Search NASA⌕ Search

SEARCH · Search NASA

Results for “early stage”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 253 records · Page 14
All sourcesNASA NTRSDOE OSTI
NASA NTRS1984

Origin and evolution of the Saturn system

As was the case for Jupiter, Saturn formed either as a result of a gas instability within the solar nebula or the accretion of a solid core that induced an instability within the surrounding solar nebula. In either case, the proto-planet's history is divided into three major stages: early, quasi-hydrostatic evolution (stage 1); hydrodynamical collapse (stage 2); and late, quasi-hydrostatic contraction (stage 3). During stage 1, Saturn had a radius of several hundred times that of its present radius, R(s), while stage 3 began when Saturn had a radius of 3.5 R(s). Stages 1 and 2 lasted one-million to 10-million years and one year, respectively, while stage 3 is continuing through the present epoch. During the early history of the Saturn system, giant impact events may have catastrophically disrupted most of the original satellites of Saturn. Such disruption, followed by reaccretion, may be responsible, in part for the occurrence of Trojans and co-orbital moons in the Saturn system, the apparent presence of a stochastic component in the trend of satellite density with radial distance, and the present population of ring particles.

Pollack, J. B.↗
DOE OSTI2025

In vitro activity and in vivo efficacy of omadacycline against Plasmodium species

Abstract Background Doxycycline is currently the only tetracycline-class antibiotic recommended for malaria prophylaxis. Omadacycline, a semisynthetic aminomethylcycline approved for treatment of adults with community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections, has a well-established safety profile. This study evaluated the in vitro activity of omadacycline againstPlasmodium falciparumandPlasmodium cynomolgiand its in vivo efficacy againstPlasmodium bergheiin experimental malaria models to assess its potential as an antimalarial drug. Methods Fluorescence-based assays were used to assess the in vitro blood and liver stage activity of omadacycline and doxycycline againstP. falciparumandP. cynomolgilaboratory clones. In vivo liver and early-stage blood stage efficacy were evaluated in a murine model ofP. bergheiinfection, utilizing in vivo imaging of luciferase-expressingP. berghei(ANKA strain) sporozoites in female albino C57Bl/6 mice. Parasitaemia was monitored by flow cytometry for up to 30 days post-infection. Results Omadacycline demonstrated comparable in vitro activity to doxycycline against both drug-sensitive and drug-resistantP. falciparumclones, while doxycycline showed reduced activity against two drug-resistant clones. Notably, omadacycline exhibited superior anti-schizont activity in theP. cynomolgiliver stage assay. In theP. bergheimurine model, omadacycline was efficacious in both liver and early blood stages compared to the untreated control group, and demonstrated improved survival compared to doxycycline. Conclusions Omadacycline demonstrated enhanced antimalarial efficacy over doxycycline in vitro in liver stage activity and in overcoming resistance in the blood stage, and in survival in an in vivo model ofP. bergheiinfection. These findings support further investigation of omadacycline as a potential candidate for malaria prophylaxis and treatment.

Infectious Diseases↗
NASA NTRS1983

A long-lived mesoscale convective complex. I - The mountain-generated component

The South Park Area Cumulus Experiment (SPACE) was conducted during the summer of 1977, and takes into account meteorological developments in a broad, elevated basin called South Park, which is located northeast of Colorado Springs, Colorado. The experiment was designed to investigate the organization of the mesoscale and storm-scale systems in detail over South Park. Many of the convective storms which were observed in the developing stages over South Park participated in the genesis of mesoscale convective complexes (MCCs) on the meso-alpha-scale. The present investigation is concerned with the evolution of the second MCC of this episode, which matured on the evening of August 4, 1977. Attention is given to the events from the preconvective stage early on August 4 to the incipient MCC stage in the early evening.

Cotton, W. R.↗
DOE OSTI2020

Large isotopic variability at the micron-scale in ‘Shuram’ excursion carbonates from South Australia

Ediacaran-aged (635–541 million years ago) marine sediments contain a large negative carbon isotope (δ 13 C) excursion, in which carbonate δ 13 C values reach -12‰ (VPDB). Known as the ‘Shuram’ excursion, many workers have interpreted this δ 13 C record as an unprecedented perturbation to the global carbon cycle, leading to speculation about a causal connection to the broadly contemporaneous rise of animal life. Others have interpreted the δ 13 C signal as a product of diagenesis, thereby minimizing its relevance for understanding the evolution of metazoans. In this work, we present SEM imaging and in-situ δ 13 C and δ 18 C values measured by secondary ion mass spectrometry (SIMS) to assess these competing hypotheses in the Wonoka Formation of South Australia. Our results from the minimum of the excursion show that rounded sedimentary grains of calcite have δ 13 C values between -12.8 to -10.6‰ and δ 18 C values between 17.8 to 15.5‰ (VPDB). Euhedral dolomite that appears to have grown unimpeded in open sedimentary pore spaces also is present. These early-stage dolomites are interpreted as early authigenic in origin and have δ 13 C values that reach +5‰, requiring a formation fluid with a substantially different δ 13 C composition from basin waters or bulk sediment. Together, these results provide little evidence for the hypothesis that a late diagenetic overprint has generated the ‘Shuram’ excursion in the Wonoka. Instead, they suggest the presence of a large carbon isotopic gradient in the surface environment, with shallow waters capable of precipitating carbonates with very low δ 13 C (down to 12‰) and deeper shelf and/or marine pore waters generating carbonates with positive carbon isotope values (up to +5‰). Because negative isotope excursions of similar magnitude are found in widely dispersed Ediacaran basins, it is likely that this gradient was characteristic of shelf environments of this period and that a still-unknown global process led to the ‘Shuram’ excursion in shallow water carbonates.

58 GEOSCIENCES↗
DOE OSTI2021

Large rotations of the grain-scale stress tensor during yielding set the stage for failure

The stress-state within individual grains in a polycrystal determine the fate of the aggregate including mechanical failure. By tracking the evolution of the stress tensor throughout the elastoplastic transition, large rotations of the stress-state, which have long been theorized to occur, are observed experimentally for the first time. These stress rotations (~15°) are more than an order of magnitude larger than the concomitant crystallographic lattice reorientations (~0.9°) well-known to occur during metal plasticity. Furthermore, these rotations are accompanied by a decrease in stress triaxiality within certain grains, promote strain softening, and set the stage for failure at an early stage of deformation. Finally, these results provide a completely new perspective through which to contemplate the question of “hot-spots” responsible for failure of high-performance structural materials.

36 MATERIALS SCIENCE↗
NASA NTRS1984

A unified N-body and statistical treatment of stellar dynamics. I - The hybrid code. II - Applications to globular cluster cores

A unified N-body and statistical treatment of stellar dynamics is developed and applied to the late stages of core collapse and early stages of post collapse evolution in globular clusters. A 'hybrid' computer code is joined to a direct N-body code which is used to calculate exactly the behavior of particles in the inner spatial region, and the combination is used to follow particles statistically in the outer spatial region. A transition zone allows the exchange of particles and energy between the two regions. The main application results include: formation of a hard central binary system, reversal of core collapse and expansion due to the heat input from this binary, ejection of the binary from the core, and recollapse of the core; density profiles that form a one-parameter sequence during the core oscillations; and indications that these oscillations will eventually cease.

Mcmillan, S. L. W.↗
NASA NTRS1985

Late-stage planetesimals: How big?

Numerical simulation of the early stages of planet growth show that a few bodies nearly 1000 km in diameter may have formed within approx. 100,000 yr after solid material grew into km scale planetesimals by gravitational instability. Even after such large bodies formed, the bulk of the mass of the future terrestrial planet zone resided in small bodies. Subsequent evolution is difficult to model because it requires simultaneous consideration of continuum (multitudinous small bodies) and discrete (a few large bodies) evolution. Some relevant issues include definition of accretional feeding zones, evaluation of the range of gravitational influence, viscous transport and diffusion, orbital commensurabilities, role of gas, etc. The first large bodies may have been (1) the embryos of the final planets, which grew by accreting tiny planetesimals, or (2) merely the first of many 1000+ km bodies, which grew independently and later collided to form the planets. Models of late stage accretion that assume all bodies to be initially nearly Moon sized provide insight into relevant collisional and dynamical processes. The chief point in this research is that the correct size distribution during the later stages of planet growth remains unknown.

Greenberg, R.↗
NASA NTRS2011

Mars Science Laboratory Flight Software Internal Testing

The Mars Science Laboratory (MSL) team is sending the rover, Curiosity, to Mars, and therefore is physically and technically complex. During my stay, I have assisted the MSL Flight Software (FSW) team in implementing functional test scripts to ensure that the FSW performs to the best of its abilities. There are a large number of FSW requirements that have been written up for implementation; however I have only been assigned a few sections of these requirements. There are many stages within testing; one of the early stages is FSW Internal Testing (FIT). The FIT team can accomplish this with simulation software and the MSL Test Automation Kit (MTAK). MTAK has the ability to integrate with the Software Simulation Equipment (SSE) and the Mission Processing and Control System (MPCS) software which makes it a powerful tool within the MSL FSW development process. The MSL team must ensure that the rover accomplishes all stages of the mission successfully. Due to the natural complexity of this project there is a strong emphasis on testing, as failure is not an option. The entire mission could be jeopardized if something is overlooked.

entry, descent, and landing (EDL)↗
NASA NTRS2014

Pre-Test CFD for the Design and Execution of the Enhanced Injection and Mixing Project at NASA Langley Research Center

With the increasing costs of physics experiments and simultaneous increase in availability and maturity of computational tools it is not surprising that computational fluid dynamics (CFD) is playing an increasingly important role, not only in post-test investigations, but also in the early stages of experimental planning. This paper describes a CFD-based effort executed in close collaboration between computational fluid dynamicists and experimentalists to develop a virtual experiment during the early planning stages of the Enhanced Injection and Mixing project at NASA Langley Research Center. This projects aims to investigate supersonic combustion ramjet (scramjet) fuel injection and mixing physics, improve the understanding of underlying physical processes, and develop enhancement strategies and functional relationships relevant to flight Mach numbers greater than 8. The purpose of the virtual experiment was to provide flow field data to aid in the design of the experimental apparatus and the in-stream rake probes, to verify the nonintrusive measurements based on NO-PLIF, and to perform pre-test analysis of quantities obtainable from the experiment and CFD. The approach also allowed for the joint team to develop common data processing and analysis tools, and to test research ideas. The virtual experiment consisted of a series of Reynolds-averaged simulations (RAS). These simulations included the facility nozzle, the experimental apparatus with a baseline strut injector, and the test cabin. Pure helium and helium-air mixtures were used to determine the efficacy of different inert gases to model hydrogen injection. The results of the simulations were analyzed by computing mixing efficiency, total pressure recovery, and stream thrust potential. As the experimental effort progresses, the simulation results will be compared with the experimental data to calibrate the modeling constants present in the CFD and validate simulation fidelity. CFD will also be used to investigate different injector concepts, improve understanding of the flow structure and flow physics, and develop functional relationships. Both RAS and large eddy simulations (LES) are planned for post-test analysis of the experimental data.

Drozda, Tomasz G.↗
DOE OSTI2024

Photon-triggered jets as probes of multi-stage jet modification

Prompt photons are created in the early stages of heavy ion collisions and traverse the QGP medium without any interaction. Therefore, photontriggered jets can be used to study the jet quenching in the QGP medium. In this work, photon-triggered jets are studied through different jet and jet substructure observables for different collision systems and energies using the JETSCAPE framework. Since the multistage evolution used in the JETSCAPE framework is adequate to describe a wide range of experimental observables simultaneously using the same parameter tune, we use the same parameters tuned for jet and leading hadron studies. The same isolation criteria used in the experimental analysis are used to identify prompt photons for better comparison. For the first time, high-accuracy JETSCAPE results are compared with multi-energy LHC and RHIC measurements to better understand the deviations observed in prior studies. This study highlights the importance of multistage evolution for the simultaneous description of experimental observables through different collision systems and energies using a single parameter tune.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
NASA NTRS1998

RNA Research

It is generally believed that an RNA World existed at an early stage in the history of life. During this early period, RNA molecules are seen to be potentially involved in both catalysis and the storage of genetic information. It is widely believed that this RNA World was extensive and therefore a sophisticated nucleic acid replication machinery would presumably predate the translation machinery which would not be needed until later stages in the development of life. This view of an extended RNA World is not necessarily correct. From the point of view of exobiology, the difference in these two views mainly affects the significance of studies of the extent of catalysis possible by RNA- In either case, the origin of the translation machinery and the principles of RNA evolution remain central problems in exobiology. Translation presents several interrelated themes of inquiry for exobiology. First, it is essential, for understanding the very origin of life, how peptides and eventually proteins might have come to be made on the early Earth in a template directed manner. Second, it is necessary to understand how a machinery of similar complexity to that found in the ribosomes of modem organisms came to exist by the time of the last common ancestor (as detected by 16S RRNA sequence studies). Third, the RNAs that comprise the ribosome are themselves likely of very early origin and studies of their history may be very informative about the nature of the RNA World. Moreover, studies of these RNAs will contribute to a better understanding of the potential roles of RNA in early evolution.

Source record↗
DOE OSTI2025

Leveraging a Southern California Energy Innovation Cluster to Pilot and Validate Emerging Energy Technologies

The EPIC Pilot Program, led by the Los Angeles Cleantech Incubator (LACI), was designed to help early-stage clean technology startups accelerate technical validation, investment readiness, and market entry. The project focused on supporting startups in designing and deploying small-scale pilots with the guidance of EPIC Partners, a network of regional stakeholders in the Southern California energy ecosystem, including but not limited to: the Los Angeles Department of Water and Power (LADWP), the California Energy Commission (CEC), Los Angeles County Metropolitan Transportation Authority (LA Metro), and Edison International, among others. Through mentorship, funding, and site access for technology deployments, the program provided a structured pathway for startups to test and refine their technologies in real-world settings.

14 SOLAR ENERGY↗
NASA NTRS1977

Prediction of elastic-airplane lateral dynamics from rigid-body aerodynamics

Control-configured vehicle technology has increased the demand for detailed analysis of dynamic stability and control, handling and ride qualities, and control system dynamics at the early stages of preliminary design and development. For these early analyses an approximate, but reasonably accurate, set of equations of motion for elastic airplanes is needed. Such a formulation is developed for the lateral dynamics of elastic airplanes. It makes use of rigid-body aerodynamic stability derivatives and the antisymmetric elastic mode shapes and frequencies in formulating the forces and moments due to elastic motion. Verification of accuracy was made by comparison with B-1 airplane dynamics obtained by other methods. Frequencies and damping ratios of the coupled modes agree acceptably well with four antisymmetric elastic modes included.

Swaim, R. L.↗
NASA NTRS1997

[Ribosomal RNA Evolution]

It is generally believed that an RNA World existed at an early stage in the history of life. During this early period, RNA molecules are seen to be potentially involved in both catalysis and the storage of genetic information. Translation presents several interrelated themes of inquiry for exobiology. First, it is essential, for understanding the very origin of life, how peptides and eventually proteins might have come to be made on the early Earth in a template directed manner. Second, it is necessary to understand how a machinery of similar complexity to that found in the ribosomes of modern organisms came to exist by the time of the last common ancestor (as detected by 16S rRNA sequence studies). Third, the ribosomal RNAs themselves likely had a very early origin and studies of their history may be very informative about the nature of the RNA World. Moreover, studies of these RNAs will contribute to a better understanding of the potential roles of RNA in early evolution.During the past year we have ave conducted a comparative study of four completely sequenced bacterial genoames. We have focused initially on conservation of gene order. The second component of the project continues to build on the model system for studying the validity of variant 5S rRNA sequences in the vicinity of the modern Vibrio proteolyticus 5S rRNA that we established earlier. This system has made it possible to conduct a detailed and extensive analysis of a local portion of the sequence space. These core methods have been used to construct numerous mutants during the last several years. Although it has been a secondary focus, this work has continued over the last year such that we now have in excess of 125 V. proteolyticus derived constructs which have been made and characterized. We have also continued high resolution NMR work on RNA oligomers originally initiated by G. Kenneth Smith who was funded by a NASA Graduate Student Researcher's Fellowship Award until May of 1996. Mr. Smith developed synthesis & purification protocols in order to obtain large quantities of RNA oligomers for NMR studies. He succeeded in obtaining preliminary one dimensional spectra for an analog of the helix II/loop B/helix III domain of 5S rRNAs well as a 29mer which includes helix III and the highly characteristic 13 nucleotide loop C. Significant progress in laying the required groundwork for this work has been accomplished during the past year. A plasmid, pLeuS-1, carrying the E. coli leucine tRNA synthetase gene (LeuRS) has been obtained and used to overexpressed the leucine synthetase. A T7 runoff transcription has been established in our laboratory and successfully used to make both minihelix RNAs and tRNAs. In addition, encapsulation studies have been conducted and we have successfully encapsulated tRNA in lipid vesicles. Initial efforts to obtain peptide bond synthesis will be underway over the next several moths.

Source record↗
NASA NTRS2012

Loading, Release, Biodegradation, and Biocompatibility of a Nanovector Delivery System

A nanovector multistage system has been created to overcome or bypass sequential barriers within the human body, in order to deliver a therapeutic or imaging agent to a specific location. This innovation consists of a composition that includes two or more stages of particles, such that smaller, later-stage particles are contained in the larger, early-stage particles. An active agent, such as a therapeutic agent or imaging agent, is preferentially delivered and/or localized to a particular target site in the body of a subject. The multistage composition overcomes multiple biological barriers in the body. The multistage composition also allows for simultaneous delivery and localization at the same or different target sites of multiple active agents.

Ferrai, Mauro↗
DOE OSTI2022

Silicon alloying enhances fast heating rate combustion of aluminum particles

Alloys and composites of aluminum (Al) have shown promise in regulating and enhancing particle combustion for energy generation applications. Recent work on aluminum-silicon (Al-Si) spherical alloy particles has shown improved combustion at low heating rates through enhanced diffusion accompanying a lower melting temperature. This study extends reactivity analysis to higher heating rates, comparing oxidation of Al-Si with Al. Flame speeds of Al-Si powder mixed with molybdenum trioxide (MoO 3 ) powder (Al-Si+MoO 3 ) exhibited a faster transition to steady propagation relative to Al+MoO 3 . Bomb calorimetry experiments revealed up to 5.8% greater early temperature rise for Al-Si powder. Rapid steady propagation for Al-Si mixture and faster temperature rise for Al-Si particles were attributed to accelerated kinetics evidenced in thermal equilibrium analysis of the mixtures using a differential scanning calorimeter (DSC). Larger DSC exotherms in the early stages of oxidation (i.e., 480–720 °C) correlated with early heat release and promoted steady flame propagation for Al-Si+MoO 3 compared with Al+MoO 3 . Furthermore, in multiple heating rate DSC studies, Al-Si+MoO 3 ignited at a lower heating rate (i.e., 15 ⁰C/min) than Al+MoO 3 (i.e., 20 ⁰C/min). Both mixtures ignited at temperatures less than 625 °C which is above the melting temperature of Al-Si (574 °C) and below Al (659 °C). Thus, alloy particle fuels with enhanced diffusion-controlled kinetics promote steady flame propagation and show promise for energy generation applications. This is especially promising for technologies driven by enhanced condensed phase combustion such as some propellant additives or applications dependent on reliable burn rates such as pyrotechnic time delay formulations and primers.

36 MATERIALS SCIENCE↗
DOE OSTI2020

SECARB-USA: Needs Assessment Framework for Storage Complexes

The goal of this task is to develop an assessment to identify data needed to advance geologic storage projects, with a focus on the SECARB region. The GCCC team considers the needs of CO2 source, storage, and utilization operators and stakeholders, finance and insurance institutions, state and local government relators and agencies, property owners, local stakeholders at prospective storage complexes, and environmental non-governmental organizations (NGOs). Many of these needs are spelled out in the requirements of the Class VI permit. However, at the initial stages of project development, the workflow will not start with permit writing. A number of other factors must be evaluated prior to this major investment. The team’s goal in this report is to inventory the range of typical needs for a wide variety of projects. For subsequent tasks, the team will consider how these needs vary among projects and through the stages of investment, so that project developers can plan the early stages of capitalization.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2020

Southeast Regional CO 2 Utilization and Storage Acceleration Partnership (SECARB-USA): Needs Assessment Framework

The goal of this task is to develop an assessment to identify data needed to advance geologic storage projects, with a focus on the SECARB region. The GCCC team considers the needs of CO 2 source, storage, and utilization operators and stakeholders, finance and insurance institutions, state and local government relators and agencies, property owners, local stakeholders at prospective storage complexes, and environmental non-governmental organizations (NGOs). Many of these needs are spelled out in the requirements of the Class VI permit. However, at the initial stages of project development, the workflow will not start with permit writing. A number of other factors must be evaluated prior to this major investment. The team’s goal in this report is to inventory the range of typical needs of for a wide variety of projects. For subsequent tasks, the team will consider how these needs vary among projects and through the stages of investment, so that project developers can plan the early stages of capitalization.

42 ENGINEERING↗