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At least 271 records · Page 15

Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures

Background: Moderate and high intensity aerobic or resistance exercise has clearly identified benefits for cardiac, muscle, and bone health. However, the impact of such exercise - either as a mitigating or an exacerbating factor - on the development of the visual impairment and intracranial pressure syndrome (VIIP) is unknown. Accordingly, our aim was to characterize the effect of an acute bout of resistance (RE), moderate-intensity continuous (CE), and high-intensity interval exercise (IE) during a cephalad fluid shift on cerebral-ocular hemodynamics and pressures. Methods: 10 male subjects (36 plus or minus 9 years) completed 4 testing days in a 15 degree head-down tilt (HDT): (1) assessment of maximum volume of O (sub 2), (2) RE session (4 sets of 12 repetition maximum leg press exercise), (3) CE session (30 minutes of cycling at 60 percent maximum volume of O (sub 2)), and (4) IE session (4 by 4-minute intervals of exercise at 85 percent maximum volume of O (sub 2) with 3-minute active rest periods). During each session, blood flow (Vivid-e, GE Healthcare) in extracranial arteries (common carotid artery, CCA; internal carotid artery, ICA; external carotid artery, ECA and vertebral artery, VA), and mean blood flow velocity in middle cerebral artery (MCA), internal jugular pressure (IJP; VeinPress), and intraocular pressure (IOP; Icare PRO) were measured at rest, at the end of each resistance or interval set, and every 5 minutes during continuous exercise. Translaminar pressure gradient (TLPG) was estimated by subtracting IJP from IOP. Results: There were no differences across days in pre-exercise resting blood flows or pressures. IOP decreased slightly from HDT rest (20.2 plus or minus 2.3 millimeters of mercury) to exercise (RE: 19.2 plus or minus 2.8 millimeters of mercury; CE: 18.9 plus or minus 3.2 millimeters of mercury; IE: 20.1 plus or minus 2.8 millimeters of mercury), while IJP decreased during CE (31.6 plus or minus 9.5 millimeters of mercury) and RE (32.0 plus or minus 8.1 millimeters of mercury), and increased during IE (35.1 plus or minus 9.5 millimeters of mercury) from HDT rest (33.3 plus or minus 6.5 millimeters of mercury). Estimated TLPG was increased during IE only. Compared to RE and CE, IE resulted in the greatest increase in MCA blood flow velocity and extracranial artery blood flow. Conclusions: These preliminary results suggest that high-intensity IE acutely increases cerebral blood flow, IJP, and TLPG. Alterations in TLPG is one mechanism that may contribute to optic nerve sheath edema in astronauts. Accordingly, acutely raising IOP and/or orbital pressure during exercise could optimize cerebral-ocular pressures during spaceflight.

Scott, J.↗

Overview of H- radio frequency ion sources for particle accelerators

Particle accelerators are among the most important scientific tools of the modern era. Large accelerator complexes have supported scientific user facilities which have had an enormous societal impact spanning many decades and enabling the work of thousands of scientific users worldwide contributing to many Nobel prizes in physics, biology and chemistry [1]. Many of the large hadron facilities employ accelerator complexes which include cyclotrons, synchrotrons, storage rings, linear or tandem accelerators and deliver ion beams of very high-intensity and/or very high-energy to their user facilities. These accelerator complexes require the injection of high-intensity beams of ions which are produced within an ion source and formed within a plasma or by bombardment of a surface [2]. Increasingly, RF systems are being utilized, to generate these ion-rich plasmas due to their high reliability and minimal use of consumable components. This report will first discuss the basic mechanisms of ion formation and plasma generation as well as some specifics of RF/microwave generators, matching circuits and plasma coupling structures typically employed. A detailed discussion will then be given of the RF-driven negative ion source systems employed by US Spallation Neutron Source as well as those used in similar facilities located around the globe. REFERENCES [1]Vladimir Shiltsev, “Particle beams behind physics discoveries”, Physics Today 73, Issue 4, 32 (2020) [2]Robert Welton et al, “Negative hydrogen ion sources for particle accelerators: Sustainability issues and recent improvements in long-term operations”, Journal of Physics Conf Series, 2244 012045

Welton, Robert F.↗

Optimization Studies of Radiation Shielding for PIP-II Project at Fermilab

The Proton Improvement Plan-II (PIP-II) at Fermilab represents a significant advancement in the quest to answer some of the most profound questions about our universe using the world's most intense high-energy neutrino beam. The project requires the construction of a new addition to the Fermilab accelerator complex – an 800-MeV high-intensity superconducting linear accelerator. Ensuring the safety and regulatory compliance of this ambitious project is paramount, necessitating thorough dose rate assessments under both normal operational and accidental scenarios to align with the Fermilab Radiological Control Manual (FRCM) standards. Our approach included a shielding optimization used for the simulations with the Monte Carlo code MARS [1,2,3] to incorporate new magnet and collimator designs, essential for reflecting the current state of PIP-II infrastructure. The implementation of high-resolution detector planes, despite their computational demands, enabled us to gather detailed radiation field data crucial for optimizing shielding configurations. To overcome the significant computational demands, we developed a branching code that drastically reduced simulation runtimes while maintaining statistical integrity. This was achieved through geometry splitting and the application of Russian Roulette techniques, tailored to prioritize regions of interest based on predefined importances and weight limits.

43 PARTICLE ACCELERATORS↗

Optimization Studies of Radiation Shielding for PIP-II Project at Fermilab

The Proton Improvement Plan-II (PIP-II) at Fermilab represents a significant advancement in the quest to answer some of the most profound questions about our universe using the world's most intense high-energy neutrino beam. The project requires the construction of a new addition to the Fermilab accelerator complex – an 800-MeV high-intensity superconducting linear accelerator. Ensuring the safety and regulatory compliance of this ambitious project is paramount, necessitating thorough dose rate assessments under both normal operational and accidental scenarios to align with the Fermilab Radiological Control Manual (FRCM) standards. Our approach included a shielding optimization used for the simulations with the Monte Carlo code MARS [1,2,3] to incorporate new magnet and collimator designs, essential for reflecting the current state of PIP-II infrastructure. The implementation of high-resolution detector planes, despite their computational demands, enabled us to gather detailed radiation field data crucial for optimizing shielding configurations. To overcome the significant computational demands, we developed a branching code that drastically reduced simulation runtimes while maintaining statistical integrity. This was achieved through geometry splitting and the application of Russian Roulette techniques, tailored to prioritize regions of interest based on predefined importances and weight limits.

Makovec, Alajos↗

Self-consistent PIC simulations of ultimate space charge compensation with electron lenses

Further progress of fundamental particle physics requires high intensity and high brightness of accelerated proton and ion beams. This goal is essential for the FAIR hadron beams at GSI, for the neutrino production at the facilities such as Fermilab and JPARC, and for the Large Hadron Collider luminosity at CERN. One of the most formidable obstacles toward that goal is the beam's own space charge, whose forces cause beam emittance growth, losses and lifetime degradation. Typically, such effects become intolerable when the space charge tune-shift parameter Δ QSC exceeds ~ - (0.25–0.5). To reduce these detrimental effects, it was suggested to use electron lenses to compensate the space charge forces. Furthermore, this paper reports on detailed particle-in-cell space charge and electron lens compensation simulations for extremely intense proton bunches whose space charge tune-shift parameter exceeds -1.0. Different scenarios were evaluated based on reduction in the emittance growth and particle loss at a 4σ aperture. Further, we investigate phenomena and issues related to the focusing lattice errors, importance of the transverse and longitudinal matching of the electron beam profiles to the proton ones, and vary the strength and the number of the electron lenses distributed around a circular machine to optimize the reduction of harmful space charge effects.

43 PARTICLE ACCELERATORS↗

ITER ECH Transmission Line System Design and Status

The electron cyclotron (EC) heating & current drive (H&CD) system on ITER provides plasma heating by generating, transmitting, and launching high-intensity, high-frequency (170 GHz) electromagnetic wave energy steerable across the plasma cross-section. The transmission line (TL) subsystem connects the Matching Optics Unit (MOU) on each of the 24 gyrotrons to the 32 feed points in the four upper launchers and the 24 feed points in the equatorial launcher. Each TL must be able to operate at up to 1.2 MW of input power for up to 1 hour pulse lengths. The TL system contains 50 mm water-cooled corrugated waveguide, 90o miter bends, 140o miter bends, polarizer miter bend pairs, switches, expansion units, pumpouts, DC breaks, MOU-TL adapters, Radio Frequency (RF) loads, and isolation shutter valves. A detailed finite element analysis has been used to verify the thermo-mechanical performance of each component. The microwave performance has been analyzed using a 2-D electromagnetic code combined with a Monte Carlo code. This approach allows the impact of manufacturing and installation tolerances to be assessed and optimized to provide a high probability of achieving the system performance requirements. Prototypes of the waveguide and TL components have been fabricated and tested at high-power. Production contracts are now being issued for fabrication and delivery of the waveguide and components to ITER.

Hanson, Gregory↗

Mirrors for petawatt lasers: Design principles, limitations, and solutions

High intensity and high energy laser facilities place increasing demands on optical components, requiring large surface area optics with exacting specifications. Petawatt lasers are high energy, short-pulse laser systems generally based on chirped-pulse amplification, where an initial low energy short pulse is stretched, amplified, and then recompressed to produce fs to ps high-power laser pulses. In such petawatt lasers, the highest demands are placed on the final optics, including gratings which compress the pulses and mirrors which direct and focus the final high-power beams. The limiting factor in these optical components is generally laser-induced damage. Designing and fabricating these optical components to meet reflection, dispersion, and other requirements while meeting laser-induced damage requirements is the primary challenge discussed in this tutorial. We will introduce the reader to the technical challenges and tradeoffs required to produce mirrors for petawatt lasers and discuss current research directions.

47 OTHER INSTRUMENTATION↗

High precision measurements of the proton elastic electromagnetic form factors and their ratio at 𝑄 2 = 0.50, 2.64, 3.20, and 4.10 GeV 2

The advent of high-intensity, high-polarization electron beams led to significantly improved measurements of the ratio of the proton’s charge to electric form factors, 𝐺 𝐸⁢ 𝑝 ⁡/𝐺 𝑀⁢ 𝑝 . However, high-𝑄 2 measurements of this ratio yielded significant disagreement with extractions based on unpolarized scattering measurements, raising questions about the reliability of the measurements and consistency of the techniques. Jefferson Lab experiment E01-001 was designed to provide a high precision extraction of 𝐺 𝐸⁢ 𝑝 ⁡/𝐺 𝑀⁢ 𝑝 from unpolarized cross-section measurements using a modified version of the Rosenbluth separation technique to allow for a more precise comparison with polarization data. Rosenbluth separations involve precise measurements of the angular dependence of the elastic 𝑒−𝑝 cross section at fixed momentum transfer, 𝑄 2 . Conventional Rosenbluth separations detect the scattered electron, requiring the comparisons of measurements with very different detected electron energy and rate for electrons at different angles. Our ‘‘super-Rosenbluth’’ measurement detected the struck proton, rather than the scattered electron to extract the elastic 𝑒−𝑝 cross section. This yielded a fixed momentum for the detected particle and dramatically reduced variation of the cross section with angle, significantly reducing rate- and momentum-dependent corrections and uncertainties. We measure the cross section vs angle with high relative precision, allowing for extremely high precision extractions of 𝐺 𝐸⁢ 𝑝 ⁡/𝐺 𝑀⁢ 𝑝 at 𝑄 2 = 2.64, 3.20, and 4.10 GeV 2 . Our results are consistent with traditional Rosenbluth extractions, but with much smaller corrections and systematic uncertainties, comparable to the uncertainties from polarization measurements. Our data confirm the discrepancy between Rosenbluth and polarization extractions of the proton form factor ratio using an improved Rosenbluth extraction that yields smaller and less-correlated uncertainties than those typical of previous Rosenbluth extractions. Here, we compare our results to calculations of two-photon exchange effects and find that the observed discrepancy can be relatively well explained by such effects.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Design of Ionization Profile Monitors at the Integrable Optics Test Accelerator Facility at Fermilab

The Integrable Optics Test Accelerator (IOTA) at Fermilab is transitioning from an electron beam facility to a proton beam facility for studies in nonlinear accelerator optics and space-charge dominated proton beams. This project involves the commissioning and fabrication of Ionization Profile Monitors (IPMs) to enable beam profile measurements at IOTA. In general, IPMs work on principle of residual gas ionization by the beam to generate beam profile. This work focuses on a mechanical design that leverages a controlled injection of noble gases, primarily Argon, as the ultra-high vacuum of the IOTA ring provides insufficient residual gas for ionization. Efforts to understand vacuum integration to ensure compatibility with the storage ring environment, the integration of real-time data acquisition systems and the commissioning of the IPMs will be discussed. This project provides a versatile diagnostic tool, supporting IOTA’s role as a testbed for larger-scale accelerator facilities and contributing to the broader understanding of beam physics in high-intensity, high-space-charge regimes.

Mwaniki, M. W. [IIT, Chicago] (ORCID:0000000169057↗

Bimodal quasi-oscillatory and spectral behavior in Sco X-1

X-ray observations were made to follow up the discovery of quasi-periodic oscillations (QPO) in Sco X-1. The QPO is observed in the quiescent state, and between flares in the active state. When the source is quiescent, the QPO frequency is 6 Hz and anticorrelated with intensity; in the active state, the frequency ranges from 10 to 20 Hz and is strongly correlated with intensity. At high intensities the QPO dissolves into continuum noise. The QPO rms amplitude decreases with count rate, and increases with photon energy. There are two modes of spectral behavior, with a one-to-one correspondence to the two modes of QPO: the spectral hardness ratio varies more steeply with intensity when the source shows 6 Hz QPO, than for 10 to 20 Hz QPO. Transitions between QPO modes, which occur when the flux is at its lowest levels, correspond to transitions between hardness ratio modes. The QPO frequency changes continuously through the transitions, which last a few hundred seconds.

Priedhorsky, W.↗

The Next Generation of Space Cells for Diverse Environments

Future science, military and commercial space missions are incredibly diverse. Military and commercial missions range from large arrays of hundreds of kilowatt to small arrays of ten watts in various Earth orbits. While science missions also have small to very large power needs there are additional unique requirements to provide power for near-sun missions and planetary exploration including orbiters, landers and rovers both to the inner planets and the outer planets with a major emphasis in the near term on Mars. These mission requirements demand cells for low intensity, low temperature applications, high intensity, high temperature applications, dusty environments and often high radiation environments. This paper discusses mission requirements, the current state of the art of space solar cells, and a variety of both evolving thin-film cells as well as new technologies that may impact the future choice of space solar cells for a specific mission application.

Landis, Geoffrey A.↗

The Next Generation of Space Cells for Diverse Environments

Future science, military and commercial space missions are incredibly diverse. Military and commercial missions range from large arrays of hundreds of kilowatt to small arrays of ten watts in various Earth orbits. While science missions also have small to very large power needs there are additional unique requirements to provide power for near-sun missions and planetary exploration including orbiters, landers and rovers both to the inner planets and the outer planets with a major emphasis in the near term on Mars. These mission requirements demand cells for low intensity, low temperature applications, high intensity, high temperature applications, dusty environments and often high radiation environments. This paper discusses mission requirements, the current state of the art of space solar cells, and a variety of both evolving thin-film cells as well as new technologies that may impact the future choice of space solar cells for a specific mission application.

Bailey, Sheila↗

Initial Assessment of Availability and Reliability for the PIP-II Superconducting Radio Frequency Linear Accelerator Facility

The Proton Improvement Plan -II (PIP-II) is a high intensity and high energy proton accelerator which will be used to support the neutrino program at Fermilab. The accelerator will deliver a 2 mA average beam current at a kinetic energy of 800 MeV. Due to the requirements from experiments, this accelerator is designed to be a highly reliable and available system. A target availability of the complete accelerator facility was prescribed to be 90%. An availability and reliability assessment of the accelerator was carried out to ascertain that the design can meet the target availability specification. The results were estimated for the nominal operational mode, when an 800 MeV beam is delivered on the target and for the critical operational mode, when a 600 MeV output beam was incident on the target. The design of a complete accel-erator system is a complex arrangement of a large number of components. To simplify the analysis, a few components were shortlisted and based on their functions, an accelerator model was created. The model is represented in the form of reliability block diagrams. Availability and reliability were estimated for each operational mode. To increase the availa-bility and reliability of the overall accelerator, redundancy of one cavity per section in the superconducting portion of the Linac was introduced.

43 PARTICLE ACCELERATORS↗

Mass distribution of orbiting man-made space debris

Three ways of producing space debris were considered, and data were analyzed to determine mass distributions for man-made space debris. Hypervelocity (3.0 to 4.5 km/sec) projectile impact with a spacecraft wall, high intensity explosions and low intensity explosions were studied. For hypervelocity projectile impact of a spacecraft wall, the number of fragments fits a power law. The number of fragments for both high intensity and low intensity explosions fits an exponential law. However, the number of fragments produced by low intensity explosions is much lower than the number of fragments produced by high intensity explosions. Fragment masses down to 10 to the -7 power gram were produced from hypervelocity impact, but the smallest fragment mass resulting from an explosion appeared to be about 10 mg. Velocities of fragments resulting from hypervelocity impact were about 10 m/sec, and those from low intensity explosions were about 100 m/sec. Velocities of fragments from high intensity explosions were about 3 km/sec.

Bess, T. D.↗

Digital twin framework for PIP-II linac: AI-driven multi-scale modeling from ion source to 800 MeV

The PIP-II superconducting linac at Fermilab is designed to deliver multi-megawatt proton beams for neutrino physics and other high-intensity applications. To expedite commissioning and enhance operational reliability, we have developed an EPICS-based data flow framework that seamlessly integrates digital twins (DT) with physical twins (PT). These digital twins comprise high-fidelity beam dynamics models or data-driven surrogate models connected to their physical counterparts through real-time diagnostics and advanced machine-learning algorithms.Central to this framework is Linac_Gen, an accelerated simulation tool that incorporates convolutional neural networks, random forests, and genetic algorithms to provide up to a tenfold speedup in optimizing the accelerator geometry model. An EPICS translator layer ensures interoperability by efficiently mapping lattice parameters across diverse simulation platforms.Our EPICS-based framework supports multiple operational modes—monitoring, passive learning, closed-loop control, and online learning—covering the entire machine lifecycle. By leveraging HPC resources and multi-objective optimization techniques, the digital twin enables adaptive trajectory correction, real-time fault detection, and predictive modeling of beam stability. This comprehensive approach paves the way for robust, high-intensity operation and data-driven accelerator R&D at Fermilab.

Pathak, Abhishek [Fermilab]↗

Concept of a polarized positron source for CEBAF

This thesis focuses on the development of polarized and unpolarized positron beams for the future experimental pro- gram of hadronic physics at the Thomas Jefferson National Accelerator Facility (JLab). The primary challenge is to produce high-duty-cycle and high-intensity polarized positron beams. The JLab positron source, which is based on the PEPPo (Polarized Electrons for Polarized Positrons) technique, aims to use a high intensity (1 mA) and highly polarized (90%) continuous electron beam of moderate energy (120 MeV) to produce either a low intensity (>50 nA), highly polarized (60%) positron beam or a high intensity (>1 ?A), unpolarized positron beam. The optimization of the layout and performance of the positron source is examined in this thesis. The source is designed with a specialized second injector to generate, transport, accelerate, and shape positron beams. It is compatible with acceleration at the Continuous Electron Beam Accelerator Facility (CEBAF), and the investigation results are presented in this document.

Habet, Sami↗