics of interest. These characteristics are capable of being estimated from samples collected possibly from several sources at varying times, with different levels of identification. Multiyear analysis techniques were extended to include partially identified samples; the best current year sampling design corresponding to a given sampling history was determined; weights reflecting the precision or confidence in each observation were identified and utilized, and the variation in estimates incorporating partially identified samples were quantified.

Sielken, R. L., Jr.↗

Delineating mid- and low-level water vapor patterns in pre-convective environments using VAS moisture channels

Infrared and visible imagery from VAS are used to delineate mid- and lower-tropospheric moisture fields for a variety of severe storm cases in the southern and central United States. The ability of sequences of images to isolate areas of large negative vertical moisture gradients and apparent convective instability prior to the onset of convective storms is assessed. A variety of image combination procedures are used to deduce the stability fields which are then compared with the available radiosonde data. The results for several severe storm cases indicate that VAS can detect mid- and low-level mesoscale water vapor fields as distinct radiometric signals. The VAS imagery shows a strong tendency for thunderstorms to develop along the edges of bands of midlevel dryness as they overtake either preexisting or developing low-level moisture maxima. Image sequences depict the speed with which deep moist and dry layers can develop and move.

Petersen, R. A.↗

Dendritic web-type solar cell mini-modules

Twenty-five minimodules composed of dendritic web solar cells with nominal glass size of 12 by 40 cm were provided for study. The modules were identical with respect to design, materials, and manufacturing and assembly processes to full scale modules. The modules were also electrically functional. These minimodules were fabricated to provide test vehicle for environmental testing and to assess reliability of process and design procedures. The module design and performance are outlined.

Campbell, R. B.↗

Global tropospheric chemistry: Chemical fluexes in the global atmosphere

In October 1987, NSF, NASA, and NOAA jointly sponsored a workshop at Columbia University to assess the experimental tools and analysis procedures in use and under development to measure and understand gas and particle fluxes across this critical air-surface boundary. Results are presented for that workshop. It is published to summarize the present understanding of the various measurement techniques that are available, identify promising new technological developments for improved measurements, and stimulate thinking about this important measurement challenge.

Lenschow, Donald H.↗

Operation and performance of the Ciba-Corning 512 coagulation monitor during parabolic flight

The goal was to assess the functionality and evaluate the procedures and operations required to operate the Ciba-Corning 512 Coagulation Monitor during parabolic flight. This monitor determines the clotting characteristics of blood. The analyzer operates by laser detection of the cessation of blood flow in a capillary channel within a test cartridge. Test simulator results were excellent for both pre-and post-flight. In-flight results were not obtained due to the warm-up time required for the simulator. Since this is an electronic function only, the expected results on the simulator would be the same in zero-g.

Gocke, Robyn↗

[EUV Spectroscopy of MrK 421]

In accordance with our proposal, we carried out and analyzed a successful Extreme Ultraviolet Explorer spectroscopic observation of the BL Lacertae object Mrk 421 in April/May 1995 (approx. 242 ksec useful time). During this period, the source underwent a flare that was detected also in simultaneous observations in the X-ray and TeV (gamma)ray energy bands. Our EUVE data, however, provided the best continuous coverage of the flare and therefore played a key role in the analysis of the multiwavelength observation campaign (Buckley et al. 1996). Our spectral analysis benefited from an efficient procedure that we employed for properly assessing the background contamination at the shortest wavelengths. As a result, we were able to identify strong absorption features at the shortest observed EUV wavelengths (approx. 65-75 A), which were missed in earlier, on axis EUVE observations that extended only down to approx. 75 A (Fruscione et al. 1996). Our observations and interpretation of Mrk 421 were described in Kartje et al. 1997 (see attached reprint). The results were also presented in a poster at the AGN session in the 18th Texas Symposium on Relativistic Astrophysicsheld (Chicago, December 1996). Our interpretation of the observations has formed the basis for a unified model of outflows in BL Lac objects and Broad Absorption Line QSOs (Kartje & Konigl 1997). Preliminary accounts of this work, which have included a description of the EUVE observations of BL Lac objects, were presented in posters in IAU Colloquium No. 163 on Accretion Phenomena and Associated Outflows (Port Douglas, July 1996) and in the Carnegie Observatories Workshop on Ejection of Matter from AGNs (Pasadena, February 1997).

Koenigl, Arieh↗

Studies Relating to EVA

In this session, Session JA1, the discussion focuses on the following topics: The Staged Decompression to the Hypobaric Atmosphere as a Prophylactic Measure Against Decompression Sickness During Repetitive EVA; A New Preoxygenation Procedure for Extravehicular Activity (EVA); Metabolic Assessments During Extra-Vehicular Activity; Evaluation of Safety of Hypobaric Decompressions and EVA From Positions of Probabilistic Theory; Fatty Acid Composition of Plasma Lipids and Erythrocyte Membranes During Simulation of Extravehicular Activity; Biomedical Studies Relating to Decompression Stress with Simulated EVA, Overview; The Joint Angle and Muscle Signature (JAMS) System - Current Uses and Future Applications; and Experimental Investigation of Cooperative Human-Robotic Roles in an EVA Work Site.

Source record↗

Sounding-Diagnosed Convective Environments and Preliminary Energy Budgets Diagnosed during the TRMM Field Campaigns

An overview of mean convective thermodynamic and wind profiles for the Tropical Rainfall Measuring Mission (TRMM) Large Scale Biosphere-Atmosphere Experiment (LBA) and Kwajalein Experiment (KWAJEX) field campaigns will be presented, highlighting the diverse continental and marine tropical environments in which rain clouds and mesoscale convective systems evolved. An assessment of ongoing sounding quality control procedures will be shown. Additionally, we will present preliminary budgets of sensible heat source (Q1) and apparent moisture sink (Q2), which have been diagnosed from the various sounding networks.

Halverson, Jeffrey B.↗

HPLC/ESI-quadrupole ion trap mass spectrometry for characterization and direct quantification of amphoteric and nonionic surfactants in aqueous samples

An amphoteric (cocamidopropylbetaine, CAPB) and a nonionic (alcohol polyethoxylate, AE) surfactant were characterized by electrospray ionization quadrupole ion trap mass spectrometry (ESI-MS) as to their homologue distribution and ionization/fragmentation chemistry. Quantitative methods involving reversed-phase gradient HPLC and (+)ESI-MSn were developed to directly determine these surfactants in hydroponic plant growth medium that received simulated graywater. The predominant homologues, 12 C alkyl CAPB and 9 EO AE, were monitored to represent the total amount of the respective surfactants. The methods demonstrated dynamic linear ranges of 0.5-250 ng (r2 > 0.996) for CAPB and 8-560 ng (r2 > 0.998) for AE homologue mixture, corresponding to minimum quantification limits of 25 ppb CAPB and 0.4 ppm AE with 20-microL injections. This translated into an even lower limit for individual components due to the polydispersive nature of the surfactants. The procedure was successfully employed for the assessment of CAPB and AE biodegradation in a hydroponic plant growth system used as a graywater bioreactor.

NASA Discipline Life Support Systems↗

Experimental Methodology for Measuring Combustion and Injection-Coupled Responses

A Russian scaling methodology for liquid rocket engines utilizing a single, full scale element is reviewed. The scaling methodology exploits the supercritical phase of the full scale propellants to simplify scaling requirements. Many assumptions are utilized in the derivation of the scaling criteria. A test apparatus design is presented to implement the Russian methodology and consequently verify the assumptions. This test apparatus will allow researchers to assess the usefulness of the scaling procedures and possibly enhance the methodology. A matrix of the apparatus capabilities for a RD-170 injector is also presented. Several methods to enhance the methodology have been generated through the design process.

Cavitt, Ryan C.↗

The Integrated Medical Model: Statistical Forecasting of Risks to Crew Health and Mission Success

The Integrated Medical Model (IMM) helps capture and use organizational knowledge across the space medicine, training, operations, engineering, and research domains. The IMM uses this domain knowledge in the context of a mission and crew profile to forecast crew health and mission success risks. The IMM is most helpful in comparing the risk of two or more mission profiles, not as a tool for predicting absolute risk. The process of building the IMM adheres to Probability Risk Assessment (PRA) techniques described in NASA Procedural Requirement (NPR) 8705.5, and uses current evidence-based information to establish a defensible position for making decisions that help ensure crew health and mission success. The IMM quantitatively describes the following input parameters: 1) medical conditions and likelihood, 2) mission duration, 3) vehicle environment, 4) crew attributes (e.g. age, sex), 5) crew activities (e.g. EVA's, Lunar excursions), 6) diagnosis and treatment protocols (e.g. medical equipment, consumables pharmaceuticals), and 7) Crew Medical Officer (CMO) training effectiveness. It is worth reiterating that the IMM uses the data sets above as inputs. Many other risk management efforts stop at determining only likelihood. The IMM is unique in that it models not only likelihood, but risk mitigations, as well as subsequent clinical outcomes based on those mitigations. Once the mathematical relationships among the above parameters are established, the IMM uses a Monte Carlo simulation technique (a random sampling of the inputs as described by their statistical distribution) to determine the probable outcomes. Because the IMM is a stochastic model (i.e. the input parameters are represented by various statistical distributions depending on the data type), when the mission is simulated 10-50,000 times with a given set of medical capabilities (risk mitigations), a prediction of the most probable outcomes can be generated. For each mission, the IMM tracks which conditions occurred and decrements the pharmaceuticals and supplies required to diagnose and treat these medical conditions. If supplies are depleted, then the medical condition goes untreated, and crew and mission risk increase. The IMM currently models approximately 30 medical conditions. By the end of FY2008, the IMM will be modeling over 100 medical conditions, approximately 60 of which have been recorded to have occurred during short and long space missions.

Fitts, M. A.↗

Legacy of Biomedical Research During the Space Shuttle Program

The Space Shuttle Program provided many opportunities to study the role of spaceflight on human life for over 30 years and represented the longest and largest US human spaceflight program. Outcomes of the research were understanding the effect of spaceflight on human physiology and performance, countermeasures, operational protocols, and hardware. The Shuttle flights were relatively short, < 16 days and routinely had 4 to 6 crewmembers for a total of 135 flights. Biomedical research was conducted on the Space Shuttle using various vehicle resources. Specially constructed pressurized laboratories called Spacelab and SPACEHAB housed many laboratory instruments to accomplish experiments in the Shuttle s large payload bay. In addition to these laboratory flights, nearly every mission had dedicated human life science research experiments conducted in the Shuttle middeck. Most Shuttle astronauts participated in some life sciences research experiments either as test subjects or test operators. While middeck experiments resulted in a low sample per mission compared to many Earth-based studies, this participation allowed investigators to have repetition of tests over the years on successive Shuttle flights. In addition, as a prelude to the International Space Station (ISS), NASA used the Space Shuttle as a platform for assessing future ISS hardware systems and procedures. The purpose of this panel is to provide an understanding of science integration activities required to implement Shuttle research, review biomedical research, characterize countermeasures developed for Shuttle and ISS as well as discuss lessons learned that may support commercial crew endeavors. Panel topics include research integration, cardiovascular physiology, neurosciences, skeletal muscle, and exercise physiology. Learning Objective: The panel provides an overview from the Space Shuttle Program regarding research integration, scientific results, lessons learned from biomedical research and countermeasure development.

Hayes, Judith C.↗