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At least 271 records · Page 15

Abstract for CRADA between National Energy Technology Laboratory and Blacksand Technology, LLC

The National Energy Technology Laboratory (NETL) and Black Sand Technology, LLC (Participant) will collaborate in the optimization of low-cost manufacturing routes to produce ultralow-oxygen reactive metal powders of M=Ti, Zr, and Nb using Mg or Ca as reduction agents. Reactive metals have a strong chemical affinity to oxygen, making it very challenging to produce high-purity metal powders of these elements with extremely low oxygen content. This project integrates multiscale modeling and experimental validation to provide fundamental understanding of the thermodynamic limits on the deoxygenation process through HDH and optimize the key deoxygenation parameters to achieve ultralow oxygen content ≤0.1 wt.% in the reactive metal powders. The collaboration will significantly expedite the optimization of deoxygenation processes, reducing the timeline for refining deoxygenation techniques for Ti, Zr and Nb and other reactive refractory metals by about 0.5 and 2 years, respectively. This accelerated timeline translates to substantial cost savings estimated at $\$$3 million in research and development expenditures.

36 MATERIALS SCIENCE↗

Open Innovation for a NASA Architecture Library

NASA’s Center of Excellence for Collaborative Innovation (CoECI) uses open innovation, or “crowdsourcing”, to access the global public to find ideas, concepts, designs, or solutions that meet a previously unmet need possibly resulting in significant advances in performance. The Center of Excellence for Collaborative Innovation was launched at the request of the White House Office of Science and Technology Policy. This is both a non-traditional method of innovation and a non-traditional method of outreach to the public to involve them in space technologies and programs. It has been used often for software development and new hardware technology. In this case we applied it to innovate with systems engineering tools for creating space architectures. The challenge was sponsored by NASA Engineering and Safety Center Systems Engineering Technical Fellow as part of a program for NASA’s adoption of MBSE. It was a trial to see if there would be as much participation or quality submissions with this more specialized topic and skill. The challenge sought space architecture representations and decompositions to create a library of modeled parts in a system modeling language (SysML). Mission architects mostly start from scratch to build model elements representing the functional and physical architecture of a system in SysML. There are a few beginning libraries, but these are also local to a program or group. A common library will save system engineers a large amount of time, will allow project stakeholders to recognize common graphics and quickly understand the architecture options. The challenge was promoted internationally, especially through professional organizations and universities with a systems engineering focus. It was open for 4 months, purposefully over the winter holiday break time to allow participants extra time outside of work or school. The challenge was designed so that expertise in space hardware was not necessary but getting to play with models of space architecture could provide motivation to participate. We did not receive as many entries as other broader outreach challenges, but the ones we received were extremely thorough and high quality. Solutions came from individuals and teams, students and professional consultants from the United States and Europe. We learned a few lessons about how to engage with the public and what characteristics of a problem result in good crowdsourcing results. The outreach challenge produced several useful ideas and modeled space elements, and the group will be engaging the winners to learn more about their new approaches.

innovation↗

Abstract for CRADA between NETL and the AZ Board of Regents on behalf of Arizona State University

Arizona State University (ASU) and the National Energy Technology Laboratory (NETL) will collaborate on the development and scale up of sorbent composites that efficiently capture carbon dioxide (CO 2 ) directly from air under an awarded project from the Department of Energy’s Direct Air Capture (DAC) Pre-Commercialization Technology Prize. For DAC to be considered a viable technology for decarbonization, the cost of carbon removal needs to decrease below the proposed carbon tax incentive outlined in the recent Inflation Reduction Act (IRA) (Section 45 Q), which is set at $\$$180 per ton of CO 2 . Achieving this goal requires the development of a cost-effective, environmentally friendly sorbent with high CO 2 sorption capacity and efficient kinetics under DAC conditions as the overall cost of CO 2 captured is highly sensitive to factors such as sorbent cost and sorbent lifetime. ASU has developed a sorbent technology that can potentially reduce CO 2 removal costs by DAC. NETL has expertise in DAC TEA and LCA development and DAC sorbent testing. The collaboration between ASU and NETL aims to accelerate development and deployment of ASU’s technology by quantifying the performance, cost and lifecycle impacts of ASU’s technology and validating sorbent performance.

54 ENVIRONMENTAL SCIENCES↗

HIFIRE Flight 2 Overview and Status Update 2011

A collaborative international effort, the Hypersonic International Flight Research Experimentation (HIFiRE) Program aims to study basic hypersonic phenomena through flight experimentation. HIFiRE Flight 2 teams the United States Air Force Research Lab (AFRL), NASA, and the Australian Defence Science and Technology Organisation (DSTO). Flight 2 will develop an alternative test technique for acquiring high enthalpy scramjet flight test data, allowing exploration of accelerating hydrocarbon-fueled scramjet performance and dual-to-scram mode transition up to and beyond Mach 8 flight. The generic scramjet flowpath is research quality and the test fuel is a simple surrogate for an endothermically cracked liquid hydrocarbon fuel. HIFiRE Flight 2 will be a first of its kind in contribution to scramjets. The HIFiRE program builds upon the HyShot and HYCAUSE programs and aims to leverage the low-cost flight test technique developed in those programs. It will explore suppressed trajectories of a sounding rocket propelled test article and their utility in studying ramjet-scramjet mode transition and flame extinction limits research. This paper describes the overall scramjet flight test experiment mission goals and objectives, flight test approach and strategy, ground test and analysis summary, development status and project schedule. A successful launch and operation will present to the scramjet community valuable flight test data in addition to a new tool, and vehicle, with which to explore high enthalpy scramjet technologies.

Jackson, Kevin R.↗

Community Extreme Tonnage User Service (CETUS): A 5000 Ton Open Research Facility in the United States

Large sample volume 5000 ton multi-anvil presses have contributed to the exploration of deep Earth and planetary interiors, synthesis of ultra-hard and other novel materials, and serve as a sample complement to pressure and temperature regimes already attainable by diamond anvil cell experiments. However, no such facility exists on the North American continent. We propose the establishment of an open user facility for COMPRES members and the entire research community, with the unique capability of a 5000 ton (or more) press, supported by a host of extant co-located experimental and analytical laboratories and research staff. We offer wide range of complementary and/or preparatory experimental options. Any required synthesis of materials or follow up experiments can be carried out controlled atmosphere furnaces, piston cylinders, multi-anvil, or experimental impact apparatus. Additionally, our division houses two machine shops that would facilitate any modification or custom work necessary for development of CETUS, one for general fabrication and one located specifically within our experimental facilities. We also have a general sample preparation laboratory, specifically for experimental samples, that allows users to quickly and easily prepare samples for ebeam analyses and more. A service we can offer to COMPRES community members in general, and CETUS visiting users specifically, is a multitude of analytical instrumentation literally steps away from the experimental laboratories. This year we will be pursuing site funding of our laboratories through NASA's Planetary Science Directorate, which should result in substantial cost savings to all visiting users, and supports our mission of interagency cooperation for the enhancement of science for all (see companion PSAMS abstract). The PI is in a unique position as an employee of Jacobs Technology to draw funding from multiple sources, including those from industry and commerce. We submitted a Planetary Major Equipment proposal to the NASA Emerging Worlds solicitation for the full cost of a press, with competitive bids submitted from Sumitomo, Rockland Research, and Voggenreiter. Additional funding is currently being sought from industry sources through the Strategic Partnerships Office at NASA JSC, External Pursuits Program Office on the JETS contract, and Jacobs corporate in the United States. Internal funding is available for JETS contract personnel to travel to large press locations worldwide to study set-up and operations. We also anticipate a fortuitous cost savings in installation of the large press because plans are already underway for major renovations to the entire experimental petrology suite within the next 2 years in order to accommodate our growing user base. Our focus as contract staff is on serving the scientific needs of our users and collaborators. We are seeking community expert input on multiple aspects of this proposed facility, such as the press type and design, access management, immediate projects, and future innovation initiatives.

Danielson, L.↗

Armstrong Flight Research Center Research Technology and Engineering 2017

I am delighted to present this report of accomplishments at NASA's Armstrong Flight Research Center. Our dedicated innovators possess a wealth of performance, safety, and technical capabilities spanning a wide variety of research areas involving aircraft, electronic sensors, instrumentation, environmental and earth science, celestial observations, and much more. They not only perform tasks necessary to safely and successfully accomplish Armstrong's flight research and test missions but also support NASA missions across the entire Agency. Armstrong's project teams have successfully accomplished many of the nation's most complex flight research projects by crafting creative solutions that advance emerging technologies from concept development and experimental formulation to final testing. We are developing and refining technologies for ultra-efficient aircraft, electric propulsion vehicles, a low boom flight demonstrator, air launch systems, and experimental x-planes, to name a few. Additionally, with our unique location and airborne research laboratories, we are testing and validating new research concepts. Summaries of each project highlighting key results and benefits of the effort are provided in the following pages. Technology areas for the projects include electric propulsion, vehicle efficiency, supersonics, space and hypersonics, autonomous systems, flight and ground experimental test technologies, and much more. Additional technical information is available in the appendix, as well as contact information for the Principal Investigator of each project. I am proud of the work we do here at Armstrong and am pleased to share these details with you. We welcome opportunities for partnership and collaboration, so please contact us to learn more about these cutting-edge innovations and how they might align with your needs.

yearbook↗

NASA Technology Demonstrations Missions Program Overview

The National Aeronautics and Space Administration (NASA) Fiscal Year 2010 (FY10) budget introduced a new strategic plan that placed renewed emphasis on advanced missions beyond Earth orbit. This supports NASA s 2011 strategic goal to create innovative new space technologies for our exploration, science, and economic future. As a result of this focus on undertaking many and more complex missions, NASA placed its attention on a greater investment in technology development, and this shift resulted in the establishment of the Technology Demonstrations Missions (TDM) Program. The TDM Program, within the newly formed NASA Office of the Chief Technologist, supports NASA s grand challenges by providing a steady cadence of advanced space technology demonstrations (Figure 1), allowing the infusion of flexible path capabilities for future exploration. The TDM Program's goal is to mature crosscutting capabilities to flight readiness in support of multiple future space missions, including flight test projects where demonstration is needed before the capability can transition to direct mission The TDM Program has several unique criteria that set it apart from other NASA program offices. For instance, the TDM Office matures a small number of technologies that are of benefit to multiple customers to flight technology readiness level (TRL) 6 through relevant environment testing on a 3-year development schedule. These technologies must be crosscutting, which is defined as technology with potential to benefit multiple mission directorates, other government agencies, or the aerospace industry, and they must capture significant public interest and awareness. These projects will rely heavily on industry partner collaboration, and funding is capped for all elements of the flight test demonstration including planning, hardware development, software development, launch costs, ground operations, and post-test assessments. In order to inspire collaboration across government and industry, more than 70% of the TDM funds will be competitively awarded as a result of yearly calls for proposed flight demonstrators and selected based on possible payoff to NASA, technology maturity, customer interest, cost, and technical risk reduction. This paper will give an overview of the TDM Program s mission and organization, as well as its current status in delivering advanced space technologies that will enable more flexible and robust future missions. It also will provide several examples of missions that fit within these parameters and expected outcomes.

Turner, Susan↗

Abstract for CRADA between Mati Car bon PBC and NETL

The National Energy Technology Laboratory (NETL) will assist Mati Carbon PBC (participant) in the design and execution of their community benefits plan (CBP) for scaling Enhanced Rock Weathering (ERW) carbon dioxide removal (CDR) in Arkansas. ERW involves spreading finely crushed rocks in agricultural fields to speed up the dissolution and release of certain minerals that amend soil acidity, replenish soil nutrients, and simultaneously converting CO 2 from the atmosphere to Dissolved Inorganic Carbon (DIC). ERW not only removes CO 2 from the atmosphere but also has the potential to generate co-benefits for famers through cost reductions and increased crop yields. The collaboration between NETL and Mati Carbon, PBC (participant) will entail a detailed review of the economic, environmental and community impact of ERW in agricultural settings. This review will guide all project related decisions. It will provide a better understanding of the scale of these potential co-benefits and quantify community needs that ERW can address.

54 ENVIRONMENTAL SCIENCES↗

Trade-Space Analysis Tool for Constellations (TAT-C)

Traditionally, space missions have relied on relatively large and monolithic satellites, but in the past few years, under a changing technological and economic environment, including instrument and spacecraft miniaturization, scalable launchers, secondary launches as well as hosted payloads, there is growing interest in implementing future NASA missions as Distributed Spacecraft Missions (DSM). The objective of our project is to provide a framework that facilitates DSM Pre-Phase A investigations and optimizes DSM designs with respect to a-priori Science goals. In this first version of our Trade-space Analysis Tool for Constellations (TAT-C), we are investigating questions such as: How many spacecraft should be included in the constellation? Which design has the best costrisk value? The main goals of TAT-C are to: Handle multiple spacecraft sharing a mission objective, from SmallSats up through flagships, Explore the variables trade space for pre-defined science, cost and risk goals, and pre-defined metrics Optimize cost and performance across multiple instruments and platforms vs. one at a time.This paper describes the overall architecture of TAT-C including: a User Interface (UI) interacting with multiple users - scientists, missions designers or program managers; an Executive Driver gathering requirements from UI, then formulating Trade-space Search Requests for the Trade-space Search Iterator first with inputs from the Knowledge Base, then, in collaboration with the Orbit Coverage, Reduction Metrics, and Cost Risk modules, generating multiple potential architectures and their associated characteristics. TAT-C leverages the use of the Goddard Mission Analysis Tool (GMAT) to compute coverage and ancillary data, streamlining the computations by modeling orbits in a way that balances accuracy and performance.TAT-C current version includes uniform Walker constellations as well as Ad-Hoc constellations, and its cost model represents an aggregate model consisting of Cost Estimating Relationships (CERs) from widely accepted models. The Knowledge Base supports both analysis and exploration, and the current GUI prototype automatically generates graphics representing metrics such as average revisit time or coverage as a function of cost.

Science Data Processing↗

Psyche Project Implementation During the COVID Pandemic

In January 2017, “Psyche: Journey to a Metal World” was selected for implementation as part of NASA’s Discovery program. The Psyche mission will utilize electric propulsion with SPT-140 Hall thrusters to rendezvous and orbit the metal-rich asteroid (16) Psyche, in the main asteroid belt between Mars and Jupiter. The Psyche spacecraft requires no chemical propulsion and, when launched in 2022, will be the first mission to use Hall thrusters beyond lunar orbit. The Psyche spacecraft is a hybrid development with Jet Propulsion Laboratory (JPL)-provided deep-space avionics and communications equipment mounted on a high-heritage MAXAR (formerly Space Systems Loral) Solar-Electric Propulsion (SEP) Chassis, based on their 1300 series of GEO communications satellites. The spacecraft is equipped to support a suite of science instruments, as well as a demonstration of the Deep Space Optical Communications (DSOC) technology. The spacecraft has sufficient onboard resources, autonomy, redundancy, and operability to complete a 3.5-year cruise to 16 Psyche, followed by a 20-month campaign of science investigations while orbiting the asteroid.The mission’s early concept design and progress through Preliminary Design Review (PDR) has been described in previous work. The paper will cover the recent mission progress from the Critical Design Review (CDR) through the start of Spacecraft Environmental Testing, which took place during the COVID pandemic.The authors will highlight the successful remote collaboration between the major partners: ASU, JPL, MAXAR, and the Payload teams that led to the initiation of the Assembly, Test, Launch, Operations Phase (ATLO) in early March 2021. Emphasis will be placed on the effects that the COVID-19 pandemic had on the work environment over the last 16+ months, including challenges to delivery of flight hardware and test equipment. In addition to the COVID-19 challenges, other significant anomalies discovered during design and test will be described along with any impacts to the overall science capability of the mission.

Lord, Peter↗

RASC-AL (Revolutionary Aerospace Systems Concepts-Academic Linkage): 2002 Advanced Concept Design Presentation

The Revolutionary Aerospace Systems Concepts-Academic Linkage (RASC-AL) is a program of the Lunar and Planetary Institute (LPI) in collaboration with the Universities Space Research Association's (USRA) ICASE institute through the NASA Langley Research Center. The RASC-AL key objectives are to develop relationships between universities and NASA that lead to opportunities for future NASA research and programs, and to develop aerospace systems concepts and technology requirements to enable future NASA missions. The program seeks to look decades into the future to explore new mission capabilities and discover what's possible. NASA seeks concepts and technologies that can make it possible to go anywhere, at anytime, safely, reliably, and affordably to accomplish strategic goals for science, exploration, and commercialization. University teams were invited to submit research topics from the following themes: Human and Robotic Space Exploration, Orbital Aggregation & Space Infrastructure Systems (OASIS), Zero-Emissions Aircraft, and Remote Sensing. RASC-AL is an outgrowth of the HEDS-UP (University Partners) Program sponsored by the LPI. HEDS-UP was a program of the Lunar and Planetary Institute designed to link universities with NASA's Human Exploration and Development of Space (HEDS) enterprise. The first RASC-AL Forum was held November 5-8, 2002, at the Hilton Cocoa Beach Oceanfront Hotel in Cocoa Beach, Florida. Representatives from 10 university teams presented student research design projects at this year's Forum. Each team contributed a written report and these reports are presented.

Source record↗

Demonstrating a Realistic IP Mission Prototype

Flight software and hardware and realistic space communications environments were elements of recent demonstrations of the Internet Protocol (IP) mission concept in the lab. The Operating Missions as Nodes on the Internet (OMNI) Project and the Flight Software Branch at NASA/GSFC collaborated to build the prototype of a representative space mission that employed unmodified off-the-shelf Internet protocols and technologies for end-to-end communications between the spacecraft/instruments and the ground system/users. The realistic elements used in the prototype included an RF communications link simulator and components of the TRIANA mission flight software and ground support system. A web-enabled camera connected to the spacecraft computer via an Ethernet LAN represented an on-board instrument creating image data. In addition to the protocols at the link layer (HDLC), transport layer (UDP, TCP), and network (IP) layer, a reliable file delivery protocol (MDP) at the application layer enabled reliable data delivery both to and from the spacecraft. The standard Network Time Protocol (NTP) performed on-board clock synchronization with a ground time standard. The demonstrations of the prototype mission illustrated some of the advantages of using Internet standards and technologies for space missions, but also helped identify issues that must be addressed. These issues include applicability to embedded real-time systems on flight-qualified hardware, range of applicability of TCP, and liability for and maintenance of commercial off-the-shelf (COTS) products. The NASA Earth Science Technology Office (ESTO) funded the collaboration to build and demonstrate the prototype IP mission.

Rash, James↗

Intelligent Systems Technologies and Utilization of Earth Observation Data

The addition of raw data and derived geophysical parameters from several Earth observing satellites over the last decade to the data held by NASA data centers has created a data rich environment for the Earth science research and applications communities. The data products are being distributed to a large and diverse community of users. Due to advances in computational hardware, networks and communications, information management and software technologies, significant progress has been made in the last decade in archiving and providing data to users. However, to realize the full potential of the growing data archives, further progress is necessary in the transformation of data into information, and information into knowledge that can be used in particular applications. Sponsored by NASA s Intelligent Systems Project within the Computing, Information and Communication Technology (CICT) Program, a conceptual architecture study has been conducted to examine ideas to improve data utilization through the addition of intelligence into the archives in the context of an overall knowledge building system (KBS). Potential Intelligent Archive concepts include: 1) Mining archived data holdings to improve metadata to facilitate data access and usability; 2) Building intelligence about transformations on data, information, knowledge, and accompanying services; 3) Recognizing the value of results, indexing and formatting them for easy access; 4) Interacting as a cooperative node in a web of distributed systems to perform knowledge building; and 5) Being aware of other nodes in the KBS, participating in open systems interfaces and protocols for virtualization, and achieving collaborative interoperability.

Ramapriyan, H. K.↗

Development of large-scale, 3D Printed high temperature ceramic material

Through this collaborative effort, a new 3D printing platform for ceramics called laser-induced slip casting (LIS) was explored and developed for improving the processing and manufacture of silicon carbide (SiC), a high temperature ceramic material. This method prints layers of ceramic slips/slurries with subsequent selective-laser heating to dry each layer to build a 3D structure. The completed and dried part is then sintered. This manufacturing process is inherently lower cost than alternative ceramic printing methods such as binder jet technology or stereolithography when it comes to the feedstock material but is more expensive than robocasting or direct ink writing. However, it has the potential to make more controlled parts with less defects compared to robocasting. The largest cost is the heating source for the printer. With this technique, there is potential to make large ceramic parts in a near-net shape. Further, there is no known commercial manufacturing of 3D printed ceramics that creates a large range of different high-density ceramics at large scale. The goals and outcomes for the development of the new printing technology were: 1) assessing the technology with alumina by characterizing coupons, 2) printing and sintering of silicon carbide (SiC), and 3) characterization and properties testing of materials printed and a scale-up of SiC part(s). Through this collaborative project, it was sought to provide the best solution to achieving highly dense and near-net shaped ceramic parts at large scale and reduced cost. The goal was to produce high density sintered materials for applications in defense, energy generating systems, armor, and wear parts using 3D printing methods. Variables including powder particle sizes, dispersant molecular weights (MWs), binders, printing parameters, and post processing were explored as well as the characterization of the physical properties (add specifics here).

36 MATERIALS SCIENCE↗

Schema Elements for Granta Annual Report: FY2024

Granta: Materials Intelligence (Granta: MI) is a commercial database software distributed by Ansys, Inc. that is utilized by the Nuclear Security Enterprise (NSE) to organize and store relevant materials data. Lack of standard and well-documented database schema is the primary obstacle to an NSE materials data management solution, so the objective of this project is to create and document such a schema. In FY21, an approach for designing, documenting, and managing a standard database schema was described based on the creation of schema elements (collections of attributes used to describe particular aspects of the data) to be used as building blocks for creating various database tables without duplication. In FY22, these methods were applied through a multi-site collaboration to create and document the schema elements necessary to build a thermogravimetric analysis (TGA) testing table. In FY23 the schema was expanded to include elements for a differential scanning calorimetry (DSC) table, along with schema for supporting metadata tables including Instruments, Projects, Documents, and Testing Series. In FY24 the following progress was made, again through multi-site collaboration: • The existing schema elements were modified to accommodate thermomechanical analysis (TMA) data, and a table, Test Data: TMA, was created for managing TMA data. • The elements necessary for the following additive manufacturing (AM) data tables (directed at data specific to selective laser sintering AM technology) were created: • AM Builds • AM Processes • AM Part Designs • Built AM Parts • AM Feedstock Materials • AM Feedstock Material Batches • The elements necessary for creating a Calibrated Material Models table were created, and the Calibrated Material Models table was created. In FY25 the existing schema will be deployed on the production enterprise Granta instance on the enterprise secure network. Schema elements will be appended, and new elements created as necessary, to allow the creation of tables specifically to support materials testing, AM process development, and design and analysis for modernization programs.

36 MATERIALS SCIENCE↗

Overview of NASA's RESOURCE (Resource Exploration and Science of OUR Cosmic Environment) Project

The RESOURCE(Resource Exploration and Science of OUR Cosmic Environment) project is supported by NASA’s SSERVI (Solar System Exploration Research Virtual Institute) and is led by Principal Investigator (PI) Dr. Jennifer L. Heldmann and Deputy PIs Dr. Matthew Deans and Dr. Alexander Sehlke at NASA Ames Research Center. RESOURCE is focused on enabling In Situ Resource Utilization (ISRU) near the sites of robotic and/or human missions to enable sustainable and affordable exploration of the Moon and near-Earth objects (NEOs). This year RESOURCE has supported the development of a summary of the current state of knowledge regarding lunar polar volatiles as well as a comprehensive catalog and analysis of NEOs. RESOURCE is developing advanced mission capabilities to enable rapid, collaborative operations for lunar resource exploration missions. Hardware testing has been conducted to evaluate potential contaminants released during lunar polar regolith heating. Volatiles and particulates are the two sources of contamination that will affect the requirements of a water cleanup system, and RESOURCE research has identified the requirement for filtration prior to electrolysis for ISRU. RESOURCE also supports development of next-generation planetary drilling systems with integrated instrumentation within the drill. RESOURCE is also deeply committed to sustained efforts to engage educators, students, and broadening participation among under represented groups, and has partnered with Howard University in Washington, DC to foster minoritized students’ interest in STEAMD (science, technology, engineering, arts, math, design) careers through direct and virtual experiences with NASA Subject Matter Experts.

Jennifer L Heldmann↗

The Impact of Reconstruction in Pandora on Sensitivity to the Low-Energy Excess Signal at MicroBooNE

With the MicroBooNE collaboration’s first low-energy excess (LEE) searches complete and twice the amount of data to analyse in future iterations, it is imperative that we begin considering the potential analysis upgrades that can be achieved, such as those in the event reconstruction level. This note identifies the areas in Pandora reconstruction framework that could be improved upon, and evaluates their impact through cheated selections using MicroBooNE’s exclusive pionless LEE search as a benchmark. Vertexing and proton reconstruction improvements are demonstrated to have significant potential benefits in terms of sensitivity to the LEE signal and thus should be prioritised. Sensitivity projections for the full 10.1e20 POT are 3.2σ and 2.3σ for vertex and proton cheated selections respectively, and 3.3σ for the combined effect of both, compared to 2.1σ in the absence of the cheated selections.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Production of High Specific Activity 155 Tb, 161 Tb and 203 Pb for Research and Clinical Applications: Effective Target Design, Target Material Recycling and Radioisotope Separation (Final Technical Report)

The overall objectives of this project were (1) to develop methods for the production and separation of a diagnostic and therapeutic or “theranostic” pair of radioisotopes, terbium-155 ( 155 Tb) and terbium-161 ( 161 Tb) and (2) to train graduate students and postdoctoral fellows in technologies and methods used in radionuclide production. Radionuclides can be incorporated into drugs called radiopharmaceuticals that target a specific disease (e.g., cancer). The need for theranostic radionuclides is escalating with the clinical translation of radiopharmaceuticals due to their implementation in personalized medicine, which has demonstrated enhanced patient treatments. High purity and high specific activity radionuclides are critical for theranostic agent development, for example to maintain diagnostic image quality, to minimize radiation dose to the patient, and to increase uptake in the targeted tissue (e.g., tumor), especially in the case of receptor- and antigen-targeted agents. The 155 Tb (diagnostic) and 161 Tb (therapeutic) radioisotopes that were generated through this project are a theranostic pair with demonstrated potential for the development and translation into individualized, targeted, and dosimetry-driven radiotherapies. However, the development of such radiotherapies has been hindered by the lack of a routine and reliable supply of these isotopes in the United States. Methods for the production, separation, and supply of 155 Tb and 161 Tb were investigated and developed in this project. Further, the strong emphasis throughout the project on the training of graduate students and postdoctoral fellows has helped to ensure and enhance the nuclear science workforce through the training of the next generation of highly qualified scientists in nuclear and radiochemistry. This grant also continued a collaboration between scientists at the University of Washington (UW), the University of Missouri (MU) and Brookhaven National Laboratory (BNL). All three institutions were involved in the project, but to different degrees on the various tasks through which the overall objectives were met.

07 ISOTOPE AND RADIATION SOURCES↗