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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 289 records · Page 16
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Interactions between land use, fires, and dust as drivers of global climate change (Final Technical Report)

This award to UC Irvine and Cornell University led to the publication of 18 papers, three of which are highly cited. According to ISI Web of Science, the body of work from this grant has been cited over 476 times by May 2025. Several additional publications remain in review. This grant contributed to several significant science advances, including an improved understanding of the influence of fire aerosols on global photosynthesis (Xu et al., 2021), dust-driven teleconnections between Africa and South America (Li et al., 2021), the role of fire aerosols in triggering phytoplankton blooms in the Arctic (Ardyna et al., 2022), and wildfire responses to heat waves (Li et al., in review). Several other studies are being written up for publication, and will acknowledge funding support. These efforts include an analysis in which the magnitude of tropical fire emissions from land use change is constrained by comparing E3SMv3 simulations with atmospheric observations. This work has revealed that carbon cycle model estimates of land use change may considerably overestimate the global tropical deforestation flux. The project also contributed to several technical advances, including a new process-based and scale-aware desert dust emission scheme for global climate models (Leung et al., 2023), an improved representation of dust and its influence on radiation in E3SM (Feng et al., 2022), an improved representation of the dust parameterization in the Community Earth System Model (Li et al., 2022), and an improved coupling of wildfires with atmospheric chemistry in E3SM v3.

58 GEOSCIENCES↗
NASA NTRS1991

A new self-calibration method applied to TOMS and SBUV backscattered ultraviolet data to determine long-term global ozone change

The currently archived (1989) total ozone mapping spectrometer (TOMS) and solar backscattered ultraviolet (SBUV) total ozone data (version 5) show a global average decrease of about 9.0 percent from November 1978 to November 1988. This large decrease disagrees with an approximate 3.5-percent decrease estimated from the ground-based Dobson network. The primary source of disagreement was found to arise from an overestimate of reflectivity change and its incorrect wavelengths dependence for the diffuse plate used when measuring solar irradiance. Both of these factors have led to an overestimate of the rate of atmospheric ozone depletion by SBUV and TOMS. For total ozone measured by TOMS, a means has been found to use the measured radiance-irradiance ratio from several wavelengths pairs to construct an internally self-consistent calibration. The method uses the wavelength dependence of the sensitivity to calibration errors and the requirement that albedo ratios for each wavelength pair yield the same total ozone amounts. Smaller errors in determining spacecraft attitude, synchronization problems with the photon counting electronics, and sea-glint contamination of boundary reflectivity data have been corrected or minimized. New climatological low-ozone profiles have been incorporated into the TOMS algorithm that are appropriate for Antarctic ozone hole conditions and other low ozone cases. The combined corrections have led to a new determination of the global average total ozone trend (version 6) as a 2.9 + or - 1.3 percent decrease over 11 years (October 1978 to November 1989).

Herman, J. R.↗
NASA NTRS1993

Mission operations update for the restructured Earth Observing System (EOS) mission

The National Aeronautics and Space Administration's (NASA) Earth Observing System (EOS) will provide a comprehensive long term set of observations of the Earth to the Earth science research community. The data will aid in determining global changes caused both naturally and through human interaction. Understanding man's impact on the global environment will allow sound policy decisions to be made to protect our future. EOS is a major component of the Mission to Planet Earth program, which is NASA's contribution to the U.S. Global Change Research Program. EOS consists of numerous instruments on multiple spacecraft and a distributed ground system. The EOS Data and Information System (EOSDIS) is the major ground system developed to support EOS. The EOSDIS will provide EOS spacecraft command and control, data processing, product generation, and data archival and distribution services for EOS spacecraft. Data from EOS instruments on other Earth science missions (e.g., Tropical Rainfall Measuring Mission (TRMM)) will also be processed, distributed, and archived in EOSDIS. The U.S. and various International Partners (IP) (e.g., the European Space Agency (ESA), the Ministry of International Trade and Industry (MITI) of Japan, and the Canadian Space Agency (CSA)) participate in and contribute to the international EOS program. The EOSDIS will also archive processed data from other designated NASA Earth science missions (e.g., UARS) that are under the broad umbrella of Mission to Planet Earth.

Kelly, Angelita Castro↗
NASA NTRS2006

Scalability, Interoperability, and Security at the Data Discovery Level: A System Administrator's Perspective

The Global Change Master Directory (GCMD) has been one of the best known Earth science and global change data discovery online resources throughout its extended operational history. The growing popularity of the system since its introduction on the World Wide Web in 1994 has created an environment where resolving issues of scalability, security, and interoperability have been critical to providing the best available service to the users and partners of the GCMD. Innovative approaches developed at the GCMD in these areas will be presented with a focus on how they relate to current and future GO-ESSP community needs.

Source record↗
NASA NTRS1998

Clouds, Radiation, and Climate from the Earth Observing System

In this presentation, I will present and discuss key areas of scientific uncertainty in understanding climate and global change, focusing on specific examples of how EOS will contribute to improving our understanding of global change. In particular, I will describe how scientists intend to use MODIS, an earth-viewing cross-track scanning spectroradiometer to be flown on the Earth Observing System (EOS) AM-1 satellite to be launched in summer 1998, for the remote sensing of cloud properties. MODIS will scan a swath width sufficient to provide nearly complete global coverage every two days from a polar-orbiting, sun-synchronous, platform at an altitude of 705 km, and will provide images in 36 spectral bands between 0.415 and 14-235 microns with spatial resolutions of 250 m (2 bands), 500 m (5 bands) and 1000 m (29 bands). These bands have been carefully selected to enable advanced studies of land, ocean, and atmosphere processes. As part of this presentation, I will review the various methods that have been developed for the remote sensing of atmospheric properties using MODIS, placing primary emphasis on the principal atmospheric applications of determining the optical, microphysical and physical properties of clouds and aerosol particles from spectral reflection and thermal emission measurements. Additional applications of MODIS data to the determination of precipitable water over land will be described, as will the MODIS cloud mask used to distinguish clouds, clear sky, heavy aerosol, shadows on the ground, and fires. The physical principles behind the determination of each of these atmospheric products will be described, together with an example of their application to aircraft and/or satellite measurements.

King, Michael D.↗
DOE OSTI2024

MSD CoP Webinar: Representing Climate Impacts in Scenaros

Context: This webinar was hosted by the MultiSector Dynamics Community of Practice (MSD CoP; https://multisectordynamics.org). Abstract: Scenarios of future emissions and land use have been most commonly produced without accounting for the effects that climate impacts linked to those emissions and land use changes may have. The questions of how important such impacts could be, at the regional or global scale, has become an increasingly cogent one. Using the Global Change Analysis Model (GCAM), we implement climate impacts on water supply, agricultural productivity, and energy demand driven by climatic impact drivers whose evolution over the 21st century is representative of a climate consistent with GCAM's reference scenario and compare the output to the reference at both regional and global scales. We show that the impacts from the version of GCAM that uses GDP as an exogenous input are not sufficient to bend emission pathways at the global scale. However, we see effects emerge at the regional scale in terms of emissions, among other metrics linked to water, land and energy. We expect the impacts to become more significant at an aggregate, global scale in a forthcoming version of the model with endogenous GDP. Meanwhile, we document the mechanisms that drive the difference at regional scales which could still be significant in their impacts for individual economies and populations. Presenters: Dr. Claudia Tebaldi (Joint Global Change Research Institute, Pacific Northwest National Laboratory) Moderator(s): Jennifer Morris (MSD CoP SSG member), Patrick Reed (MSD CoP Facilitation Team Member, Moderator and Organizer) This webinar was held on: November 5, 2024 from 1 PM - 2:15 PM ET

Climate Scenarios↗
DOE OSTI2021

The future evolution of energy-water-agriculture interconnectivity across the US

Abstract Energy, water, and agricultural resources across the globe are highly interconnected. This interconnectivity poses science challenges, such as understanding and modeling interconnections, as well as practical challenges, such as efficiently managing interdependent resource systems. Using the US as an example, this study seeks to define and explore how interconnectivity evolves over space and time under a range of influences. Concepts from graph theory and input–output analysis are used to visualize and quantify key intersectoral linkages using two new indices: the ‘Interconnectivity Magnitude Index’ and the ‘Interconnectivity Spread Index’. Using the Global Change Analysis Model (GCAM-USA), we explore the future evolution of these indices under four scenarios that explore a range of forces, including socioeconomic and technological change. Analysis is conducted at both national and state level spatial scales from 2015 to 2100. Results from a Reference scenario show that resource interconnectivity in the US is primarily driven by water use amongst different sectors, while changes in interconnectivity are driven by a decoupling of the water and electricity systems, as power plants become more water-efficient over time. High population and GDP growth results in relatively more decoupling of sectors, as a larger share of water and energy is used outside of interconnected sector feedback loops. Lower socioeconomic growth results in the opposite trend. Transitioning to a low-carbon economy increases interconnectivity because of the expansion of purpose-grown biomass, which strengthens the connections between water and energy. The results highlight that while some regions may experience similar sectoral stress projections, the composition of the intersectoral connectivity leading to that sectoral stress may call for distinctly different multi-sector co-management strategies. The methodology we introduce here can be applied in diverse geographical and sectoral contexts to enable better understanding of where, when, and how coupling or decoupling between sectors could evolve and be better managed.

Khan, Zarrar (ORCID:0000000281478553)↗
NASA NTRS2014

Total Volcanic Stratospheric Aerosol Optical Depths and Implications for Global Climate Change

Understanding the cooling effect of recent volcanoes is of particular interest in the context of the post-2000 slowing of the rate of global warming. Satellite observations of aerosol optical depth above 15 km have demonstrated that small-magnitude volcanic eruptions substantially perturb incoming solar radiation. Here we use lidar, Aerosol Robotic Network, and balloon-borne observations to provide evidence that currently available satellite databases neglect substantial amounts of volcanic aerosol between the tropopause and 15 km at middle to high latitudes and therefore underestimate total radiative forcing resulting from the recent eruptions. Incorporating these estimates into a simple climate model, we determine the global volcanic aerosol forcing since 2000 to be 0.19 +/- 0.09W/sq m. This translates into an estimated global cooling of 0.05 to 0.12 C. We conclude that recent volcanic events are responsible for more post-2000 cooling than is implied by satellite databases that neglect volcanic aerosol effects below 15 km.

aerosols↗
NASA NTRS1993

AVIRIS and TIMS data processing and distribution at the land processes distributed active archive center

The U.S. Government has initiated the Global Change Research program, a systematic study of the Earth as a complete system. NASA's contribution of the Global Change Research Program is the Earth Observing System (EOS), a series of orbital sensor platforms and an associated data processing and distribution system. The EOS Data and Information System (EOSDIS) is the archiving, production, and distribution system for data collected by the EOS space segment and uses a multilayer architecture for processing, archiving, and distributing EOS data. The first layer consists of the spacecraft ground stations and processing facilities that receive the raw data from the orbiting platforms and then separate the data by individual sensors. The second layer consists of Distributed Active Archive Centers (DAAC) that process, distribute, and archive the sensor data. The third layer consists of a user science processing network. The EOSDIS is being developed in a phased implementation. The initial phase, Version 0, is a prototype of the operational system. Version 0 activities are based upon existing systems and are designed to provide an EOSDIS-like capability for information management and distribution. An important science support task is the creation of simulated data sets for EOS instruments from precursor aircraft or satellite data. The Land Processes DAAC, at the EROS Data Center (EDC), is responsible for archiving and processing EOS precursor data from airborne instruments such as the Thermal Infrared Multispectral Scanner (TIMS), the Thematic Mapper Simulator (TMS), and Airborne Visible and Infrared Imaging Spectrometer (AVIRIS). AVIRIS, TIMS, and TMS are flown by the NASA-Ames Research Center ARC) on an ER-2. The ER-2 flies at 65000 feet and can carry up to three sensors simultaneously. Most jointly collected data sets are somewhat boresighted and roughly registered. The instrument data are being used to construct data sets that simulate the spectral and spatial characteristics of the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument scheduled to be flown on the first EOS-AM spacecraft. The ASTER is designed to acquire 14 channels of land science data in the visible and near-IR (VNIR), shortwave-IR (SWIR), and thermal-IR (TIR) regions from 0.52 micron to 11.65 micron at high spatial resolutions of 15 m to 90 m. Stereo data will also be acquired in the VNIR region in a single band. The AVIRIS and TMS cover the ASTER VNIR and SWIR bands, and the TIMS covers the TIR bands. Simulated ASTER data sets have been generated over Death Valley, California, Cuprite, Nevada, and the Drum Mountains, Utah using a combination of AVIRIS, TIMS, amd TMS data, and existing digital elevation models (DEM) for the topographic information.

Mah, G. R.↗
NASA NTRS1999

EOS Terra Validation Program

The EOS Terra mission will be launched in July 1999. This mission has great relevance to the atmospheric radiation community and global change issues. Terra instruments include ASTER, CERES, MISR, MODIS and MOPITT. In addition to the fundamental radiance data sets, numerous global science data products will be generated, including various Earth radiation budget, cloud and aerosol parameters, as well as land surface, terrestrial ecology, ocean color, and atmospheric chemistry parameters. Significant investments have been made in on-board calibration to ensure the quality of the radiance observations. A key component of the Terra mission is the validation of the science data products. This is essential for a mission focused on global change issues and the underlying processes. The Terra algorithms have been subject to extensive pre-launch testing with field data whenever possible. Intensive efforts will be made to validate the Terra data products after launch. These include validation of instrument calibration (vicarious calibration) experiments, instrument and cross-platform comparisons, routine collection of high quality correlative data from ground-based networks, such as AERONET, and intensive sites, such as the SGP ARM site, as well as a variety field experiments, cruises, etc. Airborne simulator instruments have been developed for the field experiment and underflight activities including the MODIS Airborne Simulator (MAS), AirMISR, MASTER (MODIS-ASTER), and MOPITT-A. All are integrated on the NASA ER-2, though low altitude platforms are more typically used for MASTER. MATR is an additional sensor used for MOPITT algorithm development and validation. The intensive validation activities planned for the first year of the Terra mission will be described with emphasis on derived geophysical parameters of most relevance to the atmospheric radiation community. Detailed information about the EOS Terra validation Program can be found on the EOS Validation program homepage i/e.: http://ospso.gsfc.nasa.gov/validation/valpage.html).

Starr, David↗
DOE OSTI2024

Indicators of Global Climate Change 2023: annual update of key indicators of the state of the climate system and human influence

Intergovernmental Panel on Climate Change (IPCC) assessments are the trusted source of scientific evidence for climate negotiations taking place under the United Nations Framework Convention on Climate Change (UNFCCC). Evidence-based decision-making needs to be informed by up-to-date and timely information on key indicators of the state of the climate system and of the human influence on the global climate system. However, successive IPCC reports are published at intervals of 5–10 years, creating potential for an information gap between report cycles. We follow methods as close as possible to those used in the IPCC Sixth Assessment Report (AR6) Working Group One (WGI) report. We compile monitoring datasets to produce estimates for key climate indicators related to forcing of the climate system: emissions of greenhouse gases and short-lived climate forcers, greenhouse gas concentrations, radiative forcing, the Earth's energy imbalance, surface temperature changes, warming attributed to human activities, the remaining carbon budget, and estimates of global temperature extremes. The purpose of this effort, grounded in an open-data, open-science approach, is to make annually updated reliable global climate indicators available in the public domain. As they are traceable to IPCC report methods, they can be trusted by all parties involved in UNFCCC negotiations and help convey wider understanding of the latest knowledge of the climate system and its direction of travel. The indicators show that, for the 2014–2023 decade average, observed warming was 1.19 [1.06 to 1.30] °C, of which 1.19 [1.0 to 1.4] °C was human-induced. For the single-year average, human-induced warming reached 1.31 [1.1 to 1.7] °C in 2023 relative to 1850–1900. The best estimate is below the 2023-observed warming record of 1.43 [1.32 to 1.53] °C, indicating a substantial contribution of internal variability in the 2023 record. Human-induced warming has been increasing at a rate that is unprecedented in the instrumental record, reaching 0.26 [0.2–0.4] °C per decade over 2014–2023. This high rate of warming is caused by a combination of net greenhouse gas emissions being at a persistent high of 53±5.4 Gt CO 2 e yr -1 over the last decade, as well as reductions in the strength of aerosol cooling. Despite this, there is evidence that the rate of increase in CO 2 emissions over the last decade has slowed compared to the 2000s, and depending on societal choices, a continued series of these annual updates over the critical 2020s decade could track a change of direction for some of the indicators presented here.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2021

The Response of Precipitation Extremes to the Twentieth- and Twenty-First-Century Global Temperature Change in a Comprehensive Suite of CESM1 Large Ensemble Simulation: Revisiting the Role of Forcing Agents Vs. the Role of Forcing Magnitudes

The response of precipitation extremes (PEs) to global warming is found to be nonlinear in Community Earth System Model version 1 (CESM1) and other global climate models (Pendergrass et al., 2019), which led to the concern that it is not accurate to approximate the response of PE to a single forcing as the difference between simulations with all forcing agents and those that exclude one specific forcing. This calls into question previous model-based results that the sensitivity of PE with warming due to aerosol forcing is significantly larger than that due to greenhouse gases (GHGs). We reevaluate the PE sensitivity to GHGs and aerosols using available CESM1 ensemble simulations. We show that although the PE response to warming is nonlinear in CESM1, especially for the high warming projected in the twenty-first-century, PE sensitivity to aerosols is still significantly stronger than that due to GHGs when the comparison is made within similar warming regimes to avoid the bias induced by the nonlinear behavior. But the difference is smaller than previously estimated. We also conclude that the additivity assumption is largely valid to isolate the PE response due to aerosol forcing from the paired simulations including the “all forcing” experiment when the warming regime is small (e.g., 1°C–2°C in the next few decades when aerosol forcing is projected to decline and becomes a major source of uncertainty for model projection).

58 GEOSCIENCES↗
NASA NTRS1990

The program on radiative inputs of the sun to the Earth (rise)

General concerns about changes in the Earth's climate and in the ozone layer have increased the importance of measuring and understanding variations in the sun's radiative outputs. These outputs appear, for instance, at the top of the list of global change forcing agents in the recent FY-90 document on the U.S. Global Change Program. Significant advances have been made over the past decade in radiometry of the total solar irradiance. Photometry of light variations in stars similar to the sun, but much younger, is providing new insights into the sun's variations in luminosity and UV radiation at previous epochs of interest to paleoclimate studies. Measurement of the sun's 11-year output variability in the ultraviolet and extreme ultraviolet still possess a challenge of great importance. All of these topics are addressed by the program on Radiative Inputs of the Sun to Earth (RISE). RISE is a 5-year program of observations, data analysis, and theory, that has been defined at two workshops held in Boulder, Colorado in November 1987, and in Tucson, Arizona in October 1989. These meetings involved about 60 solar and atmospheric physicists, and stellar astronomers. A proceedings of the 1987 workshop was issued in early 1988. A substantial component of the program, consisting of ground-based observations, data analysis, and theory, is directed at the National Science Foundation (NSF) and the program is seeking a FY-92 funding start at the NSF. RISE also makes recommendations on measurements required from NASA and NOAA satellites.

Foukal, Peter V.↗
DOE OSTI2026

Historical and Future Global Irrigation Energy Consumption by Fuel and Region

Irrigation energy use is a significant component of agricultural production costs, contributing directly to the energy and emissions intensity of crop production and ultimately to food prices. Understanding the existing structure of irrigation energy consumption help achieve food-energy-water security and environmental goals. We present a comprehensive global data set detailing country-level irrigation energy consumption, emphasizing the comparative use of electric, diesel, and emerging solar pumps. To our knowledge, no such data set exists. We draw from a literature review to develop a logistic transformed regression model to estimate the shares of fuel sources for irrigation across countries over historical years to construct a global data set of country-level irrigation energy consumption by multiple fuel sources. Additionally, we compare our estimates of irrigation energy use with agricultural energy use as reported by the International Energy Agency and other external sources. We then use this data to project future irrigation energy use with the Global Change Analysis Model, which is a multisector dynamics model, to showcase the usage of this data set. Projections under the reference scenario show a global shift in fuel types for irrigation pumping, while patterns vary across regions, with India and Pakistan leading in solar-powered irrigation growth and countries like the USA and China continuing to rely primarily on grid electricity. This data set provides a resource to understand the role of irrigation fuel choices within the broader energy sector, as well as the connected agricultural, land use, and water sectors under alternative future scenarios, enabling informed decision making toward efficient agricultural practices.

Global Change Analysis Model (GCAM)↗
DOE OSTI2023

Understanding local plant extinctions before it is too late: bridging evolutionary genomics with global ecology

Understanding evolutionary genomic and population processes within a species range is key to anticipating the extinction of plant species before it is too late. However, most models of biodiversity risk under global change do not account for the genetic variation and local adaptation of different populations. Population diversity is critical to understanding extinction because different populations may be more or less susceptible to global change and, if lost, would reduce the total diversity within a species. Here, two new modeling frameworks advance our understanding of extinction from a population and evolutionary angle: Rapid climate change-driven disruptions in population adaptation are predicted from associations between genomes and local climates. Furthermore, losses of population diversity from global land-use transformations are estimated by scaling relationships of species' genomic diversity with habitat area. Overall, these global eco-evolutionary methods advance the predictability – and possibly the preventability – of the ongoing extinction of plant species.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2005

NASA's Earth Observations of the Global Environment

A birds eye view of the Earth from afar and up close reveals the power and magnificence of the Earth and juxtaposes the simultaneous impacts and powerlessness of humankind. The NASA Electronic Theater presents Earth science observations and visualizations in an historical perspective. Fly in from outer space to Africa and Cape Town. See the latest spectacular images from NASA & NOAA remote sensing missions like Meteosat, TRMM, Landsat 7, and Terra, which will be visualized and explained in the context of global change. See visualizations of global data sets currently available from Earth orbiting satellites, including the Earth at night with its city lights, aerosols from biomass burning in the Middle East and Africa, and retreat of the glaciers on Mt. Kilimanjaro. See the dynamics of vegetation growth and decay over Africa over 17 years. New visualization tools allow us to roam & zoom through massive global mosaic images including Landsat and Terra tours of Africa and South America, showing land use and land cover change from Bolivian highlands. Spectacular new visualizations of the global atmosphere & oceans are shown. See massive dust storms sweeping across Africa and across the Atlantic to the Caribbean and Amazon basin. See ocean vortexes and currents that bring up the nutrients to feed tiny phytoplankton and draw the fish, pant whales and fisher- man. See how the ocean blooms in response to these currents and El Nino/La Nifia. We will illustrate these and other topics with a dynamic theater-style presentation, along with animations of satellite launch deployments and orbital mapping to highlight aspects of Earth observations from space.

King, Michael D.↗
DOE OSTI2026

High-resolution mountain topography can inform global snow vulnerability estimates

Snow is changing globally. Computationally intensive snow reanalysis products and downscaled climate model projections allow for the estimation of historical and projected changes in snow over ∼4–10 km resolutions, but these resolutions are coarse relative to the scales needed for water supply and flood planning. Fine-scale digital elevation models (DEMs) are widely available but are underutilized to make first-order assessments of snow vulnerability. Here, we leverage DEMs at a 7.5 arc s (∼250 m) resolution, combining these with historical freezing level height estimates from ERA-5 to derive estimates of changes in the snow-receiving area (SRA) and its variability across global mountain ranges. Results show estimated SRA declines in 29% (1.9 million km2) of the global mountain area from 1982–2020; 66% of the mountainous areas had no change over the historical period. At +1.5 °C of warming relative to the pre-industrial control, global mountain SRA would decline by 9.5% (1.0 million km2) relative to recent conditions. This loss would be approximately doubled with +2 °C of warming. In a +4 °C warming scenario, an additional 34% (3.6 million km2) of SRA would be lost beyond the +2 °C case. Across individual mountain ranges, SRA losses can occur nonlinearly with warming, with some locations that have historically had relatively minor SRA losses at risk of substantially larger losses in warmer climates. Analysis using coarser-resolution DEMs can underestimate or overestimate SRA and its rate of loss, with the largest impacts in relatively warm, low-elevation mountain ranges. Results of this work provide estimates of projected loss in SRA at policy-relevant warming levels; inform the resolutions needed for process-based snow modeling; identify snow vulnerability hotspots; and provide a new integrated approach to snow vulnerability assessment that is achievable at global scales and highlights potential nonlinearities from recent trends to a variety of future warming scenarios.

climate, mountains↗
DOE OSTI2020

Remodeling of the Histoplasma Capsulatum Membrane Induced by Monoclonal Antibodies

Antibodies play a central role in host immunity by directly inactivating or recognizing an invading pathogen to enhance different immune responses to combat the invader. However, the cellular responses of pathogens to the presence of antibodies are not well-characterized. Here, we used different mass spectrometry techniques to study the cellular responses of the pathogenic fungus Histoplasma capsulatum to monoclonal antibodies (mAb) against HSP60, the surface protein involved in infection. A proteomic analysis of H. capsulatum yeast cells revealed that mAb binding regulates a variety of metabolic and signaling pathways, including fatty acid metabolism, sterol metabolism, MAPK signaling and ubiquitin-mediated proteolysis. The regulation of the fatty acid metabolism was accompanied by increases in the level of polyunsaturated fatty acids, which further augmented the degree of unsaturated lipids in H. capsulatum’s membranes and energy storage lipids, such as triacylglycerols, phosphatidylcholines, phosphatidylethanolamines and phosphatidylinositols. MAb treatment also regulated sterol metabolism by increasing the levels of cholesterol and ergosterol in the cells. We also showed that global changes in the lipid profiles resulted in an increased susceptibility of H. capsulatum to the ergosterol-targeting drug amphotericin B. Overall, our data showed that mAb induction of global changes in the composition of H. capsulatum membranes can potentially impact antifungal treatment during histoplasmosis.

59 BASIC BIOLOGICAL SCIENCES↗