Results for “HUMAN REACTION” — Page 15

NASA NTRSDate not supplied

Liquid Nitrogen Testing of An Integrated Reaction Control System

Integrated Reaction Control Systems (IRCS) are considered an enabling technology for future human exploration of the solar system. An IRCS uses the same fuel and oxidizer as the main propulsion system, allowing for increased performance and simplified cryogenic fluid management operations. The IRCS team at Marshall Spaceflight Center is currently evaluating an IRCS system that uses a combination of electric pumps and pressure-regulation devices to provide a constant flow of conditioned propellant to a thruster bank during operation. In contrast to accumulator and gasifier designs, the recirculation loop design is less massive and can provide large, sustained flowrates to the thruster inlet. In the summer 2021 test series presented herein, the feasibility of this concept was evaluated using liquid nitrogen as a simulant for liquid oxygen. The goals of this test series were to demonstrate the ability of the pump and pressure regulator to maintain adequate thruster inlet conditions during transient operation, and to demonstrate the ability for the system to operate in an “idle mode” that maintains system chill between activations. During test operations, the back-pressure regulator responded more slowly than the opening/closing of valves in the thruster simulant, but it was still able to attenuate the pressure fluctuation at the pump discharge and ensure a stable flowrate through the pump. Similarly, the pump was able to be run far below its nominal operating point and successfully flow sufficient fluid to maintain chill conditions.

RCS↗

NASA NTRSDate not supplied

Liquid Nitrogen Testing of an Integrated Reaction Control System

Integrated Reaction Control Systems (IRCS) are considered an enabling technology for future human exploration of the solar system. An IRCS uses the same fuel and oxidizer as the main propulsion system, allowing for increased performance and simplified cryogenic fluid management operations. The IRCS team at Marshall Spaceflight Center is currently evaluating an IRCS system that uses a combination of electric pumps and pressure-regulation devices to provide a constant flow of conditioned propellant to a thruster bank during operation. In contrast to accumulator and gasifier designs, the recirculation loop design is less massive and can provide large, sustained flowrates to the thruster inlet. In the summer 2021 test series presented herein, the feasibility of this concept was evaluated using liquid nitrogen as a simulant for liquid oxygen. The goals of this test series were to demonstrate the ability of the pump and pressure regulator to maintain adequate thruster inlet conditions during transient operation, and to demonstrate the ability for the system to operate in an “idle mode” that maintains system chill between activations. During test operations, the back-pressure regulator responded more slowly than the opening/closing of valves in the thruster simulant, but it was still able to attenuate the pressure fluctuation at the pump discharge and ensure a stable flowrate through the pump. Similarly, the pump was able to be run far below its nominal operating point and successfully flow sufficient fluid to maintain chill conditions.

integrated RCS↗

NASA NTRSDate not supplied

Liquid Nitrogen Testing of an Integrated Reaction Control System

Integrated Reaction Control Systems (IRCS) are considered an enabling technology for future human exploration of the solar system. An IRCS uses the same fuel and oxidizer as the main propulsion system, allowing for increased performance and simplified cryogenic fluid management operations. The IRCS team at Marshall Spaceflight Center is currently evaluating an IRCS system that uses a combination of electric pumps and pressure-regulation devices to provide a constant flow of conditioned propellant to a thruster bank during operation. In contrast to accumulator and gasifier designs, the recirculation loop design is less massive and can provide large, sustained flowrates to the thruster inlet. In the summer 2021 test series presented herein, the feasibility of this concept was evaluated using liquid nitrogen as a simulant for liquid oxygen. The goals of this test series were to demonstrate the ability of the pump and pressure regulator to maintain adequate thruster inlet conditions during transient operation, and to demonstrate the ability for the system to operate in an “idle mode” that maintains system chill between activations. During test operations, the back-pressure regulator responded more slowly than the opening/closing of valves in the thruster simulant, but it was still able to attenuate the pressure fluctuation at the pump discharge and ensure a stable flowrate through the pump. Similarly, the pump was able to be run far below its nominal operating point and successfully flow sufficient fluid to maintain chill conditions.

integrated RCS↗

NASA NTRS1988

Effects of scopolamine and dextroamphetamine on human performance

The effects of two drugs used to prevent symptoms of motion sickness in the operational environment were examined in this study of human performance as measured by computer-based tests of cognitive and psychomotor skills. Each subject was exposed repetitively to five tests: symbol-digit substitution, simple reaction time, pattern recognition, digit span memory, and pattern memory. Although there have been previous reports of decreases in human performance in similar testing with higher dosages of scopolamine or dextroamphetamine, no significant decrements were observed with the operational-level combined dose used in this study (0.4 mg oral scopolamine and 5.0 mg oral dextroamphetamine.) The controversy over the use of combination drug therapy in this environnment is discussed along with the indications for further research based on the findings.

Schmedtje, John F., Jr.↗

NASA NTRS1973

Reaction time to changes in the tempo of acoustic pulse trains.

Investigation of the ability of human observers to detect accelerations and decelerations in the rate of presentation of pulsed stimuli, i.e., changes in the tempo of acoustic pulse trains. Response times to accelerations in tempo were faster than to decelerations. Overall speed of response was inversely related to the pulse repetition rate.

Smith, R. P.↗

DOE OSTI2021

Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases

Acetyl CoA synthetases (ACSs) are Acyl-CoA/NRPS/Luciferase (ANL) superfamily enzymes that couple acetate with CoA to generate acetyl CoA, a key component of central carbon metabolism in eukaryotes and prokaryotes. Normal mammalian cells are not dependent on ACSs, while tumor cells, fungi, and parasites rely on acetate as a precursor for acetyl CoA. Consequently, ACSs have emerged as a potential drug target. As part of a program to develop antifungal ACS inhibitors, we characterized fungal ACSs from five diverse human fungal pathogens using biochemical and structural studies. ACSs catalyze a two-step reaction involving adenylation of acetate followed by thioesterification with CoA. Our structural studies captured each step of these two half-reactions including the acetyl-adenylate intermediate of the first half-reaction in both the adenylation conformation and the thioesterification conformation and thus provide a detailed picture of the reaction mechanism. We also used a systematic series of increasingly larger alkyl adenosine esters as chemical probes to characterize the structural basis of the exquisite ACS specificity for acetate over larger carboxylic acid substrates. Consistent with previous biochemical and genetic data for other enzymes, structures of fungal ACSs with these probes bound show that a key tryptophan residue limits the size of the alkyl binding site and forces larger alkyl chains to adopt high energy conformers, disfavoring their efficient binding. Together, our analysis provides highly detailed structural models for both the reaction mechanism and substrate specificity that should be useful in designing selective inhibitors of eukaryotic ACSs as potential anticancer, antifungal, and antiparasitic drugs.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

NASA NTRS2004

Studying Biological Rhythms of Person's Skin-galvanic Reaction and Dynamics of Light Transmission by Isomeric Substance in Space Flight Conditions

Intensity and amplitude of human functional systems and human most important organs are wavelike, rhythmic by nature. These waves have constant periodicity, phase and amplitude. The mentioned characteristics can vary, however their variations have a pronounced reiteration in the course of time. This indicates a hashing of several wave processes and their interference. Stochastic changes in wave processes characteristics of a human organism are explained either by 'pulsations' associated with hashing (superposition) of several wave processes and their interference, or by single influence of environmental physical factors on a human organism. Human beings have respectively periods of higher and lower efficiency, state of health and so on, depending not only of environmental factors, but also of 'internal' rhythmic factor. Sometimes peaks and falls periodicity of some or other characteristics is broken. Disturbance of steady-state biological rhythms is usually accompanied by reduction of activity steadiness of the most important systems of a human organism. In its turn this has an effect on organism's adaptation to changing living conditions as well as on general condition and efficiency of a human being. The latter factor is very important for space medicine. Biological rhythmology is a special branch of biology and medicine, it studies rhythmic activity mechanisms of organs, their systems, individuals and species. Appropriate researches were also carried out in space medicine.

Glushko, Vladimir↗

NASA NTRS1980

Advection fog formation and aerosols produced by combustion-originated air pollution

The way in which pollutants produced by the photochemical reaction of NO(X) and SO(X) affect the quality of the human environment through such phenomena as the formation of advection fog is considered. These pollutants provide the major source of condensation nuclei for the formation of fog in highways, airports and seaports. Results based on the monodisperse, multicomponent aerosol model show that: (1) condensation nuclei can grow and form a dense fog without the air having attained supersaturation; (2) the mass concentration range for NO(X) is one-third that of SO(X); and (3) the greater the mass concentration, the particle concentration, and the radius of condensation nuclei, the denser the fog that is formed.

Hung, R. J.↗

NASA NTRS2002

Simultaneous dual-task performance reveals parallel response selection after practice

E. H. Schumacher, T. L. Seymour, J. M. Glass, D. E. Kieras, and D. E. Meyer (2001) reported that dual-task costs are minimal when participants are practiced and give the 2 tasks equal emphasis. The present research examined whether such findings are compatible with the operation of an efficient response selection bottleneck. Participants trained until they were able to perform both tasks simultaneously without interference. Novel stimulus pairs produced no reaction time costs, arguing against the development of compound stimulus-response associations (Experiment 1). Manipulating the relative onsets (Experiments 2 and 4) and durations (Experiments 3 and 4) of response selection processes did not lead to dual-task costs. The results indicate that the 2 tasks did not share a bottleneck after practice.

Practice (Psychology)↗

NASA NTRS2002

Repetition blindness has a perceptual locus: evidence from online processing of targets in RSVP streams

Four experiments tested whether repetition blindness (RB; reduced accuracy reporting repetitions of briefly displayed items) is a perceptual or a memory-recall phenomenon. RB was measured in rapid serial visual presentation (RSVP) streams, with the task altered to reduce memory demands. In Experiment 1 only the number of targets (1 vs. 2) was reported, eliminating the need to remember target identities. Experiment 2 segregated repeated and nonrepeated targets into separate blocks to reduce bias against repeated targets. Experiments 3 and 4 required immediate "online" buttonpress responses to targets as they occurred. All 4 experiments showed very strong RB. Furthermore, the online response data showed clearly that the 2nd of the repeated targets is the one missed. The present results show that in the RSVP paradigm, RB occurs online during initial stimulus encoding and decision making. The authors argue that RB is indeed a perceptual phenomenon.

Form Perception↗

NASA NTRS2001

Processing bottlenecks in dual-task performance: structural limitation or strategic postponement?

Recent evidence indicates that a central bottleneck causes much of the slowing that occurs when two tasks are performed at the same time. This bottleneck might reflect a structural limitation inherent in the cognitive architecture. Alternatively, the bottleneck might reflect strategic (i.e., voluntary) postponement, induced by instructions to emphasize one task over the other. To distinguish structural limitations from strategic postponement, we examine a new paradigm in which subjects are told to place equal emphasis on both tasks and to emit both responses at about the same time. An experiment using this paradigm demonstrated patterns of interference that cannot easily be attributed to strategic postponement, preparation effects, or conflicts in response production. The data conform closely to the predictions of structural central bottleneck models.

Attention↗

NASA NTRS2001

Coriolis-force-induced trajectory and endpoint deviations in the reaching movements of labyrinthine-defective subjects

When reaching movements are made during passive constant velocity body rotation, inertial Coriolis accelerations are generated that displace both movement paths and endpoints in their direction. These findings directly contradict equilibrium point theories of movement control. However, it has been argued that these movement errors relate to subjects sensing their body rotation through continuing vestibular activity and making corrective movements. In the present study, we evaluated the reaching movements of five labyrinthine-defective subjects (lacking both semicircular canal and otolith function) who cannot sense passive body rotation in the dark and five age-matched, normal control subjects. Each pointed 40 times in complete darkness to the location of a just extinguished visual target before, during, and after constant velocity rotation at 10 rpm in the center of a fully enclosed slow rotation room. All subjects, including the normal controls, always felt completely stationary when making their movements. During rotation, both groups initially showed large deviations of their movement paths and endpoints in the direction of the transient Coriolis forces generated by their movements. With additional per-rotation movements, both groups showed complete adaptation of movement curvature (restoration of straight-line reaches) during rotation. The labyrinthine-defective subjects, however, failed to regain fully accurate movement endpoints after 40 reaches, unlike the control subjects who did so within 11 reaches. Postrotation, both groups' movements initially had mirror image curvatures to their initial per-rotation reaches; the endpoint aftereffects were significantly different from prerotation baseline for the control subjects but not for the labyrinthine-defective subjects reflecting the smaller amount of endpoint adaptation they achieved during rotation. The labyrinthine-defective subjects' movements had significantly lower peak velocity, higher peak elevation, lower terminal velocity, and a more vertical touchdown than those of the control subjects. Thus the way their reaches terminated denied them the somatosensory contact cues necessary for full endpoint adaptation. These findings fully contradict equilibrium point theories of movement control. They emphasize the importance of contact cues in adaptive movement control and indicate that movement errors generated by Coriolis perturbations of limb movements reveal characteristics of motor planning and adaptation in both healthy and clinical populations.

NASA Discipline Neuroscience↗

NASA NTRS1998

Effects of sleep loss, time of day, and extended mental work on implicit and explicit learning of sequences

Tacit knowledge is part of many professional skills and can be studied experimentally with implicit-learning paradigms. The authors explored the effects of 2 different stressors, loss of sleep and mental fatigue, on implicit learning in a serial-response time (RT) task. In the 1st experiment, 1 night of sleep deprivation was shown to impair implicit but not explicit sequence learning. In the 2nd experiment, no impairment of both types of sequence learning was found after 1.5 hr of mental work. Serial-RT performance, in contrast, suffered from both stressors. These findings suggest that sleep deprivation induces specific risks for automatic, skill-based behavior that are not present in consciously controlled performance.

Learning↗

NASA NTRS1995

A psychophysiological evaluation of the perceived urgency of auditory warning signals

One significant concern that pilots have about cockpit auditory warnings is that the signals presently used lack a sense of priority. The relationship between auditory warning sound parameters and perceived urgency is, therefore, an important topic of enquiry in aviation psychology. The present investigation examined the relationship among subjective assessments of urgency, reaction time, and brainwave activity with three auditory warning signals. Subjects performed a tracking task involving automated and manual conditions, and were presented with auditory warnings having various levels of perceived and situational urgency. Subjective assessments revealed that subjects were able to rank warnings on an urgency scale, but rankings were altered after warnings were mapped to a situational urgency scale. Reaction times differed between automated and manual tracking task conditions, and physiological data showed attentional differences in response to perceived and situational warning urgency levels. This study shows that the use of physiological measures sensitive to attention and arousal, in conjunction with behavioural and subjective measures, may lead to the design of auditory warnings that produce a sense of urgency in an operator that matches the urgency of the situation.

Sound↗

NASA NTRS2002

Relationship between alertness, performance, and body temperature in humans

Body temperature has been reported to influence human performance. Performance is reported to be better when body temperature is high/near its circadian peak and worse when body temperature is low/near its circadian minimum. We assessed whether this relationship between performance and body temperature reflects the regulation of both the internal biological timekeeping system and/or the influence of body temperature on performance independent of circadian phase. Fourteen subjects participated in a forced desynchrony protocol allowing assessment of the relationship between body temperature and performance while controlling for circadian phase and hours awake. Most neurobehavioral measures varied as a function of internal biological time and duration of wakefulness. A number of performance measures were better when body temperature was elevated, including working memory, subjective alertness, visual attention, and the slowest 10% of reaction times. These findings demonstrate that an increased body temperature, associated with and independent of internal biological time, is correlated with improved performance and alertness. These results support the hypothesis that body temperature modulates neurobehavioral function in humans.

Non-NASA Center↗

NASA NTRS1998

Expression of extracellular calcium (Ca2+o)-sensing receptor in human peripheral blood monocytes

The calcium-sensing receptor (CaR) is a G protein-coupled receptor playing key roles in extracellular calcium ion (Ca2+o) homeostasis in parathyroid gland and kidney. Macrophage-like mononuclear cells appear at sites of osteoclastic bone resorption during bone turnover and may play a role in the "reversal" phase of skeletal remodeling that follows osteoclastic resorption and precedes osteoblastic bone formation. Bone resorption produces substantial local increases in Ca2+o that could provide a signal for such mononuclear cells present locally within the bone marrow microenvironment. Indeed, previous studies by other investigators have shown that raising Ca2+o either in vivo or in vitro stimulated the release of interleukin-6 (IL-6) from human peripheral blood monocytes, suggesting that these cells express a Ca2+o-sensing mechanism. In these earlier studies, however, the use of reverse transcription-polymerase chain reaction (RT-PCR) failed to detect transcripts for the CaR previously cloned from parathyroid and kidney in peripheral blood monocytes. Since we recently found that non-specific esterase-positive, putative monocytes isolated from murine bone marrow express the CaR, we reevaluated the expression of this receptor in human peripheral blood monocytes. Immunocytochemistry, flow cytometry, and Western blot analysis, performed using a polyclonal antiserum specific for the CaR, detected CaR protein in human monocytes. In addition, the use of RT-PCR with CaR-specific primers, followed by nucleotide sequencing of the amplified products, identified CaR transcripts in the cells. Therefore, taken together, our data show that human peripheral blood monocytes possess both CaR protein and mRNA very similar if not identical to those expressed in parathyroid and kidney that could mediate the previously described, direct effects of Ca2+o on these cells. Furthermore, since mononuclear cells isolated from bone marrow also express the CaR, the latter might play some role in the "reversal" phase of bone remodeling, sensing local changes in Ca2+o resulting from osteoclastic bone resorption and secreting osteotropic cytokines or performing other Ca2+o-regulated functions that contribute to the control of bone turnover.

NASA Discipline Musculoskeletal↗

NASA NTRSDate not supplied

Bio-stasis: A Strategy for Survivability and Payload Cost Reduction in Long-duration Space Missions

As humans proceed with long-term space voyages, involving flights with lasting duration of months or years, “adaptation to space” will eventually lead to hard realities resultant physiological and psychological conditions must be realistically estimated and considered before it occurs. It is obvious that humans in their lifespan cannot adopt to spaceflight environment by reversible modification of their complex biochemical reactions and physiological functions without jeopardizing sustainable homeostasis shaped by multiple generations during evolution. In this case Nature offers an evolutionary proven alternative strategy- a coordinative adjustment of metabolism in order to survive. Incorporation of this metabolic adjustment strategy along with the relevant life support system into space flight architecture would protect humans during long term space flight from many irreversible physiological alterations and may dramatically reduce overall cost of space missions. In addition to the harmful space radiation and prolonged weightlessness, incorporation of this strategy may also benefit by solving other major medical unknowns in interplanetary flight such as isolation and psychological stress which still remains a risk. It is one of the priorities of NASA and other space agencies to figure out not only how to keep long-distance travelers alive and in good cognitive health but also how to return them to normal life on Earth with a minimum rehabilitation period after prolonged exposure to space. Presently re-adaptation of astronauts to Earth conditions and recovery from spaceflight exposure may take many months and years and, in some cases, require medical intervention. Therefore, recognizing physiological adjustment of the energy-regulating system as a viable life support strategy for human space exploration beyond LEO is essential.

Bio-stasis;↗

NASA NTRS1994

Comparisons of luminaires: Efficacies and system design

Lighting designs for architectural (aesthetic) purposes, vision and safety, and plant growth have many features in common but several crucial ones that are not. The human eye is very sensitive to the color (wavelength) of light, whereas plants are less so. There are morphological reactions, particularly to the red and blue portions of the light spectrum but, in general, plants appear to accept and use light for photosynthesis everywhere over the PAR region of the spectrum. In contrast, the human eye interprets light intensity on a logarithmic scale, making people insensitive to significant differences of light intensity. As a rough rule, light intensity must change by 30 to 50% for the human eye to recognize the difference. Plants respond much more linearly to light energy, at least at intensities below photosynthetic saturation. Thus, intensity differences not noticeable to the human eye can have significant effects on total plant growth and yield, and crop timing. These factors make luminaire selection and lighting system design particularly important when designing supplemental lighting systems for plant growth. Supplemental lighting for plant growth on the scale of commercial greenhouses is a relatively expensive undertaking. Light intensities are often much higher than required for task (vision) lighting, which increases both installation and operating costs. However, and especially in the northern regions of the United States (and Canada, Europe, etc.), supplemental lighting during winter may be necessary to produce certain crops (e.g., tomatoes) and very useful to achieve full plant growth potential and crop timing with most other greenhouse crops. Operating costs over the life of a luminaire typically will exceed the initial investment, making lighting efficacy a major consideration. This report reviews tests completed to evaluate the efficiencies of various commercially-available High-Pressure Sodium luminaires, and then describes the results of using a commercial lighting design computer program, Lumen-Micro, to explore how to place luminaires within greenhouses and plant growth chambers to achieve light (PAR) uniformity and relatively high lighting efficacies. Several suggestions are presented which could encourage systematic design of plant lighting systems.

Albright, L. D.↗