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Effects of 14 days of head-down tilt bed rest on cutaneous vasoconstrictor responses in humans

This study tested the hypothesis that head-down tilt bed rest (HDBR) reduces adrenergic and nonadrenergic cutaneous vasoconstrictor responsiveness. Additionally, an exercise countermeasure group was included to identify whether exercise during bed rest might counteract any vasoconstrictor deficits that arose during HDBR. Twenty-two subjects underwent 14 days of strict 6 degrees HDBR. Eight of these 22 subjects did not exercise during HDBR, while 14 of these subjects exercised on a supine cycle ergometer for 90 min a day at 75% of pre-bed rest heart rate maximum. To assess alpha-adrenergic vasoconstrictor responsiveness, intradermal microdialysis was used to locally administer norepinephrine (NE), while forearm skin blood flow (SkBF; laser-Doppler flowmetry) was monitored over microdialysis membranes. Nonlinear regression modeling was used to identify the effective drug concentration that caused 50% of the cutaneous vasoconstrictor response (EC(50)) and minimum values from the SkBF-NE dose-response curves. In addition, the effects of HDBR on nonadrenergic cutaneous vasoconstriction were assessed via the venoarteriolar response of the forearm and leg. HDBR did not alter EC(50) or the magnitude of cutaneous vasoconstriction to exogenous NE administration regardless of whether the subjects exercised during HDBR. Moreover, HDBR did not alter the forearm venoarteriolar response in either the control or exercise groups during HDBR. However, HDBR significantly reduced the magnitude of cutaneous vasoconstriction due to the venoarteriolar response in the leg, and this response was similarly reduced in the exercise group. These data suggest that HDBR does not alter cutaneous vasoconstrictor responses to exogenous NE administration, whereas cutaneous vasoconstriction of the leg due to the venoarteriolar response is reduced after HDBR. It remains unclear whether attenuated venoarteriolar responses in the lower limbs contribute to reduced orthostatic tolerance after bed rest and spaceflight.

NASA Discipline Cardiopulmonary↗

Optimizing Hydronic Heating for Comfort and Performance in Multifamily Housing

Inefficient control settings in multifamily boilers often lead to substantial energy and cost penalties. To address this, a Fault Detection and Diagnostic (FDD) tool was developed to automate data analysis and identify operational faults such as suboptimal outdoor temperature sensor placement, misconfigured outdoor air reset (OAR) curves, excess boiler cycling, and domestic hot water (DHW) setpoint errors. By comparing pre- and post-implementation periods and applying engineering models, the tool quantifies energy savings and reduces manual analysis time by over 90%. Testing on over 100 monitored sites and a targeted subset of 12 buildings showed an average 11% energy savings from remote optimization; further validation across 19 OAR curve changes confirmed the tool’s accuracy, predicting actual savings within ±5% for most cases. Simple payback can be under three years for many multifamily buildings, though rising hardware, labor, and fuel costs create uncertainties, and decarbonization goals increasingly shift focus to electrification. The FDD tool remains invaluable for optimizing existing boilers, enhancing future electrification measures, and adapting to new technologies by refining building load estimates. In doing so, it supports both near-term efficiency and long-term transitions to low-carbon alternatives, ensuring buildings achieve substantial cost and energy benefits throughout their system lifecycles.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Time and Measurement Days

Questions in data analysis involving the concepts of time and measurement are often pushed into the background or reserved for a philosophical discussion. Some examples are: a) Is causality a consequence of the laws of physics, or can the arrow of time be reversed? b) Can we determine the arrow of time of an event? c) Do we need the continuum hypothesis for the underlying function in any measurement process? d) Can we say anything about the analyticity of the underlying process of an event? e) Would it be valid to model a non-analytical process as function of time? f) What are the implications of all these questions for classical Fourier techniques? However, in the age of big data gathered either from space missions supplying ultra-precise long time series, or e.g. LIGO data from the ground, the moment to bring these questions to the foreground seems arrived. The limitations of our understanding of some fundamental processes is emphasized by the lack of solution for problems open for more than 2 decades, such as the non-detection of solar g-modes, or the modal identification of main sequence stellar pulsators like delta Scuti stars. Flicker noise or 1/f noise, for example, attributed in solar-like stars to granulation, is analyzed mostly only to apply noise reduction techniques, neither considering the classical problem of 1/f noise that was introduced a 100 years ago, nor taking into account ergodic or non-ergodic solutions that make inapplicable spectral analysis techniques in practice. This topic was discussed by Nicholas W. Watkins during the ITISE meeting held in Granada in 2016. There he presented preliminary results of his research on Mandelbrot's related work. We reproduce here his quotation of Mandelbrot (1999) "There is a sharp contrast between a highly anomalous ("non-white") noise that proceeds in ordinary clock time and a noise whose principal anomaly is that it is restricted to fractal time", suggesting a connection with the above proposed topics that could be phrased as the following additional questions:a) Is self-organized criticality (SOC) frequent in astrophysical phenomena? b) Could all fractals in nature be considered stochastic? c) Could we establish mathematical/physical relationships between chaotic and fractal behaviors in time series? d) Could the differences between fractals and chaos in terms of analyticity be used to understand the residuals of the fitting of stellar light curves? In this meeting we would like to approximate these problems from a holistic and multidisciplinary perspective, taking into account not only technical issues but also the deeper implications. In particular the concept of connectivity (introduced in Pascual-Granado et al. A&A, 2015) could be used to implement, within the framework of ARMA processes, an "arrow of time" (see attached document), and so studying the possible implications in the concept of time as envisaged by Watkins.

data analysis↗

Application of Raman Spectroscopy to Determine Uranium Content in ADUN Solution

The work presented in this report is part of the ongoing efforts to address the nuclear material control and accounting needs for advanced reactor fuel fabrication facilities. This work was supported by the Materials Protection, Accounting, and Control Technologies (MPACT) program under the US Department of Energy Office of Nuclear Energy‘s Nuclear Fuel Cycle and Supply Chain program. The activities and engagements under the MPACT program are designed to support a robust US civilian nuclear energy enterprise. In the work described in this report, we supported MPACT objectives by developing measurement techniques that could be used for material accounting and process monitoring and by working with industry partners to identify existing gaps and areas for improvement. Oak Ridge National Laboratory has been working with commercial tristructural isotropic (TRISO) fuel fabricators such as Standard Nuclear to develop technology for rapid and cost-effective uranium content assessment. This work has focused on demonstrating advanced measurement techniques (e.g., Raman spectroscopy) that can be used for rapid, reliable, and cost-effective routine measurements of uranium content in feed solutions and liquid waste streams as well as for monitoring in-line process measurements and product streams. Specifically, this report explores techniques for accurately determining uranium content in acid-deficient uranyl nitrate (ADUN) solutions and detecting low uranium concentrations in ammonia solutions. Developing such measurement techniques will benefit TRISO fuel fabrication facilities, facilities involved in other parts of the fuel cycle that require online monitoring of aqueous solutions, and potentially molten salt fuel reactors. This work supports developing Raman spectroscopy procedures to determine uranium concentrations in ADUN solutions, which are used as feedstock in the sol–gel process for creating TRISO fuel. Some additional benefits of using Raman spectroscopy for uranium quantification in fabrication facilities include enabling online monitoring of the chemical process, which would provide near real-time feedback; eliminating the need for sample transfers, preparation, or dilution; providing nondestructive measurements; and user friendliness. In this fiscal year, FY25, we determined the identity of the unknown Raman band at approximately 853 cm−1 that was discovered in ADUN Raman spectra in FY24, created calibration curves and determined uranium concentrations of two ADUN solutions, and compared the Raman results to results obtained from inductively coupled plasma mass spectrometry and Davies–Gray titration. Furthermore, we have identified focus areas for experimentation in future fiscal years. A key result is that the accuracy of using Raman can provide accuracy comparable to destructive analysist techniques, With a well-developed calibration curve, using standards and a large number of samples (more than five samples), uncertainty on the order of 1%–3% is achievable. Given that the uncertainties achieved by Raman spectroscopy were on the order of the uncertainties achieved using ICP-MS, we conclude that with a well-developed procedure Raman spectroscopy can be used to determine uranium concentrations in ADUN solutions for NMC&A applications. The benefits of such an approach are that the time and effort will be less than that of comparable destructive analysis techniques, with approximately the same level of technical expertise. This will be attractive to operators of fuel fabrication facilities as it will lower costs and improve efficiencies.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Snow Cover, Snowmelt Timing and Stream Power in the Wind River Range, Wyoming

Earlier onset of springtime weather, including earlier snowmelt, has been documented in the western United States over at least the last 50 years. Because the majority (is greater than 70%) of the water supply in the western U.S. comes from snowmelt, analysis of the declining spring snowpack (and shrinking glaciers) has important implications for the management of streamflow. The amount of water in a snowpack influences stream discharge which can also influence erosion and sediment transport by changing stream power, or the rate at which a stream can do work, such as move sediment and erode the stream bed. The focus of this work is the Wind River Range (WRR) in west-central Wyoming. Ten years of Moderate-Resolution Imaging Spectroradiometer (MODIS) snow-cover, cloud-gap-filled (CGF) map products and 30 years of discharge and meteorological station data are studied. Streamflow data from streams in WRR drainage basins show lower annual discharge and earlier snowmelt in the decade of the 2000s than in the previous three decades, though no trend of either lower streamflow or earlier snowmelt was observed within the decade of the 2000s. Results show a statistically-significant trend at the 95% confidence level (or higher) of increasing weekly maximum air temperature (for three out of the five meteorological stations studied) in the decade of the 1970s, and also for the 40-year study period as a whole. The extent of snow-cover (percent of basin covered) derived from the lowest elevation zone (2500-3000 m) of the WRR, using MODIS CGF snow-cover maps, is strongly correlated with maximum monthly discharge on 30 April, where Spearman's Rank correlation, rs,=0.89 for the decade of the 2000s. We also investigated stream power for Bull Lake Creek above Bull Lake; and found a trend (significant at the 90% confidence level) toward reduced stream power from 1970 to 2009. Observed changes in streamflow and stream power may be related to increasing weekly maximum air temperature measured during the 40-year study period, possibly contributing to a reduction in snow cover. In addition, the strong relationship between percent of basin that was snow covered, and maximum monthly streamflow indicates that MODIS snow-cover maps are useful for predicting streamflow, and can be used to improve management of water resources in the drought-prone western United States.

MODIS↗