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At least 253 records · Page 14

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NASA NTRS1996

Transmembrane transport of peptide type compounds: prospects for oral delivery

Synthesis and delivery of potential therapeutic peptides and peptidomimetic compounds has been the focus of intense research over the last 10 years. While it is widely recognized that numerous limitations apply to oral delivery of peptides, some of the limiting factors have been addressed and their mechanisms elucidated, which has lead to promising strategies. This article will briefly summarize the challenges, results and current approaches of oral peptide delivery and give some insight on future strategies. The barriers determining peptide bioavailability after oral administration are intestinal membrane permability, size limitations, intestinal and hepatic metabolism and in some cases solubility limitations. Poor membrane permeabilities of hydrophilic peptides might be overcome by structurally modifying the compounds, thus increasing their membrane partition characteristics and/or their affinity to carrier proteins. Another approach is the site-specific delivery of the peptide to the most permeable parts of the intestine. The current view on size limitation for oral drug delivery has neglected partition considerations. Recent studies suggest that compounds with a molecular weight up to 4000 might be significantly absorbed, assuming appropriate partition behavior and stability. Metabolism, probably the most significant factor in the absorption fate of peptides, might be controlled by coadministration of competitive enzyme inhibitors, structural modifications and administration of the compound as a well absorbed prodrug that is converted into the therapeutically active agent after its absorption. For some peptides poor solubility might present a limitation to oral absorption, an issue that has been addressed by mechanistically defining and therefore improving formulation parameters. Effective oral peptide delivery requires further development in understanding these complex mechanisms in order to maximize the therapeutic potential of this class of compounds.

NASA Discipline Regulatory Physiology↗

NASA NTRS1974

Comparative magnetic studies of some Apollo 17 rocks and soils and their implications

The lunar rock and soil specimens studied include samples of the orange and gray soil strata from adjancent sites on the South rim of Shorty Crater, two vesicular mare basalts, and a mare basalt of the dense aphanitic type. The magnetic characteristics of the soils are discussed along with a hysteresis behavior analysis of Apollo 17 rocks. The remanent properties are examined, giving attention to viscous remanence, NRM stability, saturation isothermal remanence, and heating experiments.

Brecher, A.↗

NASA NTRS1991

Results of the 1989 SAR calibration experiment at Oberpfaffenhofen

Results from the 1989 Airborne Synthetic Aperture Radar (SAR) Calibration Campaign at the DLR test site in Oberpfaffenhofen are presented. Passive corner reflectors were used to derive the receiver and transmitter distortion matrices and the absolute calibration factor of the multispectral polarimetric DC-8 SAR from the complex high resolution data. A basic requirement for cross-calibration of data from different tracks is the stability of the SAR system. The polarimetric properties of the uncalibrated data were used to describe this stability. Quality criteria for a successful polarimetric calibration were provided by the channel balance and cross-talk parameters.

Zink, M.↗

NASA NTRS1997

A FLINN Station at Pinon Flat Observatory

The main objectives are: (1) To develop Pinon Flat Observatory (PFO) as a prototype 'integrated' FLINN station: one from which many types of data are collected, combined, and made available to the DOSE program to enhance studies of local and regional strains; (2) To develop the theoretical framework and methods to integrate the various types of auxiliary data which are to be collected by NASA at space-geodetic sites of the FLINN network, with the aim of learning as much as possible about the nature of earth deformation; (3) To develop procedures for the efficient and useful storage and retrieval of such auxiliary data so that they may be efficiently utilized by DOSE investigators; (4) To investigate the stability of ground monumentation now used in space-geodetic measurements, including the field testing of existing and new monument designs.

Agnew, Duncan Carr↗

NASA NTRS2012

Entry Atmospheric Flight Control Authority Impacts on GN and C and Trajectory Performance for Orion Exploration Flight Test 1

One of the key design objectives of NASA's Orion Exploration Flight Test 1 (EFT-1) is to execute a guided entry trajectory demonstrating GN&C capability. The focus of this paper is the ight control authority of the vehicle throughout the atmospheric entry ight to the target landing site and its impacts on GN&C, parachute deployment, and integrated performance. The vehicle's attitude control authority is obtained from thrusting 12 Re- action Control System (RCS) engines, with four engines to control yaw, four engines to control pitch, and four engines to control roll. The static and dynamic stability derivatives of the vehicle are determined to assess the inherent aerodynamic stability. The aerodynamic moments at various locations in the entry trajectory are calculated and compared to the available torque provided by the RCS system. Interaction between the vehicle's RCS engine plumes and the aerodynamic conditions are considered to assess thruster effectiveness. This document presents an assessment of Orion's ight control authority and its effectiveness in controlling the vehicle during critical events in the atmospheric entry trajectory.

McNamara, Luke W.↗

NASA NTRS2011

An Analysis of Database Replication Technologies with Regard to Deep Space Network Application Requirements

The Deep Space Network (DSN) has three communication facilities which handle telemetry, commands, and other data relating to spacecraft missions. The network requires these three sites to share data with each other and with the Jet Propulsion Laboratory for processing and distribution. Many database management systems have replication capabilities built in, which means that data updates made at one location will be automatically propagated to other locations. This project examines multiple replication solutions, looking for stability, automation, flexibility, performance, and cost. After comparing these features, Oracle Streams is chosen for closer analysis. Two Streams environments are configured - one with a Master/Slave architecture, in which a single server is the source for all data updates, and the second with a Multi-Master architecture, in which updates originating from any of the servers will be propagated to all of the others. These environments are tested for data type support, conflict resolution, performance, changes to the data structure, and behavior during and after network or server outages. Through this experimentation, it is determined which requirements of the DSN can be met by Oracle Streams and which cannot.

Oracle Database File System↗

NASA NTRS2003

A Proposed Mechanism for the Thermal Denaturation of a Recombinant Bacillus Halmapalus Alpha-amylase - the Effect of Calcium Ions

The thermal stability of a recombinant alpha-amylase from Bacillus halmapalus alpha-amylase (BHA) has been investigated using circular dichroism spectroscopy (CD) and differential scanning calorimetry (DSC). This alpha-amylase is homologous to other Bacillus alpha-amylases where previous crystallographic studies have identified the existence of 3 calcium binding sites in the structure. Denaturation of BHA is irreversible with a Tm of approximately 89 C, and DSC thermograms can be described using a one-step irreversible model. A 5 C increase in T(sub m) in the presence of 10 fold excess CaCl2 was observed. However, a concomitant increase in the tendency to aggregate was also observed. The presence of 30-40 fold excess calcium chelator (EDTA or EGTA) results in a large destabilization of BHA corresponding to about 40 C lower T(sub m), as determined by both CD and DSC. Ten fold excess EGTA reveals complex DSC thermograms corresponding to both reversible and irreversible transitions, which possibly originate from different populations of BHA:calcium complexes. The observations in the present study have, in combination with structural information of homologous alpha-amylases, provided the basis for the proposal of a simple denaturation mechanism of BHA. The proposed mechanism describes the irreversible thermal denaturation of different BHA:calcium complexes and the calcium binding equilibrium involved. Furthermore, the model accounts for a temperature induced reversible structural change associated with calcium binding.

Nielsen, Anders D.↗

NASA NTRS1987

Measurements of surface energy budgets in the rocky mountains of Colorado

The surface energy balance of a mountain valley and a mountain peak were continuously monitored for periods of 126 and 34 days, respectively. The data yielded temporally resolved, high-quality measurements of the radiative, soil, and total atmospheric turbulent heat fluxes. Comparative data for the two sites reveal the effects of terrain setting and surface cover in modulating the heat balance. A procedure is suggested for accommodating local advective affects due to variable terrain and surface cover to allow partitioning of the total turbulent flux into values for sensible and latent heat. This procedure relies on a stability-dependent coefficient of turbulent transfer which is locally calibrated to systematically minimize advection-related errors. Scaling functions for the transfer coeffient are based on the effective blackbody temperature of the surface. Consequently, the procedure offers an opportunity for developing reliable bulk representations of heat transfer at the surface for use with remote sensing data and with models of the soil and surface cover in complex terrain.

Sheaffer, John D.↗

NASA NTRS1988

Theoretical investigation of the role of clay edges in prebiotic peptide bond formation. II - Structures and thermodynamics of the activated complex species

Molecular orbital calculations are used to study amino acid activation by anhydride formation in neutral phosphates and in tetrahedral silicate and aluminate sites on clay edges. The results agree with previous ab initio studies of Luke et al. (1984) on the reactant species. Relative heats of formation of the anhydrides indicate the extent of anhydride formation to be the greatest for Al and the least for phosphate, which is the same order as the stability of hydrolysis.

Collins, Jack R.↗

NASA NTRSDate not supplied

PFAS Treatment Pilot Study using Granular Activated Carbon at Kennedy Space Center, Florida

Per- and polyfluoroalkyl substances (PFAS) have been found in investigative derived waste (IDW) generated from groundwater sampling and remediation activities conducted at Kennedy Space Center (KSC), Florida. PFAS are exceptionally strong compounds because of carbon-fluorine bonds resulting in resistance to degradation, low chemical reactivity, compound stability, and persistence in the environment. The regulatory status of PFAS is very dynamic. PFAS is not considered a hazardous waste and has no federal or state (Florida) cleanup requirements at this time. Due to the current and unknown future of the regulatory and treatment landscape, non-hazardous IDW, based upon site volatile organic compounds (VOCs) regulated under Title 40 of Federal Regulations part 261, containing PFAS is not being processed for off-site waste disposal under KSC’s Resource Conservation and Recovery Act permit as a proactive precaution. Long-term storage of aqueous IDW in the meantime was determined to be inadequate due to the potential for spills and/or leaks. A very limited number treatment methods are available at this time. To date, granular activated carbon (GAC) and ion exchange technologies have been found to be some of the most consistent treatment options for removing PFAS from aqueous media. Therefore, a pilot study using GAC was developed at KSC to determine the feasibility of treating non-hazardous IDW containing PFAS to reduce the total volume of PFAS waste and minimize the risk of leaks or spills while storing the waste until complete PFAS-destructive treatment options are more readily available. NASA wanted the pilot test to be able to demonstrate the ability to completely remove 18 PFAS compounds and the site VOCs to below the state of Florida groundwater cleanup target levels (GCTLs).

Michael J Deliz↗

NASA NTRS1972

Some of the mechanisms underlying motion sickness

Some of the mechanisms contributing to the occurrence of motion sickness are discussed. It is stated that the primary factor is a loss of stability in the vestibular system caused by repetitive sensory inputs that are abnormal in terms of the central vestibular patterning encountered. Evidence is presented supporting the opinion that motion sickness is an epiphenomenon superimposed on any responses in the reflex category due to vestibular influences that cross a temporary linkage to reach nonvestibular sites where first-order motion sickness symptoms have their immediate origin.

Graybiel, A.↗

NASA NTRS1977

Shuttle carrier aircraft flight tests

Since the Space Shuttle will need to be transported from its place of assembly to the launch site, a method has been developed whereby the Shuttle rides piggyback on a modified Boeing 747, called the Shuttle carrier aircraft (SCA). This paper describes tests of the SCA in its mated configuration. Tests include: flutter, found to decrease when fiberglass and wood fairings were added to the base of each supporting pylon; stability and control, found to be acceptable after damping with control pulses; noise and buffet, found high but acceptable; and climb, in which drag was marked but acceptable with the special rated thrust (SRT) power setting. Simulated launch maneuvers were undertaken at an airspeed of 273 KCAS. Transport of the Shuttle takes place with the Shuttle tail cone on, at a cruise speed of 288 KCAS at an altitude of 22,000 feet.

Fulton, F. L., Jr.↗

NASA NTRS2005

Insect-Inspired Flight Control for Unmanned Aerial Vehicles

Flight-control and navigation systems inspired by the structure and function of the visual system and brain of insects have been proposed for a class of developmental miniature robotic aircraft called "biomorphic flyers" described earlier in "Development of Biomorphic Flyers" (NPO-30554), NASA Tech Briefs, Vol. 28, No. 11 (November 2004), page 54. These form a subset of biomorphic explorers, which, as reported in several articles in past issues of NASA Tech Briefs ["Biomorphic Explorers" (NPO-20142), Vol. 22, No. 9 (September 1998), page 71; "Bio-Inspired Engineering of Exploration Systems" (NPO-21142), Vol. 27, No. 5 (May 2003), page 54; and "Cooperative Lander-Surface/Aerial Microflyer Missions for Mars Exploration" (NPO-30286), Vol. 28, No. 5 (May 2004), page 36], are proposed small robots, equipped with microsensors and communication systems, that would incorporate crucial functions of mobility, adaptability, and even cooperative behavior. These functions are inherent to biological organisms but are challenging frontiers for technical systems. Biomorphic flyers could be used on Earth or remote planets to explore otherwise difficult or impossible to reach sites. An example of an exploratory task of search/surveillance functions currently being tested is to obtain high-resolution aerial imagery, using a variety of miniaturized electronic cameras. The control functions to be implemented by the systems in development include holding altitude, avoiding hazards, following terrain, navigation by reference to recognizable terrain features, stabilization of flight, and smooth landing. Flying insects perform these and other functions remarkably well, even though insect brains contains fewer than 10(exp -4) as many neurons as does the human brain. Although most insects have immobile, fixed-focus eyes and lack stereoscopy (and hence cannot perceive depth directly), they utilize a number of ingenious strategies for perceiving, and navigating in, three dimensions. Despite their lack of stereoscopy, insects infer distances to potential obstacles and other objects from image motion cues that result from their own motions in the environment. The concept of motion of texture in images as a source of motion cues is denoted generally as the concept of optic or optical flow. Computationally, a strategy based on optical flow is simpler than is stereoscopy for avoiding hazards and following terrain. Hence, this strategy offers the potential to design vision-based control computing subsystems that would be more compact, would weigh less, and would demand less power than would subsystems of equivalent capability based on a conventional stereoscopic approach.

Thakoor, Sarita↗

NASA NTRS1999

Calibration of the Geosar Dual Frequency Interferometric SAR

GeoSAR is an airborne, interferometric Synthetic Aperture Radar (INSAR) system for terrain mapping, currently under development by a consortium including NASA's Jet Propulsion Laboratory (JPL), Calgis, Inc., and the California Department of Conservation (CalDOC) with funding provided by the Topographic Engineering Center (TEC) of the U.S. Army Corps of Engineers and the Defense Advanced Research Projects Agency (DARPA). The radar simultaneously maps swaths on both sides of the aircraft at two frequencies, X-Band and P-Band. For the P-Band system, data is collected for two across track interferometric baselines and at the crossed polarization. The aircraft position and attitude are measured using two Honeywell Embedded GPS Inertial Navigation Units (EGI) and an Ashtech Z12 GPS receiver. The mechanical orientation and position of the antennas are actively measured using a Laser Baseline Metrology System (LBMS). In the GeoSAR motion measurement software, these data are optimally combined with data from a nearby ground station using Ashtech PNAV software to produce the position, orientation, and baseline information are used to process the dual frequency radar data. Proper calibration of the GeoSAR system is essential to obtaining digital elevation models (DEMS) with the required sub-meter level planimetric and vertical accuracies. Calibration begins with the determination of the yaw and pitch biases for the two EGI units. Common range delays are determined for each mode, along with differential time and phase delays between channels. Because the antennas are measured by the LBMS, baseline calibration consists primarily of measuring a constant offset between mechanical center and the electrical phase center of the antennas. A phase screen, an offset to the interferometric phase difference which is a function of absolute phase, is applied to the interferometric data to compensate for multipath and leakage. Calibration parameters are calculated for each of the ten processing modes, each of the operational bandwidths (80 and 160 MHZ), and each aircraft altitude. In this talk we will discuss the layout calibration sites, the synthesis of data from multiple flights to improve the calibration, methods for determining time and phase delays, and techniques for determining radiometric and polarimetric quantities. We will describe how calibration quantities are incorporated into the processor and pre-processor. We will demonstrate our techniques applied to GeoSar data and assess the stability and accuracy of the calibration. This will be compared to the modeled performance determined from calibrating the output of a point target simulator. The details of baseline determination and phase screen calculation are covered in related talks.

Chapine, Elaine↗

NASA NTRS2001

Galileo Probe Doppler Residuals as the Wave-Dynamical Signature of Weakly Stable, Downward-Increasing Stratification in Jupiter's Deep Wind Layer

Doppler radio tracking of the Galileo probe-to-orbiter relay, previously analyzed for its in situ measure of Jupiter's zonal wind at the equatorial entry site, also shows a record of significant residual fluctuations apparently indicative of varying vertical motions. Regular oscillations over pressure depth in the residual Doppler measurements of roughly 1-8 Hz (increasing upward), as filtered over a 134 sec window, are most plausibly interpreted as gravity waves, and imply a weak, but downward increasing static stability within the 5 - 20 bar region of Jupiter's atmosphere. A matched extension to deeper levels of an independent inertial stability constraint from the measured vertical wind shear at 1 - 4 bars is roughly consistent with a static stability of approximately 0.5 K/km near the 20 bar level, as independently detected by the probe Atmospheric Structure Instrument.

Allison, Michael↗

NASA NTRS1998

Differences in elasticity of vinculin-deficient F9 cells measured by magnetometry and atomic force microscopy

We have investigated a mouse F9 embryonic carcinoma cell line, in which both vinculin genes were inactivated by homologous recombination, that exhibits defective adhesion and spreading [Coll et al. (1995) Proc. Natl. Acad. Sci. USA 92, 9161-9165]. Using a magnetometer and RGD-coated magnetic microbeads, we measured the local effect of loss and replacement of vinculin on mechanical force transfer across integrins. Vinculin-deficient F9Vin(-/-) cells showed a 21% difference in relative stiffness compared to wild-type cells. This was restored to near wild-type levels after transfection and constitutive expression of increasing amounts of vinculin into F9Vin(-/-) cells. In contrast, the transfection of vinculin constructs deficient in amino acids 1-288 (containing the talin- and alpha-actinin-binding site) or substituting tyrosine for phenylalanine (phosphorylation site, amino acid 822) in F9Vin(-/-) cells resulted in partial restoration of stiffness. Using atomic force microscopy to map the relative elasticity of entire F9 cells by 128 x 128 (n = 16,384) force scans, we observed a correlation with magnetometer measurements. These findings suggest that vinculin may promote cell adhesions and spreading by stabilizing focal adhesions and transferring mechanical stresses that drive cytoskeletal remodeling, thereby affecting the elastic properties of the cell.

Non-NASA Center↗

NASA NTRS2008

Rapid Ice Mass Loss: Does It Have an Influence on Earthquake Occurrence in Southern Alaska?

The glaciers of southern Alaska are extensive, and many of them have undergone gigatons of ice wastage on time scales on the order of the seismic cycle. Since the ice loss occurs directly above a shallow main thrust zone associated with subduction of the Pacific-Yakutat plate beneath continental Alaska, the region between the Malaspina and Bering Glaciers is an excellent test site for evaluating the importance of recent ice wastage on earthquake faulting potential. We demonstrate the influence of cumulative glacial mass loss following the 1899 Yakataga earthquake (M=8.1) by using a two dimensional finite element model with a simple representation of ice fluctuations to calculate the incremental stresses and change in the fault stability margin (FSM) along the main thrust zone (MTZ) and on the surface. Along the MTZ, our results indicate a decrease in FSM between 1899 and the 1979 St. Elias earthquake (M=7.4) of 0.2 - 1.2 MPa over an 80 km region between the coast and the 1979 aftershock zone; at the surface, the estimated FSM was larger but more localized to the lower reaches of glacial ablation zones. The ice-induced stresses were large enough, in theory, to promote the occurrence of shallow thrust earthquakes. To empirically test the influence of short-term ice fluctuations on fault stability, we compared the seismic rate from a reference background time period (1988-1992) against other time periods (1993-2006) with variable ice or tectonic change characteristics. We found that the frequency of small tectonic events in the Icy Bay region increased in 2002-2006 relative to the background seismic rate. We hypothesize that this was due to a significant increase in the rate of ice wastage in 2002-2006 instead of the M=7.9, 2002 Denali earthquake, located more than 100km away.

Sauber, Jeanne M.↗

NASA NTRS1992

Origin of metallic Fe-Ni in Renazzo and related chondrites

To assess the formation of metallic Fe-Ni in Renazzo and related chondrites, Ni and Co zoning profiles in metallic Fe-Ni are determined from different petrographic sites (chondrule interiors, chondrule margins, chondrule rims, and matrix) in Renazzo, Al Rais, and the related chondrite, MacAlpine Hills 87320. Metal from chondrule interiors shows flat Ni and Co concentrations and profiles, moderately large grain-to-grain compositional variations (even with chondrules), and generally high Ni and Co. Nickel concentrations extend above the kamacite stability limit; etching such 'martensite' shows high-Ni domains in some cases, but observed Ni concentrations do not exceed 190 mg/g. Metal from chondrule margins adjacent to matrix shows convex Ni and Co zoning profiles; the highest Ni and Co concentrations are at grain centers, although the mean central Ni and Co concentrations in margin grains are much lower than those from chondrule interiors; the remainder are convex. The low Co and Ni contents at the edge of grains in chondrule margins are interpreted to reflect dilution by Fe produced by FeO reduction.

Lee, Min S.↗