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Due to the location and high dose required for disease control, pediatric chordomas are theoretically well-suited for treatment with proton therapy, but their low incidence limits the clinical outcome data available in the literature. We sought to report the efficacy and toxicity of proton therapy among a single-institution cohort.
We proposed a novel tool—a dose linear energy transfer (LET)-volume histogram (DLVH)—and performed an exploratory study to investigate rectal bleeding in prostate cancer treated with intensity modulated proton therapy.
We have characterized the structural quality of Cd 0.9 Zn 0.1 Te 0.93 Se 0.07 ingot grown by the vertical Bridgman growth technique. The structural quality of Cd 0.9 Zn 0.1 Te 0.93 Se 0.07 ingot along the length was investigated via X-ray topography in the reflection mode using a white beam synchrotron radiation source. The X-ray topography data revealed the presence of very few sub grain boundaries and no sub-grain boundary network for the CdZnTeSe samples used in this study.
Prior to every ion implantation experiment a simulation of the ion range and other relevant parameters is performed using Monte-Carlo based codes. Although increasing computing power has improved the speed of these calculations, the demands on Monte-Carlo codes are also increasing, requiring evaluation of the optimal number of simulations while ensuring accuracy within threshold bounds. We evaluate the “Stopping and Range of Ions in Matter” (SRIM) code due to its widespread usage. We show how dividing simulations into multiple parallel simulations with different random seeds can lead to calculation speedup and find lower bounds for the required number of ion traces simulated based on an exemplar system of a Ga focused ion beam and a high energy C beam as used in high linear energy transfer testing. Here our results indicate simulations can yield results within the underlying data accuracy of SRIM at 10X and 100X shorter simulation time than the SRIM default values.
Abstract Ionizing radiations encountered by astronauts on deep space missions produce biological damage by two main mechanisms: (1) Targeted effects (TE) due to direct traversals of cells by ionizing tracks. (2) Non-targeted effects (NTE) caused by release of signals from directly hit cells. The combination of these mechanisms generates non-linear dose response shapes, which need to be modeled quantitatively to predict health risks from space exploration. Here we used a TE + NTE model to analyze data on APC (1638N/+) mouse tumorigenesis induced by space-relevant doses of protons, 4 He, 12 C, 16 O, 28 Si or 56 Fe ions, or γ rays. A customized weighted Negative Binomial distribution was used to describe the radiation type- and dose-dependent data variability. This approach allowed detailed quantification of dose–response shapes, NTE- and TE-related model parameters, and radiation quality metrics (relative biological effectiveness, RBE, and radiation effects ratio, RER, relative to γ rays) for each radiation type. Based on the modeled responses for each radiation type, we predicted the tumor yield for a Mars-mission-relevant mixture of these radiations, using the recently-developed incremental effect additivity (IEA) synergy theory. The proposed modeling approach can enhance current knowledge about quantification of space radiation quality effects, dose response shapes, and ultimately the health risks for astronauts.
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A low-power proton beam capability in Area-A will support NNSA, LANL, Global Security, DoD, and Office of Science missions. It will also provide a stepping-stone towards other future uses of Area-A. We propose a cost-effective technical approach to achieve this goal. The main focus of this project will be to provide beam for a radiation effect beamline and a second pRad beamline.
Development of novel high-entropy alloys (HEAs) is currently underway for potential use as beam windows in future multi-megawatt target systems at Fermilab. HEAs encompass a new class of materials with a vast design space allowing for material properties to be tailored for particular applications and to potentially offer improved resistance to beam-induced radiation damage and thermal shock effects. The alloy systems being studied consist of several compositions of AlCoCrMnTiV with 4 6 component elements. These alloys are all predicted by CALPHAD simulation to have a single-phase BCC crystal structure and low density, with some compositions displaying ordered, nanoscale precipitates. This presentation will briefly discuss alloy design and synthesis before giving a detailed description of the characterization studies of these HEAs in both the pristine state and post-irradiation by low-energy heavy ions to high damage levels. Electron microscopy techniques to quantify elemental homogeneity and composition, determine grain size, shape, and orientation, and quantify lattice parameters, defect structures and precipitate phases are all being used to study alloy microstructures. Mechanical properties of the alloys at the microscale will be reported. The evolution of these properties as a function of radiation damage will also be described. Bulk thermal characteristics of these HEAs have been tested to measure specific heat capacity and coefficient of thermal expansion as a function of temperature. To determine bulk tensile properties a miniature tensile testing apparatus is under development; it s commissioning will be covered briefly. The talk will conclude with our plans for alloy down-selection.
Alpha particle and proton beams in radiation therapy of pituitary gland tumors and adenoma
Tissue dosages from alpha particles and heavy nuclei in solar particle beams in space
Local turbulent properties of shear layer derived from covariance of two crossed perpendicular beams of radiation
Resolution and geometrical factor determination for isotropic proton fluxes by using pencil beam and measurements over many angles and positions
A review is presented of the instrumentation used for the measurement of optical polarization from aircraft, balloon, rocket, satellite, and spacecraft platforms. The four parameters which can be measured at a given wavelength, time, and direction in an incoherent beam of radiation include intensity, linear polarization, its position angle, and circular polarization. An instrument that by design is made sensitive to any of the three polarization parameters is considered a polarimeter. Attention is given to passive polarimeters operating in the range from 0.1 to 1000 micrometers. All known optical space polarimeters are listed in a table. Questions of instrument operation in space are discussed along with details of polarization analysis, aspects of accuracy and calibration, and the scientific studies conducted with the polarimeters.
The measured and calculated results from determining the operating efficiencies of a laboratory version of a system for transporting electric power from one point to another via a wireless free space radiated microwave beam are reported. The system's overall end-to-end efficiency as well as intermediated conversion efficiencies were measured. The maximum achieved end-to-end dc-to-ac system efficiency was 54.18% with a probable error of + or - 0.94%. The dc-to-RF conversion efficiency was measured to be 68.87% + or - 1.0% and the RF-to-dc conversion efficiency was 78.67 + or - 1.1%. Under these conditions a dc power of 495.62 + or - 3.57 W was received with a free space transmitter antenna receiver antenna separation of 170.2 cm (67 in).
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The period-pulse-width (P-W) distribution of sample of 41 pulsars has been reanalyzed under two versions of a model where radiation is beamed from magnetic polar caps which are isotropically oriented with respect to the rotation axis of the neutron stars (IOPC models). It is found that neither IOPC model can explain the P-W distribution of the entire sample. Pulsars with simple unimodal (U) or complicated multimodal (M) pulse shapes show significantly different P-W distributions. Class M pulsars have a narrower P-W distribution than do class U pulsars and, taken separately, are compatible with either IOPC model. Class U pulsars divide into two subgroups, those with relatively narrower pulses (UN) and those with relatively wider pulses (UW), each of which is compatible with either IOPC model. One interpretation of these results is that the pulsars in classes UN, M, and UW have different intrinsic beam sizes, roughly in the ratios 1:2:4, respectively. The possible origins of the three classes are discussed in terms of the force-balance magnetosphere model (Roberts et al., 1972, 1973), where the differences may be attributed to different-mass neutron stars and the structure of the polar caps. An alternative interpretation is that the angle between the rotation and emission axes is not isotropically distributed, but can take only certain preferred values.
A theory of the Io-independent decameter radiation is developed. The radiation results from excitation of the electromagnetic loss-cone instability by keV electrons, stably trapped near L = 6. The radiation is excited in Band 3 of the extraordinary mode. When the effects of refraction are estimated, it is shown that above 10 MHz radiation is beamed into the equatorial plane in a wide, but thin, conical sheet (Psi approximately equals 80 degrees). When the instability analysis is coupled with one of the octupole models of the Jovian magnetic field, the maximum convective growth of the instability occurs in the directions of the non-Io A, B, and C sources. The shape of the peak radio flux frequency spectrum is found to be a consequence of the loss cone shape of the electron distribution function.