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At least 271 records · Page 15

Neutrino-Nucleus Interactions in the Precision Era

Current and future accelerator-based neutrino facilities, leveraging intense neutrino beams and advanced detectors, aim to precisely determine neutrino properties and probe signals of weakly interacting beyond the Standard Model physics. Achieving discovery-level precision and fully exploring the physics potential of these experiments critically depends on the accuracy of our understanding of fundamental underlying neutrino-nucleus interaction processes. This talk will focus on neutrino interactions spanning energies from tens of MeV to a few GeV—a complex, multi-scale and multi-process domain spanning from low-energy nuclear physics to perturbative QCD, with no unified underlying framework currently known. In this seminar, I will provide an overview of the field, discuss recent advancements, and share examples of ongoing cross-community efforts addressing these challenges.

Pandey, Vishvas [Fermilab]↗

Precision Time Protocol Performance Testing Over Optical Transport Network

The US Department of Energy Office of Electricity has partnered with Oak Ridge National Laboratory (ORNL) to find alternative precision timing solutions for the nation’s power grid. This effort is in response to the vulnerabilities identified in the Global Navigation Satellite System (GNSS), of which the US Global Positioning System (GPS) platform is a part. Additionally, Executive Order 139055 has highlighted the need for alternative or backup timing solutions. ORNL has established a Timing Lab and has been testing various technologies and timing devices as part of this effort. Precision Time Protocol (PTP), and the off-the-shelf timing devices and network connections that support it, are among the alternatives being tested. This work reports the accuracy of PTP over an Optical Transport Network (OTN) and is part of a series published by the Center for Alternative Synchronization and Timing (CAST).

24 POWER TRANSMISSION AND DISTRIBUTION↗

Neutrino-Nucleus Interactions in the Precision Era

Current and future accelerator-based neutrino facilities, leveraging intense neutrino beams and advanced detectors, aim to precisely determine neutrino properties and probe signals of weakly interacting beyond the Standard Model physics. Achieving discovery-level precision and fully exploring the physics potential of these experiments critically depends on the accuracy of our understanding of fundamental underlying neutrino-nucleus interaction processes. This talk will focus on neutrino interactions spanning energies from tens of MeV to a few GeV a complex, multi-scale and multi-process domain spanning from low-energy nuclear physics to perturbative QCD, with no unified underlying framework currently known. In this talk, I will provide an overview of the field, discuss recent advancements, and share examples of ongoing cross-community efforts addressing these challenges.

Pandey, Vishvas [Fermilab] (ORCID:0000000230827987↗

Advancing Detector R&D for High-Pressure Gaseous Argon TPCs in Precision Neutrino Physics

High-pressure gaseous argon time projection chambers (HPgTPCs) represent an emerging detector paradigm for neutrino physics, combining increased target density with the intrinsic tracking and low thresholds of gaseous detectors. This approach enables detailed reconstruction of exclusive final states, improved particle identification, and sensitivity to low-energy and rare processes — capabilities that are increasingly central to precision oscillation measurements and searches for beyond-the-Standard-Model signatures. This abstract presents an overview of ongoing detector R&D toward high-pressure gaseous argon TPC operation, with emphasis on micro-pattern gas detector (MPGD) charge amplification in argon-based mixtures. We report experimental characterization of triple-GEM structures at pressures relevant for neutrino applications, including studies of multiplication factor scaling, stability, and operational voltage envelopes across gas admixtures. Measurements performed at the TOAD and GORG test stands at Fermilab help define viable amplification and electronics noise regimes in conditions where higher density imposes stricter constraints on signal formation. These results provide essential input to the optimization of high-pressure gaseous argon detectors for future neutrino experiments, including near-detector concepts such as ND-GAr in DUNE Phase II near detector upgrade. More broadly, this program shows how dedicated detector R&D can expand the precision frontier in neutrino physics by enabling complementary reconstruction capabilities beyond conventional detectors.

McConnell, Brenna [Indiana U.] (ORCID:000900041138↗

Two 28-nm front-end ASICs for ultra-fine spatial resolution and precision timing to be 3D integrated with 12 LGADs

The 3DIntSenS Collaboration—a joint effort between SLAC, Fermilab, and LLNL—is developing enabling technologies for next-generation radiation imaging detectors that combine ultra-fine spatial resolution (about 10 µm) with precision timing (<20 ps), while maintaining low power <1 W/cm2 and high data throughput. The approach leverages 3D integration between advanced CMOS readout ASICs and finely pixelated LGAD sensors to achieve the performance and scalability required for large-area, high-rate applications. High-granularity, precision-timing detectors are essential for scientific advances in HEP, NP, BES, and FES, but widespread adoption is limited by the cost and complexity of 3D integration. To close this gap, the collaboration is developing LGAD sensors compatible with 12-inch commercial CMOS processes, enabling cost-effective integration with high-performance ASICs under development. We present two 28 nm CMOS ASIC prototypes, including a low-jitter front end, and in-pixel TDC demonstrating sub-10 ps timing resolution. These advances represent a critical step toward scalable, high-resolution radiation imaging systems for future scientific instrumentation.

England, Troy [Fermilab] (ORCID:0000000154405255)↗

Two 28-nm front-end ASICs for ultra-fine spatial resolution and precision timing to be 3D integrated with 12 LGADs

The 3DIntSenS Collaboration—a joint effort between SLAC, Fermilab, and LLNL—is developing enabling technologies for next-generation radiation imaging detectors that combine ultra-fine spatial resolution (about 10 µm) with precision timing (<20 ps), while maintaining low power <1 W/cm2 and high data throughput. The approach leverages 3D integration between advanced CMOS readout ASICs and finely pixelated LGAD sensors to achieve the performance and scalability required for large-area, high-rate applications. High-granularity, precision-timing detectors are essential for scientific advances in HEP, NP, BES, and FES, but widespread adoption is limited by the cost and complexity of 3D integration. To close this gap, the collaboration is developing LGAD sensors compatible with 12-inch commercial CMOS processes, enabling cost-effective integration with high-performance ASICs under development. We present two 28 nm CMOS ASIC prototypes, including a low-jitter front end, and in-pixel TDC demonstrating sub-10 ps timing resolution. These advances represent a critical step toward scalable, high-resolution radiation imaging systems for future scientific instrumentation.

England, Troy [Fermilab] (ORCID:0000000154405255)↗

High-precision quantum algorithms for partial differential equations

Quantum computers can produce a quantum encoding of the solution of a system of differential equations exponentially faster than a classical algorithm can produce an explicit description. However, while high-precision quantum algorithms for linear ordinary differential equations are well established, the best previous quantum algorithms for linear partial differential equations (PDEs) have complexity poly(1/ϵ), where ϵ is the error tolerance. By developing quantum algorithms based on adaptive-order finite difference methods and spectral methods, we improve the complexity of quantum algorithms for linear PDEs to be poly(d,log(1/ϵ)), where d is the spatial dimension. Our algorithms apply high-precision quantum linear system algorithms to systems whose condition numbers and approximation errors we bound. We develop a finite difference algorithm for the Poisson equation and a spectral algorithm for more general second-order elliptic equations.

97 MATHEMATICS AND COMPUTING↗

Towards verifiable cancer digital twins: tissue level modeling protocol for precision medicine

Cancer exhibits substantial heterogeneity, manifesting as distinct morphological and molecular variations across tumors, which frequently undermines the efficacy of conventional oncological treatments. Developments in multiomics and sequencing technologies have paved the way for unraveling this heterogeneity. Nevertheless, the complexity of the data gathered from these methods cannot be fully interpreted through multimodal data analysis alone. Mathematical modeling plays a crucial role in delineating the underlying mechanisms to explain sources of heterogeneity using patient-specific data. Intra-tumoral diversity necessitates the development of precision oncology therapies utilizing multiphysics, multiscale mathematical models for cancer. This review discusses recent advancements in computational methodologies for precision oncology, highlighting the potential of cancer digital twins to enhance patient-specific decision-making in clinical settings. We review computational efforts in building patient-informed cellular and tissue-level models for cancer and propose a computational framework that utilizes agent-based modeling as an effective conduit to integrate cancer systems models that encode signaling at the cellular scale with digital twin models that predict tissue-level response in a tumor microenvironment customized to patient information. Furthermore, we discuss machine learning approaches to building surrogates for these complex mathematical models. These surrogates can potentially be used to conduct sensitivity analysis, verification, validation, and uncertainty quantification, which is especially important for tumor studies due to their dynamic nature.

60 APPLIED LIFE SCIENCES↗

Micromachined Silicon Platform for Precise Assembly of 2D Multilayer Laue Lenses for High-Resolution X-ray Microscopy

We report on a developed micromachined silicon platform for the precise assembly of 2D multilayer Laue lenses (MLLs) for high-resolution X-ray microscopy. The platform is 10 × 10 mm2 and is fabricated on ~500 µm thick silicon wafers through multiple steps of photolithography and deep reactive-ion etching. The platform accommodates two linear MLLs in a pre-defined configuration with precise angular and lateral position control. In this work, we discuss the design and microfabrication of the platform, and characterization regarding MLLs assembly, position control, repeatability, and stability. The results demonstrate that a micromachined platform can be used for the assembly of a variety of MLLs with different dimensions and optical parameters. The angular misalignment of 2D MLLs is well controlled in the range of the designed accuracy, down to a few millidegrees. The separation distance between MLLs is adjustable from hundreds to more than one thousand micrometers. The use of the developed platform greatly simplifies the alignment procedure of the MLL optics and reduces the complexity of the X-ray microscope. It is a significant step forward for the development of monolithic 2D MLL nanofocusing optics for high-resolution X-ray microscopy.

36 MATERIALS SCIENCE↗

Simulation Study of High-Precision Characterization of MeV Electron Interactions for Advanced Nano-Imaging of Thick Biological Samples and Microchips

The resolution of a mega-electron-volt scanning transmission electron microscope (MeV-STEM) is primarily governed by the properties of the incident electron beam and angular broadening effects that occur within thick biological samples and microchips. A precise understanding and mitigation of these constraints require detailed knowledge of beam emittance, aberrations in the STEM column optics, and energy-dependent elastic and inelastic critical angles of the materials being examined. This simulation study proposes a standardized experimental framework for comprehensively assessing beam intensity, divergence, and size at the sample exit. This framework aims to characterize electron-sample interactions, reconcile discrepancies among analytical models, and validate Monte Carlo (MC) simulations for enhanced predictive accuracy. Our numerical findings demonstrate that precise measurements of these parameters, especially angular broadening, are not only feasible but also essential for optimizing imaging resolution in thick biological samples and microchips. By utilizing an electron source with minimal emittance and tailored beam characteristics, along with amorphous ice and silicon samples as biological proxies and microchip materials, this research seeks to optimize electron beam energy by focusing on parameters to improve the resolution in MeV-STEM/TEM. This optimization is particularly crucial for in situ imaging of thick biological samples and for examining microchip defects with nanometer resolutions. Our ultimate goal is to develop a comprehensive mapping of the minimum electron energy required to achieve a nanoscale resolution, taking into account variations in sample thickness, composition, and imaging mode.

36 MATERIALS SCIENCE↗

Improving the Precision of First-Principles Calculation of Parton Physics from Lattice Quantum Chromodynamics

Large momentum effective theory (LaMET) provides a general framework for computing the multi-dimensional partonic structure of the proton from first principles using lattice quantum chromodynamics (QCD). In this effective field theory approach, LaMET predicts parton distributions through a power expansion and perturbative matching of a class of Euclidean observables—quasi-distributions—evaluated at large proton momenta. Recent advances in lattice renormalization, such as the hybrid scheme with leading renormalon resummation, together with improved matching kernel that incorporates higher-loop corrections and resummations, have enhanced both the perturbative and power accuracy of LaMET, enabling a reliable quantification of theoretical uncertainties. Moreover, the Coulomb-gauge correlator approach further simplifies lattice analyses and improves the precision of transverse-momentum-dependent structures, particularly in the non-perturbative region. State-of-the-art LaMET calculations have already yielded certain parton observables with important phenomenological impact. In addition, the recently proposed kinematically enhanced lattice interpolation operators promise access to unprecedented proton momenta with greatly improved signal-to-noise ratios, which will extend the range of LaMET prediction and further suppress the power corrections. The remaining challenges, such as controlling excited-state contamination in lattice matrix elements and extracting gluonic distributions, are expected to benefit from emerging lattice techniques for ground-state isolation and noise reduction. Thus, lattice QCD studies of parton physics have entered an exciting stage of precision control and systematic improvement, which will have a broader impact for nuclear and particle experiments.

Zhao, Yong [Argonne National Laboratory (ANL), Arg↗

Solar Contamination in Extreme-precision Radial-velocity Measurements: Deleterious Effects and Prospects for Mitigation

Solar contamination, due to moonlight and atmospheric scattering of sunlight, can cause systematic errors in stellar radial velocity (RV) measurements that significantly detract from the ∼10 cm s{sup −1} sensitivity required for the detection and characterization of terrestrial exoplanets in or near habitable zones of Sun-like stars. The addition of low-level spectral contamination at variable effective velocity offsets introduces systematic noise when measuring velocities using classical mask-based or template-based cross-correlation techniques. Here we present simulations estimating the range of RV measurement error induced by uncorrected scattered sunlight contamination. We explore potential correction techniques, using both simultaneous spectrometer sky fibers and broadband imaging via coherent fiber imaging bundles, that could reliably reduce this source of error to below the photon-noise limit of typical stellar observations. We discuss the limitations of these simulations, the underlying assumptions, and mitigation mechanisms. We also present and discuss the components designed and built into the NEID (NN-EXPLORE Exoplanet Investigations with Doppler spectroscopy) precision RV instrument for the WIYN 3.5 m telescope, to serve as an ongoing resource for the community to explore and evaluate correction techniques. We emphasize that while “bright time” has been traditionally adequate for RV science, the goal of 10 cm s{sup −1} precision on the most interesting exoplanetary systems may necessitate access to darker skies for these next-generation instruments.

79 ASTRONOMY AND ASTROPHYSICS↗

The K2 M67 Study: Precise Mass for a Turnoff Star in the Old Open Cluster M67

We present a study of the bright detached eclipsing main-sequence binary WOCS 11028 (Sanders 617) in the open cluster M67. Although the binary has only one eclipse per orbital cycle, we show that the masses of the stars can be derived very precisely thanks to a strong constraint on the orbital inclination: M {sub A} = 1.222 ± 0.006M {sub ⊙} and M {sub B} = 0.909 ± 0.004M {sub ⊙}. We use a spectral energy distribution fitting method to derive characteristics of the component stars in lieu of the precise radii that would normally be derived from a doubly eclipsing binary. The deconvolution of the SEDs reveals that the brighter component of the binary is at the faint turnoff point for the cluster—a distinct evolutionary point that occurs after the convective core has been established and while the star is in the middle of its movement toward lower surface temperatures, before the so-called hook at the end of the main sequence. The measurements are in distinct disagreement with evolution models at solar metallicity: higher metal abundances are needed to reproduce the characteristics of WOCS 11028 A. We discuss the changes to model physics that are likely to be needed to address the discrepancies. The clearest conclusions are that diffusion is probably necessary to reconcile spectroscopic abundances of M67 stars with the need for higher metallicity models and that reduced strength convective overshooting is occurring for stars at the turnoff. At super-solar bulk metallicity, various indicators agree on a cluster age between about 3.5 and 4.0 Gyr.

36 MATERIALS SCIENCE↗

Precise Transit and Radial-velocity Characterization of a Resonant Pair: The Warm Jupiter TOI-216c and Eccentric Warm Neptune TOI-216b

TOI-216 hosts a pair of warm, large exoplanets discovered by the TESS mission. These planets were found to be in or near the 2:1 resonance, and both of them exhibit transit timing variations (TTVs). Precise characterization of the planets’ masses and radii, orbital properties, and resonant behavior can test theories for the origins of planets orbiting close to their stars. Previous characterization of the system using the first six sectors of TESS data suffered from a degeneracy between planet mass and orbital eccentricity. Radial-velocity measurements using HARPS, FEROS, and the Planet Finder Spectrograph break that degeneracy, and an expanded TTV baseline from TESS and an ongoing ground-based transit observing campaign increase the precision of the mass and eccentricity measurements. We determine that TOI-216c is a warm Jupiter, TOI-216b is an eccentric warm Neptune, and that they librate in 2:1 resonance with a moderate libration amplitude of 60{sub −2}{sup +2} deg, a small but significant free eccentricity of 0.0222{sub −0.0003}{sup +0.0005} for TOI-216b, and a small but significant mutual inclination of 1.°2–3.°9 (95% confidence interval). The libration amplitude, free eccentricity, and mutual inclination imply a disturbance of TOI-216b before or after resonance capture, perhaps by an undetected third planet.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

IGRINS RV: A Precision Radial Velocity Pipeline for IGRINS Using Modified Forward Modeling in the Near-infrared

Application of the radial velocity (RV) technique in the near-infrared is valuable because of the diminished impact of stellar activity at longer wavelengths, making it particularly advantageous for the study of late-type stars but also for solar-type objects. In this paper, we present the IGRINS RV open-source python pipeline for computing infrared RV measurements from reduced spectra taken with IGRINS, an R ≡ λ/Δλ ∼ 45,000 spectrograph with simultaneous coverage of the H band (1.49–1.80 μm) and K band (1.96–2.46 μm). Using a modified forward-modeling technique, we construct high-resolution telluric templates from A0 standard observations on a nightly basis to provide a source of common-path wavelength calibration while mitigating the need to mask or correct for telluric absorption. Telluric standard observations are also used to model the variations in instrumental resolution across the detector, including a yearlong period when the K band was defocused. Without any additional instrument hardware, such as a gas cell or laser frequency comb, we are able to achieve precisions of 26.8 m s{sup −1} in the K band and 31.1 m s{sup −1} in the H band for narrow-line hosts. These precisions are empirically determined by a monitoring campaign of two RV standard stars, as well as the successful retrieval of planet-induced RV signals for both HD 189733 and τ Boo A; furthermore, our results affirm the presence of the Rossiter–McLaughlin effect for HD 189733. The IGRINS RV pipeline extends another important science capability to IGRINS, with publicly available software designed for widespread use.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Large-scale Gravitational Lens Modeling with Bayesian Neural Networks for Accurate and Precise Inference of the Hubble Constant

We investigate the use of approximate Bayesian neural networks (BNNs) in modeling hundreds of time delay gravitational lenses for Hubble constant (H 0 ) determination. Here, our BNN was trained on synthetic Hubble Space Telescope quality images of strongly lensed active galactic nuclei with lens galaxy light included. The BNN can accurately characterize the posterior probability density functions (PDFs) of model parameters governing the elliptical power-law mass profile in an external shear field. We then propagate the BNN-inferred posterior PDFs into an ensemble H 0 inference, using simulated time delay measurements from a plausible dedicated monitoring campaign. Assuming well-measured time delays and a reasonable set of priors on the environment of the lens, we achieve a median precision of 9.3% per lens in the inferred H 0 . A simple combination of a set of 200 test lenses results in a precision of 0.5 km s –1 Mpc –1 (0.7%), with no detectable bias in this H 0 recovery test. The computation time for the entire pipeline—including the generation of the training set, BNN training and H0 inference—translates to 9 minutes per lens on average for 200 lenses and converges to 6 minutes per lens as the sample size is increased. Being fully automated and efficient, our pipeline is a promising tool for exploring ensemble-level systematics in lens modeling for H 0 inference.

79 ASTRONOMY AND ASTROPHYSICS↗

High-precision Galaxy Clustering Predictions from Small-volume Hydrodynamical Simulations via Control Variates

Abstract Cosmological simulations of galaxy formation are an invaluable tool for understanding galaxy formation and its impact on cosmological parameter inference from large-scale structures. However, their high computational cost is a significant obstacle for running simulations that probe cosmological volumes comparable to those analyzed by contemporary large-scale structure experiments. In this work, we explore the possibility of obtaining high-precision galaxy clustering predictions from small-volume hydrodynamical simulations such as MillenniumTNG and FLAMINGO via control variates. In this approach, the hydrodynamical full-physics simulation is paired with a matched low-resolution gravity-only simulation. By learning the galaxy–halo connection from the hydrodynamical simulation and applying it to the gravity-only counterpart, one obtains a galaxy population that closely mimics the one in the more expensive simulation. One can then construct an estimator of galaxy clustering that combines the clustering amplitudes in the small-volume hydrodynamical and gravity-only simulations with clustering amplitudes in a large-volume gravity-only simulation. Depending on the galaxy sample, clustering statistic, and scale, this galaxy clustering estimator can have an effective volume of up to around 100 times the volume of the original hydrodynamical simulation in the nonlinear regime. With this approach, we can construct galaxy clustering predictions from existing simulations that are precise enough for mock analyses of next-generation large-scale structure surveys such as the Dark Energy Spectroscopic Instrument and the Legacy Survey of Space and Time.

Doytcheva, Alexandra (ORCID:0009000111254888)↗

Photometric Recalibration of the SDSS Stripe 82 to a Few Millimagnitude Precision with the Stellar Color Regression Method and Gaia EDR3

By combining spectroscopic data from the LAMOST DR7, Sloan Digital Sky Survey (SDSS) DR12, and corrected photometric data from the Gaia EDR3, we apply the stellar color regression (SCR) method to recalibrate the SDSS Stripe 82 standard stars catalog of Ivezic' et al. With a total number of about 30,000 spectroscopically targeted stars, we have mapped out the relatively large and strongly correlated photometric zero-point errors present in the catalog, ~2.5% in the u band and ~1% in the griz bands. Our study also confirms some small but significant magnitude dependence errors in the z band for some charge-coupled devices. Various tests show that we have achieved an internal precision of about 5 mmag in the u band and about 2 mmag in the griz bands, which is about five times better than previous results. We also apply the method to the latest version of the catalog (v4.2), and find modest systematic calibration errors of up to ~1% along the R.A. direction and smaller errors along the decl. direction. The results demonstrate the power of the SCR method when combining spectroscopic data and Gaia photometry in breaking the 1% precision barrier of ground-based photometric surveys. Our work paves the way for the recalibration of the whole SDSS photometric survey and has important implications for the calibration of future surveys. Future implementations and improvements of the SCR method under different situations are also discussed.

79 ASTRONOMY AND ASTROPHYSICS↗