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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 253 records · Page 14
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Correlating transcription and protein expression profiles of immune biomarkers following lipopolysaccharide exposure in lung epithelial cells

Universal and early recognition of pathogens occurs through recognition of evolutionarily conserved pathogen associated molecular patterns (PAMPs) by innate immune receptors and the consequent secretion of cytokines and chemokines. The intrinsic complexity of innate immune signaling and associated signal transduction challenges our ability to obtain physiologically relevant, reproducible and accurate data from experimental systems. One of the reasons for the discrepancy in observed data is the choice of measurement strategy. Immune signaling is regulated by the interplay between pathogen-derived molecules with host cells resulting in cellular expression changes. However, these cellular processes are often studied by the independent assessment of either the transcriptome or the proteome. Correlation between transcription and protein analysis is lacking in a variety of studies. In order to methodically evaluate the correlation between transcription and protein expression profiles associated with innate immune signaling, we measured cytokine and chemokine levels following exposure of human cells to the PAMP lipopolysaccharide (LPS) from the Gram-negative pathogen Pseudomonas aeruginosa . Expression of 84 messenger RNA (mRNA) transcripts and 69 proteins, including 35 overlapping targets, were measured in human lung epithelial cells. We evaluated 50 biological replicates to determine reproducibility of outcomes. Following pairwise normalization, 16 mRNA transcripts and 6 proteins were significantly upregulated following LPS exposure, while only five (CCL2, CSF3, CXCL5, CXCL8/IL8, and IL6) were upregulated in both transcriptomic and proteomic analysis. This lack of correlation between transcription and protein expression data may contribute to the discrepancy in the immune profiles reported in various studies. The use of multiomic assessments to achieve a systems-level understanding of immune signaling processes can result in the identification of host biomarker profiles for a variety of infectious diseases and facilitate countermeasure design and development.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

Utah FORGE 1-2409: PetroQuip Energy Services Zonal Isolation Solution for Geothermal Wells - 2024 Annual Workshop Presentation

This is a presentation on the Zonal Isolation Solution for Geothermal Wells by PetroQuip Energy Services, presented by Robert Coon. This video slide presentation discusses the proposed design and development of a multi-stage system consisting of an Open-Hole Packer (OHP), a Locking Bridge Plug (LBP), and a corresponding Locating Profile (LP). This presentation was featured in the Utah FORGE R&D Annual Workshop on August 14, 2024.

15 GEOTHERMAL ENERGY↗
DOE OSTI2024

TEAMER: Triton Systems Oscillating Water Column Modeling Data and Report

This dataset provides the output of six Wave Energy Converter Simulator (WEC-Sim) simulations and accompanying documentation for the modeling of Triton Systems' oscillating water column (OWC) system at tank scale (validated using available data for tuning the model, Tests 1-2) and deployment scale (for which no validation data is available, Tests 4-6). Included are the output data in a MATLAB file structure, a comprehensive report on the modeling and design of the Triton OWC system, and a link to the WEC-Sim GitHub page. This work was supported by funding from TEAMER RFTS 5 (Request for Technical Support).

16 TIDAL AND WAVE POWER↗
DOE OSTI2024

Electrolyzer Integrated Modular Nano-Array Monolithic Catalytic Reactors

The project objective is to design and develop a new class of electrolyzer-integrated, modular, nanostructure array (nano-array) monolithic catalytic reactors for high-flux, robust and selective methanol synthesis. The modular reactor features metal oxide nano-array grown on an additively-manufactured channeled honeycomb monolith made of ceramic or metals; this low-pressure carbon dioxide hydrogenation reactor is fueled with hydrogen from a low-temperature water electrolyzer having reduced platinum group metal (PGM) content. Through these nanostructured monolithic reactors, methanol synthesis is enabled with cost-effective hydrogenation reactions under low-temperature (<200°C) and low-pressure (<10 atm) conditions, thus significantly reducing the energy demand of the entire process.

08 HYDROGEN↗
DOE OSTI2024

Williston Basin Carbon Ore, Rare Earths, and Critical Minerals (CORE-CM) Program

The U.S. Department of Energy’s Office of Fossil Energy awarded 13 CORE-CM programs as part of the CORE-CM Initiative, designed to develop the technology and upstream and midstream supply chains to extract rare-earth elements (REEs) and critical minerals (CMs) from the nation’s coal supplies. The intent is to catalyze regional economic growth and job creation while strengthening the use of domestic resources. The Williston Basin CORE-CM Program aims to drive the expansion and transformation of coal and coal-based resource usage within the Williston Basin to produce REEs, CMs, and nonfuel carbon-based products (CBPs). A coalition team of nearly 30 private industry, university, and state, local, and federal government partners was formed for this task. Partners include the University of North Dakota’s Energy & Environmental Research Center, College of Engineering and Mines Research Institute, and Nistler College; North Dakota State University; Montana Tech University; Pacific Northwest National Laboratory; Critical Materials Institute; North Dakota Geological Survey; South Dakota Geological Survey; U.S. Geological Survey; North American Coal Corporation; BNI Energy; Basin Electric Power Cooperative; Minnkota Power Cooperative; and many more. This presentation will focus on the current status and results to date of the Williston Basin CORE-CM Program, with a focus on core sample characterization for REE and CM content.

Folkedahl, Bruce C.↗
DOE OSTI2024

Disruptive Technology for Carbon Negative Commodity Chemicals

This project was designed to develop an economically attractive process for the carbon negative production of the commodity biochemical succinic acid. To compete against petroleum derived biochemicals, the process must deliver high raw material conversion efficiency and high volumetric productivity to reduce both recurring and capital-related costs, respectively. The proposed process introduces additional electrons sourced from hydrogen into the biosynthetic pathway so that the carbon from two CO2 molecules can be combined with each glucose to significantly increase succinic acid yields. The process also uses ultrafiltration to continuously remove the product from the bioreactor to avoid product inhibition and extend the productive life of the cell extract. Genetic deletions and specific enzyme removal during extract preparation more efficiently direct both atomic and electronic resources toward product formation. A preliminary technoeconomic analysis indicates that these process innovations made possible by cell-free production will enable large scale production with attractive ROI and profitability. This two-year project provided some 29 distinct insights, analytical advances, and process improvements that resulted in a demonstration of process feasibility. However, an estimated two to three years of additional development will be required to achieve convincing pilot scale demonstrations that will motivate large scale investments.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

Status memorandum on ORNL support of vendor irradiation capsule design and ASME irradiation code development and new ASTM test standard development activities

This report is in submission of completion of the Level 4 milestone number M4TG-24OR0501111 within the larger Advanced Reactor Technologies Gas Cooled Reactor program at Oak Ridge National Laboratory (ORNL). The focus of this year’s efforts is to continue support of industry needs related to the development of future industry-funded irradiation programs. At ORNL these efforts included the development of a generalized three-dimensional CAD model of an irradiation creep capsules for graphite, cost estimates of the expansion of the Materials Irradiation Facility (MIF), involvement with ASTM D02.F0 “Manufactured Carbon and Graphite Products” and the ASME Boiler and Pressure Vessel Code, and publication of papers supporting these efforts. This report will document the status of these activities.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2024

Nanomanufacturing of Nanophononic Devices: Ultra-high ZT Thermoelectrics for Efficient Conversion of Waste Heat

Fabrication and Characterization Summary: For this program, the team fabricated and tested silicon thermoelectric test structures that experimentally demonstrated record thermal conductivity reduction (> 85 %) without changes in electrical properties (conductivity and Seebeck coefficient). We also demonstrated the highest ever reported energy conversion efficiency for silicon thermoelectric devices. The team developed a design for 1 cm 2 die with thousands of nanophononic metamaterial structures in the form of nanowalled membranes but were unable to solve all fabrication challenges before the end of the program. Multiple aspects of the design were submitted for patent protection. Primary challenges were related to silicon-on-insulator material quality and high-aspect-ratio etching.

30 DIRECT ENERGY CONVERSION↗
DOE OSTI2025

Application of Advanced Materials Processing to Enable Direct Production of Fast Reactor Fuel Alloys

Argonne National Laboratory (the Contractor), located in Lemont, IL, and Oklo, Inc. (the Participant), headquartered in Sunnyvale, CA, entered into a Cooperative Research and Development Agreement (CRADA) to integrate advanced electrorefining co-deposition and molten-salt monitoring technologies to produce a uranium-transuranic (U/TRU) alloy within a controlled composition range that can be used as fast reactor fuel for Oklo, Inc.’s advanced reactor technology. Argonne performed the integration of electrorefining and process monitoring technologies, determined operating parameters for producing U/TRU alloys, and developed optimized design and operating parameters for co-deposition of U/TRU alloys. Oklo, Inc. worked with Argonne and the Nuclear Regulatory Commission (NRC) to provide the necessary process documentation to begin implementing pyroprocessing technology in the fast reactor fuel production process. Outcomes of this project included a pilot-scale co-deposition cathode design and technical basis for the operation of the co-deposition electrorefiner to produce U/TRU alloys with controlled composition.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2025

Z Machine Detonator Holder Testing

Current packaging for the detonators used on the Z Machine is dirty, not well suited for reusability, and labor intensive to use. A new packaging design is developed, explosively tested, and approved by the numerous stakeholders resulting in more efficient operations and lowered costs.

42 ENGINEERING↗
DOE OSTI2025

A Pressure-Swing Process for Reactive CO2 Capture and Conversion to Methanol through Precise Control of Co-Located Active Sites in Dual Functional Materials

The goals of this project are to design and develop tailored dual-functional materials (DFMs) and the accompanying pressure-swing process for the reactive capture and conversion (RCC) of CO 2 to methanol, a vital product in the chemical market and a versatile precursor to fuels. Throughout this project, NREL researcher team has successfully developed 2 groups of DFM and associated cyclic RCC procedure to selectivity produce either methanol or CO, which is a major intermediate for methanol synthesis with commercially available technologies.

01 COAL, LIGNITE, AND PEAT↗
DOE OSTI2025

A CHIL Validation of Machine Learning-Assisted Methods for Real-Time Controls of Solar PV for Grid Services

Recent research has highlighted the potential for solar to act as a zero-marginal-cost and zero-emission flexibility resource on the bulk power system when operated with advanced control systems. To increase the performance of these systems, leading technologies, including machine learning (ML) and hierarchical inverter set point allocation, have been proposed; however, these technologies lack comprehensive validation under real-world application scenarios. This paper addresses this gap by designing and developing a controller-hardware-in-the-loop framework to evaluate the performance of different flexible solar technologies in responding to automatic generation control signals in a closed-loop fashion. Simulation results indicate the superior performance of an ML-based approach compared to the conventional reference-control grouping-based approach, showcasing its potential to support grid stability and operational efficiency.

14 SOLAR ENERGY↗
DOE OSTI2026

When and Why Hiring and Training Occur: A Survey of Building Efficiency Contractors

As state and local governments, along with homeowners, work to enhance building energy performance, a sufficiently skilled energy-efficiency workforce is essential for implementing solutions at scale. In recent years, employers in the energy efficiency sector, including building performance contractors, have frequently reported challenges finding qualified workers. Additionally, as building performance technologies evolve and become more sophisticated, current workers need to acquire new skills and practices to maintain high-quality work. This study surveyed 209 contractors involved in building energy performance projects across 37 U.S. states, Washington, D.C., Guam, and the Marshall Islands. The survey aimed to understand their experiences in the labor market, their business practices, and their decision-making processes when hiring new workers and training existing employees. The findings highlight contractors' motivations and considerations in hiring and training, as well as the most significant challenges they face in the labor market. These insights can help workforce development practitioners design training programs that are aligned with workforce needs and responsive to employer concerns.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2026

Waveform Simulation Framework: User Manual with Tutorials

This manuscript describes the Waveform Simulation Framework (WSF), a Python-based framework that provides a unified, programmable interface for generating synthetic seismograms for applications such as seismic array design, method development, and special event analysis. WSF standardizes how users define sources, receivers, and velocity models while abstracting simulator-specific configuration details, enabling workflows that are largely independent of the underlying numerical engine. The document provides installation guidance and tutorial-driven examples for three WSF simulator wrappers—WSF PyFK, WSF SW4, and WSF SPECFEM2D—illustrating end-to-end workflows from forward waveform simulation to common post-processing tasks (e.g., visualization and backprojection) using consistent data products (e.g., ObsPy Stream objects and SAC files).

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2025

REDESIGNING A PERFORMANCE MONITORING SOFTWARE FOR SUPERCOMPUTERS

The objective of this project was to improve upon the existing Watchr software that charts performance test metrics from the Trilinos project run on supercomputers at Sandia and elsewhere across the DOE complex. Software was iteratively designed and developed using Python Pandas and Dash data visualization to improve the extensibility and user experience of Watchr. Documentation is being maintained for future developers who want to extend the application.

Camacho, Dane Joseph [Sandia National Laboratories↗
DOE OSTI2024

Comparison of Approaches for CO 2 Sequestration as Solid Carbon Products

The growing global climate crisis linked to the rising atmospheric CO 2 levels calls for urgent and innovative solutions. Fixing CO 2 as valuable solid carbon products, such as carbon nanofibers or nanotubes (CNFs or CNTs), offers a promising way to potentially achieve net-negative CO 2 emissions. However, direct CO 2 -to-solid carbon faces significant thermodynamic and kinetic constraints, especially under mild reaction conditions. This mini-review compares three emerging approaches for CO 2 conversion into solid carbon: 1) using molten salt at high temperatures to produce CNFs or CNTs, 2) converting CO 2 to amorphous carbon with pyrophoric liquid metals at near room temperature, and 3) employing an electrocatalytic-thermocatalytic tandem process to produce CNFs at relatively mild temperatures. We examine the underlying principles, thermodynamic driving forces, and recent advances of each approach, and discuss the challenges and opportunities in catalyst development, reactor design, and energy management. We aim to highlight CO 2 fixation, facilitate net-negative CO 2 emissions, and stimulate more innovations for both environmental and economic benefits.

99 GENERAL AND MISCELLANEOUS↗