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NASA NTRS2015

Multi-Gas Monitor (MGM)

Multi-Gas Monitor is a flight experiment, a technology demonstration to test the ability of tunable diode laser spectroscopy based instrument to stay in calibration long term and follow events and dynamics occurring with the cabin atmosphere. MGM measures 4 gases: oxygen, carbon monoxide, ammonia and water vapor, as well as temperature and pressure. This month marked one year of successful and continuous MGM operation on ISS. The crew successfully tested the ammonia channel using a commercially available inhalant. MGM has detected some interesting dynamics inside Japanese Experiment Module (JEM) as a result of CO2 thruster firings from the SPHERES/RINGS payload and water spikes from dry out cycling of the JEM heat exchangers. Results to date have given us high confidence in the technology such that we believe this could have applications in the energy and medical sectors. This presentation will summarize the testing and results of the unit on ISS and suggest areas of use within the energy and medical arenas.

Pilgrim, Jeff↗

NASA NTRS2017

Validation of Fatigue Modeling Predictions in Aviation Operations

Bio-mathematical fatigue models that predict levels of alertness and performance are one potential tool for use within integrated fatigue risk management approaches. A number of models have been developed that provide predictions based on acute and chronic sleep loss, circadian desynchronization, and sleep inertia. Some are publicly available and gaining traction in settings such as commercial aviation as a means of evaluating flight crew schedules for potential fatigue-related risks. Yet, most models have not been rigorously evaluated and independently validated for the operations to which they are being applied and many users are not fully aware of the limitations in which model results should be interpreted and applied.

operational safety↗

NASA NTRSDate not supplied

Helicopter Pilot Evaluations of the Airborne Collision Avoidance System Xr in a High-Fidelity Motion Simulation

New aircraft and aerial Urban Air Mobility operations require updated technologies to maintain vehicle separation during flight. Specifically, higher-density airspace will need more than traditional air traffic control to keep vehicles well clear of each other and avoid Near Midair Collisions. In response, the Federal Aviation Administration is currently developing the Airborne Collision Avoidance System X (ACAS X) for next-generation air traffic deconfliction, which provides caution-level and warning-level alerts in response to multiple aircraft types. This study recruited six helicopter pilots to fly an electric vertical takeoff and landing vehicle model in simulated operations under Visual Flight Rules (VFR). Flights were accomplished using the high-fidelity Vertical Motion Simulator at the NASA Ames Research Center. Participants controlled the vehicle using two side inceptors and foot rudders. The rotorcraft variant of ACAS X (ACAS Xr) was provided for alerting and guidance during traffic conflicts. Pilots used this system while giving feedback to the researchers through questionnaires, debriefs, and other discussions. Variables of interest to the study were phases of flight (i.e., Cruise, Hover, and Approach) and ACAS Xr configurations: The Collision Avoidance System configuration behaves similarly to current commercial traffic systems used for tactical deconfliction in crewed vehicles, and the Detect and Avoid configuration was developed to provide extra, corrective-level guidance for unmanned aircraft systems. Results showed that pilots found the alerting and guidance from ACAS Xr useful, effective, and acceptable for VFR operations. Certain elements, like speed guidance and text banners, were found to be of no use to the pilots. Hover and Approach scenarios were considered the most difficult for ACAS Xr alerting. Reasons for this difficulty were partially due to learning interference (i.e., overcoming previously learned behavior) and partially due to the vehicle model (i.e., NASA’s Lift Plus Cruise design). Still, alerting-based confounds reveal the need for more development for ACAS Xr during these Hover and Approach flight phases. Study caveats and future projects are discussed.

air taxis↗

NASA NTRSDate not supplied

Helicopter Pilot Evaluations of the Airborne Collision Avoidance System Xr in a High-Fidelity Motion Simulation

air taxis↗

NASA NTRS2024

Gateway to the Future: Lessons Learned in Development of the Refueling Systems for NASA's First Lunar Space Station

Developed in collaboration with international and commercial partners, Gateway will be humanity’s first crewed space station around the Moon as a vital component of NASA’s Artemis Program for exploration to the Moon, Mars and beyond. As part of it’s focus on developing a sustainable, long term lunar capability, both Xenon based Solar Electric Propulsion System, as well as bi-propellant Reaction Control System of Gateway are designed to be on-orbit refuelable. Through design studies, numerical modeling, hardware development, and substantial testing, the system architecture has undergone significant changes to meet mission requirements and utilize evolving hardware capabilities between concept formulation and the successful completion of its Critical Design Review. This paper presents key lessons learned during this process, highlighting specific design elements and test results that contribute to a robust and adaptable refueling system for the Gateway.

Christopher Radke↗

NASA NTRSDate not supplied

Evaluation of Long-Term Storage Stability and Operational Efficiency of Rapid Cycle Amine Adsorbents

With the recent incorporation of Mars Extravehicular Activity (EVA) into the 2025 NASA roadmap, Rapid Cycle Amine (RCA) technology advancement within the Exploration Extravehicular Mobility Unit (xEMU) applies to both the upcoming Lunar Artemis missions and future human exploration of Mars. The incorporation of commercial spacesuit vendors to service NASA’s crewed-space programs since 2021 has increased the demand for regenerable, RCA-based carbon dioxide (CO2) and humidity control adsorbents. The regenerable RCA subunit is the most advanced, long-term solution for CO2 removal and humidity control, enabling both lunar and Martian EVAs. The adsorbent selected for use within the RCA unit must exhibit sufficient storage stability and operational efficiency for prolonged missions. As XploSafe worked to simultaneously develop both a recirculating sub-atmospheric test rig and adsorbents for the RCA system within the xEMU, several novel adsorbents were evaluated for long-term storage stability in support of future extended-duration missions. The chosen materials were periodically evaluated by nuclear magnetic resonance (NMR) spectroscopy, thermal desorption-coupled with gas chromatography/mass spectrometry (TD-GC/MS), and CO2 adsorption to assess long-term storage efficacy across various environmental storage conditions. NMR spectroscopy was utilized by extracting the active CO2 adsorbing chemical from the solid support with deuterated solvent and comparing the spectra over time for degradation and change. The solid adsorbents were also analyzed via TD-GC/MS to reveal any potential off-gassing chemicals over time. Additionally, XploSafe’s breakthrough test rig was utilized to dose the solid adsorbents with a 585 BTU/h metabolic rate flow-equivalent CO2 stream and monitored for 0–99% CO2 breakthrough. The performance metrics from the breakthrough analysis were compared over the storage study duration for CO2 removal and humidity control. Xplo-SA9T was evaluated for 24 months, whereas two additional adsorbent variants, MMPA-Sorbent and LPEI-Sorbent, were each evaluated for 12 months.

John R Tidwell↗

NASA NTRS2014

The Nuclear Thermal Propulsion Stage (NTPS): A Key Space Asset for Human Exploration and Commercial Missions to the Moon

The nuclear thermal rocket (NTR) has frequently been discussed as a key space asset that can bridge the gap between a sustained human presence on the Moon and the eventual human exploration of Mars. Recently, a human mission to a near Earth asteroid (NEA) has also been included as a "deep space precursor" to an orbital mission of Mars before a landing is attempted. In his "post-Apollo" Integrated Space Program Plan (1970 to 1990), Wernher von Braun, proposed a reusable Nuclear Thermal Propulsion Stage (NTPS) to deliver cargo and crew to the Moon to establish a lunar base initially before sending human missions to Mars. The NTR was selected because it was a proven technology capable of generating both high thrust and high specific impulse (Isp approx. 900 s)-twice that of today's best chemical rockets. During the Rover and NERVA programs, 20 rocket reactors were designed, built and successfully ground tested. These tests demonstrated the (1) thrust levels; (2) high fuel temperatures; (3) sustained operation; (4) accumulated lifetime; and (5) restart capability needed for an affordable in-space transportation system. In NASA's Mars Design Reference Architecture (DRA) 5.0 study, the "Copernicus" crewed NTR Mars transfer vehicle used three 25 klbf "Pewee" engines-the smallest and highest performing engine tested in the Rover program. Smaller lunar transfer vehicles-consisting of a NTPS with three approx. 16.7 klbf "SNRE-class" engines, an in-line propellant tank, plus the payload-can be delivered to LEO using a 70 t to LEO upgraded SLS, and can support reusable cargo delivery and crewed lunar landing missions. The NTPS can play an important role in returning humans to the Moon to stay by providing an affordable in-space transportation system that can allow initial lunar outposts to evolve into settlements capable of supporting commercial activities. Over the next decade collaborative efforts between NASA and private industry could open up new exploration and commercial opportunities for both organizations. With efficient NTP, commercial habitation and crew delivery systems, a "mobile cislunar research station" can transport crews to small NEAs delivered to the E-ML2 point. Also possible are week-long "lunar tourism" missions that can carry passengers into lunar orbit for sightseeing (and plenty of picture taking), then return them to Earth orbit where they would re-enter and land using a small reusable lifting body based on NASA's HL-20 design. Mission descriptions, key vehicle features and operational characteristics are described and presented.

Borowski, Stanley K.↗

NASA NTRS1983

The use of satellite observations of the ocean surface in commercial fishing operations

Commercial fishermen are interested in the safety of their crews, boats, and gear, and in making the best catch for their time and money. Rising fuel costs, increased competition from foreign fisheries, improved knowledge about fish habits and the new 200 mile economic zone have all had an impact on the U.S. fishing industry. As a consequence, the modern fisherman, more than ever, requires reliable and timely information about the marine environment. This paper describes an experimental program to utilize satellite observations of the ocean surface, in conjunction with conventional observations and products, to prepare special fisheries aids charts for daily radio facsimile broadcasts to commercial fishermen. These special fisheries products aggregate a broad set of ocean observations, including ocean color structure, to depict oceanographic conditions of importance to commercial fishing tactics. Results to date have shown that improved safety at sea and decreased fuel costs can be achieved through the applied use of these special fisheries charts.

Montgomery, D. R.↗

NASA NTRSDate not supplied

The Future of Astronaut Nutrition: Daily Production of Kefir Nutrient Packs in a Lunar Analog Mission

Astronaut nutrition will need to be supplemented with fresh nutrients and probiotics for long duration space travel. Kefir is a fermented milk beverage that provides probiotic bacteria, protein, calcium, and vitamin K. It has been historically cultured for thousands of years and is a modern-day health food. During the BioNutrients-2 experiment, one generation of kefir was cultured by astronauts on the ISS in fluorinated ethylene propylene (FEP) bags. This follow-on experiment aimed to test the hypothesis that kefir can be produced at ambient temperatures and safely passaged to make a series of nutrient packs in an analog environment. The Hawaiian Space Exploration Analog and Simulation (HI-SEAS) is a semi-controlled habitat located on the Mauna Loa volcano on the island of Hawaii at 2,500 m elevation. The recent EMMIHS (EuroMoonMars, International MoonBase Alliance, HI-SEAS) missions comprised of interdisciplinary, international crews for mock lunar missions. During a six-day mission in March 2024, crew members tested continuous passaging of kefir cultures (C-FIR commercial strain). After approximately 24 hours of growth, a portion of culture was used to seed the next generation of culture bags for four passages. A color board and pH indicator allowed the crew to easily determine when the culture had reached optimal pH. Laboratory analysis at NASA Ames Research Center showed that the pH met Kefir standards (<5). The yeast and lactic acid bacteria were in normal range and no contamination was detected in the final passage. By successfully accomplishing this experiment the team has demonstrated the ability to safely produce daily cultures of kefir in a microgravity applicable growth system.

Astronaut nutrition↗

NASA NTRS2025

Private Astronaut Post-Mission Debrief Interviews Study

BACKGROUND The commercialization of space will increasingly include individuals that are not rigorously-selected, highly-trained professional astronauts. Private astronaut missions (PAMs), such as Axiom-1 in 2022, will continue to travel to the International Space Station in the coming years, but the risk of integrating private astronauts with NASA astronauts has not been clearly quantified nor mitigated. An earlier internal NASA operations assessment, which consisted of a comprehensive literature review and interviews of current NASA experts, found that PAMs are likely to increase the risk to NASA astronauts during integrated missions (Landon, Whiting, Russell, Schorn, Passmore, & Roma, 2022). There are ongoing efforts at NASA to mitigate concerns from a medical, psychological, and technical perspective. NASA experts are working closely with PAM providers to offer recommendations and best practices beyond the limits of requirements to ensure crew health and safety. However, efforts are siloed between groups to some extent, and with the rate of PAMs likely to increase, a more comprehensive and integrated process is needed to reduce the burden on NASA resources. AIMS The purpose of this project is to understand private astronauts’ motivations for journeying to space, their pre-mission preparation period, and their experiences in space. Data will be collected via private astronaut post-mission debrief interviews. This data will inform training needs and in-mission support needed for missions that include private astronauts; the preparation NASA astronauts and mission support personnel will need to work with these integrated crews; and gaps in knowledge to guide research and countermeasure development. Our study aims to (1) Characterize risks posed by commercialization and private astronaut crew integration in spaceflight operations, as it relates to Team, Human Systems Integration Architecture (HSIA), and Behavioral Medicine (BMed) Risks, (2) Recommend potential countermeasures and identify gaps in current research. Countermeasures may be related to crew selection and composition, training, crew support systems (e.g., medical/psychological support, support from Mission Control, on-board resources), and habitability and human factors design. METHOD The BHP Lab will conduct 30-minute interviews with up to eight (8) private astronaut mission (PAM) astronauts (e.g., Axiom) and spaceflight participants (e.g., SFPs or “free flyers” on Polaris Dawn) per year from 2024-2030 to discuss knowledge gaps and needs related to selection and assessment, crew composition, training, crew support systems (e.g., medical/psychological support, support from Mission Control, onboard resources), and habitability and human factors design, which may influence the risk to NASA astronauts. Interviews will then be coded using thematic analysis and interpreted with the assistance of lexical analysis software (e.g., LIWC). As of the end of 2024, we have collected data from one PAM crew. At the conclusion of data collection in 2030, a final report will be prepared integrating all data collected by 2031. SUMMARY Post-return interviews of private astronauts are being conducted to understand their experiences and inform training and countermeasures to ensure the safety of all who journey to the ISS.

Private Astronaut Missions↗

NASA NTRS2012

Cargo Commercial Orbital Transportation Services Environmental Control and Life Support Integration

The International Space Station s (ISS) largest crew and cargo resupply vehicle, the Space Shuttle, retired in 2011. To help augment ISS resupply and return capability, NASA announced a project to promote the development of Commercial Orbital Transportation Services (COTS) for the ISS in January of 2006. By December of 2008, NASA entered into space act agreements with SpaceX and Orbital Sciences Corporation for COTS development and ISS Commercial Resupply Services (CRS). The intent of CRS is to fly multiple resupply missions each year to ISS with SpaceX s Dragon vehicle providing resupply and return capabilities and Orbital Science Corporation s Cygnus vehicle providing resupply capability to ISS. The ISS program launched an integration effort to ensure that these new commercial vehicles met the requirements of the ISS vehicle and ISS program needs. The Environmental Control and Life Support System (ECLSS) requirements cover basic cargo vehicle needs including maintaining atmosphere, providing atmosphere circulation, and fire detection and suppression. The ISS-COTS integration effort brought unique challenges combining NASA s established processes and design knowledge with the commercial companies new initiatives and limited experience with human space flight. This paper will discuss the ISS ECLS COTS integration effort including challenges, successes, and lessons learned.

Duchesne, Stephanie↗

NASA NTRS1985

An analysis of the application of AI to the development of intelligent aids for flight crew tasks

This report presents the results of a study aimed at developing a basis for applying artificial intelligence to the flight deck environment of commercial transport aircraft. In particular, the study was comprised of four tasks: (1) analysis of flight crew tasks, (2) survey of the state-of-the-art of relevant artificial intelligence areas, (3) identification of human factors issues relevant to intelligent cockpit aids, and (4) identification of artificial intelligence areas requiring further research.

Baron, S.↗

NASA NTRSDate not supplied

Speech-Enhanced and Context Dependent Alerts: Future Implications for Spacecraft Design Abstract

In the future, NASA missions will involve many different space vehicles, habitats, and surface assets working together to provide safe and productive living and working environments for crew. Because these systems will be provided by multiple commercial companies working with NASA, it will be very different from missions of the past, bringing new challenges. One of the challenges is related to whether NASA should move beyond simple tone annunciation alerting systems, to more advanced systems that include speech. The other is related to determining the level of consistency required of safety-critical alert systems across spacecraft. Two studies were completed to address these important issues. The first study investigated the advantages and disadvantages of a tone+speech alert relative to the traditional tone-only alert. Results indicate that speech-enhanced alerts initially take longer to silence (the default action to which NASA personnel are trained), due to the need to listen to the entire message, but ultimately provided for faster understanding of the alert situation. Speech-enhanced alerts were also preferred by a large majority of crew-like study participants. An unexpected finding from this first study was that participants took longer to respond to tone-only alerts when they were mixed with speech- enhanced alerts. Participants waited to hear the speech message even for alerts they were trained to know did not contain speech components. This performance error is believed to be due to negative transfer of training. A second study focused on task and alert performance using a common set of tones across two contexts (“vehicles”) versus performance with a different set of tones for each context (“vehicle”). Participants were able to manage two different alert sets successfully; results indicate that discriminability of the two alert sets played a major role in their success. Implications for the design of spacecraft alerts are discussed and future areas of research are identified.

alerts↗

NASA NTRS2023

Speech-Enhanced and Context Dependent Alerts: Future Implications for Spacecraft Design

In the future, NASA missions will involve many different space vehicles, habitats, and surface assets working together to provide safe, productive environments for crew. Because these systems will be provided by multiple commercial companies working with NASA, it will be very different from missions of the past, bringing new challenges. One of the challenges is related to whether NASA should move beyond simple tone annunciation alerting systems, to more advanced systems that include speech. The other is related to determining the level of consistency required of safety-critical alert systems across spacecraft. Two studies were completed to address these important issues. The first study investigated the advantages and disadvantages of a tone+speech alert relative to the traditional tone-only alert. Results indicate that speech-enhanced alerts initially take longer to silence (the default action to which NASA personnel are trained), due to the need to listen to the entire message, but ultimately provided for faster understanding of the alert situation. Speech-enhanced alerts were also preferred by a large majority of crew-like study participants. An unexpected finding was that participants took longer to respond to tone-only alerts that were heard in the same session as speech-enhanced alerts. Participants waited to hear a speech message even for alerts they were trained to know did not contain speech components. This performance error is believed to be due to negative transfer of training. A second study focused on task and alert performance using a common set of tones across two contexts (e.g., vehicles, habitats, suits) versus performance with a different set of tones for each context. Participants were able to manage two different alert sets successfully; results indicate that discriminability of the two alert sets played a major role in their success. Implications for the design of spacecraft alerts are discussed, and future areas of research are identified.

alerts↗

NASA NTRS2003

The X-38 Spacecraft Fault-Tolerant Avionics System

In 1995 NASA began an experimental program to develop a reusable crew return vehicle (CRV) for the International Space Station. The purpose of the CRV was threefold: (i) to bring home an injured or ill crewmember; (ii) to bring home the entire crew if the Shuttle fleet was grounded; and (iii) to evacuate the crew in the case of an imminent Station threat (i.e., fire, decompression, etc). Built at the Johnson Space Center, were two approach and landing prototypes and one spacecraft demonstrator (called V201). A series of increasingly complex ground subsystem tests were completed, and eight successful high-altitude drop tests were achieved to prove the design concept. In this program, an unprecedented amount of commercial-off-the-shelf technology was utilized in this first crewed spacecraft NASA has built since the Shuttle program. Unfortunately, in 2002 the program was canceled due to changing Agency priorities. The vehicle was 80% complete and the program was shut down in such a manner as to preserve design, development, test and engineering data. This paper describes the X-38 V201 fault-tolerant avionics system. Based on Draper Laboratory's Byzantine-resilient fault-tolerant parallel processing system and their "network element" hardware, each flight computer exchanges information on a strict timescale to process input data, compare results, and issue voted vehicle output commands. Major accomplishments achieved in this development include: (i) a space qualified two-fault tolerant design using mostly COTS (hardware and operating system); (ii) a single event upset tolerant network element board, (iii) on-the-fly recovery of a failed processor; (iv) use of synched cache; (v) realignment of memory to bring back a failed channel; (vi) flight code automatically generated from the master measurement list; and (vii) built in-house by a team of civil servants and support contractors. This paper will present an overview of the avionics system and the hardware implementation, as well as the system software and vehicle command & telemetry functions. Potential improvements and lessons learned on this program are also discussed.

Kouba,Coy↗

NASA NTRS2010

Commercial Orbital Transportation Cargo Services Environmental Control and Life Support Integration

The International Space Station s (ISS) largest crew and cargo resupply vehicle, the Space Shuttle, will retire in 2011. To help augment ISS resupply and return capability, NASA announced a project to promote the development of Commercial Orbital Transportation Services (COTS) for the ISS in January of 2006. By December of 2008, NASA entered into space act agreements with SpaceX and Orbital Sciences Corporation for COTS development and ISS Commercial Resupply Services (CRS). The intent of CRS is to fly multiple resupply missions each year to ISS with SpaceX s Dragon vehicle providing resupply and return capabilities and Orbital Science Corporation s Cygnus vehicle providing resupply capability to ISS. The ISS program launched an integration effort to ensure that these new commercial vehicles met the requirements of the ISS vehicle and ISS program needs. The Environmental Control and Life Support System (ECLSS) requirements cover basic cargo vehicle needs including maintaining atmosphere, providing atmosphere circulation, and fire detection and suppression. The ISS-COTS integration effort brought unique challenges combining NASA s established processes and design knowledge with the commercial companies new initiatives and limited experience with human space flight. This paper will discuss the ISS ECLS COTS integration effort including challenges, successes, and lessons learned.

Duchesne, Stephanie↗

NASA NTRS1989

Investigation of display issues relevant to the presentation of aircraft fault information

This research, performed as a part of NASA Langley's Faultfinder project, investigated display implementation issues related to the introduction of real time fault diagnostic systems into next generation commercial aircraft. Three major issues were investigated: visual display styles for presenting fault related information to the crew, the form the output from the expert system should take, and methods for filtering fault related information for presentation to the crew. Twenty-four flight familiar male volunteers participated as subjects. Five subjects were NASA test pilots, six were Commercial Airline Pilots, seven were Air Force Lear Jet pilots, and six were NASA personnel familiar with flight (non-pilots). Subjects were presented with aircraft subsystem information on a CRT screen. They were required to identify the subsystems presented in a display and to remember the state (normal or abnormal) of subsystem parameter information contained in the display. The results of the study indicated that in the simpler experimental test cases (i.e., those involving single subsystem failures and composite hypothesis displays) subjects' performance did not differ across the different display formats. However, for the more complex cases (i.e., those involving multiple subsystem faults and multiple hypotheses displays), subjects' performance was superior in the text- and picture-based display formats compared to the symbol-based format. In addition, the findings suggest that a layered approached to information display is appropriate.

Allen, Donald M.↗

NASA NTRS2013

Development Status of the WetLab-2 Project: New Tools for On-orbit Real-time Quantitative Gene Expression.

The primary objective of NASA Ames Research Centers WetLab-2 Project is to place on the ISS a research platform to facilitate gene expression analysis via quantitative real-time PCR (qRT-PCR) of biological specimens grown or cultured on orbit. The WetLab-2 equipment will be capable of processing multiple sample types ranging from microbial cultures to animal tissues dissected on-orbit. In addition to the logistical benefits of in-situ sample processing and analysis, conducting qRT-PCR on-orbit eliminates the confounding effects on gene expression of reentry stresses and shock acting on live cells and organisms. The system can also validate terrestrial analyses of samples returned from ISS by providing quantitative on-orbit gene expression benchmarking prior to sample return. The ability to get on orbit data will provide investigators with the opportunity to adjust experimental parameters for subsequent trials based on the real-time data analysis without need for sample return and re-flight. Finally, WetLab-2 can be used for analysis of air, surface, water, and clinical samples to monitor environmental contaminants and crew health. The verification flight of the instrument is scheduled to launch on SpaceX-5 in Aug. 2014.Progress to date: The WetLab-2 project completed a thorough study of commercially available qRT-PCR systems and performed a downselect based on both scientific and engineering requirements. The selected instrument, the Cepheid SmartCycler, has advantages including modular design (16 independent PCR modules), low power consumption, and rapid ramp times. The SmartCycler has multiplex capabilities, assaying up to four genes of interest in each of the 16 modules. The WetLab-2 team is currently working with Cepheid to modify the unit for housing within an EXPRESS rack locker on the ISS. This will enable the downlink of data to the ground and provide uplink capabilities for programming, commanding, monitoring, and instrument maintenance. The project is currently designing a module that will lyse the cells and extract RNA of sufficient quality for use in qRT-PCR reactions while using a housekeeping gene to normalize RNA concentration and integrity. Current testing focuses on two promising commercial products and chemistries that allow for RNA extraction with minimal complexity and crew time.

quantitative PCR↗