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At least 253 records · Page 14

Pharmaceutical Product Development: Intranasal Scopolamine (INSCOP) Metered Dose Spray

Motion sickness (MS) has been a problem associated with space flight, the modern military and commercial air and water transportation for many years. Clinical studies have shown that scopolamine is the most effective medication for the prevention of motion sickness (Dornhoffer et al, 2004); however, the two most common methods of administration (transdermal and oral) have performance limitations that compromise its utility. Intranasal administration offers a noninvasive treatment modality, and has been shown to counter many of the problems associated with oral and transdermal administration. With the elimination of the first pass effect by the liver, intranasal delivery achieves higher and more reliable bioavailability than an equivalent oral dose. This allows for the potential of enhanced efficacy at a reduced dose, thus minimizing the occurrence of untoward side effects. An Intranasal scopolamine (INSCOP) gel formulation was prepared and tested in four ground-based clinical trials under an active Investigational New Drug (IND) application with the Food and Drug Administration (FDA). Although there were early indicators that the intranasal gel formulation was effective, there were aspects of formulation viscosity and the delivery system that were less desirable. The INSCOP gel formulation has since been reformulated into an aqueous spray dosage form packaged in a precise, metered dose delivery system; thereby enhancing dose uniformity, increased user satisfaction and palatability, and a potentially more rapid onset of action. Recent reports of new therapeutic indications for scopolamine has prompted a wide spread interest in new scopolamine dosage forms. The novel dosage form and delivery system of INSCOP spray shows promise as an effective treatment for motion sickness targeted at the armed forces, spaceflight, and commercial sea, air, and space travel markets, as well as prospective psychotherapy for mental and emotional disorders.

Putcha, Lakshmi↗

Remote measurement of ocean temperature from depolarization in Raman scattering

Ocean temperatures may be mapped in three dimensions from an aircraft down to depths of 2 to 4 attenuation lengths by monitoring Raman radiation backscattered from a laser beam. This paper describes laboratory experiments on the temperature dependence of Raman spectra of saline solutions and calculations of the expected performance of a field system. The Raman technique is of greatest potential utility in coastal and estuarine waters where gradients are relatively high. It is estimated that seawater temperature may be measured to a statistical precision of 0.5 C at depths to four attenuation lengths in two meter water, using one Joule of transmitted laser energy.

Chang, C. H.↗

Tethered balloon-based measurements of meteorological variables and aerosols

Tethered balloon based measurements of the vertical distributions of temperature, humidity, wind speed, and aerosol concentrations were taken over a 4-hour period beginning at sunrise on June 29, 1976, at Wallops Island, Virginia. Twelve consecutive profiles of each variable were obtained from ground to about 500 meters. These measurements were in conjuction with a noise propagation study on remotely arrayed acoustic range (ROMAAR) at Wallops Flight Center. An organized listing of these vertical soundings is presented. The tethered balloon system configuration utilized for these measurements is described.

Sentell, R. J.↗

An evaluation of three experimental processes for two-dimensional transonic tests

The aerodynamic measurements in conventional wind tunnels usually suffer from the interference effects of the sting supporting the model and the test section walls. These effects are particularly severe in the transonic regime. Sting interference effects can be overcome through the Magnetic Suspension technique. Wall effects can be alleviated by: testing airfoils in conventional, ventilated tunnels at relatively small model to tunnel size ratios; treatment of the tunnel wall boundary layers; or by utilization of the Adaptive Wall Test Section (AWTS) concept. The operating capabilities and results from two of the foremost two-dimensional, transonic, AWTS facilities in existence are assessed. These facilities are the NASA 0.3-Meter Transonic Cryogenic Tunnel and the ONERA T-2 facility located in Toulouse, France. In addition, the results derived from the well known conventional facility, the NAE 5 ft x 5 ft Canadian wind tunnel will be assessed. CAST10/D0A2 Airfoil results will be used in all of the evaluations.

Zuppardi, Gennaro↗

Design for an 8 Meter Monolithic UV/OIR Space Telescope

ATLAST-8 is an 8-meter monolithic UV/optical/NIR space observatory to be placed in orbit at Sun-Earth L2 by NASA's planned Ares V cargo launch vehicle. The ATLAST-8 will yield fundamental astronomical breakthroughs. The mission concept utilizes two enabling technologies: planned Ares-V launch vehicle (scheduled for 2019) and autonomous rendezvous and docking (AR&D). The unprecedented Ares-V payload and mass capacity enables the use of a massive, monolithic, thin-meniscus primary mirror - similar to a VLT or Subaru. Furthermore, it enables simple robust design rules to mitigate cost, schedule and performance risk. AR&D enables on-orbit servicing, extending mission life and enhancing science return.

Stahl, H. Philip↗

Low SWaP Onboard Satellite Navigation, Guidance, and Control Technology

Onboard autonomy is a necessity for responsive space operations. Autonomous navigation, guidance, and control (NGC) enables space missions to reduce their dependence on high demand ground assets and costly ground personnel. It also allows for in-situ decision making and higher return on mission data. A flight software and hardware system providing this capability, called “autoNGC,” is currently being developed at NASA Goddard Space Flight Center for infusion into multiple future missions. The first build of autoNGC, providing autonomous navigation for lunar orbiting spacecraft, is targeted for completion by Fall 2024. It provides sensor fusion of multiple measurement types including pseudo-range from a weak signal Global Navigation Satellite Service (GNSS) receiver, 1-way and 2-way direct to Earth (DTE) range and Doppler, bearing and range from optical camera sensed images, and an accelerometer. AutoNGC is also being targeted for future missions that involve small body proximity operations, Sun Earth Libration point orbits, and distributed systems missions (DSMs) including those at outer planets. AutoNGC flight software is being built upon the plug-and-play architecture of the core Flight System (cFS) [Ref. 1]. Figure (Slide 7) shows the message-based software bus layout of various software applications (“apps”) consisting of the standard cFS apps and autoNGC interface apps and libraries. Accurate onboard navigation and timing is obtained through the Goddard Enhanced Onboard Navigation System (GEONS) software library [Ref. 2], which fuses different measurement types through an extended Kalman filter (EKF) framework. Optical measurements that are ingested in GEONS are provided by the cFS Goddard Image Analysis and Navigation Tool (cGIANT) app [Ref. 3]. This app processes optical images to extract the bearing angles of the centroid of the imaged body (near or far), the range to the imaged body, and/or of the features on the surface of a body to perform terrain relative navigation (TRN). Measurement of range to the body’s center of mass can also be derived from the detection of the limb. The first build of autoNGC for a lunar orbiting spacecraft is a minimal size, weight, and power (SWaP) hardware design allowing for inclusion into CubeSats and SmallSat-size class buses. Advancements in miniaturized space processors, such as the SpaceCube 3.0 Mini and the SpaceCube Mini-Z [Ref. 4] are utilized for low SWaP while maintaining a high level of performance. Figure (Slide 11) shows the composition of the first autoNGC build. The current enclosure design has dimensions 12 cm x 17 cm x 13.5 cm. The box mass is expected to be less than 2 kg, and the nominal power is 21 W. The hardware interfaces are designed for flexibility with a variety of sensor inputs. The achievable navigation performance depends on the sensors utilized, including the onboard clock for 1-way pseudo-range measurements. Analysis using a configuration that consists of weak signal GPS, TRN, and 1-way DTE has shown position and velocity accuracies of 10 meters and 2 cm/s (3-σ ) RSS, respectively, with onboard time knowledge estimated to better than 13 ns (3-σ ), for a spacecraft in a representative 12-hour eccentric lunar orbit. Other measurement types such as x-rays from known pulsars (called XNAV) and cross-links can also be processed in GEONS. With the plug-and-play architecture of autoNGC, cFS apps can easily be added and replaced, even after launch. Goddard is actively seeking partners to collaborate in the development of additional capabilities for autoNGC, including industry, academia, and others across the US Government. Plans are being formulated to make the autoNGC software platform available for use by any US government organization to leverage the non-recurring engineering associated with the development of onboard autonomous NGC 3 capabilities. As advancements in space qualified sensors, microprocessors, and algorithms are made, the autoNGC platform provides a ready starting point for inclusion of these technologies.

C. J. Gramling↗

Thermal static bending of deployable interlocked booms

Metal ribbons processed with a heat-forming treatment are enabled to form tubelike structures when deployed from a roll. Deployable booms of this have been utilized for gravity-gradient stabilization on the RAE, ATS, and Nimbus D satellites. An experimental thermal-mechanics test apparatus was developed to measure the thermal static bending and twist of booms up to 3 meters long. The apparatus was calibrated by using the correlation between calculated and observed thermal bending of a seamless tube. Thermal static bending values of 16 interlocked deployable booms were observed to be within a factor of 2.5 of the values calculated from seamless-tube theory. Out-of-Sun-plane thermal bending was caused by complex heat transfer across the interlocked seam. Significant thermal static twisting was not observed.

Staugaitis, C. L.↗

Heat Transfer in High-Temperature Fibrous Insulation

The combined radiation/conduction heat transfer in high-porosity, high-temperature fibrous insulations was investigated experimentally and numerically. The effective thermal conductivity of fibrous insulation samples was measured over the temperature range of 300-1300 K and environmental pressure range of 1.33 x 10(exp -5)-101.32 kPa. The fibrous insulation samples tested had nominal densities of 24, 48, and 72 kilograms per cubic meter and thicknesses of 13.3, 26.6 and 39.9 millimeters. Seven samples were tested such that the applied heat flux vector was aligned with local gravity vector to eliminate natural convection as a mode of heat transfer. Two samples were tested with reverse orientation to investigate natural convection effects. It was determined that for the fibrous insulation densities and thicknesses investigated no heat transfer takes place through natural convection. A finite volume numerical model was developed to solve the governing combined radiation and conduction heat transfer equations. Various methods of modeling the gas/solid conduction interaction in fibrous insulations were investigated. The radiation heat transfer was modeled using the modified two-flux approximation assuming anisotropic scattering and gray medium. A genetic-algorithm based parameter estimation technique was utilized with this model to determine the relevant radiative properties of the fibrous insulation over the temperature range of 300-1300 K. The parameter estimation was performed by least square minimization of the difference between measured and predicted values of effective thermal conductivity at a density of 24 kilograms per cubic meters and at nominal pressures of 1.33 x 10(exp -4) and 99.98 kPa. The numerical model was validated by comparison with steady-state effective thermal conductivity measurements at other densities and pressures. The numerical model was also validated by comparison with a transient thermal test simulating reentry aerodynamic heating conditions.

Daryabeigi, Kamran↗

Resource Prospector Instrumentation for Lunar Volatiles Prospecting, Sample Acquisition and Processing

Data gathered from lunar missions within the last two decades have significantly enhanced our understanding of the volatile resources available on the lunar surface, specifically focusing on the polar regions. Several orbiting missions such as Clementine and Lunar Prospector have suggested the presence of volatile ices and enhanced hydrogen concentrations in the permanently shadowed regions of the moon. The Lunar Crater Observation and Sensing Satellite (LCROSS) mission was the first to provide direct measurement of water ice in a permanently shadowed region. These missions with other orbiting assets have laid the groundwork for the next step in the exploration of the lunar surface; providing ground truth data of the volatiles by mapping the distribution and processing lunar regolith for resource extraction. This next step is the robotic mission Resource Prospector (RP).Resource Prospector is a lunar mission to investigate strategic knowledge gaps (SKGs) for in-situ resource utilization (ISRU). The mission is proposed to land in the lunar south pole near a permanently shadowed crater. The landing site will be determined by the science team with input from broader international community as being near traversable landscape that has a high potential of containing elevated concentrations of volatiles such as water while maximizing mission duration. A rover will host the Regolith Environment Science and Oxygen Lunar Volatile Extraction (RESOLVE) payload for resource mapping and processing. The science instruments on the payload include a 1-meter drill, neutron spectrometer, a near infrared spectrometer, an operations camera, and a reactor with a gas chromatograph-mass spectrometer for volatile analysis.

Lunar Crater↗

Results of the long range position-determining system tests

The long range position-determining system (LRPDS) has been developed by the Corps of Engineers to provide the Field Army with a rapid and accurate positioning capability. The LRPDS consists of an airborne reference position set (RPS), up to 30 ground based positioning sets (PS), and a position computing central (PCC). The PCC calculates the position of each PS based on the range change information provided by each Set. The positions can be relayed back to the PS again via RPS. Each PS unit contains a double oven precise crystal oscillator. The RPS contains a Hewlett-Packard cesium beam standard. Frequency drifts and off-sets of the crystal oscillators are taken in account in the data reduction process. A field test program was initiated in November 1972. A total of 54 flights were made which included six flights for equipment testing and 48 flights utilizing the field test data reduction program. The four general types of PS layouts used were: short range; medium range; long range; tactical configuration. The overall RMS radial error of the unknown positions varied from about 2.3 meters for the short range to about 15 meters for the long range. The corresponding elevation RMS errors vary from about 12 meters to 37 meters.

Rhode, F. W.↗

The Mission Oriented Terminal Area Simulation (MOTAS)

A new simulation facility is described in which flight management and flight operations research studies can be conducted in a highly realistic terminal area environment. The historical evolution and justification of the facility is discussed, along with the design configuration of the system hardware and software. Details are provided on the traffic management features of the terminal area model as well as the human controller and multicockpit interface capabilities. The facility is currently operational with two cockpit simulators, two air traffic control (ATC) stations, four pseudo pilot stations (PPS), a metering and spacing system of traffic flow control management, and terminal area models providing two route structure environments: area navigation (RNAV) for advanced-equipped aircraft and vectoring for conventionally-equipped aircraft. Plans for future experiments utilizing the facility are discussed.

Naftel, P. B.↗

PING Gamma Ray and Neutron Measurements of a Meter-Sized Carbonaceous Asteroid Analog

Determining the elemental composition of carbonaceous (spectral type C) asteroids is still one of the basic problems when studying these objects. The only main source of elemental composition information for asteroids is from their optical, NIR and IR properties, which include their spectral reflectance characteristics, albedo, polarization, and the comparison of optical spectroscopy with meteorite groups corresponding to asteroids of every spectral type. Unfortunately, these sources reflect observations from widely contrasting spatial scales that presently yield a void in the continuum of microscopic and macroscopic evidence, a lack of in situ measurement confirmation, and require deeper sensing techniques to discern the nature of these asteroids. The Probing In situ with Neutrons and Gamma rays (PING) instrument is ideally suited to address this problem because it can be used to determine the bulk elemental composition, H and C content, the average atomic weight and density of the surface and subsurface layers of C-type asteroids, and can provide measurements used to determine the difference between and distinguish between different types of asteroids. We are currently developing the PING instrument that combines gamma ray and neutron detectors with a 14 Me V pulsed neutron generator to determine the in-situ bulk elemental abundances and geochemistry of C-type asteroids with a spatial resolution of 1 m down to depths of tens of cm to 1 m. One aspect of the current work includes experimentally testing and optimizing PING on a known meter-sized Columbia River basalt C-type asteroid analog sample that has a similar composition and the same neutron response as that of a C-type asteroid. An important part of this effort focuses on utilizing timing measurements to isolate gamma rays produced by neutron inelastic scattering, neutron capture and delayed activation processes. Separating the gamma ray spectra by nuclear processes results in higher precision and sensitivity elemental composition measurements. Using gated data acquisition techniques allows for the unambiguous identification of gamma ray lines from different isotopes and nuclear processes, especially in situations when limited detector resolution results in overlapping gamma ray lines that cannot be individually resolved. In this paper, we will present the PING basalt layering experimental data, taken at the test facility at NASA Goddard Space Flight Center using the time tagged event-by-event data analysis technique, compared to our MCNPX computer simulation results for the C-type asteroid and basalt layering simulant models. Comparison of these data will show the advantages, validity, and measurement sensitivity of PING's nuclear interrogation methods to obtain more precise and sensitive in situ bulk elemental composition and density measurements of the subsurface of asteroids.

Bodnarik, J.↗

Multi-Channel Correlator Array-Fed Microwave Radiometer

Multiband passive microwave imagery in X to W Bands has a nearly 40-year history of utilization for measurement of multiple geophysical parameters (e.g., precipitation rate, ocean surface wind speed, sea ice concentration, and land surface temperature). Spatial resolution is limited by aperture size, and although aperture sizes have grown to 1-2 meters, current capability will not meet future spatial resolution needs. As aperture size increases, new antenna feed techniques are needed to maintain contiguous coverage and obtain Nyquist sampling. Here we apply the correlator array fed radiometer architecture adapted from radio astronomy and show how it can meet emerging needs. Simulation results of a 0.8-m, 36.5-GHz, array-fed reflector (equivalent to 20 meters at 1.41 GHz) show the feasibility of creating multiple over-lapping beams.

Microwave radiometer↗

Solar Array Disturbances to Spacecraft Pointing During the Lunar Reconnaissance Orbiter (LRO) Mission

The Lunar Reconnaissance Orbiter (LRO), the first spacecraft to support NASA s return to the Moon, launched on June 18, 2009 from the Cape Canaveral Air Force Station aboard an Atlas V launch vehicle. It was initially inserted into a direct trans-lunar trajectory to the Moon. After a five day transit to the Moon, LRO was inserted into the Lunar orbit and successfully lowered to a low altitude elliptical polar orbit for spacecraft commissioning. Successful commissioning was completed in October 2009 when LRO was placed in its near circular mission orbit with an approximate altitude of 50km. LRO will spend at least one year orbiting the Moon, collecting lunar environment science and mapping data, utilizing a suite of seven instruments to enable future human exploration. The objective is to provide key science data necessary to facilitate human return to the Moon as well as identification of opportunities for future science missions. LRO's instrument suite will provide the high resolution imaging data with sub-meter accuracy, highly accurate lunar cartographic maps, mineralogy mapping, amongst other science data of interest. LRO employs a 3-axis stabilized attitude control system (ACS) whose primary control mode, the "Observing Mode", provides Lunar nadir, off-nadir, and inertial fine pointing for the science data collection and instrument calibration. This controller combines the capability of fine pointing with on-demand large angle full-sky attitude reorientation. It provides simplicity of spacecraft operation as well as additional flexibility for science data collection. A conventional suite of ACS components is employed in the Observing Mode to meet the pointing and control objectives. Actuation is provided by a set of four reaction wheels developed in-house at NASA Goddard Space Flight Center (GSFC). Attitude feedback is provided by a six state Kalman filter which utilizes two SELEX Galileo Star Trackers for attitude updates, and a single Honeywell Miniature Inertial Measurement Unit (MIMU) to provide body rates for attitude propagation. Rate is computed by differentiating accumulated angle provided by the MIMU. The Observing Mode controller is required to maintain fine pointing while a large fully-articulated solar array (SA) maintains its panel normal to the solar incidence. This paper describes the disturbances to the attitude control resulting from the SA articulation. Observing Mode performance in the presence of this disturbance was assessed while the spacecraft was in an initial elliptical low altitude orbit during the commissioning phase, which started about two weeks after launch and lasted for 90 days. LRO demonstrated excellent pointing performance during Observing Mode nadir and inertial attitude target operations during this phase. Transient LRO attitude errors observed during commissioning resulted primarily from three sources, Diviner instrument calibrations, RW zero crossings, and SA articulation. Even during times of considerable disturbance from SA articulation, the attitude errors were maintained below the statistical attitude error requirement level of 15 arc-sec (3 sigma).

Calhoun, Philip↗

NASA's Orbital Debris Optical and IR Ground-Based Observing Program Utilizing the MCAT, UKIRT, and Magellan Telescopes

Characterizing debris in Earth-orbit has become increasingly important as the population growth rises steadily, posing greater and greater threats to active satellites with each passing year. Currently, the Joint Space Operations is tracking over 23,000 pieces of debris, ranging in size from 1-meter and larger in geosychronous orbits (GEO) to 10-cm and larger at low-Earth orbits (LEO). Model estimates suggest that there may be more than 500,000 pieces of spacecraft debris larger than 1 cm currently in orbit around the Earth. With such a small fraction of the total population being tracked, and new break-ups occurring in LEO, GEO, and Geo Transfer Orbits, new assets, techniques, and approaches for characterizing this debris are needed. With this in mind, NASA's Orbital Debris Program Office has actively tasked a suite of telescopes around the world. In 2015, the newly-built 1.3m optical Meter Class Autonomous Telescope (MCAT) came on-line on Ascension Island in the South Atlantic Ocean and is currently in its commissioning phase. MCAT is designed to track Earth-orbiting objects above 200km, conduct surveys at GEO, and work in tandem with a newly-installed Raven-class commercial-off-the-shelf system, a 0.4-meter telescope co-located on Ascension with a field-of-view similar to MCAT's and research-grade instrumentation designed to complement MCAT for observations taken either simultaneously or in tandem. The 3.8m infrared UKIRT telescope on Mauna Kea, Hawaii, has been heavily tasked throughout 2015 and into 2016, collecting data on individual targets as well as in survey modes to study both the general GEO population as well as an individual break-up event of a BRIZ-M Rocket body that occurred in January 2016. Data collected include photometry and spectroscopy in the near-Infrared (0.85-2.5 m) and the mid-infrared (8-16 m). Finally, the 6.5-m Baade Magellan telescope at Las Campanas Observatory in Chile was used to collect optical photometric survey data in October 2015 of two GEO Titan breakups, focusing on locations of possible debris concentrations as indicated by the NASA standard break-up model.

Lederer, Susan↗

Precision Landing and Hazard Avoidance Doman

The Precision Landing and Hazard Avoidance (PL&HA) domain addresses the development, integration, testing, and spaceflight infusion of sensing, processing, and GN&C functions critical to the success and safety of future human and robotic exploration missions. PL&HA sensors also have applications to other mission events, such as rendezvous and docking. Autonomous PL&HA builds upon the core GN&C capabilities developed to enable soft, controlled landings on the Moon, Mars, and other solar system bodies. Through the addition of a Terrain Relative Navigation (TRN) function, precision landing within tens of meters of a map-based target is possible. The addition of a 3-D terrain mapping lidar sensor improves the probability of a safe landing via autonomous, real-time Hazard Detection and Avoidance (HDA). PL&HA significantly improves the probability of mission success and enhances access to sites of scientific interest located in challenging terrain. PL&HA can also utilize external navigation aids, such as navigation satellites and surface beacons. Advanced Lidar Sensors High precision ranging, velocimetry, and 3-D terrain mapping Terrain Relative Navigation (TRN) TRN compares onboard reconnaissance data with real-time terrain imaging data to update the S/C position estimate Hazard Detection and Avoidance (HDA) Generates a high-resolution, 3-D terrain map in real-time during the approach trajectory to identify safe landing targets Inertial Navigation During Terminal Descent High precision surface relative sensors enable accurate inertial navigation during terminal descent and a tightly controlled touchdown within meters of the selected safe landing target.

Robertson, Edward A.↗

Meter-Scale 3-D Models of the Martian Surface from Combining MOC and MOLA Data

We have extended our previous efforts to derive through controlled photoclinometry, accurate, calibrated, high-resolution topographic models of the martian surface. The process involves combining MGS MOLA topographic profiles and MGS MOC Narrow Angle images. The earlier work utilized, along with a particular MOC NA image, the MOLA topographic profile that was acquired simultaneously, in order to derive photometric and scattering properties of the surface and atmosphere so as to force the low spatial frequencies of a one-dimensional MOC photoclinometric model to match the MOLA profile. Both that work and the new results reported here depend heavily on successful efforts to: 1) refine the radiometric calibration of MOC NA; 2) register the MOC to MOLA coordinate systems and refine the pointing; and 3) provide the ability to project into a common coordinate system, simultaneously acquired MOC and MOLA with a single set of SPICE kernels utilizing the USGS ISIS cartographic image processing tools. The approach described in this paper extends the MOC-MOLA integration and cross-calibration procedures from one-dimensional profiles to full two-dimensional photoclinometry and image simulations. Included are methods to account for low-frequency albedo variations within the scene.

Soderblom, Laurence A.↗

Infrared-temperature variability in a large agricultural field

The combined effect of water carved gullies, varying soil color, moisture state of the soil and crop, nonuniform phenology, and bare spots was measured for commercially grown barley planted on varying terrain. For all but the most rugged terrain, over 80% of the area within 4, 16, 65, and 259 ha cells was at temperatures within 3 C of the mean cell temperature. The result of using relatively small, 4 ha instantaneous field of views for remote sensing applications is that either the worst or the best of conditions is often observed. There appears to be no great advantage in utilizing a small instantaneous field of view instead of a large one for remote sensing of crop canopy temperatures. The two alternatives for design purposes are then either a very high spatial resolution, of the order of a meter or so, where the field is very accurately temperature mapped, or a low resolution, where the actual size seems to make little difference.

Millard, J. P.↗