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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 271 records · Page 15
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Chemoproteogenomic stratification of the missense variant cysteinome

Abstract Cancer genomes are rife with genetic variants; one key outcome of this variation is widespread gain-of-cysteine mutations. These acquired cysteines can be both driver mutations and sites targeted by precision therapies. However, despite their ubiquity, nearly all acquired cysteines remain unidentified via chemoproteomics; identification is a critical step to enable functional analysis, including assessment of potential druggability and susceptibility to oxidation. Here, we pair cysteine chemoproteomics—a technique that enables proteome-wide pinpointing of functional, redox sensitive, and potentially druggable residues—with genomics to reveal the hidden landscape of cysteine genetic variation. Our chemoproteogenomics platform integrates chemoproteomic, whole exome, and RNA-seq data, with a customized two-stage false discovery rate (FDR) error controlled proteomic search, which is further enhanced with a user-friendly FragPipe interface. Chemoproteogenomics analysis reveals that cysteine acquisition is a ubiquitous feature of both healthy and cancer genomes that is further elevated in the context of decreased DNA repair. Reference cysteines proximal to missense variants are also found to be pervasive, supporting heretofore untapped opportunities for variant-specific chemical probe development campaigns. As chemoproteogenomics is further distinguished by sample-matched combinatorial variant databases and is compatible with redox proteomics and small molecule screening, we expect widespread utility in guiding proteoform-specific biology and therapeutic discovery.

Desai, Heta (ORCID:0000000343621707)↗
DOE OSTI2023

Fungal organic acid uptake of mineral-derived K is dependent on distance from carbon hotspot

Fungal mineral weathering regulates the bioavailability of inorganic nutrients from mineral surfaces to organic matter and increase the bioavailable fraction of nutrients. Such weathering strategies are classified as biomechanical or biochemical. In the case of fungal uptake of mineral nutrients through biochemical weathering, it is widely hypothesized that uptake of inorganic nutrients occurs through organic acid chelation, but such processes have not been directly visualized. This is in part due to challenges in probing the complex and heterogeneous soil environment. Here, using an epoxy-based, mineral-doped soil micromodel platform, which emulates soil mineralogy and porosity, we visualize the molecular mechanisms of mineral weathering. Mass spectrometry imaging revealed differences in the distribution of fungal exudates, citric acid, and tartaric acid on the soil micromodels in presence of minerals. Citric acid was detected closer to the nutrient-rich inoculation point, whereas tartaric acid was highly abundant away from inoculation point. This suggested that the organic acid exuded by the fungi depended on the proximity from the carbon-rich organic substrate at the point of inoculation. Using a combination of X-ray fluorescence and X-ray near edge structure analysis, we identified citric acid- and tartaric acid-bound K within fungal hyphae networks grown in the presence of minerals. Combined, our results provide direct evidence that fungi uptake and transport mineral derived nutrient organic acid chelation. The results of this study provided unprecedented visualization of fungal uptake and transport of K + , while resolving the indirect weathering mechanism of fungal K uptake from mineral interfaces.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Performance Analysis and Radiation Damage Estimation of the Stopping Target Monitor Detectors in Mu2e

The Mu2e experiment aims to search for the charged lepton flavour violating (CLFV) process of a coherent, neutrinoless, conversion of a muon into an electron within the proximity of an aluminium nucleus. Mu2e seeks to measure the ratio (R μe ) of the rate of this conversion process, relative to that of ordinary muon capture. Mu2e will achieve world-leading sensitivity, improving the current limit of Rμe < 7 ×10 -13 (90% C.L.),set by the SINDRUM-II experiment, by an order of 104. This corresponds to a single-event sensitivity of Rμe < 2.87 × 10 -17 (90% C.L.). Many beyond Standard Model (BSM) theories require CLFV to occur at a rate accessible by Mu2e. Any observation of CLFV at Mu2e would have profound implications on particle physics. The Stopping Target Monitor (STM) will be comprised of both a HPGe and a LaBr3 detector which will monitor the signals of photons produced in stopped-muon processes to a required accuracy of 10%. To achieve the desired sensitivity, it is imperative that the detectors perform at their optimal level. The STM detectors are placed within a harsh radiation environment in the form of a high energy ‘flash’ of gamma radiation as well as a flux of fast neutrons. Estimations of radiation damage to HPGe in literature is limited. This thesis reports an approach which utilizes the Kinetic-Energy Released in Matter (KERMA) parameter that considers the energy dependence of the incident flux and the cross-section information for the incident particle. Resampling schemes have been adopted to give a realistic rate over the experiment run time. The results have then been normalized to the radiation damage caused by a 252 Cf source. The estimated time before annealing of the detector is necessary is found to be 75 and 78 months in the case of neutron damage and τ ~ 24 years, 11 months in the case of electron/positron induced damage. This shows significant improvement on the previous estimations.

36 MATERIALS SCIENCE↗
NASA NTRS1979

The characteristics of a lift cruise fan V/STOL configuration in near proximity to a small deck with finite edge positions

Two V/STOL model configurations utilizing lift-cruise-fans for the propulsion system have been tested in the presence of a small landing platform with finite deck edge positions. Results and analysis of these tests are presented. The model was tested at both static (zero velocity) and forward speed conditions with several heights and deck edge positions. Configurations utilizing three fans and four fans were investigated. Incremental forces and moments induced by the various deck edge positions are analyzed as relating to the model height above the ground and the thrust velocity relationships. The test and analysis show the induced forces to be relatively unaffected by deck edge.

Stewart, V. R.↗
NASA NTRS1985

Estimation of lift losses of hovering vehicles using a single jet

This paper discusses the development of handbook techniques for the preliminary assessment of V/STOL aircraft performance while hovering in the proximity of the ground. In particular, the suckdown forces due to entrainment are described for configurations using a single jet. Corrections to current methods are suggested from an analysis of recent large-scale test data.

Christiansen, R. S.↗
NASA NTRS1992

Interactive collision detection

The assembly of Space Station Freedom will require operations where large bodies are manipulated in close proximity to one other. A fast and reliable method for performing collision detection would greatly benefit the development and verification of such operations. The Interactive Graphics and Operations Analysis Laboratory (IGOAL) has developed an algorithm for performing collision detection which provides accurate results at interactive speeds. This algorithm uses a highly-optimized ray tracer for performing the analysis. The purpose of this presentation is to describe the algorithm and demonstrate its capabilities.

Bell, Brad↗
NASA NTRS1992

Reference equations of motion for automatic rendezvous and capture

The analysis presented in this paper defines the reference coordinate frames, equations of motion, and control parameters necessary to model the relative motion and attitude of spacecraft in close proximity with another space system during the Automatic Rendezvous and Capture phase of an on-orbit operation. The relative docking port target position vector and the attitude control matrix are defined based upon an arbitrary spacecraft design. These translation and rotation control parameters could be used to drive the error signal input to the vehicle flight control system. Measurements for these control parameters would become the bases for an autopilot or feedback control system (FCS) design for a specific spacecraft.

Henderson, David M.↗
NASA NTRS2006

Simulation Modeling and Performance Evaluation of Space Networks

In space exploration missions, the coordinated use of spacecraft as communication relays increases the efficiency of the endeavors. To conduct trade-off studies of the performance and resource usage of different communication protocols and network designs, JPL designed a comprehensive extendable tool, the Multi-mission Advanced Communications Hybrid Environment for Test and Evaluation (MACHETE). The design and development of MACHETE began in 2000 and is constantly evolving. Currently, MACHETE contains Consultative Committee for Space Data Systems (CCSDS) protocol standards such as Proximity-1, Advanced Orbiting Systems (AOS), Packet Telemetry/Telecommand, Space Communications Protocol Specification (SCPS), and the CCSDS File Delivery Protocol (CFDP). MACHETE uses the Aerospace Corporation s Satellite Orbital Analysis Program (SOAP) to generate the orbital geometry information and contact opportunities. Matlab scripts provide the link characteristics. At the core of MACHETE is a discrete event simulator, QualNet. Delay Tolerant Networking (DTN) is an end-to-end architecture providing communication in and/or through highly stressed networking environments. Stressed networking environments include those with intermittent connectivity, large and/or variable delays, and high bit error rates. To provide its services, the DTN protocols reside at the application layer of the constituent internets, forming a store-and-forward overlay network. The key capabilities of the bundling protocols include custody-based reliability, ability to cope with intermittent connectivity, ability to take advantage of scheduled and opportunistic connectivity, and late binding of names to addresses. In this presentation, we report on the addition of MACHETE models needed to support DTN, namely: the Bundle Protocol (BP) model. To illustrate the use of MACHETE with the additional DTN model, we provide an example simulation to benchmark its performance. We demonstrate the use of the DTN protocol and discuss statistics gathered concerning the total time needed to simulate numerous bundle transmissions

network protocols↗
NASA NTRSDate not supplied

A Data-Driven Reduced Order Model of an Isolated Rotor

There are numerous conceptual design stage rotorcraft analysis tasks which demand a high-fidelity and low cost method for rotor load distribution predictions. Considering Urban Air Mobility (UAM) vehicles aim to operate in close proximity to buildings and with unique rotor configurations, there is a significant challenge in quickly and accurately modeling rotors operating in complex, turbulent flow fields. One potential path for deriving a high-fidelity, low cost rotor model is with data-driven surrogate modeling. In this study, an initial investigation is taken to apply a proper orthogonal decomposition (POD) based reduced order model (ROM) for the purpose of pressure distribution prediction. In this study, a POD ROM was derived to produce distributed pressure predictions on rotor blades subjected to topology change due to variation in twist and taper ratio. Rotor twist was varied between 0◦, 10◦, 20◦, and 30◦ while taper ratio was varied between 1.0, 0.9, 0.8, and 0.7. All rotors consisted of a single blade. The POD ROM was validated for three demonstration cases; a high thrust rotor in hover, a low thrust rotor in hover, and a rotor in forward flight with a flight speed of M = 0.1. Results showed highly accurate distributed load predictions could be achieved at minimal computational cost. Computational cost for hovering blade surface pressure modeling was reduced from 12 hours on 440 cores to 10−5 seconds on a single core. For blade in forward flight cost was reduced from 20 hours on 440 cores to 0.6 seconds on a single core. For cases of high thrust and low thrust rotors, POD ROM was used to undergo a design optimization of the rotor such that figure of merit was maximized. Total optimization time for each case was 1 minute.

Data-Driven↗
DOE OSTI2020

Observational Study of the Thermodynamics and Morphological Characteristics of a Midlatitude Continental Cold Pool Event

Abstract Convectively generated cold pools are important to the Earth system as they exert strong controls on deep convective-storm initiation, intensity, and life cycle. Despite their importance, efforts to introduce such cold pool controls into weather and climate models lack guidance and/or physical constraints from cold pool observations. This work presents a detailed, purely observational analysis of a cold pool event that took place on 23–24 May 2011 in north-central Oklahoma. The characteristics of the cold pool, and the spatiotemporal evolution of the hydrometeors and dynamics in the proximity of the cold pool, are studied with high-resolution observations. The unprecedented dataset used in this work to study cold pool characteristics includes an enhanced network of surface weather stations, a high-temporal-frequency sounding array, and the NEXRAD and Atmospheric Radiation Measurement (ARM) Southern Great Plains radar networks. The potential use of NEXRAD surveillance scans to estimate height and propagation speed of the leading edge of the cold pool (LECP) is presented in this work. Manual identification and tracking of the LECP from NEXRAD imagery shows a spatial and temporal heterogeneity of the LECP properties. Surprisingly, over its detected life cycle, the LECP speed remains almost constant, even though the strength of the cold pool diminishes in time and its height varies. Radar analysis shows that pulses of graupel and hail within downdrafts in the convective system generating the cold pool appeared to be related to temporary increases in the LECP height.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1994

Mapping ERS-1 wind fields over north west Atlantic using a variational objective analysis

A variational method is implemented to produce five day mean gridded ERS-1 analyzed wind fields in the north west Atlantic with the aim of providing for wind forcing of basin scale ocean models. The method consists of minimizing a cost functional, designed to measure misfits to prescribed weighted constraints which express a smoothed behavior and the proximity to input data vectors and curl. The weights are empirically determined by comparison with independent ship and buoy data over four five day periods. Root mean square differences between analyzed winds and independent data are thus further decreased: they range from 0.8 up to 1.8 m/s. Some problems present in the initial data remain; they are principally due to incomplete data coverage (instrumental problems), and possibly unresolved ambiguities. The resulting curl fields are smoothed and show coherent patterns. A comparison with the European Center for Medium range Weather Forecasting (ECMWF) analysis is encouraging.

Siefridt, L.↗
DOE OSTI2019

Temporal multispectral and 3D analysis of Cerro de Pasco, Peru

Mining operations across the world often lead to contamination of land, water resources, ecosystems and in some cases, entire communities.Results of recent health and ground sampling studies revealed extensive lead contamination within the populace and around the City of Cerro de Pasco, Peru. Tailings excavated from a large open pit zinc mine in the center of the city have been aggregated in four large stockpiles within close proximity to neighborhoods, schools, and hospitals. Visual comparison of ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer) imagery from 2001 and Sentinel-2 imagery from 2018 suggests a size increase in one tailing stockpile in particular near the neighborhood of Paragsha. Due to ongoing mining efforts, the hypothesis motivating the work presented here is that Pb-bearing minerals would be detectable through multispectral analysis, an increase in Pb mineral percent abundance would be observed and tailing stockpile volume would be detectable between 2001 and 2016. This hypothesis is tested using Spectral Angle Mapper (SAM), Adaptive Coherence Estimator (ACE), and Jeffries-Matusita distance calculation on ASTER (2001) and Sentinel-2 (2018) VNIR and SWIR bands. Volume and area estimate of tailing stockpiles were calculated using a photogrammetrically derived point cloud. SAM detected the presence of five Pb-bearing minerals around Cerro de Pasco and Paragsha. The results of the temporal SAM analysis displayed an increase of approximately 17% of Pb-bearing minerals around the greater Cerro de Pasco city area and approximately 11% for the neighborhood of Paragsha. Jeffries-Matusita distance results suggest clear correlation between contamination sources and affected locations. Total tailing stockpile volume was measured to be approximately 200,300,000 m 3 . Volume for Pile 4 was estimated to have increased by approximately 46,000,000 m 3 between 2001 and 2018. Lastly, these presented results will hopefully inspire and guide future remote sensing campaigns, perhaps involving a UAV or aircraft-based hyperspectral instrument.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2024

Transportation and System Analysis Collaborations in Support of a Federal Consolidated Interim Storage Facility

The U.S. Department of Energy’s Integrated Waste Management (IWM) program under the Office of Nuclear Energy is planning for the future transportation, storage, and eventual disposal of spent nuclear fuel (SNF) and high-level radioactive waste (HLW) from nuclear power plant and waste custodian sites across the United States. To better enable informed decision-making regarding the back end of the nuclear fuel cycle, the IWM program has been sponsoring the development and application of system analysis tools capable of analyzing various options for managing SNF and HLW. With these tools, integrated waste management system (IWMS) architecture analyses are being conducted to support the future deployment of a comprehensive nuclear waste management system that considers all major back-end aspects of the nuclear fuel cycle (i.e., transportation, storage, and disposal). System analyses and assessments typically use these modeling and simulation tools to investigate implications of changes in various assumptions and parameters such as acceptance rates, receipt logic, facility capacities and capabilities, use of standardized canisters, start and stop dates of facilities, etc. The Next Generation System Analysis Model (NGSAM) is an agent-based simulation toolkit that is used for a system-level simulation and analysis focused on SNF management in the United States. NGSAM’s primary purpose is to provide a system analyst with capabilities to model the IWMS and gain insights into SNF and HLW management alternatives including the impact of system choices, associated cost estimates, and development of integrated yet flexible approaches. An analyst using NGSAM can define several factors like the number of storage facilities, capacity at each facility, transportation schedules, shipment rates, and other conditions. IWM is also developing the Stakeholder Tool for Assessing Radioactive Transportation (START). START is a web-based geospatial tool developed to provide the visualization and initial evaluation of transportation options associated with future SNF and HLW shipment planning and operations. This includes characterizing safety, economic, and environmental conditions at and in proximity to shipment origins as well as along prospective transportation routes. Information from the START tool can be presented/shared as maps, graphics, geospatial files, and tabular form to enable easy data representation and export functionality. The system analysis, NGSAM, and START teams have been working closely for several years before formalizing this collaboration. START provides the SNF transportation routing information for use in NGSAM. System analysts use the NGSAM tool to generate results (schedule, costs, infrastructure acquisitions, shipment rates, etc.). Subject-matter experts and system analysts work together to inform how NGSAM should model the waste management system. Specifically, this paper discusses the collaborations between the system analysis, NGSAM, and START teams and their accomplishments over the past year. Some examples of these efforts include calibrating and adding data to the START output files to meet NGSAM needs, gaining a better understanding of START data used in NGSAM as well as how updates in START data could result in an improved NGSAM analysis. Detailed examples of various tasks that have been performed by the team will be discussed in the full paper. Continued efforts in this direction are expected in the coming years.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2022

Computational analysis of the tryptophan cation radical energetics in peroxidase Compound $\mathrm{I}$

Three well-characterized heme peroxidases (cytochrome c peroxidase = CCP, ascorbate peroxidase = APX, and Leishmania major peroxidase = LMP) all have a Trp residue tucked under the heme stacked against the proximal His heme ligand. The reaction of peroxidases with H 2 O 2 to give Compound I results in the oxidation of this Trp to a cationic radical in CCP and LMP but not in APX. Considerable experimental data indicate that the local electrostatic environment controls whether this Trp or the porphyrin is oxidized in Compound I. Attempts have been made to place the differences between these peroxidases on a quantitative basis using computational methods. These efforts have been somewhat limited by the approximations required owing to the computational cost of using fully solvated atomistic models with well-developed forcefields. This now has changed with available GPU computing power and the associated development of software. Here we employ thermodynamic integration and multistate Bennett acceptance ratio methods to help fine-tune our understanding on the energetic differences in Trp radical stabilization in all three peroxidases. These results indicate that the local solvent structure near the redox active Trp plays a significant role in stabilization of the cationic Trp radical.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS1972

Study of ground proximity effects on powered-lift STOL landing performance

Data from wind-tunnel measurements are presented to show the magnitude of adverse ground effects on the longitudinal aerodynamic coefficients of a powered-lift STOL airplane. A steady-state analysis shows the changes in thrust and angle of attack required during the landing approach and flare as the airplane flies close to the ground. The piloting problems that these ground effects may create were investigated with an in-flight simulator to find the consequences of lift loss during the landing-flare maneuver for a STOL transport. Flight tests were made using the variable stability Navion setup with STOL transport aerodynamics and control responses and were flown at design approach speeds and descent conditions.

Hassell, J. L., Jr.↗
DOE OSTI2024

Transportation and Systems Analysis Collaborations in Support of a Federal Consolidated Interim Storage Facility

The U.S. Department of Energy’s Integrated Waste Management (IWM) program under the Office of Nuclear Energy is planning for the future transportation, storage, and eventual disposal of spent nuclear fuel (SNF) and high-level radioactive waste (HLW) from nuclear power plant sites across the United States. To better enable informed decision-making regarding the back end of the nuclear fuel cycle, the IWM program has been sponsoring the development and application of system analysis tools capable of analyzing various options for managing SNF and HLW. With these tools, integrated waste management system (IWMS) architecture analyses are being conducted to support the future deployment of a comprehensive nuclear waste management system that considers all major back-end aspects of the nuclear fuel cycle (i.e., transportation, storage, and disposal). System analyses and assessments typically use these modeling and simulation tools to investigate implications of changes in various assumptions and parameters such as acceptance rates, receipt logic, facility capacities and capabilities, use of standardized canisters, start and stop dates of facilities, etc. The Next Generation System Analysis Model (NGSAM) is an agent-based simulation toolkit that is used for a system-level simulation and analysis focused on SNF management in the United States. An analyst using NGSAM has the ability to define several factors like the number of storage facilities, capacity at each facility, transportation schedules, shipment rates, and other conditions. NGSAM’s primary purpose is to provide a system analyst with capabilities to model the IWMS and gain insights into SNF and HLW management alternatives including the impact of system choices, associated cost estimates, and development of integrated yet flexible approaches. IWM is also developing the Stakeholder Tool for Assessing Radioactive Transportation (START). START is a web-based geospatial tool developed to provide visualization and initial evaluation of transportation options associated with future SNF and HLW shipment planning and operations. This includes characterizing safety, economic, and environmental conditions on and in proximity to shipment origins as well as along prospective transportation routes. Information from the START tool can be presented/shared as maps, graphics, geospatial files, and tabular form to enable easy data representation and export functionality. The system analysis, NGSAM, and START teams had been working closely for several years before formalizing this collaboration. START provides the SNF routing information for use in NGSAM. System analysts use the NGSAM tool to generate results (schedule, costs, infrastructure acquisitions, shipment rates, etc.). Subject-matter experts and system analysts work together to inform how NGSAM should model the waste management system. Specifically, this paper discusses the collaborations between the system analysis, NGSAM, and START teams and their accomplishments over the past year. Some examples of these efforts include calibrating and adding data to the START output files to meet NGSAM needs, gaining a better understanding of START data used in NGSAM, as well as how updates in START data could result in an improved NGSAM analysis. Detailed examples of various tasks that have been performed by the team will be discussed in the full paper. Continued efforts in this direction are expected in the coming years.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
NASA NTRS2001

Analysis of fractal dimensions of rat bones from film and digital images

OBJECTIVES: (1) To compare the effect of two different intra-oral image receptors on estimates of fractal dimension; and (2) to determine the variations in fractal dimensions between the femur, tibia and humerus of the rat and between their proximal, middle and distal regions. METHODS: The left femur, tibia and humerus from 24 4-6-month-old Sprague-Dawley rats were radiographed using intra-oral film and a charge-coupled device (CCD). Films were digitized at a pixel density comparable to the CCD using a flat-bed scanner. Square regions of interest were selected from proximal, middle, and distal regions of each bone. Fractal dimensions were estimated from the slope of regression lines fitted to plots of log power against log spatial frequency. RESULTS: The fractal dimensions estimates from digitized films were significantly greater than those produced from the CCD (P=0.0008). Estimated fractal dimensions of three types of bone were not significantly different (P=0.0544); however, the three regions of bones were significantly different (P=0.0239). The fractal dimensions estimated from radiographs of the proximal and distal regions of the bones were lower than comparable estimates obtained from the middle region. CONCLUSIONS: Different types of image receptors significantly affect estimates of fractal dimension. There was no difference in the fractal dimensions of the different bones but the three regions differed significantly.

NASA Discipline Musculoskeletal↗
DOE OSTI2022

Inter-valley coherent order and isospin fluctuation mediated superconductivity in rhombohedral trilayer graphene

Superconductivity was recently discovered in rhombohedral trilayer graphene (RTG) in the absence of a moiré potential. Superconductivity is observed proximate to a metallic state with reduced isospin symmetry, but it remains unknown whether this is a coincidence or a key ingredient for superconductivity. Using a Hartree-Fock analysis and constraints from experiments, we argue that the symmetry breaking is inter-valley coherent (IVC) in nature. We evaluate IVC fluctuations as a possible pairing glue, and find that they lead to chiral unconventional superconductivity when the fluctuations are strong. We further elucidate how the inter-valley Hund’s coupling determines the spin-structure of the IVC ground state and breaks the degeneracy between spin-singlet and triplet superconductivity. Remarkably, if the normal state is spin-unpolarized, we find that a ferromagnetic Hund’s coupling favors spin-singlet superconductivity, in agreement with experiments. Instead, if the normal state is spin-polarized, then IVC fluctuations lead to spin-triplet pairing.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗